期刊
BIOMATERIALS
卷 280, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2021.121289
关键词
Bioactive glass nanoparticles; Tumor inhibition; Antibacterial; Wound healing; Photothermal-chemodynamic therapy
资金
- NNSF of China [51803091, 61935004]
- Jiangsu Province Policy Guidance Plan [BZ2019014]
- Six talent peak innovation team in Jiangsu Province [TD-SWYY-009]
- 'Taishan scholars' construction special fund of Shandong Province
A light-activated injectable hydrogel has been developed to inhibit tumor growth, treat bacterial infection, and promote wound healing. Through photothermal and chemodynamic effects, the hydrogel can eliminate tumors and multidrug-resistant bacteria, as well as accelerate wound healing during treatment.
Tumor surgery is usually accompanied by neoplasm residual, tissue defects, and multi-drug resistant bacterial infection, causing high tumor recurrence, low survival rate, and chronic wounds. Herein, a light-activated injectable hydrogel based on bioactive nanocomposite system is developed by incorporating Ag2S nanodots conjugated Fe-doped bioactive glass nanoparticles (BGN-Fe-Ag2S) into biodegradable PEGDA and AIPH solution for inhibiting tumor growth, treating bacterial infection, and promoting wound healing. Under laser irradiation, the photothermal effect mediated by Ag2S nanodots would trigger the decomposition of AIPH, generating alkyl radicals to initiate the gelation of PEGDA. The in-situ gelatinized hydrogel, with outstanding photothermal effect and chemodynamic effect derived from the doped Fe in BGN-Fe-Ag2S, can not only eliminate multidrug-resistant bacteria but also efficiently ablated tumor during treatment. Moreover, the hydrogel significantly accelerated wound healing with more skin appendages in the full-thickness cutaneous wounds model because of the hydrolysis of bioactive glass. These results manifest that this multifunctional hydrogel is a suitable biomaterial to inhibit tumor proliferation and overcome tissue bacterial infection after surgical removal of tumors.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据