The need for high-quality oocyte mitochondria at extreme ploidy dictates mammalian germline development

Actin cables and comet tails organize mitochondrial networks in mitosis

(2021) Andrew S. Moore et al.   NATURE

Cellular mechanisms of mtDNA heteroplasmy dynamics

(2021) Claudia V. Pereira et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Mitochondrial DNA segregation and replication restrict the transmission of detrimental mutation

(2020) Zhe Chen et al.   JOURNAL OF CELL BIOLOGY

Age-related accumulation of de novo mitochondrial mutations in mammalian oocytes and somatic tissues

(2020) Barbara Arbeithuber et al.   PLOS BIOLOGY

Regulation of nuclear epigenome by mitochondrial DNA heteroplasmy

(2019) Piotr K. Kopinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial DNA Heteroplasmy and Purifying Selection in the Mammalian Female Germ Line

(2018) Stephen P. Burr et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos

(2018) Vasileios I. Floros et al.   NATURE CELL BIOLOGY

Do plants have a segregated germline?

(2018) Robert Lanfear   PLOS BIOLOGY

Germ plasm provides clues on meiosis: the concerted action of germ plasm granules and mitochondria in gametogenesis of the clam Ruditapes philippinarum

(2018) Arkadiy Reunov et al.   ZYGOTE

Selection of mitochondria in female germline cells: is Balbiani body implicated in this process?

(2017) Szczepan M. Bilinski et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Large Variation in the Ratio of Mitochondrial to Nuclear Mutation Rate across Animals: Implications for Genetic Diversity and the Use of Mitochondrial DNA as a Molecular Marker

(2017) Remi Allio et al.   MOLECULAR BIOLOGY AND EVOLUTION

Intracellular evolution of mitochondrial DNA (mtDNA) and the tragedy of the cytoplasmic commons

(2016) David Haig   BIOESSAYS

Exclusion of dysfunctional mitochondria from Balbiani body during early oogenesis of Thermobia

(2016) Waclaw Tworzydlo et al.   CELL AND TISSUE RESEARCH

Transmission of human mtDNA heteroplasmy in the Genome of the Netherlands families: support for a variable-size bottleneck

(2016) Mingkun Li et al.   GENOME RESEARCH

Mitophagy plays a central role in mitochondrial ageing

(2016) Alan Diot et al.   MAMMALIAN GENOME

Mouse oocytes differentiate through organelle enrichment from sister cyst germ cells

(2016) L. Lei et al.   SCIENCE

Selection for Mitochondrial Quality Drives Evolution of the Germline

(2016) Arunas L. Radzvilavicius et al.   PLOS BIOLOGY

Mitochondria: Biogenesis and mitophagy balance in segregation and clonal expansion of mitochondrial DNA mutations

(2015) Valerio Carelli et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The rate of adaptive evolution in animal mitochondria

(2015) Jennifer E. James et al.   MOLECULAR ECOLOGY

The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease

(2015) James B. Stewart et al.   NATURE REVIEWS GENETICS

Stochastic modelling, Bayesian inference, and new in vivo measurements elucidate the debated mtDNA bottleneck mechanism

(2015) Iain G Johnston et al.   eLife

Germline Quality Control: eEF2K Stands Guard to Eliminate Defective Oocytes

(2014) Hsueh-Ping Chu et al.   DEVELOPMENTAL CELL

Selective propagation of functional mitochondrial DNA during oogenesis restricts the transmission of a deleterious mitochondrial variant

(2014) Jahda H Hill et al.   NATURE GENETICS

Prooxidant Properties of p66shc Are Mediated by Mitochondria in Human Cells

(2014) Evgeny R. Galimov et al.   PLoS One

Maternal age effect and severe germ-line bottleneck in the inheritance of human mitochondrial DNA

(2014) B. Rebolledo-Jaramillo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Keeping mtDNA in Shape between Generations

(2014) James B. Stewart et al.   PLoS Genetics

Mitochondrial genome function and maternal inheritance

(2013) John F. Allen et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Biased inheritance of mitochondria during asymmetric cell division in the mouse oocyte

(2013) C. M. Dalton et al.   JOURNAL OF CELL SCIENCE

Very Low-Level Heteroplasmy mtDNA Variations Are Inherited in Humans

(2013) Yan Guo et al.   Journal of Genetics and Genomics

Energy, ageing, fidelity and sex: oocyte mitochondrial DNA as a protected genetic template

(2013) W. B. M. de Paula et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Dynamics of mitochondrial inheritance in the evolution of binary mating types and two sexes

(2013) Z. Hadjivasiliou et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Mitochondrial DNA Genetics and the Heteroplasmy Conundrum in Evolution and Disease

(2013) D. C. Wallace et al.   Cold Spring Harbor Perspectives in Biology

Mitofusin 1 is degraded at G2/M phase through ubiquitylation by MARCH5

(2012) Yong-Yea Park et al.   Cell Division

High Mutation Rates in the Mitochondrial Genomes of Daphnia pulex

(2011) S. Xu et al.   MOLECULAR BIOLOGY AND EVOLUTION

Is the mitochondrial cloud the selection machinery for preferentially transmitting wild-type mtDNA between generations? Rewinding Müller’s ratchet efficiently

(2010) Rong Rong Zhou et al.   CURRENT GENETICS

Multiple mechanisms of germ cell loss in the perinatal mouse ovary

(2009) Patricia Rodrigues et al.   REPRODUCTION

New Evidence Confirms That the Mitochondrial Bottleneck Is Generated without Reduction of Mitochondrial DNA Content in Early Primordial Germ Cells of Mice

(2009) Liqin Cao et al.   PLoS Genetics

Pathogenic Mitochondrial DNA Mutations Are Common in the General Population

(2008) Hannah R. Elliott et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The adaptive evolution of the mammalian mitochondrial genome

(2008) Rute R da Fonseca et al.   BMC GENOMICS

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

The developing human ovary: immunohistochemical analysis of germ-cell-specific VASA protein, BCL-2/BAX expression balance and apoptosis

(2008) M. S. Albamonte et al.   HUMAN REPRODUCTION

Mutation-Selection Models of Codon Substitution and Their Use to Estimate Selective Strengths on Codon Usage

(2008) Z. Yang et al.   MOLECULAR BIOLOGY AND EVOLUTION

The mitochondrial DNA genetic bottleneck results from replication of a subpopulation of genomes

(2008) Timothy Wai et al.   NATURE GENETICS

A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes

(2008) Lynsey M Cree et al.   NATURE GENETICS

A Mouse Model of Mitochondrial Disease Reveals Germline Selection Against Severe mtDNA Mutations

(2008) Weiwei Fan et al.   SCIENCE

Strong Purifying Selection in Transmission of Mammalian Mitochondrial DNA

(2008) James Bruce Stewart et al.   PLOS BIOLOGY

Direct Estimation of the Mitochondrial DNA Mutation Rate in Drosophila melanogaster

(2008) Cathy Haag-Liautard et al.   PLOS BIOLOGY

Prevalence of mitochondrial DNA disease in adults

(2007) Andrew M. Schaefer et al.   ANNALS OF NEUROLOGY