Visualizing the Interplay of Lipid Droplets and Protein Aggregates During Aging via a Dual-Functional Fluorescent Probe

Light-Up Lipid Droplets Dynamic Behaviors Using a Red-Emitting Fluorogenic Probe

(2020) Xin Zhang et al.   ANALYTICAL CHEMISTRY

Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain

(2020) Julia Marschallinger et al.   NATURE NEUROSCIENCE

Aurone Derivative Revealing the Metabolism of Lipid Droplets and Monitoring Oxidative Stress in Living Cells

(2020) Kangnan Wang et al.   ANALYTICAL CHEMISTRY

Ageing, metabolism and the intestine

(2020) Maja C Funk et al.   EMBO REPORTS

Monitoring plasma protein aggregation during aging using conformation-specific antibodies and FTIR spectroscopy

(2019) Sandra Magalhães et al.   CLINICA CHIMICA ACTA

Interface-Targeting Strategy Enables Two-Photon Fluorescent Lipid Droplet Probes for High-Fidelity Imaging of Turbid Tissues and Detecting Fatty Liver

(2018) Lifang Guo et al.   ACS Applied Materials & Interfaces

Ultrabright and Fluorogenic Probes for Multicolor Imaging and Tracking of Lipid Droplets in Cells and Tissues

(2018) Mayeul Collot et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Mitochondria-Specific Fluorescent Probe for Visualizing Endogenous Hydrogen Cyanide Fluctuations in Neurons

(2018) Lingliang Long et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein aggregates and proteostasis in aging: Amylin and β-cell function

(2018) Michaela Press et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Autophagy as a promoter of longevity: insights from model organisms

(2018) Malene Hansen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human aging and disease: Lessons from age-related macular degeneration

(2018) Jennings Luu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Seipin deficiency in mice causes loss of dopaminergic neurons via aggregation and phosphorylation of α-synuclein and neuroinflammation

(2018) Ling Wang et al.   Cell Death & Disease

Wnt signaling in bone, kidney, intestine, and adipose tissue and interorgan interaction in aging

(2018) Di Chen et al.   Annals of the New York Academy of Sciences

Protein aggregation – Mechanisms, detection, and control

(2018) Wei Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Coumarin-Based Fluorescent Probes for Super-resolution and Dynamic Tracking of Lipid Droplets

(2018) Hongkang Xu et al.   ANALYTICAL CHEMISTRY

Dynamics and functions of lipid droplets

(2018) James A. Olzmann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tuning the stereo-hindrance of a curcumin scaffold for the selective imaging of the soluble forms of amyloid beta species

(2017) Yuyan Li et al.   Chemical Science

Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice

(2016) Natalie E. de Picciotto et al.   AGING CELL

Lipid droplets, lipophagy, and beyond

(2016) Chao-Wen Wang   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome

(2016) Roland Hjerpe et al.   CELL

Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice

(2016) Kathryn F. Mills et al.   Cell Metabolism

A pyrazolo[1,5-a]pyridine-fused pyrimidine based novel fluorophore and its bioapplication to probing lipid droplets

(2016) Heejun Kim et al.   CHEMICAL COMMUNICATIONS

MARCKS-dependent mucin clearance and lipid metabolism in ependymal cells are required for maintenance of forebrain homeostasis during aging

(2015) Nagendran Muthusamy et al.   AGING CELL

Widespread Proteome Remodeling and Aggregation in Aging C. elegans

(2015) Dirk M. Walther et al.   CELL

Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration

(2015) Lucy Liu et al.   CELL

A fluorescent probe for hypochlorite based on the modulation of the unique rotation of the N–N single bond in acetohydrazide

(2015) Lingliang Long et al.   CHEMICAL COMMUNICATIONS

Lipid Droplets Are Essential for Efficient Clearance of Cytosolic Inclusion Bodies

(2015) Ofer Moldavski et al.   DEVELOPMENTAL CELL

Role for Lipid Droplet Biogenesis and Microlipophagy in Adaptation to Lipid Imbalance in Yeast

(2015) Jason D. Vevea et al.   DEVELOPMENTAL CELL

Chemical Fluorescent Probe for Detection of Aβ Oligomers

(2015) Chai Lean Teoh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Proteostasis and aging

(2015) Susmita Kaushik et al.   NATURE MEDICINE

Protein aggregates are associated with replicative aging without compromising protein quality control

(2015) Juha Saarikangas et al.   eLife

Geroscience: Linking Aging to Chronic Disease

(2014) Brian K. Kennedy et al.   CELL

The impact of ageing on the intestinal epithelial barrier and immune system

(2014) Angela L. Man et al.   CELLULAR IMMUNOLOGY

Accumulation of modified proteins and aggregate formation in aging

(2014) Kerstin Nowotny et al.   EXPERIMENTAL GERONTOLOGY

Activation of Autophagy by Rapamycin Does Not Protect Oligodendrocytes Against Protein Aggregate Formation and Cell Death Induced by Proteasomal Inhibition

(2014) Monika Noack et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Spectral properties of Nile red in solutions and thin films

(2014) L. G. Samsonova et al.   OPTICS AND SPECTROSCOPY

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

The Structural Basis for Optimal Performance of Oligothiophene-Based Fluorescent Amyloid Ligands: Conformational Flexibility is Essential for Spectral Assignment of a Diversity of Protein Aggregates

(2013) Therése Klingstedt et al.   CHEMISTRY-A EUROPEAN JOURNAL

Design and Synthesis of Curcumin Analogues for in Vivo Fluorescence Imaging and Inhibiting Copper-Induced Cross-Linking of Amyloid Beta Species in Alzheimer’s Disease

(2013) Xueli Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural, functional and molecular analysis of the effects of aging in the small intestine and colon of C57BL/6J mice

(2012) Wilma T Steegenga et al.   BMC Medical Genomics

Luminescent Chemodosimeters for Bioimaging

(2012) Yuming Yang et al.   CHEMICAL REVIEWS

Ageing as a Risk Factor for Disease

(2012) Teresa Niccoli et al.   CURRENT BIOLOGY

Raster Image Correlation Spectroscopy As a Novel Tool for the Quantitative Assessment of Protein Diffusional Behaviour in Solution

(2012) Zahra Hamrang et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Aging and disease: connections to sirtuins

(2010) Gizem Donmez et al.   AGING CELL

Novel Cell- and Tissue-Based Assays for Detecting Misfolded and Aggregated Protein Accumulation Within Aggresomes and Inclusion Bodies

(2010) Dee Shen et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

A pitfall in using BODIPY dyes to label lipid droplets for fluorescence microscopy

(2010) Yuki Ohsaki et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Cell biology of lipid droplets

(2008) Christoph Thiele et al.   CURRENT OPINION IN CELL BIOLOGY

Asymmetric segregation of protein aggregates is associated with cellular aging and rejuvenation

(2008) A. B. Lindner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA