AMPK activation by SC4 inhibits noradrenaline-induced lipolysis and insulin-stimulated lipogenesis in white adipose tissue

A-769662 inhibits adipocyte glucose uptake in an AMPK-independent manner

(2021) Franziska Kopietz et al.   BIOCHEMICAL JOURNAL

Effects of PKB/Akt inhibitors on insulin-stimulated lipogenesis and phosphorylation state of lipogenic enzymes in white adipose tissue

(2020) Nusrat Hussain et al.   BIOCHEMICAL JOURNAL

Inhibition of AMPK activity in response to insulin in adipocytes - involvement of AMPK pS485, PDEs and cellular energy levels

(2020) Franziska Kopietz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

AMP-activated protein kinase: the current landscape for drug development

(2019) Gregory R. Steinberg et al.   NATURE REVIEWS DRUG DISCOVERY

Genetic deletion of soluble 5′-nucleotidase II reduces body weight gain and insulin resistance induced by a high-fat diet

(2019) Manuel Johanns et al.   MOLECULAR GENETICS AND METABOLISM

Adipose Tissue Dysfunction as Determinant of Obesity-Associated Metabolic Complications

(2019) Michele Longo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Resveratrol improves glucose uptake in insulin-resistant adipocytes via Sirt1

(2018) Sifan Chen et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

AMPK activation by A-769662 and 991 does not affect catecholamine-induced lipolysis in human adipocytes

(2018) Franziska Kopietz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy

(2017) Robert W. Myers et al.   SCIENCE

Targeting an energy sensor to treat diabetes

(2017) D. Grahame Hardie   SCIENCE

Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle

(2016) Laurent Bultot et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function

(2016) Emilio P. Mottillo et al.   Cell Metabolism

AMPK Phosphorylates Desnutrin/ATGL and Hormone-Sensitive Lipase To Regulate Lipolysis and Fatty Acid Oxidation within Adipose Tissue

(2016) Sun-Joong Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B

(2016) M. Johanns et al.   Nature Communications

Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity

(2015) Rebecca J. Ford et al.   BIOCHEMICAL JOURNAL

Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates

(2015) Nolan J. Hoffman et al.   Cell Metabolism

A small-molecule benzimidazole derivative that potently activates AMPK to increase glucose transport in skeletal muscle: comparison with effects of contraction and other AMPK activators

(2014) Yu-Chiang Lai et al.   BIOCHEMICAL JOURNAL

Choreography of AMPK activation

(2014) Christopher G Langendorf et al.   CELL RESEARCH

Small Molecule Drug A-769662 and AMP Synergistically Activate Naive AMPK Independent of Upstream Kinase Signaling

(2014) John W. Scott et al.   CHEMISTRY & BIOLOGY

Role of AMP-activated protein kinase in adipose tissue metabolism and inflammation

(2013) Silvia Bijland et al.   CLINICAL SCIENCE

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

(2013) Morgan D Fullerton et al.   NATURE MEDICINE

Structural basis of AMPK regulation by small molecule activators

(2013) Bing Xiao et al.   Nature Communications

De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health

(2013) Leah Eissing et al.   Nature Communications

Identification and Functional Characterization of Protein Kinase A Phosphorylation Sites in the Major Lipolytic Protein, Adipose Triglyceride Lipase

(2012) Joanne Pagnon et al.   ENDOCRINOLOGY

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

(2012) S. A. Hawley et al.   SCIENCE

Mapping Insulin/GLUT4 Circuitry

(2011) Alexander F. Rowland et al.   TRAFFIC

Protein kinase B activity is required for the effects of insulin on lipid metabolism in adipocytes

(2009) Christine Berggreen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Thienopyridone Drugs Are Selective Activators of AMP-Activated Protein Kinase β1-Containing Complexes

(2008) John W. Scott et al.   CHEMISTRY & BIOLOGY

AMP-activated Protein Kinase Is Activated as a Consequence of Lipolysis in the Adipocyte

(2008) Marie-Soleil Gauthier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY