Article
Cardiac & Cardiovascular Systems
Kamalika Mukherjee, Ajeeth K. Pingili, Purnima Singh, Ahmad N. Dhodi, Shubha R. Dutta, Frank J. Gonzalez, Kafait U. Malik
Summary: The study demonstrated that the testosterone-cytochrome P450 1B1-generated metabolite 6 beta-OHT contributes to the development of Ang II-induced AAAs in Apoe(-/-) male mice, while castration or Cyp1b1 knockout can reduce the severity of AAAs.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Biochemistry & Molecular Biology
Aida Javidan, Weihua Jiang, Lihua Yang, Ana Clara Frony, Venkateswaran Subramanian
Summary: The aim of this study is to investigate the effect of Celastrol on angiotensin II-induced abdominal aortic aneurysms (AAA) in hypercholesterolemic mice. The results showed that Celastrol supplementation significantly increased the dilation of abdominal aorta and incidence of AAA induced by AngII.
Article
Immunology
Cheng Xu, Xiaowei Liu, Lei Yu, Xiaoxin Fang, Lei Yao, HuiChong Lau, Punit Vyas, Luke Pryke, Baohui Xu, Lijiang Tang, Jianjun Jiang, Xiaofeng Chen
Summary: In this study, it was found that CD147 monoclonal antibody effectively suppresses Ang II-induced AAA formation in apoE-/- mice by reducing aortic expansion, elastic lamina degradation, and inflammatory cells accumulation. Protein-protein interaction analysis revealed that Ptk6, Itch, Casp3, and Oas1a were the hub differentially expressed proteins, which were mainly involved in collagen fibril organization, extracellular matrix organization, and muscle contraction. Therefore, CD147 monoclonal antibody may be a promising target for the treatment of abdominal aortic aneurysm.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Daniel Zalewski, Paulina Chmiel, Przemyslaw Kolodziej, Grzegorz Borowski, Marcin Feldo, Janusz Kocki, Anna Bogucka-Kocka
Summary: Abdominal aortic aneurysm (AAA) is a chronic vascular disease with high mortality rate. Abnormal regulation of angiogenesis and inflammation contributes to the disease progression. Dysregulations in key molecular pathways associated with AAA need to be further investigated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Hematology
Xia Guo, Dunpeng Cai, Kun Dong, Chenxiao Li, Zaiyan Xu, Shi-You Chen
Summary: DOCK2 is identified as a novel regulator for AAA formation, playing a role in promoting vascular inflammation and elastin degradation by upregulating MCP-1 and MMP2 expression.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Haruhito A. Uchida, Tetsuharu Takatsuka, Yoshiko Hada, Ryoko Umebayashi, Hidemi Takeuchi, Kenichi Shikata, Venkateswaran Subramanian, Alan Daugherty, Jun Wada
Summary: The study found that edaravone can attenuate angiotensin II-induced abdominal aortic aneurysms and atherosclerosis through its antioxidant and anti-inflammatory effects.
Article
Peripheral Vascular Disease
Nozomu Otaka, Haruhito A. Uchida, Michihiro Okuyama, Yoshiko Hada, Yasuhiro Onishi, Yuki Kakio, Hidemi Takeuchi, Ryoko Umebayashi, Katsuyuki Tanabe, Venkateswaran Subramanian, Alan Daugherty, Yasufumi Sato, Jun Wada
Summary: Exogenous VASH2 had no significant effect on AngII-induced abdominal aortic aneurysms or atherosclerosis, but increased dilation in the ascending aorta.
AMERICAN JOURNAL OF HYPERTENSION
(2021)
Article
Biochemistry & Molecular Biology
Yifei Zhou, Hao Chai, Yuntao Hu, Renjie Liu, Hongwei Jiang, Wen Chen, Xin Chen, Fuhua Huang
Summary: Research has identified the significant role of DDX3x in the development of abdominal aortic aneurysm (AAA), suggesting it as a potential new target for the treatment of AAA progression.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Dunpeng Cai, Chenming Sun, Gui Zhang, Xingyi Que, Ken Fujise, Neal L. Weintraub, Shi-You Chen
Summary: The study identified ADAR1 as a novel regulator of AAA development, showing its interaction with HuR to regulate the stability of MMP2 and MMP9 mRNA, leading to increased MMP levels and activities that may represent a potential new therapeutic target to hinder AAA growth and rupture.
CIRCULATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Naofumi Amioka, Toru Miyoshi, Tomoko Yonezawa, Megumi Kondo, Satoshi Akagi, Masashi Yoshida, Yukihiro Saito, Kazufumi Nakamura, Hiroshi Ito
Summary: This study found that Pemafibrate has a preventive effect on AAA rupture, reducing ROS, inflammation, and extracellular matrix degradation. The protective effect against AAA rupture is partly mediated by the antioxidative effect of catalase induced by Pemafibrate.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Takahiro Shoji, Jia Guo, Yingbin Ge, Yankui Li, Gang Li, Toru Ikezoe, Wei Wang, Xiaoya Zheng, Sihai Zhao, Naoki Fujimura, Jianhua Huang, Baohui Xu, Ronald L. Dalman
Summary: This study assessed the influence of type I interferon receptor deficiency on the formation and progression of experimental abdominal aortic aneurysms. The results showed that IFNAR1 deficiency can limit the progression of experimental AAA and suggest an important role for IFNAR1 in AAA pathogenesis.
Article
Biochemistry & Molecular Biology
Toru Ikezoe, Takahiro Shoji, Jia Guo, Fanru Shen, Hong S. Lu, Alan Daugherty, Masao Nunokawa, Hiroshi Kubota, Masaaki Miyata, Baohui Xu, Ronald L. Dalman
Summary: This study found that hypercholesterolemia had no noticeable impact on elastase-induced experimental abdominal aortic aneurysm progression in mice, adding further uncertainty to the controversy surrounding the efficacy of statin therapy in clinical AAA disease.
Article
Biochemistry & Molecular Biology
Chih-Pei Lin, Po-Hsun Huang, Chi-Yu Chen, I-Shiang Tzeng, Meng-Yu Wu, Jia-Shiong Chen, Jaw-Wen Chen, Shing-Jong Lin
Summary: Abdominal aortic aneurysm (AAA) is a cardiovascular disease that causes vascular dilatation in the infrarenal aorta, leading to a high risk of death. The pathogenesis of AAA involves oxidative stress, inflammation, and vascular smooth muscle cell dysregulation. Tributyrin (TB) has a potential protective effect against AAA by inhibiting HDAC activity and attenuating the AngII-induced AT1R signaling cascade. This study provides insights into the potential therapeutic role of TB in the treatment of AAA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Hao Li, Haochen Xu, Hongyan Wen, Hongyue Wang, Ranxu Zhao, Yingying Sun, Congxia Bai, Jiedan Ping, Li Song, Mingyao Luo, Jingzhou Chen
Summary: Deficiency of LH1 contributes to the pathogenesis of dissecting AAA by upregulating thrombospondin-1 expression, which leads to proinflammatory processes, MMP activation, and VSMCs apoptosis. Restoring LH1 expression could be a potential therapeutic target for AAA.
Article
Geriatrics & Gerontology
Mojtaba Parvizi, Federico Franchi, Bonnie K. Arendt, Sanam Ebtehaj, Martin Rodriguez-Porcel, Ian R. Lanza
Summary: Age is a major risk factor for abdominal aortic aneurysm (AAA). Aging is associated with transcriptional changes in abdominal aortic tissue, accumulation of senescent cells, and development of AAA. Reducing senescent cell burden may lessen the severity of AAA.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Medicine, Research & Experimental
Patrice Marques, Elena Domingo, Arantxa Rubio, Sergio Martinez-Hervas, Juan F. Ascaso, Laura Piqueras, Jose T. Real, Maria-Jesus Sanz
Summary: Inhibiting PCSK9 function can impact systemic inflammation and endothelial dysfunction by constraining leukocyte-endothelium interactions, enhancing T-regulatory cell activation, and reducing inflammatory response.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Laura Vila, Nuria Cabedo, Carlos Villarroel-Vicente, Ainhoa Garcia, Alvaro Bernabeu, Nathalie Hennuyer, Bart Staels, Xavier Franck, Bruno Figadere, Maria-Jesus Sanz, Diego Cortes
Summary: The study synthesized three new series of prenylated benzopyrans containing different numbers of isoprenoid units and explored their hPPAR transactivation activity and structure activity relationships. The results demonstrated that 2-prenylated benzopyrans with seven-carbon and nine-carbon side chains are good lead compounds for preventing cardiovascular diseases.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Macarena Corro-Moron, Albert Granell, Varbina Ivanova, Elena Domingo, Raul Beltran-Debon, Xavier Barril, Maria-Jesus Sanz, M. Isabel Matheu, Sergio Castillon, Yolanda Diaz
Summary: This study describes the synthesis of new sphingosine derivatives and identifies hydrazino and alkynyl moieties as the best combination for selective SphK2 inhibition. Docking studies reveal that compounds 19a-b can bind to SphK2 through both polar and hydrophobic interactions, leading to their selective activity against SphK2.
BIOORGANIC CHEMISTRY
(2022)
Article
Peripheral Vascular Disease
Beatriz Moreno, Luisa Hueso, Rebeca Ortega, Esther Benito, Sergio Martinez-Hervas, Marta Peiro, Miguel Civera, Maria-Jesus Sanz, Laura Piqueras, Jose T. Real
Summary: The study analyzed the role of CXCR3 ligands on insulin resistance and endothelial dysfunction in obese patients. It found that CXCL10 and CXCL11 are associated with insulin resistance and enhance leukocyte endothelial arrest in obese subjects, suggesting that targeting CXCR3 signaling could be a new therapeutic approach for preventing obesity-associated cardiovascular co-morbidities.
MICROVASCULAR RESEARCH
(2022)
Article
Endocrinology & Metabolism
Wan Chen Gu Hong, Jordi Ferri, Francisco Javier Ampudia-Blasco, Ramon Martin-Brufau, Marta Peiro, Esther Benito, Sergio Martinez-Hervas, Maria Jesus Sanz, Jose Tomas Real
Summary: This study analyzed the relationship between personality traits and blood glucose control in patients with type 1 diabetes mellitus (DM1). The study found that patients with poor blood glucose control had higher scores in feeling-guided, innovation-seeking, dissenting, submissive, and dissatisfied scales. The rebellious or non-conformist personality type was closely associated with poor blood glucose control.
ENDOCRINOLOGIA DIABETES Y NUTRICION
(2022)
Article
Medicine, General & Internal
Patrice Marques, Lucia Fernandez-Presa, Aitor Carretero, Maria-Carmen Gomez-Cabrera, Jose Vina, Jaime Signes-Costa, Maria-Jesus Sanz
Summary: This study analyzed the inflammatory state of COVID-19 patients and identified admission biomarkers for predicting disease worsening.
FRONTIERS IN MEDICINE
(2022)
Review
Biology
Vera Francisco, Maria Jesus Sanz, Jose T. Real, Patrice Marques, Maurizio Capuozzo, Djedjiga Ait Eldjoudi, Oreste Gualillo
Summary: Non-alcoholic fatty liver disease (NAFLD) is a significant medical concern due to its high incidence, severe consequences, and lack of effective diagnostic tools and drugs. This review examines the role of adipokines, cytokine-like hormones secreted by adipose tissue, in NAFLD and their potential as diagnostic biomarkers and therapeutic targets. The limitations of current research are discussed and future directions are outlined. NAFLD is a leading cause of chronic liver disease and associated with other non-communicable diseases. The communication between adipose tissue and liver plays a key role in NAFLD pathophysiology. Adipokines have been linked to the development and progression of NAFLD. This review provides an overview of the current knowledge on specific adipokines and their impact on NAFLD, as well as the potential of using adipokines as therapeutic targets and biomarkers for NAFLD management.
Review
Biochemistry & Molecular Biology
Patrice Marques, Vera Francisco, Laura Martinez-Arenas, Angela Carvalho-Gomes, Elena Domingo, Laura Piqueras, Marina Berenguer, Maria-Jesus Sanz
Summary: Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease in Western countries, affecting about 25% of adults. It encompasses a range of liver diseases characterized by abnormal fat accumulation in the liver tissue, which can progress to inflammation and damage. This can ultimately lead to irreversible conditions like cirrhosis and hepatocarcinoma, resulting in high mortality rates and economic burden. Understanding the immune status of NAFLD patients is crucial for therapeutic approaches, early diagnosis, and prevention.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Patrice Marques, Carlos Villarroel-Vicente, Aida Collado, Ainhoa Garcia, Laura Vila, Isabelle Duplan, Nathalie Hennuyer, Francisco Garibotto, Ricardo D. Enriz, Catherine Dacquet, Bart Staels, Laura Piqueras, Diego Cortes, Maria-Jesus Sanz, Nuria Cabedo
Summary: The authors synthesized a new prenylated benzopyran (BP-2) and evaluated its PPAR-activating properties, anti-inflammatory effects, and impact on metabolic derangements. BP-2 displayed strong PPAR alpha activity, moderate activity against PPAR beta/delta, and weak activity against PPAR gamma. In vivo, BP-2 improved glucose and triglyceride levels, suppressed inflammation, and increased M2-like macrophage markers in obese mice.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Clinical Neurology
Vera Francisco, Djedjiga Ait Eldjoudi, Maria Gonzalez-Rodriguez, Clara Ruiz-Fernandez, Alfonso Cordero-Barreal, Patrice Marques, Maria Jesus Sanz, Jose T. Real, Francisca Lago, Jesus Pino, Yousof Farrag, Oreste Gualillo
Summary: This study aims to characterize the metabolomic and gene expression changes in human disc degeneration and reveal new molecular targets for developing new biological approaches for IVDD.
Article
Endocrinology & Metabolism
Luisa Hueso, Patrice Marques, Brenda Morant, Herminia Gonzalez-Navarro, Joaquin Ortega, Jose T. Real, Maria J. Sanz, Laura Piqueras
Summary: This study aimed to investigate the role of chemokine receptor CCR4 and its ligands CCL17 and CCL22 in morbid obesity. The circulating levels of CCL17 and CCL22 were found to be elevated in morbidly obese patients and positively correlated with BMI and HOMA-IR Index. Inhibition of CCR4 function reduced leucocyte adhesiveness and activation of the ERK1/2 pathway. These findings suggest that pharmacological modulation of the CCR4 axis could be a potential therapeutic approach for preventing adipose tissue dysfunction in obesity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
