Oocyte mitochondria—key regulators of oocyte function and potential therapeutic targets for improving fertility

The need for high-quality oocyte mitochondria at extreme ploidy dictates mammalian germline development

(2021) Marco Colnaghi et al.   eLife

NAD+ Repletion Rescues Female Fertility during Reproductive Aging

(2020) Michael J. Bertoldo et al.   Cell Reports

Prenatal androgen induced lean PCOS impairs mitochondria and mRNA profiles in oocytes

(2020) Neil R Chappell et al.   Endocrine Connections

Mitofusin 1 is required for oocyte growth and communication with follicular somatic cells

(2020) Karen F. Carvalho et al.   FASEB JOURNAL

RNA-Seq transcriptome reveals different molecular responses during human and mouse oocyte maturation and fertilization

(2020) Zheng-Hui Zhao et al.   BMC GENOMICS

Nicotinamide Mononucleotide Supplementation Reverses the Declining Quality of Maternally Aged Oocytes

(2020) Yilong Miao et al.   Cell Reports

Cytoplasmic maturation in human oocytes: an ultrastructural study.†

(2020) Z Trebichalská et al.   BIOLOGY OF REPRODUCTION

Increased transcriptome variation and localised DNA methylation changes in oocytes from aged mice revealed by parallel single‐cell analysis

(2020) Juan Castillo‐Fernandez et al.   AGING CELL

Mitochondria-targeted therapeutics, MitoQ and BGP-15, reverse aging-associated meiotic spindle defects in mouse and human oocytes

(2020) Usama Al-Zubaidi et al.   HUMAN REPRODUCTION

Mitofusin1 in oocyte is essential for female fertility

(2019) Xiaojing Hou et al.   Redox Biology

Mitochondrial unfolded protein response: a stress response with implications for fertility and reproductive aging

(2019) Emre Seli et al.   FERTILITY AND STERILITY

A maternal high-fat, high-sucrose diet induces transgenerational cardiac mitochondrial dysfunction independently of maternal mitochondrial inheritance

(2019) Jeremie L. A. Ferey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mitofusin 2 plays a role in oocyte and follicle development, and is required to maintain ovarian follicular reserve during reproductive aging

(2019) Man Zhang et al.   Aging-US

Regulation of nuclear epigenome by mitochondrial DNA heteroplasmy

(2019) Piotr K. Kopinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitofusin 1 is required for female fertility and to maintain ovarian follicular reserve

(2019) Man Zhang et al.   Cell Death & Disease

Mitochondria-targeted therapy rescues development and quality of embryos derived from oocytes matured under oxidative stress conditions: a bovine in vitro model

(2019) Waleed F A Marei et al.   HUMAN REPRODUCTION

Melatonin promotes the development of immature oocytes from the COH cycle into healthy offspring by protecting mitochondrial function

(2019) Huijuan Zou et al.   JOURNAL OF PINEAL RESEARCH

Melatonin maintains mitochondrial membrane potential and decreases excessive intracellular Ca2+ levels in immature human oocytes

(2019) Ya-Jing Liu et al.   LIFE SCIENCES

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

(2018) Sarah Pickles et al.   CURRENT BIOLOGY

Miro proteins coordinate microtubule‐ and actin‐dependent mitochondrial transport and distribution

(2018) Guillermo López‐Doménech et al.   EMBO JOURNAL

Resveratrol improves in vitro maturation of oocytes in aged mice and humans

(2018) Mei-Ju Liu et al.   FERTILITY AND STERILITY

Epigenomic drugs and the germline: Collateral damage in the home of heritability?

(2018) Patrick S. Western   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Mitochondrial Dynamics at the Interface of Immune Cell Metabolism and Function

(2018) Angelika S. Rambold et al.   TRENDS IN IMMUNOLOGY

Metabolic intermediates – Cellular messengers talking to chromatin modifiers

(2018) Anna Nieborak et al.   Molecular Metabolism

Alterations in oocyte mitochondrial number and function are related to spindle defects and occur with maternal aging in mice and humans†

(2018) Rolando Pasquariello et al.   BIOLOGY OF REPRODUCTION

Autologous mitochondrial transfer as a complementary technique to intracytoplasmic sperm injection to improve embryo quality in patients undergoing in vitro fertilization—a randomized pilot study

(2018) Elena Labarta et al.   FERTILITY AND STERILITY

Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2

(2018) David E. Sanin et al.   IMMUNITY

Mitochondrial genetic medicine

(2018) Douglas C. Wallace   NATURE GENETICS

Type 2 diabetes increases oocyte mtDNA mutations which are eliminated in the offspring by bottleneck effect

(2018) Li Li et al.   Reproductive Biology and Endocrinology

BGP-15 Protects against Oxidative Stress- or Lipopolysaccharide-Induced Mitochondrial Destabilization and Reduces Mitochondrial Production of Reactive Oxygen Species

(2017) Katalin Sumegi et al.   PLoS One

The lipid peroxidation product 4-hydroxynonenal contributes to oxidative stress-mediated deterioration of the ageing oocyte

(2017) Bettina P. Mihalas et al.   Scientific Reports

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

(2016) Michael D. Buck et al.   CELL

Mitochondrial Dynamics Impacts Stem Cell Identity and Fate Decisions by Regulating a Nuclear Transcriptional Program

(2016) Mireille Khacho et al.   Cell Stem Cell

Obesity-induced oocyte mitochondrial defects are partially prevented and rescued by supplementation with co-enzyme Q10 in a mouse model

(2016) C.E. Boots et al.   HUMAN REPRODUCTION

Metabolic regulation of mitochondrial dynamics

(2016) Prashant Mishra et al.   JOURNAL OF CELL BIOLOGY

Interplay between Metabolism and Epigenetics: A Nuclear Adaptation to Environmental Changes

(2016) Jean-Pierre Etchegaray et al.   MOLECULAR CELL

Mouse oocytes differentiate through organelle enrichment from sister cyst germ cells

(2016) L. Lei et al.   SCIENCE

Mitochondrial Dynamics and Metabolic Regulation

(2016) Timothy Wai et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mitofusin-2 is required for mouse oocyte meiotic maturation

(2016) Jing-Hua Zhang et al.   Scientific Reports

Maternal Metabolic Syndrome Programs Mitochondrial Dysfunction via Germline Changes across Three Generations

(2016) Jessica L. Saben et al.   Cell Reports

Mitochondrial diseases

(2016) Gráinne S. Gorman et al.   Nature Reviews Disease Primers

Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging

(2015) Assaf Ben-Meir et al.   AGING CELL

The histone deacetylase inhibitor butyrate improves metabolism and reduces muscle atrophy during aging

(2015) Michael E. Walsh et al.   AGING CELL

Oocyte mitochondrial function and reproduction

(2015) Elnur Babayev et al.   CURRENT OPINION IN OBSTETRICS & GYNECOLOGY

Mitochondrial dysfunction in oocytes of obese mothers: transmission to offspring and reversal by pharmacological endoplasmic reticulum stress inhibitors

(2015) L. L. Wu et al.   DEVELOPMENT

Adult human and mouse ovaries lack DDX4-expressing functional oogonial stem cells

(2015) Hua Zhang et al.   NATURE MEDICINE

Autologous Germline Mitochondrial Energy Transfer (AUGMENT) in Human Assisted Reproduction

(2015) Dori Woods et al.   SEMINARS IN REPRODUCTIVE MEDICINE

Mitochondria as signaling organelles

(2014) Navdeep S Chandel   BMC BIOLOGY

Mitochondrial Fission Factor Drp1 Maintains Oocyte Quality via Dynamic Rearrangement of Multiple Organelles

(2014) Osamu Udagawa et al.   CURRENT BIOLOGY

Myo19 Ensures Symmetric Partitioning of Mitochondria and Coupling of Mitochondrial Segregation to Cell Division

(2014) Jennifer L. Rohn et al.   CURRENT BIOLOGY

Mitochondrial dynamics controlled by mitofusins define organelle positioning and movement during mouse oocyte maturation

(2014) Takuya Wakai et al.   MOLECULAR HUMAN REPRODUCTION

Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells

(2014) Bryce W. Carey et al.   NATURE

Mitochondrial dynamics and inheritance during cell division, development and disease

(2014) Prashant Mishra et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Measurement of ATP in Single Oocytes: Impact of Maturation and Cumulus Cells on Levels and Consumption

(2013) Caroline M. Dalton et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Dimethyl fumarate regulates histone deacetylase expression in astrocytes

(2013) Sergey Kalinin et al.   JOURNAL OF NEUROIMMUNOLOGY

Isolation, characterization and propagation of mitotically active germ cells from adult mouse and human ovaries

(2013) Dori C Woods et al.   Nature Protocols

Age-Associated Metabolic and Morphologic Changes in Mitochondria of Individual Mouse and Hamster Oocytes

(2013) Fatma Simsek-Duran et al.   PLoS One

Mitochondrial DNA Genetics and the Heteroplasmy Conundrum in Evolution and Disease

(2013) D. C. Wallace et al.   Cold Spring Harbor Perspectives in Biology

Mitochondrial Trafficking in Neurons

(2013) T. L. Schwarz   Cold Spring Harbor Perspectives in Biology

Metabolic Regulation of Epigenetics

(2012) Chao Lu et al.   Cell Metabolism

Should I stay or should I go: Protection and maintenance of DNA methylation at imprinted genes

(2012) Daniel Messerschmidt   Epigenetics

Delay in oocyte aging in mice by the antioxidant N-acetyl-l-cysteine (NAC)

(2012) Jinmiao Liu et al.   HUMAN REPRODUCTION

Abnormal DNA methylation in oocytes could be associated with a decrease in reproductive potential in old mice

(2012) Ming-xing Yue et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Does supplementation of in-vitro culture medium with melatonin improve IVF outcome in PCOS?

(2012) Mi Kyoung Kim et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Mitochondrial dynamics in neurodegeneration

(2012) Kie Itoh et al.   TRENDS IN CELL BIOLOGY

An actin-dependent mechanism for long-range vesicle transport

(2011) Melina Schuh   NATURE CELL BIOLOGY

Prevention of maternal aging-associated oocyte aneuploidy and meiotic spindle defects in mice by dietary and genetic strategies

(2011) K. Selesniemi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beta-Oxidation Is Essential for Mouse Oocyte Developmental Competence and Early Embryo Development1

(2010) Kylie R. Dunning et al.   BIOLOGY OF REPRODUCTION

The Role of Mitochondrial DNA Copy Number in Mammalian Fertility1

(2010) Timothy Wai et al.   BIOLOGY OF REPRODUCTION

Redistribution of mitochondria leads to bursts of ATP production during spontaneous mouse oocyte maturation

(2010) Yuansong Yu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mitochondrial function in the human oocyte and embryo and their role in developmental competence

(2010) Jonathan Van Blerkom   MITOCHONDRION

Reassessing evidence for a postnatal mitochondrial genetic bottleneck

(2010) David C Samuels et al.   NATURE GENETICS

Maternal Diet-Induced Obesity Alters Mitochondrial Activity and Redox Status in Mouse Oocytes and Zygotes

(2010) Natalia Igosheva et al.   PLoS One

Transcript expression of mitochondria related genes is correlated with bovine oocyte selection by BCB test

(2009) Jolanta Opiela et al.   ANIMAL REPRODUCTION SCIENCE

Human Myo19 Is a Novel Myosin that Associates with Mitochondria

(2009) Omar A. Quintero et al.   CURRENT BIOLOGY

Drp1 levels constitutively regulate mitochondrial dynamics and cell survival in cortical neurons

(2009) Takuma Uo et al.   EXPERIMENTAL NEUROLOGY

The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice

(2009) Junko Wakabayashi et al.   JOURNAL OF CELL BIOLOGY

Maternal Diabetes Causes Mitochondrial Dysfunction and Meiotic Defects in Murine Oocytes

(2009) Qiang Wang et al.   MOLECULAR ENDOCRINOLOGY

The primordial pool of follicles and nest breakdown in mammalian ovaries

(2009) C. Tingen et al.   MOLECULAR HUMAN REPRODUCTION

Fatty acid oxidation and meiotic resumption in mouse oocytes

(2009) Stephen M. Downs et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice

(2009) Naotada Ishihara et al.   NATURE CELL BIOLOGY

A hyperfused mitochondrial state achieved at G1-S regulates cyclin E buildup and entry into S phase

(2009) K. Mitra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New Evidence Confirms That the Mitochondrial Bottleneck Is Generated without Reduction of Mitochondrial DNA Content in Early Primordial Germ Cells of Mice

(2009) Liqin Cao et al.   PLoS Genetics

The mitochondrial DNA genetic bottleneck results from replication of a subpopulation of genomes

(2008) Timothy Wai et al.   NATURE GENETICS

A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes

(2008) Lynsey M Cree et al.   NATURE GENETICS