The parasitophorous vacuole nutrient channel is critical for drug access in malaria parasites and modulates the artemisinin resistance fitness cost

Artemisinin-resistant K13 mutations rewire Plasmodium falciparum’s intra-erythrocytic metabolic program to enhance survival

(2021) Sachel Mok et al.   Nature Communications

Amino Acid Metabolism in Apicomplexan Parasites

(2021) Aarti Krishnan et al.   Metabolites

EXP1 is required for organisation of EXP2 in the intraerythrocytic malaria parasite vacuole

(2020) Timothy Nessel et al.   CELLULAR MICROBIOLOGY

A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malaria parasites

(2020) Jakob Birnbaum et al.   SCIENCE

Influence of Plasmodium falciparum Calcium-Dependent Protein Kinase 5 (PfCDPK5) on the Late Schizont Stage Phosphoproteome

(2020) Karin Blomqvist et al.   mSphere

Triple artemisinin-based combination therapies versus artemisinin-based combination therapies for uncomplicated Plasmodium falciparum malaria: a multicentre, open-label, randomised clinical trial

(2020) Rob W van der Pluijm et al.   LANCET

Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda

(2020) Aline Uwimana et al.   NATURE MEDICINE

Endocytosis in Plasmodium and Toxoplasma Parasites

(2020) Tobias Spielmann et al.   TRENDS IN PARASITOLOGY

Artemisinin Resistance and the Unique Selection Pressure of a Short-acting Antimalarial

(2020) David S. Khoury et al.   TRENDS IN PARASITOLOGY

Glutamine reliance in cell metabolism

(2020) Hee Chan Yoo et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Artemisinin susceptibility in the malaria parasite Plasmodium falciparum: propellers, adaptor proteins and the need for cellular healing

(2020) Colin J Sutherland et al.   FEMS MICROBIOLOGY REVIEWS

A comprehensive RNA handling and transcriptomics guide for high-throughput processing of Plasmodium blood-stage samples

(2020) Michal Kucharski et al.   MALARIA JOURNAL

Linking nutrient sensing and gene expression in Plasmodium falciparum blood‐stage parasites

(2020) Manish Kumar et al.   MOLECULAR MICROBIOLOGY

Determinants of dihydroartemisinin-piperaquine treatment failure in Plasmodium falciparum malaria in Cambodia, Thailand, and Vietnam: a prospective clinical, pharmacological, and genetic study

(2019) Rob W van der Pluijm et al.   LANCET INFECTIOUS DISEASES

Deletion of Plasmodium falciparum Protein RON3 Affects the Functional Translocation of Exported Proteins and Glucose Uptake

(2019) Leanne M. Low et al.   mBio

EXP1 is critical for nutrient uptake across the parasitophorous vacuole membrane of malaria parasites

(2019) Paolo Mesén-Ramírez et al.   PLOS BIOLOGY

Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance

(2019) Tuo Yang et al.   Cell Reports

Do fitness costs explain the rapid spread of kelch13-C580Y substitutions conferring artemisinin resistance?

(2018) Shalini Nair et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Plasmepsin II–III copy number accounts for bimodal piperaquine resistance among Cambodian Plasmodium falciparum

(2018) Selina Bopp et al.   Nature Communications

Oxidative stress and protein damage responses mediate artemisinin resistance in malaria parasites

(2018) Frances Rocamora et al.   PLoS Pathogens

Fitness Loss under Amino Acid Starvation in Artemisinin-Resistant Plasmodium falciparum Isolates from Cambodia

(2018) Duangkamon Bunditvorapoom et al.   Scientific Reports

EXP2 is a nutrient-permeable channel in the vacuolar membrane of Plasmodium and is essential for protein export via PTEX

(2018) Matthias Garten et al.   Nature Microbiology

The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background

(2018) Lei Zhu et al.   Nature Communications

Multi-omics Based Identification of Specific Biochemical Changes Associated With PfKelch13-Mutant Artemisinin-Resistant Plasmodium falciparum

(2017) Ghizal Siddiqui et al.   JOURNAL OF INFECTIOUS DISEASES

A genetic system to study Plasmodium falciparum protein function

(2017) Jakob Birnbaum et al.   NATURE METHODS

A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug Piperaquine

(2017) Satish K. Dhingra et al.   mBio

Plasmodium falciparum K13 Mutations Differentially Impact Ozonide Susceptibility and Parasite Fitness In Vitro

(2017) Judith Straimer et al.   mBio

Substrate-analogous inhibitors exert antimalarial action by targeting the Plasmodium lactate transporter PfFNT at nanomolar scale

(2017) André Golldack et al.   PLoS Pathogens

Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis

(2017) Wilson Wong et al.   Nature Microbiology

Stable Translocation Intermediates Jam Global Protein Export in Plasmodium falciparum Parasites and Link the PTEX Component EXP2 with Translocation Activity

(2016) Paolo Mesén-Ramírez et al.   PLoS Pathogens

A Redox-Active Fluorescent pH Indicator for Detecting Plasmodium falciparum Strains with Reduced Responsiveness to Quinoline Antimalarial Drugs

(2016) Mouhamad Jida et al.   ACS Infectious Diseases

Child Stunting is Associated with Low Circulating Essential Amino Acids

(2016) Richard D. Semba et al.   EBioMedicine

Artemisinin-Resistant Plasmodium falciparum Parasites Exhibit Altered Patterns of Development in Infected Erythrocytes

(2015) Amanda Hott et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Evidence of Plasmodium falciparum Malaria Multidrug Resistance to Artemisinin and Piperaquine in Western Cambodia: Dihydroartemisinin-Piperaquine Open-Label Multicenter Clinical Assessment

(2015) Rithea Leang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Plasmodium falciparum dihydroartemisinin-piperaquine failures in Cambodia are associated with mutant K13 parasites presenting high survival rates in novel piperaquine in vitro assays: retrospective and prospective investigations

(2015) Valentine Duru et al.   BMC Medicine

Supergenomic Network Compression and the Discovery of EXP1 as a Glutathione Transferase Inhibited by Artesunate

(2014) Andreas Martin Lisewski et al.   CELL

Dihydroartemisinin–Piperaquine Failure in Cambodia

(2014) David L. Saunders et al.   NEW ENGLAND JOURNAL OF MEDICINE

K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates

(2014) J. Straimer et al.   SCIENCE

Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance

(2014) S. Mok et al.   SCIENCE

Mitochondrial metabolism of sexual and asexual blood stages of the malaria parasite Plasmodium falciparum

(2013) James I MacRae et al.   BMC BIOLOGY

Iron and heme metabolism in Plasmodium falciparum and the mechanism of action of artemisinins

(2013) Nectarios Klonis et al.   CURRENT OPINION IN MICROBIOLOGY

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

(2013) Frédéric Ariey et al.   NATURE

Identification of New PNEPs Indicates a Substantial Non-PEXEL Exportome and Underpins Common Features in Plasmodium falciparum Protein Export

(2013) Arlett Heiber et al.   PLoS Pathogens

Insights into the Role of Heme in the Mechanism of Action of Antimalarials

(2012) Jill M. Combrinck et al.   ACS Chemical Biology

Reduced Artemisinin Susceptibility of Plasmodium falciparum Ring Stages in Western Cambodia

(2012) B. Witkowski et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Molecular make-up of the Plasmodium parasitophorous vacuolar membrane

(2012) Tobias Spielmann et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Artemisinin-resistant Plasmodium falciparum in Pursat province, western Cambodia: a parasite clearance rate study

(2012) Chanaki Amaratunga et al.   LANCET INFECTIOUS DISEASES

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Plasmodium falciparum responds to amino acid starvation by entering into a hibernatory state

(2012) S. E. Babbitt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription

(2011) Sachel Mok et al.   BMC GENOMICS

Ultrastructural and Real-time Microscopic Changes inP. falciparum-infected Red Blood Cells Following Treatment with Antimalarial Drugs

(2011) Navakanit Sachanonta et al.   ULTRASTRUCTURAL PATHOLOGY

Fatty acid transport across the cell membrane: Regulation by fatty acid transporters

(2010) Robert W. Schwenk et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

The Malaria Parasite Cyclic GMP-Dependent Protein Kinase Plays a Central Role in Blood-Stage Schizogony

(2009) Helen M. Taylor et al.   EUKARYOTIC CELL

PfeIK1, a eukaryotic initiation factor 2α kinase of the human malaria parasite Plasmodium falciparum, regulates stress-response to amino-acid starvation

(2009) Clare Fennell et al.   MALARIA JOURNAL

Artemisinin Resistance inPlasmodium falciparumMalaria

(2009) Arjen M. Dondorp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Statistical estimation of cell-cycle progression and lineage commitment in Plasmodium falciparum reveals a homogeneous pattern of transcription in ex vivo culture

(2009) J. E. Lemieux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA