Article
Biochemistry & Molecular Biology
Margaux Wieckowski, Stephanie Ranga, Delphine Moison, Sebastien Messiaen, Sonia Abdallah, Sylvie Granon, Rene Habert, Virginie Rouiller-Fabre, Gabriel Livera, Marie-Justine Guerquin
Summary: This study demonstrates that co-exposure to BPA and gamma-ray in mice can induce DNA damage in fetal germ cells, leading to a decrease in germ cell abundance and impact testicular function. Additionally, exposure to gamma-ray alone significantly alters adult steroidogenesis, affecting courtship behavior. The findings highlight the importance of considering physical agents as endocrine disruptors and the need for reevaluation of risk management and regulatory decisions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Justyna Milczarek-Banach, Dominik Rachon, Tomasz Bednarczuk, Katarzyna Mysliwiec-Czajka, Andrzej Wasik, Piotr Miskiewicz
Summary: This study found a correlation between the bisphenol compound BPC and thyroid volume and function, which may lead to hypothyroidism. Other bisphenol compounds showed no significant relationship with the thyroid.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Pharmacology & Pharmacy
Ylenia Della Rocca, Enrico Matteo Traini, Francesca Diomede, Luigia Fonticoli, Oriana Trubiani, Alessia Paganelli, Jacopo Pizzicannella, Guya Diletta Marconi
Summary: Bisphenol A (BPA), an endocrine disrupting chemical (EDC), is believed to be involved in the pathogenesis of various diseases, including immune-mediated disorders, type-2 diabetes mellitus, cardiovascular diseases, and cancer. This review aims to analyze the mechanism of action of BPA, with a specific focus on mesenchymal stromal/stem cells (MSCs) and adipogenesis. The uses of BPA in dental, orthopedic, and industrial fields will be assessed, as well as the impact on different pathological or physiological conditions and related molecular pathways.
Article
Environmental Sciences
Kamila Rybczynska-Tkaczyk, Bartosz Skora, Konrad A. Szychowski
Summary: The aim of this study was to determine the toxicity of bisphenol A (BPA) and its derivatives on various organisms. The results showed that BPA, BPS, and BPF exhibited high toxicity on bacteria, reaching concentrations of 0.018-0.031 mg/L. These compounds also showed genotoxicity and cytotoxicity effects on human cells, as well as phytotoxicity effects on plants. The findings suggest that BPA and its derivatives have a negative impact on living organisms through apoptosis and genotoxic mechanisms.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Christian Giommi, Hamid R. Habibi, Michela Candelma, Oliana Carnevali, Francesca Maradonna
Summary: This study investigated the impact of a probiotic mixture on BPA-induced effects on reproduction in zebrafish. The results demonstrated that in fish exposed to the combination of BPA and probiotic, most transcripts were closer to control or probiotic-treated levels, suggesting the potential of the probiotic mixture to counteract BPA toxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Erica Kassia Sousa-Vidal, Guilherme Henrique, Renata Elen Costa da Silva, Caroline Serrano-Nascimento
Summary: This study aimed to investigate the impact of intrauterine exposure to DEHP on the hypothalamic-pituitary-thyroid (HPT) axis function programming of the offspring animals during adulthood. The results showed that DEHP exposure decreased TSH levels and reduced the gene expression and protein content of thyroid-related genes in female offspring rats. In male offspring rats, DEHP exposure increased TSH expression and levels. These findings suggest that DEHP exposure disrupts the HPT axis function and increases the susceptibility of the offspring animals to develop thyroid dysfunctions during adulthood.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Bruno Garcia Montagnini, Simone Forcato, Karine Vandressa Pernoncine, Mariana Cunha Monteiro, Marina Rangel Ferro Pereira, Nathalia Orlandini Costa, Estefania Gastadello Moreira, Janete Aparecida Anselmo-Franci, Daniela Cristina Ceccatto Gerardin
Summary: The study found that TCS may act as an endocrine disruptor for the reproductive system. Exposure to TCS was shown to decrease sperm viability and motility, potentially related to the programming of reproductive cells during fetal/neonatal development.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Reproductive Biology
Elodie Person, Sandrine Bruel, Trishabelle I. Manzano, Emilien L. Jamin, Daniel Zalko, Catherine M. H. Combelles
Summary: Ovarian cells have the ability to metabolize bisphenols, such as BPA and BPS, into their respective sulfo-conjugates, with sulfation being the main metabolic route. The persistence of BPA residues is higher than that of BPS in theca cells, and only theca explants can deconjugate inactive BPA-glucuronide and BPS-glucuronide back into their biologically active forms. These findings raise concerns about the direct release of bisphenols in the ovary and highlight the importance of studying the biotransformation of bisphenols in different ovarian cells for risk assessment.
REPRODUCTIVE TOXICOLOGY
(2023)
Article
Cell Biology
Matteo Spaziani, Chiara Tarantino, Natascia Tahani, Daniele Gianfrilli, Emilia Sbardella, Andrea Lenzi, Antonio F. Radicioni
Summary: Puberty is a complex process that involves a delicate balance of neuroendocrine mechanisms and hormones to achieve psychophysical maturity and reproductive capacity. The onset of puberty is triggered by interactions between the hypothalamus, pituitary gland, and gonads, with significant variations between genders and individuals, as well as possible pathological variations such as precocious and delayed puberty.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Environmental Sciences
Inae Lee, Young Joo Park, Min Joo Kim, Sunmi Kim, Sohyeon Choi, Jeongim Park, Yoon Hee Cho, Sooyeon Hong, Jiyoung Yoo, Hyunwoong Park, Gi Jeong Cheon, Kyungho Choi, Min Kyong Moon
Summary: This study in the adult Korean population found that the direction of associations between exposure to phthalates, BPA, and parabens and obesity and diabetes mellitus varied depending on the method used to adjust urinary dilution. It highlights the importance of choosing an appropriate adjustment method when studying the associations between these chemical exposures and health outcomes. Further research in other populations is needed to confirm these findings.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Giulia Guarnieri, Matteo Becatti, Roberta Squecco, Paolo Comeglio, Rachele Garella, Lara Tamburrino, Sara Marchiani, Linda Vignozzi, Gabriella Barbara Vannelli, Mario Maggi, Annamaria Morelli
Summary: The neuroendocrine control of reproduction is regulated by the pulsatile release of GnRH by hypothalamic neurons. BaP, a pollutant, can disrupt endocrine function and affect gonadal function and gamete maturation. This study found that BaP alters the phenotype and function of GnRH neurons by interfering with KISS1R signaling and GnRH secretion, highlighting its importance in the central neuroendocrine control of reproduction.
ENVIRONMENTAL POLLUTION
(2023)
Article
Pharmacology & Pharmacy
Chiara Castellini, Mario Muselli, Antonio Parisi, Maria Totaro, Daniele Tienforti, Giuliana Cordeschi, Macro Giorgio Baroni, Mauro Maccarrone, Stefano Necozione, Sandro Francavilla, Arcangelo Barbonetti
Summary: This meta-analysis study found a weak negative association between urinary levels of BPA and sperm motility. The overall estimates of data produced by clinical studies indicate a clinically negligible association between urinary BPA concentrations and semen quality.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Environmental Sciences
A. Martinez-Ibarra, L. D. Martinez-Razo, K. MacDonald-Ramos, M. Morales-Pacheco, E. R. Vazquez-Martinez, M. Lopez-Lopez, M. Rodriguez Dorantes, M. Cerbon
Summary: Bisphenol A (BPA) and phthalates, as endocrine-disrupting chemicals, are widely distributed in the environment and can affect cellular proliferation, tissue development, and various physiological processes through interference with hormone synthesis and action. Exposure to these compounds is inevitable and unintentional for humans and living organisms, potentially leading to a wide range of chronic diseases later in life. Monitoring of EDC levels and their impact on human health is crucial for the general population and the healthcare system.
ENVIRONMENTAL POLLUTION
(2021)
Article
Obstetrics & Gynecology
A. Togola, A. Desmarchais, O. Teteau, C. Vignault, V Maillard, C. Buron, S. Bristeau, F. Guerif, A. Binet, S. Elis
Summary: The majority of human embryo culture media assessed contained bisphenol S, while no release of bisphenols by plastic consumables was detected under routine conditions. Further studies are needed to investigate a greater number of ART media to identify less potentially harmful ones in terms of bisphenol content.
HUMAN REPRODUCTION
(2021)
Article
Reproductive Biology
Ophelie Teteau, Anais Vitorino Carvalho, Pascal Papillier, Beatrice Mandon-Pepin, Luc Jouneau, Peggy Jarrier-Gaillard, Alice Desmarchais, Marie-Emilie Lebachelier de la Riviere, Claire Vignault, Virginie Maillard, Aurelien Binet, Svetlana Uzbekova, Sebastien Elis
Summary: This study analyzed the effects of BPA and BPS on steroidogenesis in ovine granulosa cells in vitro and compared the effects of GPER agonist and antagonist. The results showed that both BPA and BPS affected progesterone secretion, while only BPS affected estradiol secretion. RNA-seq analysis revealed that BPA mainly disrupted the expression of genes involved in metabolism and transcription, while BPS mainly impaired cellular communication. These findings are important for further investigations on the temporal changes of these genes and the biological processes involved.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Biochemical Research Methods
Aboyeji Lukuman Oyewole, Kehinde Olumide Oyafemi, Kolade Samson Badmus, Janet Omotola Omoleye, Midrar Folahanmi Abubakar, Omolade Adeniyi-Raheem, Abdul-hameed Amedu, Dolapo Latifah Lawal, Aishat Oluwakemi Ijiyode, Ateeqah Oreoluwa Yussuf, Solomon Sunday Ishola, Fatimo Ajoke Sulaimon, Abdulmusawwir O. Alli-Oluwafuyi, Abdulrazaq Bidemi Nafiu, Olugbenga Akinola, Olayemi Joseph Olajide, Abdulbasit Amin, Wahab Imam Abdulmajeed, Olugbenga Samuel Michael, Oluwaseun Aremu Adeyanju, Gbowoloye Lanre Ogunjimi
JOURNAL OF NEUROSCIENCE METHODS
(2020)
Article
Biochemistry & Molecular Biology
Olayemi Joseph Olajide, Ismail Tayo Gbadamosi, Emmanuel Olusola Yawson, Tolulope Arogundade, Folashade Susan Lewu, Kehinde Yomi Ogunrinola, Oluwaseun Olaniyi Adigun, Olawande Bamisi, Ezra Lambe, Leviticus Ogbenevurinrin Arietarhire, Olushola Oladapo Oluyomi, Olumayowa Kolawole Idowu, Rukayat Kareem, Nnaemeka Tobechukwu Asogwa, Philip Adeyemi Adeniyi
Summary: The study investigated the acute effects of glutamate injection on behavior and molecular expression in the dentate gyrus, showing that glutamate induced anxiogenic responses and spatial memory impairments, which were inhibited by the NMDAR antagonist memantine.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2021)
Review
Biology
Olayemi Joseph Olajide, Marcus E. Suvanto, Clifton Andrew Chapman
Summary: The entorhinal cortex plays a crucial role in the early development of Alzheimer's disease, with degenerative changes impacting memory and cognitive function, signaling pathways involving oxidative stress, neuroinflammation, and neuronal loss are key factors in the pathogenesis.
Article
Geriatrics & Gerontology
Olayemi Joseph Olajide, Clifton Andrew Chapman
Summary: The study found that Aβ(1-42) can rapidly disrupt glutamatergic transmission in the entorhinal cortex, primarily by affecting molecular levels presynaptically and postsynaptically, and involving concurrent activation of GluN2A- and GluN2B-containing NMDA receptors.
NEUROBIOLOGY OF AGING
(2021)
Article
Neurosciences
Olayemi Joseph Olajide, Zainab Omolara Alliy, Daniel Oluwapelumi Ojo, Olajumoke Olamipe Osinubi, Sofiyat Opeyemi Bello, Faaizah Eniola Ibrahim, Faith Ojochenemi Adukwu, Tolulope Olabisi Abikoye, Ismail Temitayo Gbadamosi, Nafisat Yetunde Mutholib, Olawande Bamisi, Olaolu Joseph Ajiboye, Akeem Ayodeji Okesina, Abdulmusawwir Alli-Oluwafuyi, Aboyeji Lukuman Oyewole, Abdulrazaq Bidemi Nafiu, Olugbenga Akinola
Summary: The study indicates that prenatal exposure to chloroquine may lead to abnormal behaviors and neurotoxic changes in offspring, especially during midgestation and throughout gestation.
NEUROTOXICOLOGY AND TERATOLOGY
(2021)
Article
Neurosciences
Aminu Imam, Adhil Bhagwandin, Moyosore S. Ajao, Paul R. Manger
Summary: This study provides a detailed analysis of the subpallial telencephalon in tree pangolins, revealing a high degree of similarity with other mammals, indicating evolutionary conservation. The functions associated with subpallial nuclei in other mammals may be directly applicable to tree pangolins, albeit with consideration for specific stimuli related to the life history requirements of the species.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Article
Neurosciences
Aminu Imam, Adhil Bhagwandin, Moyosore S. Ajao, Paul R. Manger
Summary: Despite its short length, the spinal cord of the tree pangolin has a similar anatomical organization to that of other mammals, indicating potential similarities in its functional aspects.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Ariel A. Batallan Burrowes, Olayemi Joseph Olajide, Isabella A. Iasenza, Waqqas M. Shams, Francis Carter, C. Andrew Chapman
Summary: Estrogens play a role in promoting the function of cholinergic neurons and have an impact on cognitive function. This study found that ovariectomy reduces the expression of cholinergic synaptic proteins in the entorhinal cortex, and this reduction can be prevented by estradiol replacement. Ovariectomy also impairs the cholinergic modulation of excitatory transmission in the entorhinal cortex, which may be related to the changes in cholinergic proteins.
Article
Biochemistry & Molecular Biology
Bhaswati Banerjee, Olayemi Joseph Olajide, Giulia Bortolussi, Andres F. Muro
Summary: Bilirubin is a byproduct of heme metabolism, and Ugt1a1 is the enzyme responsible for its elimination. Dysfunctional Ugt1a1 can lead to the accumulation of unconjugated bilirubin in the brain, causing neuronal damage and death. Understanding alternative bilirubin detoxification mechanisms is crucial for developing new therapeutic strategies. Activation of alternative clearance pathways can partially improve hyperbilirubinemic conditions in the absence of Ugt1a1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Olayemi Joseph Olajide, Claudia La Rue, Andreas Bergdahl, Clifton Andrew Chapman
Summary: Increasing evidence suggests that mitochondrial dysfunction and aberrant release of mitochondrial reactive oxygen species (ROS) play crucial roles in early synaptic perturbations and neuropathology that drive memory deficits in Alzheimer's disease (AD). Solubilized human amyloid beta peptide 1-42 (hA beta(1-42)) causes rapid alterations at glutamatergic synapses in the entorhinal cortex (EC) through the activation of both GluN2A- and GluN2B-containing NMDA receptors. This study reveals that hA beta(1-42) disrupts mitochondrial respiratory functions and increases ROS in the entorhinal cortex, leading to synaptic dysfunctions that may contribute to early AD-related neuropathology.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Peripheral Vascular Disease
Olufunto O. Badmus, Emmanuel D. Areola, Eleojo Benjamin, Matthew A. Obekpa, Tolulope E. Adegoke, Oluwatobi E. Elijah, Aminu Imam, Olayemi J. Olajide, Lawrence A. Olatunji
Summary: The study demonstrated that postpartum COC treatment induced renal dysfunction through oxidative stress, and blockade of mineralocorticoid receptor or glucocorticoid receptor could alleviate the damage caused by COC.
JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
(2021)
Meeting Abstract
Neurosciences
Olayemi Olajide, Dominic Butler, Chapman Andrew
BIOLOGICAL PSYCHIATRY
(2021)
