Review
Biochemistry & Molecular Biology
Roxana Carbo, Emma Rodriguez
Summary: Sugar transport through the plasma membrane is a critical event in cellular nutrient transport. Complex systems and diverse protein systems are involved in this process, making it highly regulated and modulated to meet the needs of different types of cells. The deregulation of these systems can lead to diseases, so it is important to study and correct the alterations to promote health. This review highlights the mechanisms of importing valuable sugars for cellular homeostasis and survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Plant Sciences
Simranjeet Singh, Vijay Kumar, Parul Parihar, Daljeet Singh Dhanjal, Rachana Singh, Praveen C. Ramamurthy, Ram Prasad, Joginder Singh
Summary: This article discusses the impact of stress caused by abiotic factors on plant growth and productivity, especially how drought conditions affect plants by disrupting water balance and ion homeostasis. Plants have evolved transportation systems to survive under drought stress, utilizing channels and transporters such as ABA, proteins, and carbohydrates.
PLANT CELL REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Solveig G. Schmidt, Ulrik Gether, Claus J. Loland
Summary: Sodium-coupled neurotransmitter transporters are important in terminating synaptic neurotransmission, and research into their molecular transport mechanisms has been enlightening. Despite their structural differences, studies on neurotransmitter: sodium symporters and excitatory amino acid transporters are crucial in understanding their ion-dependence and transport kinetics. Single-molecule studies have been instrumental in expanding the understanding of protein-level transport across membranes.
NEUROCHEMICAL RESEARCH
(2022)
Article
Physiology
Nedra Abdelli, Alison Ramser, Elizabeth S. Greene, Lesleigh Beer, Travis W. Tabler, Sara K. Orlowski, Jose Francisco Perez, David Sola-Oriol, Nicholas B. Anthony, Sami Dridi
Summary: The study revealed that heat stress affects body weight and the gene expression of nutrient transporters in the jejunum of different broiler populations, showing diverse impacts among populations.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marta Baczewska, Elzbieta Supruniuk, Klaudia Bojczuk, Pawel Guzik, Patrycja Milewska, Katarzyna Kononczuk, Jakub Dobroch, Adrian Chabowski, Pawel Knapp
Summary: The study aimed to assess the dominant energy substrate transport mechanism in ovarian cancer cells and predict clinical outcomes using genomic aberrations. The researchers found differential gene expression in high-grade serous carcinoma and suggested the potential use of glucose and lactate transport as therapeutic targets to impede ovarian cancer growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Liting Zhai, Jonathan Chiu-Chun Chou, Hannah Oo, Laura M. K. Dassama
Summary: Bacterial acquisition of metabolites is facilitated by transporters with unique substrate scopes. The tripartite ATP-independent periplasmic (TRAP) transporters are a large family of bacterial proteins that uptake a variety of small molecules. The T-component, or TatT, is predicted to be a periplasmic-facing lipoprotein that enables the uptake of metabolites from the outer membrane. However, its functional role(s) remained unclear until recently when several homologs with specific preferences for sterols and long-chain fatty acids were identified. These findings suggest that TatTs may represent a new class of bacterial lipid and fatty acid transporters.
Review
Biochemistry & Molecular Biology
Souvik Mukerjee, Abdulaziz S. Saeedan, Mohd Nazam Ansari, Manjari Singh
Summary: Dramatic macromolecule proteins play a crucial role in cellular events, while lipids have gained attention for their impact on cellular function and health. The lipid bilayer P-L-P design forms biological membranes, maintaining balance in the body through communication pathways. Changes in biological membrane composition in diseases like cancer can be addressed with essential dietary fatty acids like omega-3, which regulate cellular composition and membrane fluidity in cancer cells.
Article
Cell Biology
Graham P. Holloway, James G. Nickerson, James S. Lally, Heather L. Petrick, Kaitlyn M. J. H. Dennis, Swati S. Jain, Hakam Alkhateeb, Arend Bonen
Summary: The combined effects of overexpressing plasma membrane fatty acid binding protein (FABPpm) and fatty acid translocase (CD36) on skeletal muscle fatty acid transport were investigated. The results showed that increasing CD36 and FABPpm altered fatty acid transport rates additively but not synergistically, suggesting independent mechanisms of action within muscle for each transporter.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Michiko Yamashita, Udo R. Markert
Summary: This review summarizes the current knowledge of drug transporters in the human placenta, emphasizing the importance for the health of pregnant women and their fetuses in need of drug treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Xiang Wang, Srinivasan Balamurugan, Si-Fen Liu, Chang-Yang Ji, Yu-Hong Liu, Wei-Dong Yang, Liwen Jiang, Hong-Ye Li
Summary: PAP1 enhances cellular growth and biochemical composition in Phaeodactylum tricornutum under organic phosphorus conditions, providing novel insights into phosphorus metabolism in algae.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Plant Sciences
Ewelina Stolarska, Umesh Kumar Tanwar, Yufeng Guan, Magda Grabsztunowicz, Magdalena Arasimowicz-Jelonek, Otto Phanstiel, Ewa Sobieszczuk-Nowicka
Summary: Nitrogen (N) is an expensive nutrient in plant production. Polyamines (PAs) serve as important nitrogen storage compounds in plants. Understanding the molecular characteristics and functions of PA transporters in barley can help improve nitrogen use efficiency and stress response, leading to improved barley production.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Jeffry C. Granados, Anisha K. Nigam, Kevin T. Bush, Neema Jamshidi, Sanjay K. Nigam
Summary: The drug transporter OAT1 plays a role in regulating various lipid classes, as evidenced by metabolic abnormalities in Oat1 knockout mice, supporting its involvement in systemic lipid metabolism.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Wei Tan, Pei Jiang, Wanjun Zhang, Zhaohua Hu, Shaofeng Lin, Lulu Chen, Yingge Li, Changmin Peng, Zhuqing Li, Aihua Sun, Yali Chen, Wenge Zhu, Yu Xue, Yi Yao, Xiangpan Li, Qibin Song, Fuchu He, Weijie Qin, Huadong Pei
Summary: This study demonstrates that the posttranslational modification of SRPK2 by O-GlcNAc plays a key role in regulating de novo lipogenesis by controlling pre-mRNA splicing. O-GlcNAcylation of SRPK2 at a nuclear localization signal and subsequent nuclear import through binding to importin a reveals a general mechanism for protein nuclear import in cells. This work highlights the important role of O-GlcNAc in posttranscriptional regulation and suggests importin a as a reader of an O-GlcNAcylated nuclear localization signal.
Review
Biotechnology & Applied Microbiology
Jose M. Salvador Lopez, Inge N. A. Van Bogaert
Summary: Fatty acid metabolism is well-studied, but fatty acid transport is overlooked; there are important knowledge gaps in understanding how fatty acids cross biological membranes, particularly in microorganisms; identifying fatty acid transporters in microorganisms could lead to new drug targets or improvements in microbial cell factories.
BIOTECHNOLOGY AND BIOENGINEERING
(2021)
Article
Cell Biology
Ertan Kuecueksayan, Anna Sansone, Chryssostomos Chatgilialoglu, Tomris Ozben, Demet Tekeli, Guenel Talibova, Carla Ferreri
Summary: This study assessed the importance of sapienic acid metabolism and signaling cascades in cancer, and found consistent differences among different cell lines. The findings propose a new role of sapienic acid in breast cancer cell metabolism, suggesting potential translational applications for tailored membrane lipid strategies in pharmacological interventions.