Article
Chemistry, Analytical
Shimeles Addisu Kitte, Terefe Tafese, Chen Xu, Muhammad Saqib, Haijuan Li, Yongdong Jin
Summary: The research demonstrated a highly sensitive electrochemiluminescence (ECL) immunosensor using functional nanoparticles as signal amplifiers for the detection of cardiac troponin I (cTnI), showing a significant signal enhancement compared to systems without gold nanoparticles. Utilizing a sandwich-type structure, the ECL platform exhibited a low detection limit and a wide linear range for cTnI detection.
Article
Chemistry, Multidisciplinary
Q. M. Kamrunnahar, Firoz Haider, Rifat Ahmmed Aoni, Jannatul Robaiat Mou, Shamsuttiyeba Shifa, Feroza Begum, Hairul Azhar Abdul-Rashid, Rajib Ahmed
Summary: A dual-channel propagation controlled plasmonic sensor based on photonic crystal fiber (PCF) was presented for simultaneous detection of multiple analytes. The sensor was numerically investigated and optimized, showing excellent performance in terms of sensitivity, resolution, and detection range. This proposed sensor can be a prominent candidate in biosensing and chemical sensing applications.
Article
Engineering, Electrical & Electronic
Ilgim Gokturk, Monireh Bakhshpour, Duygu Cimen, Fatma Yilmaz, Nilay Bereli, Adil Denizli
Summary: In this study, a sensitive, simple, and low-cost adenosine-imprinted sensor was successfully fabricated for label-free determination of adenosine in aqueous solution. The sensor showed high selectivity towards adenosine and demonstrated good repeatability.
IEEE SENSORS JOURNAL
(2022)
Article
Nanoscience & Nanotechnology
Kirthika Senthil Kumar, Lei Zhang, Manivannan Sivaperuman Kalairaj, Hritwick Banerjee, Xiao Xiao, Catherine Cai Jiayi, Hui Huang, Chwee Ming Lim, Jianyong Ouyang, Hongliang Ren
Summary: This study presents a highly stretchable skin-like strain sensor based on silver nanowires and hydrogel, with high tensile properties and sensitivity. The sensor modulates the gauge factor through thermal annealing, forming multidimensional wrinkles and a layered conductive network. It demonstrates effectiveness in integration and motion monitoring with good adaptability.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Pediatrics
Jinfeng Zhao, Xiaodan Xu, Qingyun Gou, Qipeng Zheng, Liang Ge, Lingzhi Chen, Cong Zhang, Hui Ma, Shuxiang Lin, Xiaoli Hu, Jianghua Zhan
Summary: LECT2 is highly expressed in patients with biliary atresia (BA) and is associated with fibrosis. Serum levels of LECT2 may serve as a potential diagnostic biomarker for BA. Additionally, TGF-beta 1 regulates LECT2 in relation to BA liver fibrosis.
FRONTIERS IN PEDIATRICS
(2022)
Article
Chemistry, Applied
Liyuan Zhang, Jiayu Chen, Lifeng Lu, Runzhong Yu, Dongjie Zhang
Summary: A simple, fast, low-cost, sensitive, intuitive, visual, label-free, and smartphone-assisted aptamer sensor based on colorimetric assay was developed for measuring zearalenone in maize. The sensor utilized a nucleic acid aptamer as the recognition element and gold nanoparticles as the indicator. Various factors including aptamer and NaCl concentration, incubation time, and specificity were investigated. The results demonstrated a good linear relationship between the signal and zearalenone concentration (5-300 ng/mL) under optimal conditions, with a linear regression equation of Y = 0.0003X + 0.5128 (R2 = 0.9989) and a limit of detection of 5 ng/mL. The sensor exhibited good specificity and successfully measured zearalenone in maize samples, achieving recoveries of 81.3% - 96.4%. The entire process could be completed within 15 minutes. This smartphone-assisted colorimetric aptamer sensor holds promise for zearalenone detection in maize.
Article
Gastroenterology & Hepatology
Jinghua Wang, Yishu Chen, Ran Pan, Chao Wu, Shenghui Chen, Lan Li, Youming Li, Chaohui Yu, Zhuo-xian Meng, Chengfu Xu
Summary: LECT2 expression is significantly elevated in NAFLD patients and HFD-fed mice. LECT2 induces the occurrence and development of NAFLD through the STAT-1 pathway. LECT2 may be a potential therapeutic target for NAFLD.
LIVER INTERNATIONAL
(2021)
Article
Chemistry, Analytical
Aleksei Furletov, Vladimir Apyari, Alexey Garshev, Stanislava Dmitrienko, Yury Zolotov
Summary: In this study, the potential of silver triangular nanoplates (AgTNPs) as a colorimetric probe for the fast and sensitive determination of bioflavonoids was assessed. The interaction between AgTNPs and bioflavonoids in the presence of silver(I) ions resulted in a bathochromic shift and increased intensity of the nanoparticles' local surface plasmon resonance band. The detection limits of different bioflavonoids were determined and the influence of analyte structure and external factors on the analytical signal was discussed.
Article
Chemistry, Analytical
Ching-Hsu Yang, Tzu-Heng Wu, Chia-Chen Chang, Hui-Yun Lo, Hui-Wen Liu, Nien-Tsu Huang, Chii-Wann Lin
Summary: Surface Plasmon Resonance (SPR) is widely used in biological and chemical sensing, but its application is hindered by non-specific binding and low signal. Hybridization chain reaction (HCR) can amplify signals and provide an enzyme-free alternative for biosensing, by utilizing DNA as an amplifying transducer. Integrating HCR with phase-sensitive SPR (pSPR) can lead to highly informative sensing in biosensing applications.
Article
Chemistry, Applied
Bing Han, Cheng Fang, Lingjun Sha, Mohammed Jalalah, M. S. Al-Assiri, Farid A. Harraz, Ya Cao
Summary: A new fluorescent aptasensor using cascade strand displacement reaction was proposed for the detection of ochratoxin A, achieving an improved detection limit and short assay time. The method showed potential for use in food quality control in the future.
Article
Chemistry, Analytical
Minghui Nan, Bobby Aditya Darmawan, Gwangjun Go, Shirong Zheng, Junhyeok Lee, Seokjae Kim, Taeksu Lee, Eunpyo Choi, Jong-Oh Park, Doyeon Bang
Summary: A flexible localized surface plasmon resonance biosensor was manufactured to detect cortisol levels in the human body. The biosensor exhibited excellent detection ability in cortisol solutions of various concentrations and demonstrated good stability under mechanical deformations. These biosensors can be versatile candidates for measuring human stress levels by combining flexible sensors with sensitive cortisol-detecting molecules.
Article
Materials Science, Multidisciplinary
Lakhvir Singh, Kamalesh Tripathy, Mitradip Bhattacharjee
Summary: This study presents a flexible PDMS-based pressure sensor with hemispherical microstructures, achieving high sensitivity and operation range. Experiments and simulations show that decreasing the substrate thickness and adding porosity can further improve the sensor performance.
ADVANCED ENGINEERING MATERIALS
(2022)
Article
Chemistry, Analytical
Valentina Lucarelli, Damon Colbert, Shiwei Li, Mathew Cumming, Wayne Linklater, John Mitchell, Jadranka Travas-Sejdic, Andrew Kralicek
Summary: Rats, as invasive mammalian predators, pose a major threat to ecosystem functioning globally. This study developed a new sensing paradigm using a specific rat urine biomarker to detect and monitor the presence of rats more sensitively and at a lower cost. The researchers successfully selected aptamers and characterized their affinity and specificity towards the biomarker. The developed biosensor platforms showed high specificity and nanomolar range dissociation constants, indicating their potential for remote surveillance of rats.
Article
Microbiology
Issam Hmila, Boutheina Marnissi, Masood Kamali-Moghaddam, Abdeljelil Ghram
Summary: Infectious bronchitis virus (IBV) is a major health problem in the poultry industry, causing high morbidity, high mortality, and large economic losses. The virus can mutate into new strains, leading to devastating disease and outbreaks.
MICROBIOLOGY SPECTRUM
(2023)
Article
Chemistry, Analytical
Xiaoyan Yang, Rong Huang, Lulu Xiong, Feng Chen, Wei Sun, Ling Yu
Summary: A novel colorimetric aptasensor was developed to detect ochratoxin A (OTA) by utilizing charge effect-assisted silver enhancement. Gold nanoparticles (AuNPs) were used as carriers of aptamers tagged with a positively charged tetramethylrhodamine (TAMRA), which catalyzed silver reduction and deposition. The TAMRA attracted and retained the silver lactate around the AuNPs due to the attraction between positive and negative charges, increasing the chance of AuNP-catalyzed silver reduction. The charge effect-assisted silver enhancement was confirmed by tagging aptamers of different base pair lengths with TAMRA. The as-prepared OTA aptasensor exhibited a working range of 1 x 10(2)-1 x 10(6) pg mL(-1) and a detection limit of 28.18 pg mL(-1). It was successfully applied to determine OTA in actual samples with satisfactory results.
