Article
Engineering, Biomedical
Wenzhao Zhong, Ka Hong Wong, Fujian Xu, Nana Zhao, Meiwan Chen
Summary: This study successfully improved the anticancer efficacy of artesunate (AS) by combining chemical modification and photothermal therapy. Hydrophobic-modified AS was integrated with biomimetic polydopamine and biomineral calcium carbonate to fabricate a high AS-loaded nanomedicine for cancer chemo-photothermal therapy. The hybrid nanoparticles demonstrated a combinational antitumor effect of photothermal therapy and chemotherapy, inhibiting cancer cell growth without systemic toxicity.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Yupeng Shi, Mengyang Zhou, Yong Zhang, Yifei Wang, Jingliang Cheng
Summary: Image-guided stimulus-responsive theranostics have been developed for enhanced tumor cell clearance through identification of malignant lesions and integration of multiple cell-killing mechanisms. In this study, an intelligent dual-responsive nanostructure (HSPMH-DOX) was designed for MRI-guided synergistic chemo-photothermal therapy and chemodynamic therapy. The nanoagent demonstrated both endogenous and external dual responses, allowing triggered drug release and localized overheating under specific tumor microenvironment and external near-infrared light irradiation. The prepared dual-response nanoagent exhibited excellent biocompatibility, targeting ability, and efficiency for MRI-guided combined therapy in vitro and in vivo. The combination of chemo-PTT and CDT achieved effective tumor eradication in animal models within a short period of time. This work holds great promise for future applications in stimulus-responsive synergistic theranostics.
ACTA BIOMATERIALIA
(2023)
Review
Chemistry, Multidisciplinary
Peng Yang, Fang Zhu, Zhengbiao Zhang, Yiyun Cheng, Zhao Wang, Yiwen Li
Summary: PDA is a promising candidate for stimuli-responsive smart materials, with excellent photo-responsive properties and active surface functionality for loading various responsive motifs. This review summarizes recent advances in design strategies, responsive mechanisms, and diverse applications of stimuli-responsive PDA-based materials, covering stimuli such as light, pH, chemicals, temperature, etc.
CHEMICAL SOCIETY REVIEWS
(2021)
Article
Biotechnology & Applied Microbiology
Junke Leng, Xiaofeng Dai, Xiao Cheng, Hao Zhou, Dong Wang, Jing Zhao, Kun Ma, Changhao Cui, Li Wang, Zhaoming Guo
Summary: In this study, a biomimetic nano-platform PDA@MB was developed for the combination treatment of photothermal therapy and chemotherapy for breast cancer. The results showed that PDA@MB exhibited excellent photothermal performance and demonstrated significant anti-tumor effects both in vitro and in vivo, with good biocompatibility and safety.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Xiao Chu, Liufang Zhang, Yiling Li, Yue He, Yu Zhang, Chang Du
Summary: This study develops a nanocatalytic platform that enhances the efficacy of chemodynamic therapy (CDT) for osteosarcoma treatment. The platform depletes excess glutathione (GSH) and triggers the generation of highly toxic hydroxyl radicals by converting endogenous hydrogen peroxide. Both in vitro and in vivo experiments demonstrate the significantly improved anti-osteosarcoma effect of the synergistic chemodynamic/photothermal/chemo-therapy.
Article
Materials Science, Multidisciplinary
Fang Wang, Naipin Chen, Jiarui Li, Ziqi Xu
Summary: In this study, dual photosensitizer drug loaded microspheres were prepared by modifying Carbon dots with polydopamine and encapsulating them using chitosan. The microspheres showed excellent photothermal conversion efficiency and drug release performance, making them suitable for synergistic chemo-photothermal treatment of tumor cells.
Article
Chemistry, Physical
Ruihong Lv, Xinyi Li, Shuhui Song, Haohao Wang, Shanshan Gao, Shanshan Zhang, Yingli An, Hongying Zhou, Yongsheng Ji, Zhigang Xu
Summary: A versatile drug delivery system with simultaneous multimodal therapeutic and stimuli-responsive capabilities was engineered. The system showed controlled drug release under low pH and high GSH concentration environment, and exhibited improved cell inhibition through chemo-photothermal treatment.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Nanoscience & Nanotechnology
Qian Xie, Shi Gao, Rui Tian, Guohao Wang, Zainen Qin, Minglong Chen, Wenhui Zhang, Qiang Wen, Qingjie Ma, Lei Zhu
Summary: We developed a hyaluronic acid nanoparticle that carries a chemotherapy drug and a photosensitizer, and demonstrated its efficacy in tumor-bearing mice. This smart drug delivery system improves traditional chemotherapy and enhances photodynamic therapy. The nanoparticles release drugs in the tumor, providing effective treatment.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yanfei Zhu, Junhong Ling, Xinyi Xu, Xiao-kun Ouyang, Nan Wang
Summary: The high expression of reduced glutathione (GSH) and low pH in tumor sites have led to the development of active mesoporous polydopamine nanoparticles for targeted drug release. The polydopamine nanoparticles are loaded with doxorubicin and functionalized with N,N'-bis(acryloyl)cystamine (BAC) and cross-linked carboxymethyl chitosan (CMC) to achieve simultaneous redox- and pH-sensitive activity for photothermal enhanced synergistic chemotherapy. The nanocomposite showed improved selective doxorubicin release in conditions mimicking the tumor microenvironment and low toxicity towards non-cancerous tissues, suggesting high potential for clinical translation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Kaushik Pal, Priya Mahato, Swati Singh, Partha Roy
Summary: Here, copper sulfide covellite nanoplates were developed using H2S gas to precipitate Cu2+ cations in an aqueous solution. The obtained polygonal CuS nanoplates were coated with polydopamine and chitosan for the development of a stimuli-responsive nanoplatform for cancer cell ablation. The nanoconjugate, CuS-5-FU-PDA@CS-FA, showed excellent biocompatibility and photothermal conversion efficiency under an 808 nm laser irradiation, demonstrating its potential in cancer therapy.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Xingyu Wang, Changwei Li, Junchao Qian, Xiaotong Lv, Hong Li, Jinglu Zou, Jiahui Zhang, Xiangfu Meng, Hongji Liu, Yong Qian, Wenchu Lin, Hui Wang
Summary: This paper reports a new hollow magnetite nanocluster (HMNC) responsive to the second near-infrared (NIR-II) window for targeted and imaging-guided cancer therapy. The HMNC serves as a contrast agent for tumor-targeted magnetic resonance imaging and can trigger drug release and hydroxyl radical formation for chemotherapy and chemodynamic therapy. It also converts NIR-II light into local heat for photothermal therapy, showing great potential as a versatile nanoplatform for trimodal cancer therapy.
Article
Pharmacology & Pharmacy
Huai-An Chen, Yu-Jen Lu, Banendu Sunder Dash, Yin-Kai Chao, Jyh-Ping Chen
Summary: Combination chemo-photothermal therapy using HA/PMNPc nanoparticles can effectively treat cancer by reducing the dose of chemotherapeutic drugs and inducing cell death through heat generation. The nanoparticles exhibit targeted delivery, pH-sensitive drug release, and hyperthermia effects, resulting in higher cytotoxicity and apoptosis in cancer cells. In vivo studies demonstrate that the treatment modality inhibits tumor growth and increases survival time in mice.
Article
Chemistry, Multidisciplinary
Zhaokui Jin, Yanhong Duo, Yang Li, Meng Qiu, Mengna Jiang, Quan Liu, Penghe Zhao, Tian Yang, Weiyuan Liang, Han Zhang, Yihai Cao, Qianjun He
Summary: The study presents a novel gasothermal therapy concept, utilizing light-sensitive nanomaterial to generate cancer-causing gas in the tumor microenvironment for tumor cell eradication, with promising therapeutic efficacy demonstrated in preclinical experiments.
Article
Pharmacology & Pharmacy
Xiaowei Wang, Yufen Li, Ji Li, Yaxuan Gu, Lihong Sang, Dongkai Wang
Summary: The combination of multiple therapies can significantly improve the treatment efficiency of malignant tumors, and the combination of AS-IV and ICG enhances the anti-tumor effect. Liposomes co-loaded with AS-IV and ICG for chemo-photothermal therapy of breast cancer show promising results in vitro and in vivo, providing a safe and efficient strategy for synergistic combination therapy.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Ruihong Lv, Haohao Wang, Yongsheng Ji, Shanshan Gao, Ning Hao, Shanshan Zhang, Yanna Lv, Qilin Zhang, Xiyu Han, Yanting Liu, Zhigang Xu
Summary: This study developed pH and photothermal responsive doxorubicin/curcumin-loaded degradable dendritic mesoporous silica nanoparticles (DNCPDH), in which curcumin acted as an antitumor sensitizer by increasing intracellular ROS level. The DNCPDH nanocarriers exhibited enhanced chemo-photothermal synergistic tumor treatment, efficient intracellular uptake, and high cellular accumulation.
Article
Chemistry, Multidisciplinary
Lan Mei, Bo Chen, Rangrang Fan, Min Wu, Chengxin Weng, Aiping Tong, Bingwen Zou, Hui Yang, Chunlai Nie, Gang Guo
Summary: This study constructs DNase-resistant and tumor-distinguishing DNA nano-assemblies based on crossover motifs, and found that 3HB equipped with three aptamers shows the best tumor discriminating ability.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Chemistry, Applied
Xiaoyan Liang, Min Mu, Rangrang Fan, Bingwen Zou, Gang Guo
Summary: Chitosan, with its biodegradable, biocompatible, nonimmunogenic and nontoxic properties, has shown great potential as a delivery material in cancer immunotherapy, improving drug effectiveness and offering broad application prospects.
CARBOHYDRATE POLYMERS
(2022)
Article
Oncology
Shasha Zhao, Yuelong Wang, Nian Yang, Min Mu, Zhiguo Wu, Hexian Li, Xin Tang, Kunhong Zhong, Zongliang Zhang, Cheng Huang, Ting Cao, Meijun Zheng, Guoqing Wang, Chunlai Nie, Hui Yang, Gang Guo, Liangxue Zhou, Xi Zheng, Aiping Tong
Summary: This study identified the crucial role of transcription factor SP20H in regulating B7-H3 expression and tumor progression, suggesting its potential as a target for improving anti-B7-H3 therapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Pharmacology & Pharmacy
Min Mu, Xiaoyan Liang, Na Zhao, Di Chuan, Bo Chen, Shasha Zhao, Guoqing Wang, Rangrang Fan, Bingwen Zou, Bo Han, Gang Guo
Summary: A supramolecular nanoreactor (DOC@TA-Fe3+) based on tannic acid (TA), iron ion (Fe3+), and docetaxel (DOC) was developed for ferroptosis/apoptosis treatment in colorectal cancer, with microtubule inhibition, reactive oxygen species (ROS) generation, and glutathione peroxidase 4 (GPX4) inhibition.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2023)
Article
Engineering, Biomedical
Rangrang Fan, Caili Chen, Junshan Hu, Min Mu, Di Chuan, Zhouyun Chen, Gang Guo, Jianguo Xu
Summary: A multifunctional gold nanorod-based nanosystem was developed in this study by attaching siRNA against B7-H3, glucose oxidase (GOx), and hyaluronic acid (HA), which enables efficient low-temperature photothermal therapy. The nanoplatform can induce tumor ablation without damage to healthy tissues by exhaust glucose to induce starvation therapy and reduce HSP. It also promotes treatment effectiveness by downregulating B7-H3 with siRNA.
ACTA BIOMATERIALIA
(2023)
Article
Materials Science, Multidisciplinary
Bo Chen, Linrui Cai, Rangrang Fan, Min Mu, Di Chuan, Yangmei Ren, Haifeng Chen, Gang Guo
Summary: This study introduces a novel nanoplatform (CBDM) for cancer therapy that can ameliorate tumor hypoxia and promote oxygen production, thus enhancing the therapeutic effect of photodynamic therapy.
MATERIALS & DESIGN
(2023)
Article
Chemistry, Multidisciplinary
Cheng Huang, Xing Duan, Jichao Wang, Qingqing Tian, Yangmei Ren, Kepan Chen, Zongliang Zhang, Yuanyou Li, Yunyu Feng, Kunhong Zhong, Yuelong Wang, Liangxue Zhou, Gang Guo, Xiangrong Song, Aiping Tong
Summary: The study developed a treatment strategy based on mRNA expression, utilizing LNPs to achieve high transfection efficiency and a potent antitumor effect.
Article
Pharmacology & Pharmacy
Bo Chena, Lan Mei, Rangrang Fan, Di Chuan, Yangmei Ren, Min Mua, Haifeng Chen, Bingwen Zou, Gang Guo
Summary: The combination of photothermal therapy with chemotherapy using a nanoplatform based on polydopamine-coated gold nanoparticles has shown promising potential in cancer treatment. The nanoplatform exhibited enhanced photothermal conversion efficiency and colloidal stability. By assembling an i-motif DNA nanostructure on the nanoplatform, pH-responsive characteristics were achieved. The addition of a targeting ligand, AS1411 aptamer, enhanced specific cellular uptake. The nanoplatform also showed excellent photothermal performance and efficient cancer cell inhibition under near-infrared irradiation. Overall, this nanoplatform has great potential in synergistic photothermal-chemotherapy.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Materials Science, Multidisciplinary
Xiaoyan Liang, Min Mu, Bo Chen, Di Chuan, Na Zhao, Rangrang Fan, Xin Tang, Haifeng Chen, Bo Han, Gang Guo
Summary: Colorectal cancer is one of the most common and deadliest cancers globally. In this study, a metal polyphenol network based on EGCG was used for the co-delivery of targeted photosensitizers to achieve comprehensive treatment for colorectal cancer.
MATERIALS TODAY ADVANCES
(2022)
Article
Chemistry, Multidisciplinary
Rangrang Fan, Caili Chen, Min Mu, Di Chuan, Hao Liu, Huan Hou, Jianhan Huang, Aiping Tong, Gang Guo, Jianguo Xu
Summary: Recombinant anti-B7-H3xCD3 bispecific antibodies (biAbs) were prepared and MMP-2-sensitive S-biAb/dEGCG@NPs were constructed for efficient and systemic glioblastoma (GBM) elimination. S-biAb/dEGCG@NPs showed enhanced intracranial accumulation compared to biAb/dEGCG@NPs, biAb/dEGCG complexes, and free biAbs. Furthermore, S-biAb/dEGCG@NPs induced GBM elimination by boosting the ferroptosis effect and enhancing immune checkpoint blockade (ICB) immunotherapy, making them promising antibody nanocarriers for enhanced cancer therapy.
Review
Biochemistry & Molecular Biology
Chenqian Feng, Bo Chen, Rangrang Fan, Bingwen Zou, Bo Han, Gang Guo
Summary: With the advancement of cancer treatment and precision medicine, there is a growing demand for advanced and versatile drug delivery systems. Polyphenols, which can act as both active ingredients and building blocks, are being explored as potential multifunctional carriers for efficient and safe cancer therapy. This review discusses the recent advances in the design, synthesis, and application of polyphenol-based nanosystems and highlights the challenges and optimization needed for their clinical translation.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Polymer Science
Youping Li, Gaixia Liu, Mengting Wang, Yuling Zhang, Shiwan You, Jing Zhang, Gang Guo, Bo Han, Le Li, Na Zhao
Summary: In this study, a thermosensitive hydrogel (PPH hydrogel) was developed using poloxamer 407, poloxamer 188, and hydroxypropyl methylcellulose. The hydrogel loaded with tannic acid and mitomycin C showed excellent controlled drug release and anti-adhesive effects, making it a potential solution for preventing postoperative abdominal adhesion.
Review
Biotechnology & Applied Microbiology
Hui Li, Rangrang Fan, Bingwen Zou, Jiazhen Yan, Qiwu Shi, Gang Guo
Summary: With the rapid advancement of nanomedical technology, novel nanomaterials known as MXenes have gained significant attention in the field of biomedicine. MXenes, featuring ultrathin atomic thickness and high specific surface area, have shown great promise in various biomedical applications, including biosensors, diagnosis, therapy, antibacterial agents, implants, wearable devices, and immunotherapy. This review comprehensively summarizes the synthesis methods, surface modification strategies, and research progress of MXene-based materials, while also addressing the challenges associated with their clinical translation in biomedical applications.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Di Chuan, Huan Hou, Yuelong Wang, Min Mu, Jinglun Li, Yangmei Ren, Na Zhao, Bo Han, Haifeng Chen, Gang Guo
Summary: Due to the hypoxic state of the tumor microenvironment (TME), photodynamic therapy (PDT) suffers from insufficient ROS production. The metal-polyphenol network-mediated Fenton reaction can generate reactive oxygen species (ROS) by consuming H2O2 in TME, improving the inadequate ROS generation problem of PDT. Therefore, synergistic therapy combining PDT and Fenton response-based CDT is a promising approach for cancer treatment.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Yangmei Ren, Lan Mei, Cheng Huang, Rangrang Fan, Bo Chen, Aiping Tong, Chao Wang, Haifeng Chen, Gang Guo
Summary: The researchers synthesized a photosensitive material based on nano-crystalline cellulose and further obtained stereocomplex crystallite (SC)-based micelle with folic acid for improved type I PDT. The SC-based micelle co-delivering DOX and MTH1 inhibitor could enhance ROS-induced oxidative stress injury and disrupt the ROS defense system of tumor tissues. The designed system combining PDT and chemotherapy displays an enhanced cell apoptosis process, inhibiting or eliminating tumors without toxic side effects.
ACS MATERIALS LETTERS
(2023)
