期刊
BIOMATERIALS
卷 279, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2021.121227
关键词
Aggregation-induced emission; Self-reporting; Photodynamic therapy; Bacteria killing; Keratitis treatment
资金
- National Nat-ural Science Foundation of China [21788102, 22002137]
- Research Grants Council of Hong Kong [16306620, C6009-17G, N-HKUST609/19, C6014-20W]
- Innovation and Technology Com-mission [ITC-CNERC14SC01, ITC.PD/17-9]
- Natural Science Foundation of Jiangsu Province [BK20200920]
- China Postdoctoral Science Foundation [2020M671680]
- Zhejiang National Nature Science Foundation [LQ21H120008]
IQ-Cm is a cationic diphenyl luminogen with aggregation-induced emission, which shows potential applications in BK theranostic study. It can rapidly discriminate live and dead bacteria by visual emission colors, and exhibits excellent antibacterial activity against bacteria.
Bacterial keratitis (BK) is one of the most commonly leading causes of visual impairment and blindness worldwide, and suffers the risk of drug-resistant infections due to the abuse of antibiotics. Herein, we report a cationic diphenyl luminogen with aggregation-induced emission called IQ-Cm containing isoquinolinium and coumarin units for theranostic study of BK. IQ-Cm has no obvious cytotoxicity to mammalian cells below a certain concentration, and could preferentially bind to bacteria over mammalian cells. IQ-Cm can be used as a sensitive self-reporting probe to rapidly discriminate live and dead bacteria by the visual emission colors. The intrinsic dark toxicity to bacteria and generation of reactive oxygen species under light irradiation endow IQ-Cm with excellent antibacterial activity in vitro and in BK rabbit models infected with S. aureus. The present study provides a sensitive and efficient theranostic strategy for rapid discrimination of various bacterial states and the combined treatment of BK based on the intrinsic dark antibacterial activity and photodynamic therapy effect.
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