Differential requirement forde novolipogenesis in cholangiocarcinoma and hepatocellular carcinoma of mice and humans

Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans

(2016) Lei Li et al.   JOURNAL OF HEPATOLOGY

Progress in the development of fatty acid synthase inhibitors as anticancer targets

(2015) Genevieve E. Mullen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

IL-33 facilitates oncogene-induced cholangiocarcinoma in mice by an interleukin-6-sensitive mechanism

(2015) Daisaku Yamada et al.   HEPATOLOGY

Distinct anti-oncogenic effect of various microRNAs in different mouse models of liver cancer

(2015) Junyan Tao et al.   Oncotarget

Dependence of Brown Adipose Tissue Function on CD36-Mediated Coenzyme Q Uptake

(2015) Courtney M. Anderson et al.   Cell Reports

Hydrodynamic Transfection for Generation of Novel Mouse Models for Liver Cancer Research

(2014) Xin Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

4EBP1/eIF4E and p70S6K/RPS6 axes play critical and distinct roles in hepatocarcinogenesis driven by AKT and N-Ras proto-oncogenes in mice

(2014) Chunmei Wang et al.   HEPATOLOGY

A screen in mice uncovers repression of lipoprotein lipase by microRNA-29a as a mechanism for lipid distribution away from the liver

(2014) Aras N. Mattis et al.   HEPATOLOGY

Cholangiocarcinoma

(2014) Nataliya Razumilava et al.   LANCET

CRISPR-mediated direct mutation of cancer genes in the mouse liver

(2014) Wen Xue et al.   NATURE

Mutational landscape of HCC—the end of the beginning

(2014) Augusto Villanueva et al.   Nature Reviews Clinical Oncology

Cholangiocarcinoma: Molecular Pathways and Therapeutic Opportunities

(2014) Sumera Rizvi et al.   SEMINARS IN LIVER DISEASE

Regulation of lipoprotein lipase by Angptl4

(2014) Wieneke Dijk et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Arylpiperazines as fatty acid transport protein 1 (FATP1) inhibitors with improved potency and pharmacokinetic properties

(2013) Tetsuyoshi Matsufuji et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cellular Fatty Acid Metabolism and Cancer

(2013) Erin Currie et al.   Cell Metabolism

Epidemiology of Hepatocellular Carcinoma

(2013) Sahil Mittal et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Incidence and mortality trends for biliary tract cancers in Austria

(2013) Matthias Pinter et al.   LIVER INTERNATIONAL

SLC27 fatty acid transport proteins

(2013) Courtney M. Anderson et al.   MOLECULAR ASPECTS OF MEDICINE

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Lipid metabolism in cancer

(2012) Claudio R. Santos et al.   FEBS Journal

Epidemiology of Viral Hepatitis and Hepatocellular Carcinoma

(2012) Hashem B. El-Serag   GASTROENTEROLOGY

Cholangiocarcinomas can originate from hepatocytes in mice

(2012) Biao Fan et al.   JOURNAL OF CLINICAL INVESTIGATION

How cancer metabolism is tuned for proliferation and vulnerable to disruption

(2012) Almut Schulze et al.   NATURE

Cancer Cell Metabolism: One Hallmark, Many Faces

(2012) Jason R. Cantor et al.   Cancer Discovery

Targeted Therapies for Hepatocellular Carcinoma

(2011) Augusto Villanueva et al.   GASTROENTEROLOGY

Genomic and Genetic Characterization of Cholangiocarcinoma Identifies Therapeutic Targets for Tyrosine Kinase Inhibitors

(2011) Jesper B. Andersen et al.   GASTROENTEROLOGY

AKT (v-akt murine thymoma viral oncogene homolog 1) and N-Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/SKP2,

(2011) Coral Ho et al.   HEPATOLOGY

Lipoprotein Lipase Links Dietary Fat to Solid Tumor Cell Proliferation

(2011) N. B. Kuemmerle et al.   MOLECULAR CANCER THERAPEUTICS

FATP2 is a hepatic fatty acid transporter and peroxisomal very long-chain acyl-CoA synthetase

(2010) Alaric Falcon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Cholangiocarcinoma: Update and future perspectives

(2010) Manuela Gatto et al.   DIGESTIVE AND LIVER DISEASE

Fatty acid synthase as a potential therapeutic target in cancer

(2010) Richard Flavin et al.   Future Oncology

Increased Lipogenesis, Induced by AKT-mTORC1-RPS6 Signaling, Promotes Development of Human Hepatocellular Carcinoma

(2010) Diego F. Calvisi et al.   GASTROENTEROLOGY

Lipoprotein lipase: from gene to obesity

(2009) Hong Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Fatty Acid Synthase: A Metabolic Enzyme and Candidate Oncogene in Prostate Cancer

(2009) Toshiro Migita et al.   JNCI-Journal of the National Cancer Institute

Sorafenib for the Treatment of Unresectable Hepatocellular Carcinoma

(2009) R. C. Kane et al.   ONCOLOGIST

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Silencing of Hepatic Fatty Acid Transporter Protein 5in VivoReverses Diet-induced Non-alcoholic Fatty Liver Disease and Improves Hyperglycemia

(2008) Holger Doege et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE