Article
Neurosciences
Bar Richmond-Hacham, Haim Izchak, Tomer Elbaum, Doaa Qubty, Miaad Bader, Vardit Rubovitch, Chaim C. G. Pick
Summary: This study aimed to evaluate the effect of mTBI on cognition in different injury locations and found sex differences in these effects. The results showed that different mTBI impact sites result in dissociable patterns of cognitive deficits, with variations across sexes, time points, and memory domains.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Clinical Neurology
Neha Atulkumar Singh, Nirubol Tosakulwong, Jonathan Graff-Radford, Mary M. Machulda, Nha Trang Thu Pham, Irene Sintini, Stephen D. Weigand, Christopher G. Schwarz, Matthew L. Senjem, Minerva M. Carrasquillo, Nilufer Ertekin-Taner, Clifford R. Jack, Val J. Lowe, Keith A. Josephs, Jennifer L. Whitwell
Summary: APOE epsilon 4 is an important genetic risk factor for typical Alzheimer's disease (AD), but its influence in atypical presentations of AD is not well-known. This study found that APOE epsilon 4 carriers had smaller hippocampal and amygdala volumes and greater tau deposition, while non-carriers showed faster rates of atrophy and tau accumulation in certain brain regions.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Sadhana Ravikumar, Laura E. M. Wisse, Sydney Lim, Ranjit Ittyerah, Long Xie, Madigan L. Bedard, Sandhitsu R. Das, Edward B. Lee, M. Dylan Tisdall, Karthik Prabhakaran, Jacqueline Lane, John A. Detre, Gabor Mizsei, John Q. Trojanowski, John L. Robinson, Theresa Schuck, Murray Grossman, Emilio Artacho-Perula, Maria Mercedes Iniguez de Onzono Martin, Maria Del Mar Arroyo Jimenez, Monica Munoz, Francisco Javier Molina Romero, Maria Del Pilar Marcos Rabal, Sandra Cebada Sanchez, Jose Carlos Delgado Gonzalez, Carlos de la Rosa Prieto, Marta Corcoles Parada, David J. Irwin, David A. Wolk, Ricardo Insausti, Paul A. Yushkevich
Summary: The study revealed a close association between tau neurofibrillary tangle pathology and neurodegeneration in the medial temporal lobe. Significant correlations were found between regional thickness in the entorhinal cortex and stratum radiatum lacunosum moleculare and tau pathology severity, especially in cases with low levels of TDP-43 pathology.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Clinical Neurology
Xiaoqian Niu, Yuye Wang, Xiangfei Zhang, Yu Wang, Wen Shao, Leian Chen, Ziyuan Yang, Dantao Peng
Summary: This study investigated the diagnostic value of qEEG, APOA-I, and APOE e4 allele in aMCI and AD patients, as well as the correlation between qEEG (DTABR) and different cognitive domains. The results showed that DTABR was correlated with MMSE, MoCA, instantaneous memory, and language ability. Significant differences in DTABR were found between AD and NCs, as well as aMCI and NCs. T5 combined with APOA-I and APOE e4 had the highest AUC value (0.889) for AD diagnosis.
NEUROLOGICAL SCIENCES
(2023)
Article
Neurosciences
Daniela J. Palombo, Virginie M. Patt, Renee Hunsberger, Mieke Verfaellie
Summary: A prevailing view in cognitive neuroscience suggests that different forms of learning are mediated by dissociable memory systems; however, growing evidence suggests that the hippocampus may also be important for trial-and-error learning, particularly value or reward-based learning. The study found that patients with hippocampal damage were significantly impaired in a learning task, indicating a role of the hippocampus beyond episodic memory tasks.
Article
Geriatrics & Gerontology
Boung Chul Lee, Young Min Choe, Guk-Hee Suh, Ihn-Geun Choi, Hyun Soo Kim, Jaeuk Hwang, Dahyun Yi, Jin Hyeong Jhoo, Jee Wook Kim
Summary: This study examines the association between ginseng intake and AD-specific cognition in older adults and the moderating effect of APOE4 status. The results suggest that ginseng intake (with high duration and midlife onset) has a beneficial effect on AD-specific cognitive decline, specifically in delayed episodic memory. Furthermore, APOE4 status moderates the association between ginseng intake and AD-specific cognitive decline.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neurosciences
Robin de Flores, Sandhitsu R. Das, Long Xie, Laura E. M. Wisse, Xueying Lyu, Preya Shah, Paul A. Yushkevich, David A. Wolk
Summary: This study reveals the relationship between the medial temporal lobe and the anterior-temporal and posterior-medial networks, and explores the vulnerability of these networks to proteinopathies in Alzheimer's disease. The results show that the atrophy of distinct subregions in the medial temporal lobe propagates differently within the anterior-temporal and posterior-medial networks. Additionally, these networks are differentially associated with relative tau and amyloid burden.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Behavioral Sciences
Elizabeth R. Paitel, Marielle R. Samii, Kristy A. Nielson
Summary: This systematic review suggests that event-related potentials (ERPs) may be able to detect early signs of neurodegenerative diseases, particularly in the diagnosis and prediction of Alzheimer's disease (AD).
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Cell Biology
Alexander M. Kulminski, Ethan Jain-Washburn, Elena Loiko, Yury Loika, Fan Feng, Irina Culminskaya, Alzheimer's Disease Neuroimaging Initiative Alzheimers Dis Neuroimaging Initiative
Summary: This study examined the associations of APOE alleles and polygenic profiles with cerebrospinal fluid and plasma biomarkers, revealing differential effects of specific alleles on different biomarkers.
Article
Geriatrics & Gerontology
Jiao-Jiao Ren, Pei-Dong Zhang, Zhi-Hao Li, Xi-Ru Zhang, Wen-Fang Zhong, Pei-Liang Chen, Qing-Mei Huang, Xiao-Meng Wang, Ping-Ming Gao, Chen Mao
Summary: This study investigated the combined relationship between night shifts and unhealthy lifestyle risks with incident dementia and found that the combination of night shifts and unhealthy lifestyle factors increased the risk of dementia. The combined impact was greater than the individual effects of each factor, suggesting that a healthy lifestyle could prevent most cases of dementia, with greater benefits for night shift workers.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Rebecca Piccarducci, Chiara Giacomelli, Maria Sofia Bertilacchi, Andrea Benito-Martinez, Nicoletta Di Giorgi, Simona Daniele, Giovanni Signore, Silvia Rocchiccioli, Marcal Vilar, Laura Marchetti, Claudia Martini
Summary: The ApoE epsilon 4 polymorphic variant is a major risk factor for Alzheimer's Disease (AD) due to its effects on cholesterol metabolism and cholinergic pathway impairment. In this study, in vitro cholinergic neuron models were used to investigate the interplay between ApoE epsilon 4-related cholesterol metabolism dysregulation and cholinergic system degeneration. The results showed that ApoE epsilon 4 expression led to intracellular cholesterol accumulation and reduced acetylcholine synthesis, resulting in cholinergic pathway impairment and neuronal death.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Clinical Neurology
Paul A. Yushkevich, Monica Munoz Lopez, Maria Mercedes Iniguez de Onzono Martin, Ranjit Ittyerah, Sydney Lim, Sadhana Ravikumar, Madigan L. Bedard, Stephen Pickup, Weixia Liu, Jiancong Wang, Ling Yu Hung, Jade Lasserve, Nicolas Vergnet, Long Xie, Mengjin Dong, Salena Cui, Lauren McCollum, John L. Robinson, Theresa Schuck, Robin de Flores, Murray Grossman, M. Dylan Tisdall, Karthik Prabhakaran, Gabor Mizsei, Sandhitsu R. Das, Emilio Artacho-Perula, Mari'a Del Mar Arroyo Jimenez, Mari'a Pilar Marcos Raba, Francisco Javier Molina Romero, Sandra Cebada Sanchez, Jose Carlos Delgado Gonzalez, Carlos De la Rosa-Prieto, Marta Corcoles Parada, Edward B. Lee, John Q. Trojanowski, Daniel T. Ohm, Laura E. M. Wisse, David A. Wolk, David J. Irwin, Ricardo Insausti
Summary: This study utilized ex vivo MRI and dense serial histological imaging to construct three-dimensional quantitative maps of neurofibrillary tangle burden in the medial temporal lobe, revealing significant variation along different anatomical regions. The findings provide valuable insights into the distribution of this neurodegenerative pathology and may support the development and validation of neuroimaging biomarkers.
Article
Clinical Neurology
Andreas Giannisis, Asma Al-Grety, Henrik Carlsson, Kalicharan Patra, Daniel Twohig, Sigrid Botne Sando, Camilla Lauridsen, Guro Berge, Goril Rolfseng Grontvedt, Geir Brathen, Linda R. White, Kim Kultima, Henrietta M. Nielsen
Summary: This study found important associations between low plasma apoE levels and increased risk of Alzheimer's disease (AD), as well as progression from mild cognitive impairment to a clinical AD diagnosis.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Nutrition & Dietetics
Aline Thomas, Cecile Proust-Lima, Marion Baillet, Catherine Helmer, Cecile Delcourt, Alexandra Foubert-Samier, Gwenaelle Catheline, Catherine Feart, Cecilia Samieri
Summary: This study found that an increase in plasma levels of total carotenoids and beta-carotene was associated with a smaller annual loss of medial temporal lobe volume, suggesting a potential beneficial role of carotenoids in preventing age-related neurodegeneration.
CLINICAL NUTRITION
(2021)
Article
Neurosciences
Jenna N. Adams, Anne Maass, David Berron, Theresa M. Harrison, Suzanne L. Baker, Wesley P. Thomas, Morgan Stanfill, William J. Jagust
Summary: Tau deposition in aging and Alzheimer's disease affects medial temporal lobe (MTL) neural function, impacting repetition suppression. Different levels of tau pathology are associated with activity changes in distinct MTL subregions, with high tau pathology leading to widespread neural dysfunction.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Sang Won Seo, Marie-Pierre Thibodeau, David C. Perry, Alice Hua, Manu Sidhu, Isabel Sible, Jose Norberto S. Vargas, Stephanie E. Gaus, Gil D. Rabinovici, Katherine D. Rankin, Adam L. Boxer, Joel H. Kramer, Howard J. Rosen, Maria Luisa Gorno-Tempini, Lea T. Grinberg, Eric J. Huang, Stephen J. DeArmond, John Q. Trojanowski, Bruce L. Miller, William W. Seeley
Article
Clinical Neurology
Alice Y. Hua, Isabel J. Sible, David C. Perry, Katherine P. Rankin, Joel H. Kramer, Bruce L. Miller, Howard J. Rosen, Virginia E. Sturm
FRONTIERS IN NEUROLOGY
(2018)
Article
Neurosciences
Jesse A. Brown, Jersey Deng, John Neuhaus, Isabel J. Sible, Ana C. Sias, Suzee E. Lee, John Kornak, Gabe A. Marx, Anna M. Karydas, Salvatore Spina, Lea T. Grinberg, Giovanni Coppola, Dan H. Geschwind, Joel H. Kramer, Maria Luisa Gorno-Tempini, Bruce L. Miller, Howard J. Rosen, William W. Seeley
Article
Neurosciences
Isabel J. Sible, Daniel A. Nation
JOURNAL OF ALZHEIMERS DISEASE
(2020)
Article
Behavioral Sciences
Virginia E. Sturm, Ashlin R. K. Roy, Samir Datta, Cheng Wang, Isabel J. Sible, Sarah R. Holley, Christa Watson, Eleanor R. Palser, Nathaniel A. Morris, Giovanni Battistella, Esther Rah, Marita Meyer, Mikhail Pakvasa, Maria Luisa Mandelli, Jessica Deleon, Fumiko Hoeft, Eduardo Caverzasi, Zachary A. Miller, Kevin A. Shapiro, Robert Hendren, Bruce L. Miller, Maria Luisa Gorno-Tempini
Summary: The study found that children with dyslexia exhibit heightened emotional reactivity, stronger connectivity, better social skills, and higher levels of anxiety and depression compared to children without dyslexia.
Article
Geriatrics & Gerontology
Isabel J. Sible, Belinda Yew, Shubir Dutt, Katherine J. Bangen, Yanrong Li, Daniel A. Nation
Summary: Research shows that increased blood pressure variability in older adults is associated with a decline in regional cerebral perfusion, potentially serving as an early marker of vascular dysfunction in aging.
NEUROBIOLOGY OF AGING
(2021)
Article
Neurosciences
Isabel J. Sible, Katherine J. Bangen, Anna E. Blanken, Jean K. Ho, Daniel A. Nation
Summary: Elevated blood pressure variability is associated with postmortem cerebrovascular lesion burden in autopsy-confirmed AD, independent of average blood pressure and AD neuropathology. Blood pressure fluctuation may selectively promote specific cerebrovascular lesions, with potential implications for cognitive impairment and dementia.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Geriatrics & Gerontology
Belinda Yew, Jung Yun Jang, Shubir Dutt, Yanrong Li, Isabel J. Sible, Aimee Gaubert, Jean K. Ho, Anna E. Blanken, Anisa Marshall, Xingfeng Shao, Danny J. J. Wang, Daniel A. Nation
Summary: This study compared cerebrovascular reactivity (CVR) in cognitively unimpaired older adults and younger adults. The results showed that older adults had lower levels of global CVR under both hypercapnia and hypocapnia compared to younger adults. Region-of-interest analyses revealed attenuated CVR to hypocapnia in select frontal and temporal regions, and lower CVR to hypercapnia in all cortical, limbic, and subcortical regions examined in older adults compared to younger adults. The findings suggest age-related deficits in CVR, especially in vasodilatory responses, even in cognitively unimpaired older adults.
NEUROBIOLOGY OF AGING
(2022)
Article
Geriatrics & Gerontology
Arunima Kapoor, Aimee Gaubert, Anisa Marshall, Irene B. Meier, Belinda Yew, Jean K. Ho, Anna E. Blanken, Shubir Dutt, Isabel J. Sible, Yanrong Li, Jung Yun Jang, Adam M. Brickman, Kathleen Rodgers, Daniel A. Nation
Summary: The study found that elevated levels of circulating EPCs and VEGF-D are associated with greater cerebral SVD burden in older adults. This suggests that activation of systemic angiogenic growth factors and EPCs may represent an early attempt to rescue the vascular endothelium and repair damage in SVD.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Peripheral Vascular Disease
Isabel J. Sible, Daniel A. Nation
Summary: This study found that blood pressure variability (BPV) in older adults is related to tau accumulation in brain regions vulnerable to Alzheimer's disease, independent of average blood pressure levels. The relationship is modified by APOE ε4 carrier status. BPV may serve as a marker of vascular dysfunction contributing to early-stage tau pathology in Alzheimer's disease.
Article
Clinical Neurology
Isabel J. Sible, Daniel A. Nation
Summary: This study found that elevated blood pressure variability in older adults may be associated with increased CSF phosphorylated tau and total tau levels, as well as decreased beta-amyloid levels over time. The relationship between blood pressure variability and CSF phosphorylated tau may be moderated by APOE epsilon 4 carrier status.
Article
Psychology, Experimental
Virginia E. Sturm, Samir Datta, Ashlin R. K. Roy, Isabel J. Sible, Eena L. Kosik, Christina R. Veziris, Tiffany E. Chow, Nathaniel A. Morris, John Neuhaus, Joel H. Kramer, Bruce L. Miller, Sarah R. Holley, Dacher Keltner
Summary: Aging into later life often leads to social disconnection, anxiety, and sadness. This study shows that cultivating the emotion of awe can reduce self-focus, promote social connection, and foster prosocial actions. A novel awe walk intervention for healthy older adults resulted in increased feelings of awe, joy, and prosocial positive emotions during the walks, as well as decreased distress in daily life. This suggests that cultivating awe can enhance positive emotions and diminish negative emotions in older adults.
Article
Behavioral Sciences
Suzanne M. Shdo, Ashlin R. K. Roy, Samir Datta, Isabel J. Sible, Sladjana Lukic, David C. Perry, Katherine P. Rankin, Joel H. Kramer, Howard J. Rosen, Bruce L. Miller, William W. Seeley, Sarah R. Holley, Maria L. Gorno-Tempini, Virginia E. Sturm
Summary: This study investigated whether positive emotional reactivity was enhanced in patients with semantic variant primary progressive aphasia (svPPA), and found that they showed elevated positive emotional experience and smiling in response to various affective and non-affective stimuli. Voxel-based morphometry analyses revealed that these enhancements were associated with smaller gray matter volume in the left superior temporal gyrus.
Article
Cardiac & Cardiovascular Systems
Isabel J. Sible, Daniel A. Nation
Summary: Blood pressure variability (BPV) is associated with cerebral blood flow (CBF) decline, especially under standard blood pressure-lowering strategies. However, the relationship between BPV and CBF in samples with strictly controlled blood pressure remains understudied. This study found that higher BPV in the standard treatment group was associated with CBF decline in all regions, particularly in medial temporal regions. In the intensive treatment group, elevated BPV was related to CBF decline only in the hippocampus.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)