Article
Chemistry, Multidisciplinary
Qing Liu, Hong-Bo Cheng, Rui Ma, Mingming Yu, Yuanyu Huang, Lele Li, Jian Zhao
Summary: A near-infrared light-guided DNA nanodevice is developed for precise drug delivery and tumor therapy. The nanodevice consists of GC-rich DNA duplexes with a UV light labile moiety and upconversion nanoparticles. Upon NIR light irradiation, the nanoparticles emit UV light to break the pho-tolabile moiety, resulting in controlled drug release and fluorescence signal recovery. This modular strategy enables remotely controlled drug delivery and in situ imaging.
Article
Engineering, Biomedical
Gaizhen Kuang, Hongtong Lu, Shasha He, Hejian Xiong, Jie Yu, Qingfei Zhang, Yubin Huang
Summary: Multifunctional nanoparticles combining multiple imaging modes and NIR light-activated drug/gene delivery have great potential in cancer therapy, displaying excellent therapeutic efficacy both in vitro and in vivo.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Rangrang Fan, Caili Chen, Huan Hou, Di Chuan, Min Mu, Zhiyong Liu, Ruichao Liang, Gang Guo, Jianguo Xu
Summary: The development of folic acid functionalized polydopamine nanoparticles for dual delivery of doxorubicin and epigallocatechin-3-gallate has shown promising results in enhancing cellular uptake and anti-tumor efficacy with the assistance of near-infrared light. In vivo studies demonstrate improved drug accumulation, penetration, and retention in tumors, leading to significant suppression of tumor growth and improved survival rates in breast cancer-bearing mice. These nanoparticles have the potential to serve as an effective nanoscale vector for enhanced cancer therapy.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Xiaoyun Li, Rui Wu, Huan Chen, Ting Li, Huiming Jiang, Xingquan Xu, Xueting Tang, Mimi Wan, Chun Mao, Dongquan Shi
Summary: This near-infrared light-driven multifunctional micromotor can rapidly target damaged blood vessels and release different drugs, promoting penetration into plaque sites through motion effects and achieving photothermal ablation of inflammatory macrophages through heat effects. In vivo experiments have demonstrated that these micromotors can provide good therapeutic effects for atherosclerosis.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Engineering, Environmental
Xinyu Cui, Minghui Li, Feng Wei, Xuefeng Tang, Weili Xu, Miaojing Li, Xiaojun Han
Summary: This study successfully constructed a nanodrug carrier with high loading rate via lipid self-assembly, enabling synergistic chemophotothermal therapy for efficient solid tumor removal in vivo. The excellent integration of mesoporous-silica-coated rGO and lipid bilayer demonstrated great potential for graphene-based nanomaterials in biomedical applications.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Multidisciplinary Sciences
Yu Chen, Zhongzheng Yu, Kai Zheng, Yaguang Ren, Meng Wang, Qiang Wu, Feifan Zhou, Chengbo Liu, Liwei Liu, Jun Song, Junle Qu
Summary: Metallic and semimetallic mesoporous frameworks have unique properties and wide applications. However, semimetallic mesoporous structures are difficult to obtain using traditional methods. In this study, monodisperse mesoporous antimony nanospheres were successfully synthesized using a selective etching route, with tunable pore sizes. The antimony nanospheres showed wide absorption in the visible to second near-infrared (NIR-II) region, with promising NIR-II photothermal performance and photoacoustic signal. These multifunctional nanospheres could be used for synergistic photothermal/chemo therapy guided by NIR-II photoacoustic imaging.
NATURE COMMUNICATIONS
(2022)
Article
Robotics
Erina Baynojir Joyee, Adam Szmelter, David Eddington, Yayue Pan
Summary: This study presents a 3D-printed soft robot with varied material compositions and hierarchical surface structures. The robot exhibits superior locomotion capabilities and versatile functionalities, making it suitable for tasks in harsh environments.
Article
Chemistry, Multidisciplinary
Chuangui Sheng, Fangzhi Yu, Youming Feng, Ming Gao, Wei Li, Lele Li, Jian Zhao
Summary: Metal-organic frameworks (MOFs) are used as a promising platform for protein delivery due to their high loading capacity and tunable functionality. However, the controlled release of proteins from MOFs-based nanocarriers is still a challenge. In this study, a MOFs-based protein delivery system that can precisely control protein release using near-infrared (NIR) light is reported. The system involves the encapsulation of proteins and upconversion nanoparticles (UCNPs) within MOFs and the use of NIR light to trigger the release of the proteins.
Article
Pharmacology & Pharmacy
Kerong Deng, Donglian Liu, Ziyan Wang, Zhaoru Zhou, Qianyi Chen, Jiamin Luo, Yaru Zhang, Zhiyao Hou, Jun Lin
Summary: Development of nanotheranostic agents with near-infrared absorption provides an effective tool for fighting malignant diseases. In this study, a nanoplatform based on gadolinium-ion-doped NdVO4 nanoplates was employed for multiple-imaging-assisted photothermal therapy.
Review
Chemistry, Multidisciplinary
Alexandre Adam, Damien Mertz
Summary: This review article discusses the applications of core-shell nanocomposites composed of an iron oxide core and a silica shell in the field of nanomedicine, particularly for the development of efficient theranostic systems for cancer treatments. It reviews the different methods to build iron oxide@silica core-shell nanoparticles and their properties and developments in hyperthermia therapies (magnetically or light-induced) and drug delivery and MRI imaging. The article also highlights various challenges encountered, such as NP-cell interactions during in vivo injection and the control of heat dissipation from the NP core to the external environment.
Article
Pharmacology & Pharmacy
Baljinder Singh, Sunyoung Yun, Myoung-Hwan Park
Summary: Sequential release-based drug delivery systems with layer-by-layer assembled nanofiber platform were investigated in this study, which can provide a flexible framework for regulated, sequential, and safe drug delivery in specific areas.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Chang Liu, Long Xi, Yihan Liu, Judith Choi Wo Mak, Shirui Mao, Zhenping Wang, Ying Zheng
Summary: This study developed an inhalable biomimetic sequential drug-releasing nanoplatform for the combinatorial treatment of acute lung injury (ALI). The nanoplatform effectively inhibited the coordinated action of neutrophils and macrophages, modulated the hyper-inflammatory condition, and promoted lung tissue repair. The dual-stage drug release behavior facilitated down-regulation of pro-inflammatory cytokines and remodeling of lung immune homeostasis.
Article
Chemistry, Multidisciplinary
Lei Chen, Gaigai Li, Xingxing Wang, Jinbo Li, Yan Zhang
Summary: This study developed a PSNA for carrier-free and NIR photocontrolled self-delivery of siRNA and ASO, which could selectively release therapeutic agents in tumor cells under NIR light irradiation. PSNA showed promising potential for cancer therapy by combining gene therapy and photodynamic therapy.
Article
Biochemistry & Molecular Biology
Edelweiss Moyano Rodriguez, Miguel Gomez-Mendoza, Raul Perez-Ruiz, Beatriz Penin, Diego Sampedro, Antonio Caamano, Victor A. de la Pena O'shea
Summary: The study focused on the application of NaYF4:Yb,Tm up-converted material in drug release, achieving excellent luminescence properties through controlled synthesis conditions, and promoting research and development in light-driven drug release systems.
Review
Biotechnology & Applied Microbiology
Enrica Soprano, Ester Polo, Beatriz Pelaz, Pablo del Pino
Summary: Nanoparticles have demonstrated attractive capabilities in biology and medicine. However, the number of candidates reaching clinical trials or commercialization is minimal due to issues with their synthetic and foreign surface. The use of cell-derived surfaces as an alternative to artificial coatings has emerged, aiming to improve therapeutic behavior and overcome limitations of synthetic approaches. These biomimetic formulations have the potential to address challenges in drug delivery and show promise in cancer therapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Hong Pan, Fu-guo Shi, Chao Fang, Jing-shan Shi
Summary: This study investigated the metabolic characteristics of dendrobine in vitro and in rats, revealing rapid and extensive metabolism primarily mediated by cytochrome P450 enzymes. The major metabolic pathways of dendrobine were N-demethylation, N-oxidation, and dehydrogenation, with minor pathways including hydroxylation and glucuronidation. An accumulation of 50 metabolites were identified and characterized in liver microsomal incubation and rats, shedding light on the pharmacological efficiency of high exposure metabolites.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Engineering, Biomedical
Peiyan Yuan, Fen Yang, Si Si Liew, Jiachang Yan, Xiao Dong, Jinfeng Wang, Shubo Du, Xin Mao, Liqian Gao, Shao Q. Yao
Summary: Combination therapy is a promising strategy for treating multidrug-resistant cancers. A highly versatile nanomaterial-based strategy for co-encapsulation and intracellular co-delivery of different macromolecule combinations has been developed using biodegradable silica nanocapsules. This strategy has shown potential as a novel delivery platform for combination cancer therapy.
Article
Biotechnology & Applied Microbiology
Xiang-Yu Liu, Mao-Hua Zhu, Xiao-Yu Wang, Xiao Dong, Hai-Jun Liu, Rui-Yang Li, Shi-Chong Jia, Qin Lu, Mei Zhao, Peng Sun, Hong-Zhuan Chen, Chao Fang
Summary: By conjugating multivalent Fc fragments onto the surface of mesoporous silica nanoparticles (MSN), a nanoparticle-based innate immune system activator (NISA) was developed for breast cancer immunotherapy. The Fc fragments of NISA can be exposed through hydrolysis of long-chain PEG(5000) by highly expressed MMP-2 in the tumor microenvironment, resulting in the activation of multiple components of the innate immune system, including complement, macrophages, and dendritic cells, and efficient antitumor effect.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Toxicology
Kaili Wu, Hong Pan, Yi Li, Linyan Huang, Chao Fang, Fuguo Shi
Summary: This study demonstrates that the metabolic activation of furanoids in Cortex Dictamni (CD) is responsible for liver injury in mice. Multiple furanoids can modify hepatic proteins through reactive metabolites, and the levels of protein adducts are correlated with the severity of liver injury. Early absorbed furanoids mainly bind with glutathione, while later absorbed furanoids modify hepatic proteins.
TOXICOLOGY LETTERS
(2022)
Article
Multidisciplinary Sciences
Yuanyuan Gong, Zukai Liu, Yihang Yuan, Zhenzhen Yang, Jiawei Zhang, Qin Lu, Wei Wang, Chao Fang, Haifan Lin, Sanhong Liu
Summary: RNA binding proteins PUM1 and PUM2 promote colorectal cancer growth by inhibiting p21 expression. Knockout of PUM1 and PUM2 inhibits CRC progression. PUM1 is found to have a suppressive effect on p21/Cdkn1a.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Analytical
Hong Pan, Lin Chen, Guohong Zhai, Qi Luo, Chao Fang, Fuguo Shi
Summary: This study presents a novel approach for non-targeted profiling of bioactivation of unknown furanoids in vitro and in vivo. By utilizing the unique structure and high abundance of cyclic pyrrole-glutathione conjugates, along with the consistency and specificity of CID fragmentation, this method exhibits high selectivity and reliability in identifying bioactivated furanoids. The method has been validated and successfully applied to detect and identify furanoids and their metabolites in urine samples of mice treated with herbal extracts.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Chemistry, Multidisciplinary
Mao-Hua Zhu, Xin-Di Zhu, Mei Long, Xing Lai, Yihang Yuan, Yanhu Huang, Lele Zhang, Yuhao Gao, Jiangpei Shi, Qin Lu, Peng Sun, Jonathan F. Lovell, Hong-Zhuan Chen, Chao Fang
Summary: A method is established to externally adsorb nanocarriers onto living cells, reducing cytotoxicity and enabling improved drug release. By attaching multi-functional metal ion-phenolic networks onto macrophage surfaces, bioactivity of carrier cells is maintained, and chemotherapy is improved. This facile and efficient method provides a platform technology for the development of living cell-based drug delivery systems.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Engineering, Biomedical
Wei Du, Shubo Du, Xiao Dong, Hua Bai, Jiamin Jiang, Shiping Hao, Fen Yang, Qicai Xiao, Bei Zhang, Jingyan Ge, Liqian Gao, Lin Li, Shao Q. Yao, Wei Huang
Summary: This study presents a convenient and highly efficient method for delivering native proteins/antibodies to the cell nucleus using biodegradable silica nanocapsules (BSNPs) modified with nuclear localization signals (NLS) peptides.
Article
Chemistry, Multidisciplinary
Xiao Dong, Shu Xia, Shubo Du, Mao-Hua Zhu, Xing Lai, Shao Q. Yao, Hong-Zhuan Chen, Chao Fang
Summary: Cancer immunotherapy is a established therapeutic approach in oncology, but its effectiveness in most cancer patients is still unsatisfactory. The tumor microenvironment, characterized by acidity, oxygen and nutrient deprivation, and immunosuppressive metabolites, can impair the function of tumor-infiltrating immune cells and compromise immunotherapy. Tumor metabolism-rewriting nanomedicines have emerged as an attractive strategy to enhance antitumor immunity by targeting tumor metabolism. This review summarizes the progress in the development of multifunctional tumor metabolism-rewriting nanomedicines and discusses the prospects and challenges in this field.
ACS CENTRAL SCIENCE
(2023)
Review
Chemistry, Multidisciplinary
Xiao Dong, Rajeev K. Brahma, Chao Fang, Shao Q. Yao
Summary: This review summarizes the application of self-assembled prodrugs in cancer drug development. Self-assembled prodrugs can improve the physicochemical properties of drugs and achieve controlled release at tumor sites, thus showing potential for clinical applications.