Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein

Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis

(2016) Xin Chen et al.   CELL RESEARCH

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Genetic effects of multiple asthma loci identified by genomewide association studies on asthma and spirometric indices

(2016) Man Fung Tang et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

(2016) Robin A. Aglietti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation

(2016) Sudipta Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of conservedGsdma3self-regulation causes autophagy and cell death

(2015) Peiliang Shi et al.   BIOCHEMICAL JOURNAL

Genetic Basis of Common Human Disease: Insight into the Role of Missense SNPs from Genome-Wide Association Studies

(2015) Lipika R. Pal et al.   JOURNAL OF MOLECULAR BIOLOGY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

IL-13Rα2-bearing, type II NKT cells reactive to sulfatide self-antigen populate the mucosa of ulcerative colitis

(2014) Ivan J Fuss et al.   GUT

Deciphering key features in protein structures with the new ENDscript server

(2014) Xavier Robert et al.   NUCLEIC ACIDS RESEARCH

Gasdermin-B Promotes Invasion and Metastasis in Breast Cancer Cells

(2014) Marta Hergueta-Redondo et al.   PLoS One

Caspase Cleavage Sites in the Human Proteome: CaspDB, a Database of Predicted Substrates

(2014) Sonu Kumar et al.   PLoS One

Expression of GSDML Associates with Tumor Progression in Uterine Cervix Cancer

(2014) Qiao Sun et al.   Translational Oncology

Regulation of integrin αV subunit expression by sulfatide in hepatocellular carcinoma cells

(2013) Wei Wu et al.   JOURNAL OF LIPID RESEARCH

Examination of the relationship between variation at 17q21 and childhood wheeze phenotypes

(2012) Raquel Granell et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Role of sulfatide in normal and pathological cells and tissues

(2012) Tadanobu Takahashi et al.   JOURNAL OF LIPID RESEARCH

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

An integrated map of genetic variation from 1,092 human genomes

(2012)   NATURE

iMOSFLM: a new graphical interface for diffraction-image processing withMOSFLM

(2011) T. Geoff G. Battye et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Genetic association analyses of atopic illness and proinflammatory cytokine genes with type 1 diabetes

(2011) Nada M. Saleh et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Polymorphisms in GSDMA and GSDMB are associated with asthma susceptibility, atopy and BHR

(2011) Jinho Yu et al.   PEDIATRIC PULMONOLOGY

Membrane lipidome of an epithelial cell line

(2011) Julio L. Sampaio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A sequence variant on 17q21 is associated with age at onset and severity of asthma

(2010) Eva Halapi et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Alu-derived cis-element regulates tumorigenesis-dependent gastric expression of GASDERMIN B (GSDMB)

(2010) Hiromitsu Komiyama et al.   GENES & GENETIC SYSTEMS

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

(2010) Eli A Stahl et al.   NATURE GENETICS

A synergistic approach to protein crystallization: Combination of a fixed-arm carrier with surface entropy reduction

(2010) Andrea F. Moon et al.   PROTEIN SCIENCE

Asthma and atopy are associated with chromosome 17q21 markers in Chinese children

(2009) T. F. Leung et al.   ALLERGY

Genetic variation in ORM1-like 3 (ORMDL3) and gasdermin-like (GSDML) and childhood asthma

(2009) H. Wu et al.   ALLERGY

17q12-21 variants interact with smoke exposure as a risk factor for pediatric asthma but are equally associated with early-onset versus late-onset asthma in North Americans of European ancestry

(2009) James H. Flory et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

ORMDL3Gene Is Associated with Asthma in Three Ethnically Diverse Populations

(2008) Joshua Galanter et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Chromosome 17q21 Gene Variants Are Associated with Asthma and Exacerbations but Not Atopy in Early Childhood

(2008) Hans Bisgaard et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Distinctive expression and function of fourGSDMfamily genes (GSDMA-D) in normal and malignant upper gastrointestinal epithelium

(2008) Norihisa Saeki et al.   GENES CHROMOSOMES & CANCER

Effect of 17q21 Variants and Smoking Exposure in Early-Onset Asthma

(2008) Emmanuelle Bouzigon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sulfatides inhibit leukotriene synthesis in human polymorphonuclear granulocytes by a mechanism involving lipid rearrangement in intracellular membranes

(2007) Zoryana V. Grishina et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Differential expression and localisation of gasdermin-like (GSDML), a novel member of the cancer-associated GSDMDC protein family, in neoplastic and non-neoplastic gastric, hepatic, and colon tissues

(2007) Stacy Carl-McGrath et al.   PATHOLOGY