Transcription factors in glioblastoma – Molecular pathogenesis and clinical implications

The Role and Therapeutic Targeting of JAK/STAT Signaling in Glioblastoma

(2021) Alexander Ou et al.   Cancers

Reprogramming transcription factors Oct4 and Sox2 induces a BRD-dependent immunosuppressive transcriptome in GBM-propagating cells

(2021) John Laterra et al.   CANCER RESEARCH

Targeting the YAP-TEAD interaction interface for therapeutic intervention in glioblastoma

(2021) Jacquelyn T. Saunders et al.   JOURNAL OF NEURO-ONCOLOGY

Differentiated glioblastoma cells accelerate tumor progression by shaping the tumor microenvironment via CCN1-mediated macrophage infiltration

(2021) Atsuhito Uneda et al.   Acta Neuropathologica Communications

SFRP2 induces a mesenchymal subtype transition by suppression of SOX2 in glioblastoma

(2021) Min Guo et al.   ONCOGENE

Indoleamine 2,3-dioxygenase 1 is highly expressed in glioma stem cells

(2020) Yoshinari Ozawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

c-Src Phosphorylates and Inhibits the Function of the CIC Tumor Suppressor Protein

(2020) Severa Bunda et al.   MOLECULAR CANCER RESEARCH

The T‐box transcription factor brachyury behaves as a tumor suppressor in gliomas

(2020) Filipe Pinto et al.   JOURNAL OF PATHOLOGY

Constitutive Expression of the Immunosuppressive Tryptophan Dioxygenase TDO2 in Glioblastoma Is Driven by the Transcription Factor C/EBPβ

(2020) Takumi Kudo et al.   Frontiers in Immunology

C/EBPβ mediates NQO1 and GSTP1 anti-oxidative reductases expression in glioblastoma, promoting brain tumor proliferation

(2020) Kecheng Lei et al.   Redox Biology

Transcription Factors in Cancer Development and Therapy

(2020) Kanchan Vishnoi et al.   Cancers

NFIA and NFIB function as tumour suppressors in high-grade glioma in mice

(2020) Kok-Siong Chen et al.   CARCINOGENESIS

CIC protein instability contributes to tumorigenesis in glioblastoma

(2019) Severa Bunda et al.   Nature Communications

MiR-9 promotes tumorigenesis and angiogenesis and is activated by MYC and OCT4 in human glioma

(2019) Xu Chen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

A positive feedback loop involving nuclear factor IB and calpain 1 suppresses glioblastoma cell migration

(2019) The Minh Vo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Prognostic Signature of Transcription Factors for the Prediction in Patients With GBM

(2019) Quan Cheng et al.   Frontiers in Genetics

Transcription factors NFIA and NFIB induce cellular differentiation in high-grade astrocytoma

(2019) Kok-Siong Chen et al.   JOURNAL OF NEURO-ONCOLOGY

Nuclear factor I A promotes temozolomide resistance in glioblastoma via activation of nuclear factor κB pathway

(2019) Xiao Yu et al.   LIFE SCIENCES

A STAT3-based gene signature stratifies glioma patients for targeted therapy

(2019) Melanie Si Yan Tan et al.   Nature Communications

Pivotal Role of STAT3 in Shaping Glioblastoma Immune Microenvironment

(2019) Christina Piperi et al.   Cells

Absence of host NF-κB p50 induces murine glioblastoma tumor regression, increases survival, and decreases T-cell induction of tumor-associated macrophage M2 polarization

(2018) Theresa Barberi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Truncated Glioma-Associated Oncogene Homolog 1 (tGLI1) Mediates Mesenchymal Glioblastoma via Transcriptional Activation of CD44

(2018) Tadas K. Rimkus et al.   CANCER RESEARCH

The Human Transcription Factors

(2018) Samuel A. Lambert et al.   CELL

TP53 gain-of-function mutation promotes inflammation in glioblastoma

(2018) Seok Won Ham et al.   CELL DEATH AND DIFFERENTIATION

Activity of Metabotropic Glutamate Receptor 4 Suppresses Proliferation and Promotes Apoptosis With Inhibition of Gli-1 in Human Glioblastoma Cells

(2018) Zhichao Zhang et al.   Frontiers in Neuroscience

Analysis of chromatin accessibility uncovers TEAD1 as a regulator of migration in human glioblastoma

(2018) Jessica Tome-Garcia et al.   Nature Communications

Nuclear Factor I Represses the Notch Effector HEY1 in Glioblastoma

(2018) Miranda Brun et al.   NEOPLASIA

The p53 Pathway in Glioblastoma

(2018) Ying Zhang et al.   Cancers

Myt1 and Myt1l transcription factors limit proliferation in GBM cells by repressing YAP1 expression

(2018) Tiffany A. Melhuish et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

IKBKE regulates cell proliferation and epithelial–mesenchymal transition of human malignant glioma via the Hippo pathway

(2017) Jie Lu et al.   Oncotarget

MicroRNA-141-3p promotes glioma cell growth and temozolomide resistance by directly targeting p53

(2017) Xu Zhou et al.   Oncotarget

MIF Maintains the Tumorigenic Capacity of Brain Tumor-Initiating Cells by Directly Inhibiting p53

(2016) R. Fukaya et al.   CANCER RESEARCH

Myc-Driven Glycolysis Is a Therapeutic Target in Glioblastoma

(2016) K. Tateishi et al.   CLINICAL CANCER RESEARCH

mTOR inhibition decreases SOX2-SOX9 mediated glioma stem cell activity and temozolomide resistance

(2016) Laura Garros-Regulez et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

EGFR and C/EBP-β oncogenic signaling is bidirectional in human glioma and varies with the C/EBP-β isoform

(2016) Ligia Selagea et al.   FASEB JOURNAL

ODZ1 allows glioblastoma to sustain invasiveness through a Myc-dependent transcriptional upregulation of RhoA

(2016) A Talamillo et al.   ONCOGENE

The role of transcriptional coactivator TAZ in gliomas

(2016) Weijie Li et al.   Oncotarget

Sensitivity to PRIMA-1MET is associated with decreased MGMT in human glioblastoma cells and glioblastoma stem cells irrespective of p53 status

(2016) Mariia Patyka et al.   Oncotarget

Nuclear factor one B (NFIB) encodes a subtype-specific tumour suppressor in glioblastoma

(2016) Brett W. Stringer et al.   Oncotarget

FOXM1 and STAT3 interaction confers radioresistance in glioblastoma cells

(2016) Uday B. Maachani et al.   Oncotarget

Targeting SOX2 as a Therapeutic Strategy in Glioblastoma

(2016) Laura Garros-Regulez et al.   Frontiers in Oncology

c-Myc–miR-29c–REV3L signalling pathway drives the acquisition of temozolomide resistance in glioblastoma

(2015) Hui Luo et al.   BRAIN

Eva1 Maintains the Stem-like Character of Glioblastoma-Initiating Cells by Activating the Noncanonical NF- B Signaling Pathway

(2015) N. Ohtsu et al.   CANCER RESEARCH

Modulation of Sonic hedgehog signaling and WW domain containing oxidoreductase WOX1 expression enhances radiosensitivity of human glioblastoma cells

(2015) Ming-Fu Chiang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Nuclear factor-κB in glioblastoma: insights into regulators and targeted therapy

(2015) Kirk E. Cahill et al.   NEURO-ONCOLOGY

Dynamic epigenetic regulation of glioblastoma tumorigenicity through LSD1 modulation of MYC expression

(2015) David Kozono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CCAAT/enhancer binding protein β induces motility and invasion of glioblastoma cells through transcriptional regulation of the calcium binding protein S100A4

(2015) Diana Aguilar-Morante et al.   Oncotarget

The gain-of-function GLI1 transcription factor TGLI1 enhances expression of VEGF-C and TEM7 to promote glioblastoma angiogenesis

(2015) Richard L. Carpenter et al.   Oncotarget

Modulating Antiangiogenic Resistance by Inhibiting the Signal Transducer and Activator of Transcription 3 Pathway in Glioblastoma

(2015) John de Groot et al.   Oncotarget

Identification of Causal Genetic Drivers of Human Disease through Systems-Level Analysis of Regulatory Networks

(2014) James C. Chen et al.   CELL

Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells

(2014) Mario L. Suvà et al.   CELL

C/EBPβ promotes angiogenesis through secretion of IL-6, which is inhibited by genistein, in EGFRvIII-positive glioblastoma

(2014) Xujie Liu et al.   INTERNATIONAL JOURNAL OF CANCER

JAK2/STAT3 targeted therapy suppresses tumor invasion via disruption of the EGFRvIII/JAK2/STAT3 axis and associated focal adhesion in EGFRvIII-expressing glioblastoma

(2014) Q. Zheng et al.   NEURO-ONCOLOGY

Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis

(2014) Daniela Annibali et al.   Nature Communications

Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma

(2013) Krishna P.L. Bhat et al.   CANCER CELL

The GLI1 splice variant TGLI1 promotes glioblastoma angiogenesis and growth

(2013) Hu Zhu et al.   CANCER LETTERS

NPV-LDE-225 (Erismodegib) inhibits epithelial mesenchymal transition and self-renewal of glioblastoma initiating cells by regulating miR-21, miR-128, and miR-200

(2013) J. Fu et al.   NEURO-ONCOLOGY

A novel tumor-promoting role for nuclear factor IA in glioblastomas is mediated through negative regulation of p53, p21, and PAI1

(2013) Jun Sung Lee et al.   NEURO-ONCOLOGY

Hedgehog Signaling Regulates Telomerase Reverse Transcriptase in Human Cancer Cells

(2013) Tapati Mazumdar et al.   PLoS One

Neutralization of terminal differentiation in gliomagenesis

(2013) Jian Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STAT3 Inhibition Overcomes Temozolomide Resistance in Glioblastoma by Downregulating MGMT Expression

(2012) Shinji Kohsaka et al.   MOLECULAR CANCER THERAPEUTICS

EGFR-Induced and PKCε Monoubiquitylation-Dependent NF-κB Activation Upregulates PKM2 Expression and Promotes Tumorigenesis

(2012) Weiwei Yang et al.   MOLECULAR CELL

R280T mutation of p53 gene promotes proliferation of human glioma cells through GSK-3β/PTEN pathway

(2012) Chenli Lin et al.   NEUROSCIENCE LETTERS

Gene Therapy-Mediated Reprogramming Tumor Infiltrating T Cells Using IL-2 and Inhibiting NF-κB Signaling Improves the Efficacy of Immunotherapy in a Brain Cancer Model

(2012) Yohei Mineharu et al.   Neurotherapeutics

The SOX2 response program in glioblastoma multiforme: an integrated ChIP-seq, expression microarray, and microRNA analysis

(2011) Xuefeng Fang et al.   BMC GENOMICS

Nonreceptor Tyrosine Kinase BMX Maintains Self-Renewal and Tumorigenic Potential of Glioblastoma Stem Cells by Activating STAT3

(2011) Olga A. Guryanova et al.   CANCER CELL

L1CAM regulates DNA damage checkpoint response of glioblastoma stem cells through NBS1

(2011) Lin Cheng et al.   EMBO JOURNAL

The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma

(2011) K. P. L. Bhat et al.   GENES & DEVELOPMENT

Seeing the Future of Cancer-Associated Transcription Factor Drug Targets

(2011) Panagiotis A. Konstantinopoulos   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

SOX2-RNAi attenuates S-phase entry and induces RhoA-dependent switch to protease-independent amoeboid migration in human glioma cells

(2011) Felix Oppel et al.   Molecular Cancer

Antitumor effect of dehydroxymethylepoxyquinomicin, a small molecule inhibitor of nuclear factor- B, on glioblastoma

(2011) T. Fukushima et al.   NEURO-ONCOLOGY

Myt/NZF family transcription factors regulate neuronal differentiation of P19 cells

(2011) Toshiki Kameyama et al.   NEUROSCIENCE LETTERS

EGFRvIII promotes glioma angiogenesis and growth through the NF-κB, interleukin-8 pathway

(2011) R Bonavia et al.   ONCOGENE

Glioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressor

(2010) A. H. Stegh et al.   GENES & DEVELOPMENT

Decreased CCAAT/enhancer binding protein β expression inhibits the growth of glioblastoma cells

(2010) D. Aguilar-Morante et al.   NEUROSCIENCE

Activated STAT3 Regulates Hypoxia-Induced Angiogenesis and Cell Migration in Human Glioblastoma

(2010) Shin-Hyuk Kang et al.   NEUROSURGERY

A Novel Splice Variant of GLI1 That Promotes Glioblastoma Cell Migration and Invasion

(2009) H.-W. Lo et al.   CANCER RESEARCH

A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers

(2009) Barbara Stecca et al.   EMBO JOURNAL

A survey of glioblastoma genomic amplifications and deletions

(2009) Shailaja K. Rao et al.   JOURNAL OF NEURO-ONCOLOGY

The transcriptional network for mesenchymal transformation of brain tumours

(2009) Maria Stella Carro et al.   NATURE

c -MYC amplification and expression in astrocytic tumors

(2008) Mário Henrique Faria et al.   ACTA NEUROPATHOLOGICA

PTEN Has Tumor-Promoting Properties in the Setting of Gain-of-Function p53 Mutations

(2008) Y. Li et al.   CANCER RESEARCH

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

(2008) N. de la Iglesia et al.   GENES & DEVELOPMENT

Blockage of the STAT3 signaling pathway with a decoy oligonucleotide suppresses growth of human malignant glioma cells

(2008) Jinhai Gu et al.   JOURNAL OF NEURO-ONCOLOGY

Deregulation of a STAT3-Interleukin 8 Signaling Pathway Promotes Human Glioblastoma Cell Proliferation and Invasiveness

(2008) N. de la Iglesia et al.   JOURNAL OF NEUROSCIENCE

c-Myc Is Required for Maintenance of Glioma Cancer Stem Cells

(2008) Jialiang Wang et al.   PLoS One