Role and Regulation of Wnt/β-Catenin in Hepatic Perivenous Zonation and Physiological Homeostasis

Metabolic and non-metabolic liver zonation is established non-synchronously and requires sinusoidal Wnts

(2020) Ruihua Ma et al.   eLife

Mitochondrial Heme Synthesis Enzymes as Therapeutic Targets in Vascular Diseases

(2020) Trupti Shetty et al.   Frontiers in Pharmacology

Functional compensation precedes recovery of tissue mass following acute liver injury

(2020) Chad M. Walesky et al.   Nature Communications

Inhibiting Glutamine-Dependent mTORC1 Activation Ameliorates Liver Cancers Driven by β-Catenin Mutations

(2019) Adeola O. Adebayo Michael et al.   Cell Metabolism

HO-1 overexpression and underexpression: Clinical implications

(2019) George S. Drummond et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Wnt/β‐Catenin signaling plays a protective role in the Mdr2 KO murine model of cholestatic liver disease

(2019) Tirthadipa Pradhan‐Sundd et al.   HEPATOLOGY

The developmental Wnt signaling pathway effector β-catenin/TCF mediates hepatic functions of the sex hormone estradiol in regulating lipid metabolism

(2019) Lili Tian et al.   PLOS BIOLOGY

Overview of organic anion transporters and organic anion transporter polypeptides and their roles in the liver

(2019) Ting-Ting Li et al.   World Journal of Clinical Cases

Wnt/β-Catenin Signaling in Liver Development, Homeostasis, and Pathobiology

(2018) Jacquelyn O. Russell et al.   Annual Review of Pathology-Mechanisms of Disease

Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice

(2018) Thomas Leibing et al.   HEPATOLOGY

β-Catenin regulation of farnesoid X receptor signaling and bile acid metabolism during murine cholestasis

(2018) Michael D. Thompson et al.   HEPATOLOGY

Hepatic IRS1 and ß-catenin expression is associated with histological progression and overt diabetes emergence in NAFLD patients

(2018) Kenichiro Enooku et al.   JOURNAL OF GASTROENTEROLOGY

Glucagon contributes to liver zonation

(2018) Xiping Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A multiscale modelling approach to assess the impact of metabolic zonation and microperfusion on the hepatic carbohydrate metabolism

(2018) Nikolaus Berndt et al.   PLoS Computational Biology

The association between chemical-induced porphyria and hepatic cancer

(2018) Andrew G. Smith et al.   Toxicology Research

Paired-cell sequencing enables spatial gene expression mapping of liver endothelial cells

(2018) Keren Bahar Halpern et al.   NATURE BIOTECHNOLOGY

Investigation of the Lipid-Lowering Effect of Vitamin C Through GSK-3β/β-Catenin Signaling in Zebrafish

(2018) Dongwu Liu et al.   Frontiers in Physiology

Loss of hepatocyte β-catenin protects mice from experimental porphyria-associated liver injury

(2018) Harvinder Saggi et al.   JOURNAL OF HEPATOLOGY

Vitamin C and Immune Function

(2017) Anitra Carr et al.   Nutrients

Second-generation antisense oligonucleotides against β-catenin protect mice against diet-induced hepatic steatosis and hepatic and peripheral insulin resistance

(2016) Violeta B. Popov et al.   FASEB JOURNAL

The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size

(2016) Lara Planas-Paz et al.   NATURE CELL BIOLOGY

Hepatocyte specific expression of an oncogenic variant of β-catenin results in cholestatic liver disease

(2016) Ursula J. Lemberger et al.   Oncotarget

Zonation of hepatic fatty acid metabolism — The diversity of its regulation and the benefit of modeling

(2015) J. Schleicher et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

β-Catenin Signaling and Roles in Liver Homeostasis, Injury, and Tumorigenesis

(2015) Satdarshan Pal Monga   GASTROENTEROLOGY

Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver

(2015) Bruce Wang et al.   NATURE

Morphologic and Molecular Features of Hepatocellular Adenoma with Gadoxetic Acid–enhanced MR Imaging

(2015) Ahmed Ba-Ssalamah et al.   RADIOLOGY

A metabolic stress-inducible miR-34a-HNF4α pathway regulates lipid and lipoprotein metabolism

(2015) Yang Xu et al.   Nature Communications

The Angiocrine Factor Rspondin3 Is a Key Determinant of Liver Zonation

(2015) Ana Sofia Rocha et al.   Cell Reports

Pro-Regenerative Signaling after Acetaminophen-Induced Acute Liver Injury in Mice Identified Using a Novel Incremental Dose Model

(2014) Bharat Bhushan et al.   AMERICAN JOURNAL OF PATHOLOGY

β-Catenin Links Hepatic Metabolic Zonation with Lipid Metabolism and Diet-Induced Obesity in Mice

(2014) Jaideep Behari et al.   AMERICAN JOURNAL OF PATHOLOGY

The Combined Hyperlipidemia Caused by Impaired Wnt-LRP6 Signaling Is Reversed by Wnt3a Rescue

(2014) Gwang-woong Go et al.   Cell Metabolism

Beta-catenin signaling in murine liver zonation and regeneration: A Wnt-Wnt situation!

(2014) Jing Yang et al.   HEPATOLOGY

OATP1B3 expression is strongly associated with Wnt/β-catenin signalling and represents the transporter of gadoxetic acid in hepatocellular carcinoma

(2014) Akihisa Ueno et al.   JOURNAL OF HEPATOLOGY

Liver zonation: Novel aspects of its regulation and its impact on homeostasis

(2014) Rolf Gebhardt   WORLD JOURNAL OF GASTROENTEROLOGY

Toggling a conformational switch in Wnt/β-catenin signaling: Regulation of Axin phosphorylation

(2013) Ofelia Tacchelly-Benites et al.   BIOESSAYS

T-cell factor 4 and β-catenin chromatin occupancies pattern zonal liver metabolism in mice

(2013) Angélique Gougelet et al.   HEPATOLOGY

The Wnt signaling pathway effector TCF7L2 is upregulated by insulin and represses hepatic gluconeogenesis

(2012) Wilfred Ip et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hepatocyte-specific deletion of hepatocyte nuclear factor-4α in adult mice results in increased hepatocyte proliferation

(2012) Chad Walesky et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

β-Catenin Regulates Hepatic Mitochondrial Function and Energy Balance in Mice

(2012) Nadja Lehwald et al.   GASTROENTEROLOGY

Beta-catenin-activated hepatocellular adenoma showing hyperintensity on hepatobiliary-phase gadoxetic-enhanced magnetic resonance imaging and overexpression of OATP8

(2012) Norihide Yoneda et al.   JAPANESE JOURNAL OF RADIOLOGY

Low Density Lipoprotein (LDL) Receptor-related Protein 6 (LRP6) Regulates Body Fat and Glucose Homeostasis by Modulating Nutrient Sensing Pathways and Mitochondrial Energy Expenditure

(2012) Wenzhong Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Expression and Function of Organic Anion Transporting Polypeptides in Normal Tissues and in Cancer

(2011) Amanda Obaidat et al.   Annual Review of Pharmacology and Toxicology

Expression of SLCO1B3 is associated with intratumoral cholestasis and CTNNB1 mutations in hepatocellular carcinoma

(2011) Shigeki Sekine et al.   CANCER SCIENCE

β-Catenin is essential for ethanol metabolism and protection against alcohol-mediated liver steatosis in mice

(2011) Shiguang Liu et al.   HEPATOLOGY

Wnt Signaling Regulates Hepatic Metabolism

(2011) H. Liu et al.   Science Signaling

Hepatic Hepatocyte Nuclear Factor 4α Is Essential for Maintaining Triglyceride and Cholesterol Homeostasis

(2010) Liya Yin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Zonation of heme synthesis enzymes in mouse liver and their regulation by β-catenin and Ha-ras

(2010) Albert Braeuning et al.   BIOLOGICAL CHEMISTRY

Liver-specific β-catenin knockout mice have bile canalicular abnormalities, bile secretory defect, and intrahepatic cholestasis

(2010) Tzu-Hsuan Yeh et al.   HEPATOLOGY

Wnt/β-Catenin Signaling Activates and Determines Hepatic Zonal Expression of Glutathione S-Transferases in Mouse Liver

(2010) Stefanie Giera et al.   TOXICOLOGICAL SCIENCES

Liver-Specific β-Catenin Knockout Mice Exhibit Defective Bile Acid and Cholesterol Homeostasis and Increased Susceptibility to Diet-Induced Steatohepatitis

(2009) Jaideep Behari et al.   AMERICAN JOURNAL OF PATHOLOGY

β-Catenin as a multilayer modulator of zonal cytochrome P450 expression in mouse liver

(2009) Albert Braeuning et al.   BIOLOGICAL CHEMISTRY

Inducibility of Drug-Metabolizing Enzymes by Xenobiotics in Mice with Liver-Specific Knockout of Ctnnb1

(2009) A. Braeuning et al.   DRUG METABOLISM AND DISPOSITION

Liver Zonation Occurs Through a β-Catenin–Dependent, c-Myc–Independent Mechanism

(2009) Zoé D. Burke et al.   GASTROENTEROLOGY

Convergence of Wnt Signaling on the HNF4α-Driven Transcription in Controlling Liver Zonation

(2009) Marta Colletti et al.   GASTROENTEROLOGY

Transcription dynamics in a physiological process: β-Catenin signaling directs liver metabolic zonation

(2009) Cyril Torre et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

β-Catenin Regulates Vitamin C Biosynthesis and Cell Survival in Murine Liver

(2009) Kari N. Nejak-Bowen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New molecular insights into the mechanisms of cholestasis

(2009) Martin Wagner et al.   JOURNAL OF HEPATOLOGY

Proteomic analysis of β-catenin activation in mouse liver by DIGE analysis identifies glucose metabolism as a new target of the Wnt pathway

(2009) Philippe Chafey et al.   PROTEOMICS

Coordinate regulation of human drug-metabolizing enzymes, and conjugate transporters by the Ah receptor, pregnane X receptor and constitutive androstane receptor

(2008) Christoph Köhle et al.   BIOCHEMICAL PHARMACOLOGY

β-Catenin deletion in hepatoblasts disrupts hepatic morphogenesis and survival during mouse development

(2008) Xinping Tan et al.   HEPATOLOGY

Knockdown of tight junction protein claudin-2 prevents bile canalicular formation in WIF-B9 cells

(2008) Seiichi Son et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Interaction of FOXO with β-Catenin Inhibits β-Catenin/T Cell Factor Activity

(2008) Diana Hoogeboom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver

(2008) K. R. Reed et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis

(2007) Jason H. Cheng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY