Development of novel indolin-2-one derivative incorporating thiazole moiety as DHFR and quorum sensing inhibitors: Synthesis, antimicrobial, and antibiofilm activities with molecular modelling study
出版年份 2021 全文链接
标题
Development of novel indolin-2-one derivative incorporating thiazole moiety as DHFR and quorum sensing inhibitors: Synthesis, antimicrobial, and antibiofilm activities with molecular modelling study
作者
关键词
Indoline-2,3-dione, Antimicrobial activity and SAR study, Antibiofilm activity, Quorum sensing inhibitors, Dihydrofolate reductase, Drug combination, DFT, Molecular docking, Toxicity prediction
出版物
BIOORGANIC CHEMISTRY
Volume 119, Issue -, Pages 105571
出版商
Elsevier BV
发表日期
2021-12-21
DOI
10.1016/j.bioorg.2021.105571
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- An Overview of the Synthesis and Antimicrobial, Antiprotozoal, and Antitumor Activity of Thiazole and Bisthiazole Derivatives
- (2021) Anca-Maria Borcea et al. MOLECULES
- Novel Structural hybrids of quinolone and thiazole moieties: Synthesis and evaluation of antibacterial and antifungal activities with molecular modeling studies
- (2021) Sally I. Eissa et al. BIOORGANIC CHEMISTRY
- Development of adamantane scaffold containing 1,3,4-thiadiazole derivatives: design, synthesis, anti-proliferative activity and molecular docking study targeting EGFR
- (2021) Mohammed M. S. Wassel et al. BIOORGANIC CHEMISTRY
- 5-Substituted isatin thiosemicarbazones as inhibitors of tyrosinase: Insights of substituent effects
- (2021) Run Cheng et al. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
- Does Fluoroquinolones and Third-Generation Cephalosporins Restriction Reverse Extended-Spectrum β-Lactamases Klebsiella pneumoniae Resistance Rates?
- (2021) Mirjana Stanić Benić et al. Microbial Drug Resistance
- Isatin-derived azoles as new potential antimicrobial agents: Design, synthesis and biological evaluation
- (2021) Vijai Kumar Reddy Tangadanchu et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Design, synthesis of new magenta dyestuffs based on thiazole azomethine disperse reactive dyes with antibacterial potential on both dyes and gamma-irradiated dyed fabric
- (2021) Seham A. Ibrahim et al. DYES AND PIGMENTS
- UPLC-ESI-MS/MS profiling of the underground parts of common Iris species in relation to their anti-virulence activities against Staphylococcus aureus
- (2021) Mona M. Okba et al. JOURNAL OF ETHNOPHARMACOLOGY
- Design, synthesis, antiproliferative evaluation, and molecular docking study of new quinoxaline derivatives as apoptotic inducers and EGFR inhibitors
- (2021) Eman A. Fayed et al. JOURNAL OF MOLECULAR STRUCTURE
- HPLC-PDA-ESI-MS/MS Profiling and Anti-Biofilm Potential of Eucalyptussideroxylon Flowers
- (2021) Mona M. Okba et al. Antibiotics-Basel
- In vivo screening and toxicity studies of indolinone incorporated thiosemicarbazone, thiazole and piperidinosulfonyl moieties as anticonvulsant agents
- (2021) Eman A. Fayed et al. BIOORGANIC CHEMISTRY
- Hydrazonoyl bromide precursors as DHFR inhibitors for the synthesis of bis-thiazolyl pyrazole derivatives; antimicrobial activities, antibiofilm, and drug combination studies against MRSA
- (2021) Seham A. Ibrahim et al. BIOORGANIC CHEMISTRY
- Novel benzenesulfonamides aryl and arylsulfone conjugates adopting tail/dual tail approaches: Synthesis, carbonic anhydrase inhibitory activity and molecular modeling studies
- (2021) Assem H. Eldeeb et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of metal-based complexes as promising antimicrobial agents
- (2021) Jing Liang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Therapeutic strategies for Covid-19 based on molecular docking and dynamic studies to the ACE-2 receptors, Furin, and viral spike proteins
- (2021) Essam S. A. E. H. Khattab et al. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
- One-pot strategy for thiazole tethered 7-ethoxy quinoline hybrids: Synthesis and potential antimicrobial agents as dihydrofolate reductase (DHFR) inhibitors with molecular docking study
- (2021) Yousry A. Ammar et al. JOURNAL OF MOLECULAR STRUCTURE
- Experimental and theoretical investigation for 6-Morpholinosulfonylquinoxalin-2(1H)-one and its haydrazone derivate: Synthesis, characterization, tautomerization and antimicrobial evaluation
- (2021) Doaa M. Elsisi et al. JOURNAL OF MOLECULAR STRUCTURE
- Design, synthesis of new novel quinoxalin-2(1H)-one derivatives incorporating hydrazone, hydrazine, and pyrazole moieties as antimicrobial potential with in-silico ADME and molecular docking simulation
- (2021) Ahmed Ragab et al. Arabian Journal of Chemistry
- Design, synthesis, in vitro antimicrobial evaluation and molecular docking studies of indol-2-one tagged with morpholinosulfonyl moiety as DNA gyrase inhibitors
- (2020) Mohamed A. Salem et al. BIOORGANIC CHEMISTRY
- The Lancet Infectious Diseases Commission on antimicrobial resistance: 6 years later
- (2020) Ramanan Laxminarayan et al. LANCET INFECTIOUS DISEASES
- Design, synthesis, biological evaluation and molecular docking study based on novel fused pyrazolothiazole scaffold
- (2020) Hala F. Rizk et al. Journal of the Iranian Chemical Society
- Resisting antimicrobial resistance
- (2020) Carl Nathan NATURE REVIEWS MICROBIOLOGY
- The rational design, synthesis, and antimicrobial investigation of 2-Amino-4-Methylthiazole analogues inhibitors of GlcN-6-P synthase
- (2020) Abdelsattar M. Omar et al. BIOORGANIC CHEMISTRY
- Antimicrobial evaluation of thiadiazino and thiazolo quinoxaline hybrids as potential DNA gyrase inhibitors; design, synthesis, characterization and morphological studies
- (2020) Yousry A. Ammar et al. BIOORGANIC CHEMISTRY
- In vitro cytotoxic activity of thiazole-indenoquinoxaline hybrids as apoptotic agents, design, synthesis, physicochemical and pharmacokinetic studies
- (2020) Eman A. Fayed et al. BIOORGANIC CHEMISTRY
- Discovery of New Schiff Bases Tethered Pyrazole Moiety: Design, Synthesis, Biological Evaluation, and Molecular Docking Study as Dual Targeting DHFR/DNA Gyrase Inhibitors with Immunomodulatory Activity
- (2020) Ashraf S. Hassan et al. MOLECULES
- Transmission of Antibiotic Resistant Bacteria and Genes: Unveiling the Jigsaw Pieces of a One Health Problem
- (2020) Carla Novais et al. Pathogens
- New pyrazole‐4‐carbothioamide‐based metal complexes: Synthesis, spectral characterization, computational, antimicrobial, and antitumor investigations
- (2020) Ahmed M. Ramadan et al. APPLIED ORGANOMETALLIC CHEMISTRY
- Determination of potential inhibitors based on isatin derivatives against SARS-CoV-2 main protease (mpro): a molecular docking, molecular dynamics and structure-activity relationship studies
- (2020) Vishnu Nayak Badavath et al. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
- Thiazole Analogues of the Marine Alkaloid Nortopsentin as Inhibitors of Bacterial Biofilm Formation
- (2020) Anna Carbone et al. MOLECULES
- Novel Schiff base-bridged multi-component sulfonamide imidazole hybrids as potentially highly selective DNA-targeting membrane active repressors against methicillin-resistant Staphylococcus aureus
- (2020) Yuanyuan Hu et al. BIOORGANIC CHEMISTRY
- First Evidence of the Cysteine and Glutathione Conjugates of 3-Sulfanylpentan-1-ol in Hop (Humulus lupulus L.)
- (2019) Cécile Chenot et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Design, synthesis, molecular docking and biological activity evaluation of some novel indole derivatives as potent anticancer active agents and apoptosis inducers
- (2019) Ahmed M. Sh. El-Sharief et al. BIOORGANIC CHEMISTRY
- Biofilms: Novel Strategies Based on Antimicrobial Peptides
- (2019) Emilia Galdiero et al. Pharmaceutics
- Synthesis, antimicrobial activity, and determination of the lipophilicity of ((cyclohex-3-enylmethylene)hydrazinyl)thiazole derivatives
- (2019) Anna Biernasiuk et al. MEDICINAL CHEMISTRY RESEARCH
- Nanoparticle–Biofilm Interactions: The Role of the EPS Matrix
- (2019) Stephanie Fulaz et al. TRENDS IN MICROBIOLOGY
- Crisis of Antimicrobial Resistance in China: Now and the Future
- (2019) Junyan Qu et al. Frontiers in Microbiology
- A new exploration towards aminothiazolquinolone oximes as potentially multi-targeting antibacterial agents: Design, synthesis and evaluation acting on microbes, DNA, HSA and topoisomerase IV
- (2019) Liang-Liang Wang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Design, synthesis and biological evaluation of novel diazaspiro[4.5]decan-1-one derivatives as potential chitin synthase inhibitors and antifungal agents
- (2019) Bing Li et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Antibacterial, antibiofilm and molecular modeling study of some antitumor thiazole based chalcones as a new class of DHFR inhibitors
- (2019) Waad D. Alrohily et al. MICROBIAL PATHOGENESIS
- One-pot synthesis and molecular docking of some new spiropyranindol-2-one derivatives as immunomodulatory agents and in vitro antimicrobial potential with DNA gyrase inhibitor
- (2019) Mohamed A. Salem et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Investigation of photophysical behaviours and antimicrobial activity of novel benzo-15-crown-5 substituted coumarin and chromone derivatives
- (2019) Duygu Şahin Gül et al. JOURNAL OF MOLECULAR STRUCTURE
- Design, synthesis, antiproliferative activity, molecular docking and cell cycle analysis of some novel (morpholinosulfonyl) isatins with potential EGFR inhibitory activity
- (2018) Yousry A. Ammar et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Antimicrobial peptides and their interaction with biofilms of medically relevant bacteria
- (2016) Giovanna Batoni et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Antitumor and immunomodulatory activities of thiosemicarbazones and 1,3-Thiazoles in Jurkat and HT-29 cells
- (2016) Thiago André R. dos Santos et al. BIOMEDICINE & PHARMACOTHERAPY
- New Imidazolidineiminothione, Imidazolidin-2-one and Imidazoquinoxaline Derivatives: Synthesis and Evaluation of Antibacterial and Antifungal Activities
- (2016) Yousry A. Ammar et al. CURRENT ORGANIC SYNTHESIS
- Synthesis and anti-cancer activity evaluation of 5-(2-carboxyethenyl)-isatin derivatives
- (2016) Yu-Ou Teng et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- New 1,3-diaryl-5-thioxo-imidazolidin-2,4-dione derivatives: synthesis, reactions and evaluation of antibacterial and antifungal activities
- (2016) Marwa A.M.Sh. El-Sharief et al. ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES
- Recent applications of 1,3-thiazole core structure in the identification of new lead compounds and drug discovery
- (2015) Adile Ayati et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of acylurea isosteres of 2-acylaminothiadiazole in the azaxanthene series of glucocorticoid receptor agonists
- (2014) Hua Gong et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Recent Progress on Routes to Spirooxindole Systems Derived from Isatin
- (2013) Min Xia et al. JOURNAL OF HETEROCYCLIC CHEMISTRY
- Enhanced bactericidal action of SnO2 nanostructures having different morphologies under visible light: Influence of surfactant
- (2013) Nasrin Talebian et al. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
- Isatins As Privileged Molecules in Design and Synthesis of Spiro-Fused Cyclic Frameworks
- (2012) Girija S. Singh et al. CHEMICAL REVIEWS
- Design, synthesis and in vitro evaluation of tetrahydropyrimidine–isatin hybrids as potential antitubercular and antimalarial agents
- (2012) Tarunkumar Nanjibhai Akhaja et al. CHINESE CHEMICAL LETTERS
- Strategies for the enantioselective synthesis of spirooxindoles
- (2012) Nicolas R. Ball-Jones et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Synthesis of mono, bis-2-(2-arylideneaminophenyl) indole azomethines as potential antimicrobial agents
- (2011) Rondla Rohini et al. ARCHIVES OF PHARMACAL RESEARCH
- Novel Orally Active Antimalarial Thiazoles
- (2011) Diego González Cabrera et al. JOURNAL OF MEDICINAL CHEMISTRY
- Inhibition of monoamine oxidase by selected C5- and C6-substituted isatin analogues
- (2010) Clarina I. Manley-King et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Synthesis, anti-bacterial and anti-fungal activities of some novel Schiff bases containing 2,4-disubstituted thiazole ring
- (2009) S.K. Bharti et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation