Article
Geriatrics & Gerontology
Chiara de Lucia, Tytus Murphy, Aleksandra Maruszak, Paul Wright, Timothy R. Powell, Naomi Hartopp, Simone de Jong, Michael J. O'Sullivan, Gerome Breen, Jack Price, Simon Lovestone, Sandrine Thuret
Summary: The study found that exposure to older human serum can increase apoptotic cell death of hippocampal progenitor cells, leading to changes in hippocampal morphology. Additionally, the use of antihypertensive medication and mild cognitive decline in elderly subjects were shown to impact the variability in cell proliferation and differentiation markers. The findings suggest a role for the systemic environment in neural stem cell maintenance, with implications for understanding the effects of environmental exposures and age-related changes on health and disease.
Article
Biochemistry & Molecular Biology
Kathrin Barth, Verica Vasic, Brennan McDonald, Nora Heinig, Marc-Christoph Wagner, Ulrike Schumann, Cora Roehlecke, Frank Bicker, Lana Schumann, Konstantin Radyushkin, Jan Baumgart, Stefan Tenzer, Frauke Zipp, Matthias Meinhardt, Kari Alitalo, Irmgard Tegeder, Mirko H. H. Schmidt
Summary: Mature neurons, neural stem cells, and neural precursor cells secrete the neurovascular protein EGFL7 to shape the neurogenic niche of the hippocampus. Ablation of EGFL7 leads to increased neurogenesis and is correlated with elevated expression of VEGF-D. Infusion of VEGF-D increases neurogenesis, while its knockout decreases neurogenesis. Furthermore, EGFL7 knockout mice show improved spatial memory and memory consolidation in the hippocampus.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Cell & Tissue Engineering
Sebastian B. Arredondo, Daniela Valenzuela-Bezanilla, Sebastian H. Santibanez, Lorena Varela-Nallar
Summary: The subgranular zone of the hippocampal dentate gyrus is a neurogenic niche that contains neural stem cells capable of generating granule neurons. Wnt ligands play diverse roles in regulating adult hippocampal neurogenesis. Understanding the cellular source and mechanisms of Wnt signaling will be crucial for future therapeutic interventions.
Review
Neurosciences
Saeid Bagheri-Mohammadi
Summary: This article discusses the role of molecular signaling pathways in hippocampal neurogenesis in the adult brain, focusing on the collaboration between the Notch signaling pathway and other signaling pathways.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Taeko Kobayashi, Ryoichiro Kageyama
Summary: Quiescence is a cellular strategy that maintains somatic stem cells in a low metabolic state in a specific niche to prevent premature exhaustion in the brain. During development, neural stem cells actively proliferate and differentiate, while most adult neural stem cells are quiescent to ensure a sustainable source of stem cells throughout life. The transition between quiescence and proliferation is tightly regulated by various signaling pathways, with recent studies highlighting the role of proteostasis and lysosomes in the quiescence of adult NSCs.
Review
Cell Biology
Shuzo Matsubara, Taito Matsuda, Kinichi Nakashima
Summary: Tissue-specific stem cells generate new functional cells to maintain tissue homeostasis and repair damaged tissue. Neurogenesis of endogenous NSCs alone is insufficient for complete brain repair, leading to exploration of direct reprogramming as an innovative approach. This review discusses the control of NSCs and neurogenesis in the adult brain, as well as the potential of direct neuronal reprogramming for future clinical applications.
Article
Neurosciences
Michele Longoni Calio, Amanda Cristina Mosini, Darci Souza Marinho, Geisa Nogueira Salles, Fernando Henrique Massinhani, Gui Mi Ko, Marimelia Aparecida Porcionatto
Summary: The study demonstrates that leptin administration can promote neurogenesis in adult and aged mice, leading to significant effects on proliferation and differentiation of newborn cells, while reducing the formation of senile plaques and neurodegenerative damage. By modulating the number of surrounding cells and inhibiting the production of superoxide anions, leptin may potentially serve as a new therapy for Alzheimer's disease.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Cell Biology
Joshua D. Rieskamp, Patricia Sarchet, Bryon M. Smith, Elizabeth D. Kirby
Summary: The study estimated the cell density of neural stem/progenitor cells in the dentate gyrus of adult mice using immunohistochemical methods and found that they had similar density as other cell types with secretory functions. These findings contribute to refining hypotheses about the roles of these cell types in regulating hippocampal function and their potential therapeutic uses.
NEURAL REGENERATION RESEARCH
(2022)
Article
Neurosciences
Ane Rodriguez-Bodero, Juan Manuel Encinas-Perez
Summary: Postnatal and adult neurogenesis occur in the dentate gyrus of the hippocampus in most mammals. Neural stem cells and newborn neurons serve as biosensors of hippocampal health, providing valuable information about neuronal activity and disease injuries.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Medicine, Research & Experimental
Salinee Naewla, Ram Prajit, Nataya Sritawan, Kornrawee Suwannakot, Apiwat Sirichoat, Anusara Aranarochana, Peter Wigmore, Jariya Umka Welbat
Summary: This study investigated the effects of the flavonoid Hesperidin (Hsd), found in citrus fruits, on MTX-induced apoptosis of hippocampal neural stem cells. The results showed that Hsd can attenuate the impairments of hippocampal NSC proliferation and neuronal apoptosis caused by MTX.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biology
Nannan Guo, Kelsey D. McDermott, Yu-Tzu Shih, Haley Zanga, Debolina Ghosh, Charlotte Herber, William R. Meara, James Coleman, Alexia Zagouras, Lai Ping Wong, Ruslan Sadreyev, J. Tiago Goncalves, Amar Sahay
Summary: This study reveals that the transcription factor Klf9 functions as a brake on symmetric self-renewal of radial-glial neural stem cells (RGLs) in mice. The loss of Klf9 promotes the activation state of RGLs and leads to increased symmetric self-renewal. The study also provides molecular insights into the genetic programs underlying RGL symmetric self-renewal, including Notch and mitogen signaling, cell cycle, fatty acid oxidation, and lipogenesis.
Article
Neurosciences
Natalie N. Nawarawong, K. Ryan Thompson, Steven P. Guerin, Chinchusha Anasooya Shaji, Hui Peng, Kimberly Nixon
Summary: Recent studies suggest that females may be more susceptible to alcohol-induced brain damage, and during abstinence from alcohol dependence, adult female rats also exhibit similar reactive increases in hippocampal neurogenesis. These data suggest that reactive, adult neurogenesis may be a means of recovery for the hippocampus after alcohol dependence in females.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Jie Li, Yiqian Ding, Jianhua Zhang, Yating Zhang, Yiduo Cui, Yi Zhang, Shiyang Chang, Yan-Zhong Chang, Guofen Gao
Summary: This study found that brain iron overload has detrimental effects on adult hippocampal neurogenesis, leading to memory decline and anxiety-like behavior. The damage is possibly caused by iron-mediated downregulation of proprotein convertase furin, resulting in decreased maturation of brain-derived neurotrophic factor (BDNF), which affects neural stem cell differentiation. Thus, modulating iron homeostasis and furin expression could be potential therapeutic strategies for neurological diseases.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Biochemistry & Molecular Biology
Ying Zhang, Chi Xu
Summary: This review introduces the synthesis and secretion mechanism of exosomes, discusses their relationship with hippocampal neurogenesis, mood and cognition, and psychiatric disorders. It also explores their roles in regulating depression, epilepsy, and schizophrenia, as well as their prospects in diagnosing CNS disorders.
MOLECULAR BIOLOGY REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Il Bin Kim, Seon-Cheol Park
Summary: Depression is characterized by impairments in adult neurogenesis, particularly in the hippocampus. Disruption of hippocampal neurogenesis in depression may be a consequence of neural circuitry impairments, with the entorhinal cortex playing a regulatory role. However, the exact mechanisms by which disruption of neural circuitry leads to neurogenesis impairments in depression, specifically regarding the regulatory role of the entorhinal cortex, remain unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Giacomo Masserdotti, Sebastien Gillotin, Bernd Sutor, Daniela Drechsel, Martin Irmler, Helle F. Jorgensen, Steffen Sass, Fabian J. Theis, Johannes Beckers, Benedikt Berninger, Francois Guillemot, Magdalena Goetz
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Cell Biology
Alexandre A. S. F. Raposo, Francisca F. Vasconcelos, Daniela Drechsel, Corentine Marie, Caroline Johnston, Dirk Dolle, Angela Bithell, Sebastien Gillotin, Debbie L. C. van den Berg, Laurence Ettwiller, Paul Flicek, Gregory E. Crawford, Carlos M. Parras, Benedikt Berninger, Noel J. Buckley, Francois Guillemot, Diogo S. Castro
Article
Multidisciplinary Sciences
Sebastien Gillotin, John D. Davies, Anna Philpott
SCIENTIFIC REPORTS
(2018)
Article
Cell Biology
Sebastien Gillotin, Damian Yap, Xin Lu
Article
Biochemistry & Molecular Biology
Sebastien Gillotin, Xin Lu
Editorial Material
Oncology
Sebastien Gillotin
Article
Multidisciplinary Sciences
Roberta Azzarelli, Steffen Rulands, Sonia Nestorowa, John Davies, Sara Campinoti, Sebastien Gillotin, Paola Bonfanti, Berthold Gottgens, Meritxell Huch, Benjamin Simons, Anna Philpott
SCIENTIFIC REPORTS
(2018)
Article
Biology
Sebastien Gillotin
Article
Biochemistry & Molecular Biology
EA Slee, S Gillotin, D Bergamaschi, C Royer, S Llanos, S Ali, BQ Jin, G Trigiante, X Lu