Dysfunction of Cullin 3 RING E3 ubiquitin ligase causes vasoconstriction and increased sodium reabsorption in diabetes

Metformin and Vascular Diseases: A Focused Review on Smooth Muscle Cell Function

(2020) Mingying Deng et al.   Frontiers in Pharmacology

ROCK (RhoA/Rho Kinase) in Cardiovascular–Renal Pathophysiology: A Review of New Advancements

(2020) Teresa M. Seccia et al.   Journal of Clinical Medicine

Inhibition of Sodium Glucose Cotransporter 2 Attenuates the Dysregulation of Kelch-Like 3 and NaCl Cotransporter in Obese Diabetic Mice

(2019) Kenichi Ishizawa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

RhoBTB1 protects against hypertension and arterial stiffness by restraining phosphodiesterase 5 activity

(2019) Masashi Mukohda et al.   JOURNAL OF CLINICAL INVESTIGATION

Vascular smooth muscle cells in atherosclerosis

(2019) Gemma L. Basatemur et al.   Nature Reviews Cardiology

Tanshinone IIA attenuates high glucose induced human VSMC proliferation and migration through miR-21-5p-mediated tropomyosin 1 downregulation

(2019) Shan Jia et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

PPARγ and RhoBTB1 in hypertension

(2019) Shi Fang et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

The Calcium-Sensing Receptor Increases Activity of the Renal NCC through the WNK4-SPAK Pathway

(2018) Silvana Bazúa-Valenti et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Excess mortality and cardiovascular disease in young adults with type 1 diabetes in relation to age at onset: a nationwide, register-based cohort study

(2018) Araz Rawshani et al.   LANCET

KLHL3 Knockout Mice Reveal the Physiological Role of KLHL3 and the Pathophysiology of Pseudohypoaldosteronism Type II Caused by Mutant KLHL3

(2017) Emi Sasaki et al.   MOLECULAR AND CELLULAR BIOLOGY

Phosphorylation by PKC and PKA regulate the kinase activity and downstream signaling of WNK4

(2017) Maria Castañeda-Bueno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dietary Approaches in the Management of Diabetic Patients with Kidney Disease

(2017) Gang Ko et al.   Nutrients

Involvement of selective autophagy mediated by p62/SQSTM1 in KLHL3-dependent WNK4 degradation

(2015) Y. Mori et al.   BIOCHEMICAL JOURNAL

Potassium Modulates Electrolyte Balance and Blood Pressure through Effects on Distal Cell Voltage and Chloride

(2015) Andrew S. Terker et al.   Cell Metabolism

Elevated Glucose Levels Promote Contractile and Cytoskeletal Gene Expression in Vascular Smooth Muscle via Rho/Protein Kinase C and Actin Polymerization

(2015) Tran Thi Hien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kelch-Like Protein 2 Mediates Angiotensin II-With No Lysine 3 Signaling in the Regulation of Vascular Tonus

(2015) M. Zeniya et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Toll-like receptor 2 mediates vascular contraction and activates RhoA signaling in vascular smooth muscle cells from STZ-induced type 1 diabetic rats

(2015) Luke Schmidt et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Hyperkalemic hypertension–associated cullin 3 promotes WNK signaling by degrading KLHL3

(2014) James A. McCormick et al.   JOURNAL OF CLINICAL INVESTIGATION

Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK

(2014) Hashem A. Dbouk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of ROCK upregulation in endothelial and smooth muscle vascular functions in diabetic rat aorta

(2013) Figen Amber Cicek et al.   Cardiovascular Diabetology

LINGO-1 Receptor Promotes Neuronal Apoptosis by Inhibiting WNK3 Kinase Activity

(2013) Zhaohuan Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4

(2013) S. Shibata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prevention of diabetes-induced arginase activation and vascular dysfunction by Rho kinase (ROCK) knockout

(2012) Lin Yao et al.   CARDIOVASCULAR RESEARCH

Phosphatidylinositol 3-Kinase/Akt Signaling Pathway Activates the WNK-OSR1/SPAK-NCC Phosphorylation Cascade in Hyperinsulinemic db/db Mice

(2012) Hidenori Nishida et al.   HYPERTENSION

Macrovascular angiopathy in children and adolescents with type 1 diabetes

(2011) Cosimo Giannini et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Improvement of vascular function by acute and chronic treatment with the PDE-5 inhibitor sildenafil in experimental diabetes mellitus

(2007) A Schäfer et al.   BRITISH JOURNAL OF PHARMACOLOGY