Recent advances in the asymmetric phosphoric acid-catalyzed synthesis of axially chiral compounds

Chiral Pd-Catalyzed Enantioselective Syntheses of Various N–C Axially Chiral Compounds and Their Synthetic Applications

(2021) Osamu Kitagawa   ACCOUNTS OF CHEMICAL RESEARCH

Chiral Phosphoric Acid Catalyzed Asymmetric Synthesis of Axially Chiral Compounds

(2021) Bing‐Chao Da et al.   CHINESE JOURNAL OF CHEMISTRY

Organocatalytic Asymmetric Dearomatization Reaction for the Synthesis of Axial Chiral Allene-Derived Naphthalenones Bearing Quaternary Stereocenters

(2021) Alemayehu Gashaw Woldegiorgis et al.   ORGANIC LETTERS

Chiral-Phosphoric-Acid-Catalyzed Atroposelective C-H Amination of Arenes

(2020) Bin Tan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Axially Chiral Biaryl-2-amines by PdII -Catalyzed Free-Amine-Directed Atroposelective C−H Olefination

(2020) Bei-Bei Zhan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Atroposelective Synthesis of 3,3’‐Bisindoles Bearing Axial and Central Chirality: Using Isatin‐Derived Imines as Electrophiles

(2020) Feng‐Tao Sheng et al.   CHINESE JOURNAL OF CHEMISTRY

Catalytic Atroposelective Synthesis of N-Aryl Quinoid Compounds

(2020) Sagar D. Vaidya et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Synthesis of Atropisomers with Multiple Stereogenic Axes

(2020) Xiaoze Bao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Asymmetric Construction of Axially Chiral Indole‐Based Frameworks: An Emerging Area

(2020) Tian-Zhen Li et al.   CHEMISTRY-A EUROPEAN JOURNAL

Axially Chiral Aryl‐Alkene‐Indole Framework: A Nascent Member of the Atropisomeric Family and Its Catalytic Asymmetric Construction

(2020) Cong‐Shuai Wang et al.   CHINESE JOURNAL OF CHEMISTRY

Catalytic Asymmetric Synthesis of 3,3′-Bisindoles Bearing Single Axial Chirality

(2020) Ke-Wei Chen et al.   JOURNAL OF ORGANIC CHEMISTRY

Organocatalytic Atroposelective Construction of Axially Chiral N-Aryl Benzimidazoles Involving Carbon–Carbon Bond Cleavage

(2020) Ningning Man et al.   ORGANIC LETTERS

DFT-Guided Phosphoric-Acid-Catalyzed Atroposelective Arene Functionalization of Nitrosonaphthalene

(2020) Wei-Yi Ding et al.   Chem

Atroposelective Access to Oxindole-Based Axially Chiral Styrenes via the Strategy of Catalytic Kinetic Resolution

(2020) Chun Ma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Dehydrative γ-Arylation of α-Indolyl Propargylic Alcohols with Phenols: Access to Chiral Tetrasubstituted Allenes and Naphthopyrans

(2020) Wen-Run Zhu et al.   ORGANIC LETTERS

Chiral Phosphoric Acid: A Powerful Organocatalyst for the Asymmetric Synthesis of Heterocycles with Chiral Atropisomerism

(2020) You‐Dong Shao et al.   ChemCatChem

Palladium-Catalyzed Directed Atroposelective C–H Allylation via β-H Elimination: 1,1-Disubstituted Alkenes as Allyl Surrogates

(2020) Bei-Bei Zhan et al.   ORGANIC LETTERS

Remote Stereocontrolled Construction of Vicinal Axially Chiral Tetrasubstituted Allenes and Heteroatom-Functionalized Quaternary Carbon Stereocenters

(2019) Pei Zhang et al.   ORGANIC LETTERS

Phosphoric acid-catalyzed atroposelective construction of axially chiral arylpyrroles

(2019) Lei Zhang et al.   Nature Communications

Disparate Catalytic Scaffolds for Atroposelective Cyclodehydration

(2019) Yongseok Kwon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalytic Desymmetrization Reactions for the Synthesis of Axially Chiral Compounds

(2019) Nicola Di Iorio et al.   CHEMICAL RECORD

Enantioselective Synthesis of Biaryl Atropisomers via Pd-Catalyzed C-H Olefination using Chiral Spiro Phosphoric Acid Ligands

(2019) Jun Luo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Kinetic Resolution by Enantioselective Aromatization: Conversion of Racemic Intermediates of the Barton-Zard Reaction into Enantioenriched 3-Arylpyrroles

(2019) Sheng-Cai Zheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rh(III)-Catalyzed Asymmetric Synthesis of Axially Chiral Biindolyls by Merging C–H Activation and Nucleophilic Cyclization

(2019) Miaomiao Tian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalytic Atroposelective Friedländer Quinoline Heteroannulation

(2019) You-Dong Shao et al.   ORGANIC LETTERS

Atroposelective Construction of Arylindoles by Chiral Phosphoric Acid-Catalyzed Cross-Coupling of Indoles and Quinones

(2019) Dong-Liang Lu et al.   ORGANIC LETTERS

Highly atroposelective synthesis of nonbiaryl naphthalene-1,2-diamine N-C atropisomers through direct enantioselective C-H amination

(2019) He-Yuan Bai et al.   Nature Communications

NHC-catalyzed atropoenantioselective synthesis of axially chiral biaryl amino alcohols via a cooperative strategy

(2019) Gongming Yang et al.   Nature Communications

Central‐to‐Axial Chirality Conversion Approach Designed on Organocatalytic Enantioselective Povarov Cycloadditions: First Access to Configurationally Stable Indole‐Quinoline Atropisomers

(2019) Vasco Corti et al.   CHEMISTRY-A EUROPEAN JOURNAL

Atroposelective Phosphoric Acid Catalyzed Three-Component Cascade Reaction: Enantioselective Synthesis of Axially Chiral N-Arylindoles

(2019) Lei Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic Enantioselective Synthesis of Tetrasubstituted α-Amino Allenoates by Dearomative γ-Addition of 2,3-Disubstituted Indoles to β,γ-Alkynyl-α-imino Esters

(2019) Junxian Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Strategy for Synthesizing Axially Chiral Naphthyl-Indoles: Catalytic Asymmetric Addition Reactions of Racemic Substrates

(2019) Fei Jiang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Construction of Axially Chiral Compounds via Asymmetric Organocatalysis

(2018) Yong-Bin Wang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Two Stereoinduction Events in One C−H Activation Step: A Route towards Terphenyl Ligands with Two Atropisomeric Axes

(2018) Quentin Dherbassy et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chiral phosphoric acid catalysis: from numbers to insights

(2018) Rajat Maji et al.   CHEMICAL SOCIETY REVIEWS

Application of Naphthylindole-Derived Phosphines as Organocatalysts in [4 + 1] Cyclizations of o-Quinone Methides with Morita–Baylis–Hillman Carbonates

(2018) Fei Jiang et al.   JOURNAL OF ORGANIC CHEMISTRY

Design and Catalytic Asymmetric Construction of Axially Chiral 3,3′-Bisindole Skeletons

(2018) Chun Ma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A review of binimetinib for the treatment of mutant cutaneous melanoma

(2017) Peter Koelblinger et al.   Future Oncology

Highly Atroposelective Synthesis of Arylpyrroles by Catalytic Asymmetric Paal–Knorr Reaction

(2017) Lei Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalytic asymmetric arylation of indoles enabled by azo groups

(2017) Liang-Wen Qi et al.   Nature Chemistry

Organocatalytic synthesis of axially chiral atropisomers

(2017) P. Renzi   ORGANIC & BIOMOLECULAR CHEMISTRY

Chiral Phosphoric Acid Catalyzed Intramolecular Dearomative Michael Addition of Indoles to Enones

(2017) Yong Zhou et al.   ORGANIC LETTERS

Highly efficient enantioselective liquid–liquid extraction of 1,2-amino-alcohols using SPINOL based phosphoric acid hosts

(2017) Erik B. Pinxterhuis et al.   Chemical Science

Brønsted acid-catalysed enantioselective construction of axially chiral arylquinazolinones

(2017) Yong-Bin Wang et al.   Nature Communications

Organocatalytic synthesis of chiral tetrasubstituted allenes from racemic propargylic alcohols

(2017) Deyun Qian et al.   Nature Communications

Accessing Axially Chiral Biaryls via Organocatalytic Enantioselective Dynamic-Kinetic Resolution-Semipinacol Rearrangement

(2017) Yi Liu et al.   ACS Catalysis

Enantioselective Synthesis of Indole-Based Biaryl Atropisomers via Palladium-Catalyzed Dynamic Kinetic Intramolecular C–H Cyclization

(2017) Congfa He et al.   ACS Catalysis

Selective Palladium-Catalyzed Aminocarbonylation of Olefins to Branched Amides

(2016) Jie Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design and Enantioselective Construction of Axially Chiral Naphthyl-Indole Skeletons

(2016) Hong-Hao Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of axially chiral biaryl compounds by asymmetric catalytic reactions with transition metals

(2016) Pauline Loxq et al.   COORDINATION CHEMISTRY REVIEWS

Phosphoric Acid-Catalyzed Asymmetric Synthesis of SPINOL Derivatives

(2016) Shaoyu Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Symmetry in Cascade Chirality-Transfer Processes: A Catalytic Atroposelective Direct Arylation Approach to BINOL Derivatives

(2016) Jin-Zheng Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery and enantiocontrol of axially chiral urazoles via organocatalytic tyrosine click reaction

(2016) Ji-Wei Zhang et al.   Nature Communications

Asymmetric synthesis of pyrazoles and pyrazolones employing the reactivity of pyrazolin-5-one derivatives

(2015) Pankaj Chauhan et al.   CHEMICAL COMMUNICATIONS

Nonbiaryl and Heterobiaryl Atropisomers: Molecular Templates with Promise for Atropselective Chemical Transformations

(2015) Elango Kumarasamy et al.   CHEMICAL REVIEWS

Stronger Brønsted Acids: Recent Progress

(2015) Takahiko Akiyama et al.   CHEMICAL REVIEWS

Organocatalyzed Asymmetric Synthesis of Axially, Planar, and Helical Chiral Compounds

(2015) Seiji Shirakawa et al.   Chemistry-An Asian Journal

Atroposelective Synthesis of Axially Chiral Biaryldiols via Organocatalytic Arylation of 2-Naphthols

(2015) Ye-Hui Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Enantioselective Synthesis of Atropisomeric Biaryls: A Cation-Directed Nucleophilic Aromatic Substitution Reaction

(2014) Roly J. Armstrong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chiral phosphines in nucleophilic organocatalysis

(2014) Yumei Xiao et al.   Beilstein Journal of Organic Chemistry

Complete Field Guide to Asymmetric BINOL-Phosphate Derived Brønsted Acid and Metal Catalysis: History and Classification by Mode of Activation; Brønsted Acidity, Hydrogen Bonding, Ion Pairing, and Metal Phosphates

(2014) Dixit Parmar et al.   CHEMICAL REVIEWS

Rings in Drugs

(2014) Richard D. Taylor et al.   JOURNAL OF MEDICINAL CHEMISTRY

Planar Chiral Phosphoric Acids with Biphenylene-Tethered Paracyclophane Scaffolds: Synthesis, Characterization, and Catalytic Screening

(2014) Kévin Isaac et al.   JOURNAL OF ORGANIC CHEMISTRY

Pd(II)-Catalyzed Intermolecular Direct C–H Bond Iodination: An Efficient Approach toward the Synthesis of Axially Chiral Compounds via Kinetic Resolution

(2014) De-Wei Gao et al.   ACS Catalysis

Conquering three-carbon axial chirality of allenes

(2014) Juntao Ye et al.   Organic Chemistry Frontiers

Developing Irreversible Inhibitors of the Protein Kinase Cysteinome

(2013) Qingsong Liu et al.   CHEMISTRY & BIOLOGY

Dynamic Kinetic Cross-Coupling Strategy for the Asymmetric Synthesis of Axially Chiral Heterobiaryls

(2013) Abel Ros et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Synthesis of Multisubstituted Biaryl Skeleton by Chiral Phosphoric Acid Catalyzed Desymmetrization/Kinetic Resolution Sequence

(2013) Keiji Mori et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalytic Aryl–Aryl Bond Formation: An Atroposelective [3,3]-Rearrangement Approach to BINAM Derivatives

(2013) Gong-Qiang Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Catalysis for the Synthesis of Spirocyclic Compounds

(2013) Annaliese K. Franz et al.   ACS Catalysis

Advanced polyimide materials: Syntheses, physical properties and applications

(2012) Der-Jang Liaw et al.   PROGRESS IN POLYMER SCIENCE

I. Novel HCV NS5B polymerase inhibitors: Discovery of indole 2-carboxylic acids with C3-heterocycles

(2011) Gopinadhan N. Anilkumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Effect of CYP2C19 Genetic Polymorphism on Pharmacokinetics and Pharmacodynamics and Pharmacodynamics of a New Proton Pump Inhibitor, Ilaprazole

(2011) Hoon Cho et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Resolution of 1-[2-carboxy-6-(trifluoromethyl)phenyl]-1H-pyrrole-2-carboxylic acid with methyl (R)-2-phenylglycinate, reciprocal resolution and second order asymmetric transformation

(2011) Ferenc Faigl et al.   TETRAHEDRON-ASYMMETRY

SPINOL-Derived Phosphoric Acids: Synthesis and Application in Enantioselective Friedel−Crafts Reaction of Indoles with Imines

(2010) Fangxi Xu et al.   JOURNAL OF ORGANIC CHEMISTRY

The Challenge of Atropisomerism in Drug Discovery

(2009) Jonathan Clayden et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic enantioselective synthesis of axially chiral allenes

(2009) Masamichi Ogasawara   TETRAHEDRON-ASYMMETRY

Chiral Diphosphine and Monodentate Phosphorus Ligands on a Spiro Scaffold for Transition-Metal-Catalyzed Asymmetric Reactions

(2008) Jian-Hua Xie et al.   ACCOUNTS OF CHEMICAL RESEARCH

Binaphthol-derived phosphoric acid as a versatile catalyst for enantioselective carbon–carbon bond forming reactions

(2008) Masahiro Terada   CHEMICAL COMMUNICATIONS

The Marinopyrroles, Antibiotics of an Unprecedented Structure Class from a MarineStreptomycessp.

(2008) Chambers C. Hughes et al.   ORGANIC LETTERS

Recent Advances in Direct Arylation via Palladium-Catalyzed Aromatic C-H Activation

(2008) Zhang-Jie Shi et al.   SYNLETT