GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis
出版年份 2022 全文链接
标题
GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis
作者
关键词
gasdermins, gasdermin B, GSDMB, inflammatory bowel disease, intestinal epithelial cells, epithelial organoids, single-cell profiling, single-cell RNA-seq, GSDMB, genetic polymorphisms, methotrexate, Mtx, platelet-derived growth factor A, PDGFA, focal adhesion kinase, FAK, epithelial restitution and repair, resolution of inflammation
出版物
CELL
Volume 185, Issue 2, Pages 283-298.e17
出版商
Elsevier BV
发表日期
2022-01-11
DOI
10.1016/j.cell.2021.12.024
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- HOXD13 suppresses prostate cancer metastasis and BMP4 ‐induced epithelial‐mesenchymal transition by inhibiting SMAD1
- (2021) Fan Xu et al. INTERNATIONAL JOURNAL OF CANCER
- ZINC40099027 activates human focal adhesion kinase by accelerating the enzymatic activity of the FAK kinase domain
- (2021) Rashmi et al. Pharmacology Research & Perspectives
- Pathogenic ubiquitination of GSDMB inhibits NK cell bactericidal functions
- (2021) Justin M. Hansen et al. CELL
- Methotrexate and its mechanisms of action in inflammatory arthritis
- (2020) Bruce N. Cronstein et al. Nature Reviews Rheumatology
- PHLDA2 regulates EMT and autophagy in colorectal cancer via the PI3K/AKT signaling pathway
- (2020) Zhan Ma et al. Aging-US
- Downregulation of glypican-4 facilitates breast cancer progression by inducing cell migration and proliferation
- (2020) Javaria Munir et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Head-to-head trials in inflammatory bowel disease: past, present and future
- (2020) Lieven Pouillon et al. Nature Reviews Gastroenterology & Hepatology
- Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells
- (2020) Zhiwei Zhou et al. SCIENCE
- Role of GSDMB in Pyroptosis and Cancer
- (2020) Lisha Li et al. Cancer Management and Research
- Genetic analyses identify GSDMB associated with asthma severity, exacerbations, and antiviral pathways
- (2020) Xingnan Li et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Single-cell atlas of colonic CD8+ T cells in ulcerative colitis
- (2020) Daniele Corridoni et al. NATURE MEDICINE
- Role of PDGF-A-Activated ERK Signaling Mediated FAK-Paxillin Interaction in Oligodendrocyte Progenitor Cell Migration
- (2019) Juhi Singh et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- The Crohn’s Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy
- (2019) Subhash Mehto et al. MOLECULAR CELL
- CDX2 inhibits the proliferation and tumor formation of colon cancer cells by suppressing Wnt/β-catenin signaling via transactivation of GSK-3β and Axin2 expression
- (2019) Junhui Yu et al. Cell Death & Disease
- Colonic epithelial cell diversity in health and inflammatory bowel disease
- (2019) Kaushal Parikh et al. NATURE
- Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis
- (2019) W. Vallen Graham et al. NATURE MEDICINE
- LncRNA EPR controls epithelial proliferation by coordinating Cdkn1a transcription and mRNA decay response to TGF-β
- (2019) Martina Rossi et al. Nature Communications
- Epithelial CD47 is critical for mucosal repair in the murine intestine in vivo
- (2019) Michelle Reed et al. Nature Communications
- The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages
- (2018) Charles L. Evavold et al. IMMUNITY
- A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle
- (2018) Michelle M. Stein et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Integrating single-cell transcriptomic data across different conditions, technologies, and species
- (2018) Andrew Butler et al. NATURE BIOTECHNOLOGY
- Cancer-predicting transcriptomic and epigenetic signatures revealed for ulcerative colitis in patient-derived epithelial organoids
- (2018) Samaneh K. Sarvestani et al. Oncotarget
- CD99 at the crossroads of physiology and pathology
- (2018) Michela Pasello et al. Journal of Cell Communication and Signaling
- IL-33 promotes recovery from acute colitis by inducing miR-320 to stimulate epithelial restitution and repair
- (2018) Loris R. Lopetuso et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Adducins inhibit lung cancer cell migration through mechanisms involving regulation of cell-matrix adhesion and cadherin-11 expression
- (2018) Susana Lechuga et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Chondroitin sulfate proteoglycan protein is stimulated by interleukin 11 and promotes endometrial epithelial cancer cell proliferation and migration
- (2017) Amy Winship et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein
- (2017) Kinlin L. Chao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Use of Methotrexate in the Treatment of Inflammatory Bowel Diseases
- (2016) Hans H. Herfarth et al. INFLAMMATORY BOWEL DISEASES
- Pore-forming activity and structural autoinhibition of the gasdermin family
- (2016) Jingjin Ding et al. NATURE
- The intestinal epithelial barrier: a therapeutic target?
- (2016) Matthew A. Odenwald et al. Nature Reviews Gastroenterology & Hepatology
- Emerging pathogenic links between microbiota and the gut–lung axis
- (2016) Kurtis F. Budden et al. NATURE REVIEWS MICROBIOLOGY
- GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation
- (2016) Sudipta Das et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mobilization of epithelial mesenchymal transition genes distinguishes active from inactive lesional tissue in patients with ulcerative colitis
- (2015) Xinmei Zhao et al. HUMAN MOLECULAR GENETICS
- Wound repair: role of immune–epithelial interactions
- (2015) G Leoni et al. Mucosal Immunology
- Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
- (2015) Jianjin Shi et al. NATURE
- limma powers differential expression analyses for RNA-sequencing and microarray studies
- (2015) Matthew E. Ritchie et al. NUCLEIC ACIDS RESEARCH
- FAK and paxillin dynamics at focal adhesions in the protrusions of migrating cells
- (2014) Ying-Li Hu et al. Scientific Reports
- Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics
- (2013) Linn Fagerberg et al. MOLECULAR & CELLULAR PROTEOMICS
- In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture
- (2013) Hiroyuki Miyoshi et al. Nature Protocols
- Genome engineering using the CRISPR-Cas9 system
- (2013) F Ann Ran et al. Nature Protocols
- Rhinovirus Wheezing Illness and Genetic Risk of Childhood-Onset Asthma
- (2013) Minal Çalışkan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Cadherin-17 interacts with α2β1 integrin to regulate cell proliferation and adhesion in colorectal cancer cells causing liver metastasis
- (2013) R A Bartolomé et al. ONCOGENE
- Platelet-derived growth factors and their receptors: Structural and functional perspectives
- (2012) Po-Han Chen et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- STAR: ultrafast universal RNA-seq aligner
- (2012) Alexander Dobin et al. BIOINFORMATICS
- Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease
- (2012) Luke Jostins et al. NATURE
- NIH Image to ImageJ: 25 years of image analysis
- (2012) Caroline A Schneider et al. NATURE METHODS
- clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
- (2012) Guangchuang Yu et al. OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
- Slit-Robo signaling induces malignant transformation through Hakai-mediated E-cadherin degradation during colorectal epithelial cell carcinogenesis
- (2011) Wei-Jie Zhou et al. CELL RESEARCH
- Characterization of intestinal gene expression profiles in Crohnʼs disease by genome-wide microarray analysis
- (2010) Colin L. Noble et al. INFLAMMATORY BOWEL DISEASES
- Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions
- (2010) M. D. Schaller JOURNAL OF CELL SCIENCE
- Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation
- (2010) Cole Trapnell et al. NATURE BIOTECHNOLOGY
- Kif26b, a kinesin family gene, regulates adhesion of the embryonic kidney mesenchyme
- (2010) Y. Uchiyama et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Epithelial-derived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Th1/Th2 driven enteritis
- (2010) Luca Pastorelli et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TGF-β-induced epithelial to mesenchymal transition
- (2009) Jian Xu et al. CELL RESEARCH
- Increased HLA-DMB Expression in the Tumor Epithelium Is Associated with Increased CTL Infiltration and Improved Prognosis in Advanced-Stage Serous Ovarian Cancer
- (2008) M. J. Callahan et al. CLINICAL CANCER RESEARCH
- Distinctive expression and function of fourGSDMfamily genes (GSDMA-D) in normal and malignant upper gastrointestinal epithelium
- (2008) Norihisa Saeki et al. GENES CHROMOSOMES & CANCER
- Caveolin-1 Up-regulation during Epithelial to Mesenchymal Transition Is Mediated by Focal Adhesion Kinase
- (2008) Kelly M. Bailey et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Wound repair and regeneration
- (2008) Geoffrey C. Gurtner et al. NATURE
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