4.8 Article

Large-scale cultured meat production: Trends, challenges and promising biomanufacturing technologies

期刊

BIOMATERIALS
卷 280, 期 -, 页码 -

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ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2021.121274

关键词

Cultured meat; Alternative protein; Biomanufacturing; Bioprocess design

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This paper analyzes the challenges facing the future food systems and presents the technologies needed for cell-based meat production and the obstacles to reaching commercial scale. It also explores the potential opportunities and factors influencing the success of cultured meat as a protein alternative.
Food systems of the future will need to face an increasingly clear reality - that a protein-rich diet is essential for good health, but traditional meat products will not suffice to ensure safety, sustainability, and equity of food supply chains at a global scale. This paper provides an in-depth analysis of bioprocess technologies needed for cell-based meat production and challenges in reaching commercial scale. Specifically, it reviews state-of-the-art bioprocess technologies, current limitations, and opportunities for research across four domains: cell line development, cell culture media, scaffolding, and bioreactors. This also includes exploring innovations to make cultured meat a viable protein alternative across numerous key performance indicators and for specific applications where traditional livestock is not an option (e.g., local production, space exploration). The paper explores tradeoffs between production scale, product quality, production cost, and footprint over different time horizons. Finally, a discussion explores various factors that may impact the ability to successfully scale and market cultured meat products: social acceptance, environmental tradeoffs, regulatory guidance, and public health benefits. While the exact nature of the transition from traditional livestock to alternative protein products is uncertain, it has already started and will likely continue to build momentum in the next decade.

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