N-Acetylcysteine: A Review of Clinical Usefulness (an Old Drug with New Tricks)

N-acetyl Cysteine Administration Is Associated With Increased Cerebral Glucose Metabolism in Patients With Multiple Sclerosis: An Exploratory Study

(2020) Daniel A. Monti et al.   Frontiers in Neurology

Evaluation of the effect of N-acetylcysteine on the prevention and amelioration of paclitaxel-induced peripheral neuropathy in breast cancer patients: a randomized controlled study

(2020) Hadeer G. Khalefa et al.   BREAST CANCER RESEARCH AND TREATMENT

Rationale for the use of N -acetylcysteine in both prevention and adjuvant therapy of COVID-19

(2020) Silvio De Flora et al.   FASEB JOURNAL

N-acetylcysteine as a potential treatment for novel coronavirus disease 2019

(2020) Rangel-Méndez Jorge-Aarón et al.   Future Microbiology

Experience of N-acetylcysteine airway management in the successful treatment of one case of critical condition with COVID-19

(2020) Yan Liu et al.   MEDICINE

N-Acetyl Cysteine Targets Hepatic Lipid Accumulation to Curb Oxidative Stress and Inflammation in NAFLD: A Comprehensive Analysis of the Literature

(2020) Phiwayinkosi V. Dludla et al.   Antioxidants

N-acetylcysteine decreases malignant characteristics of glioblastoma cells by inhibiting Notch2 signaling

(2019) Jie Deng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Differential effects of N-acetylcysteine on retinal degeneration in two mouse models of normal tension glaucoma

(2019) Hiroki Sano et al.   Cell Death & Disease

N-Acetylcysteine: Antioxidant, Aldehyde Scavenger, and More

(2019) Anatoly Zhitkovich   CHEMICAL RESEARCH IN TOXICOLOGY

N-Acetylcysteine Attenuates Cisplatin-Induced Acute Kidney Injury by Inhibiting the C5a Receptor

(2019) Shuai Huang et al.   Biomed Research International

Crohn’s Disease in Clinical Remission Is Marked by Systemic Oxidative Stress

(2019) Arno R. Bourgonje et al.   Frontiers in Physiology

N‐Acetyl Cysteine Is Associated With Dopaminergic Improvement in Parkinson's Disease

(2019) Daniel A. Monti et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

N-acetylcysteine reverses the decrease of DNA methylation status caused by engineered gold, silicon, and chitosan nanoparticles

(2019) Kanidta Sooklert et al.   International Journal of Nanomedicine

N-Acetyl-L-cysteine Protects Human Retinal Pigment Epithelial Cells from Oxidative Damage: Implications for Age-Related Macular Degeneration

(2019) Marcia R. Terluk et al.   Oxidative Medicine and Cellular Longevity

The beneficial effects of N-acetyl cysteine (NAC) against obesity associated complications: A systematic review of pre-clinical studies

(2019) Phiwayinkosi V. Dludla et al.   PHARMACOLOGICAL RESEARCH

Novel insights into the mechanism of cyclophosphamide-induced bladder toxicity: chloroacetaldehyde’s contribution to urothelial dysfunction in vitro

(2019) Kylie A. Mills et al.   ARCHIVES OF TOXICOLOGY

Ameliorative Effects Of N-Acetylcysteine As Adjunct Therapy On Symptoms Of Painful Diabetic Neuropathy

(2019) Narges Heidari et al.   Journal of Pain Research

Meta-analysis of randomised controlled trials with N-acetylcysteine in the treatment of schizophrenia

(2019) Caitlin OB Yolland et al.   AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY

N-acetylcysteine protects against diabetic nephropathy through control of oxidative and nitrosative stress by recovery of nitric oxide in rats

(2018) Guilherme B. Nogueira et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Protective Effects of Brain Infarction byN-Acetylcysteine Derivatives

(2018) Takeshi Uemura et al.   STROKE

Interventions and mechanisms of N‑acetylcysteine on monocrotaline‑induced pulmonary arterial hypertension

(2018) Wencheng Yu et al.   Experimental and Therapeutic Medicine

Overview on the Effects of N-Acetylcysteine in Neurodegenerative Diseases

(2018) Giuseppe Tardiolo et al.   MOLECULES

N-Acetylcysteine for the Treatment of Psychiatric Disorders: A Review of Current Evidence

(2018) Soo Liang Ooi et al.   Biomed Research International

The effect of N-acetylcysteine on exacerbations of chronic obstructive pulmonary disease: A meta-analysis and systematic review

(2017) Kaushal Fowdar et al.   HEART & LUNG

Randomized, Double-Blind, Placebo-Controlled Trial of N-Acetylcysteine Augmentation for Treatment-Resistant Obsessive-Compulsive Disorder

(2017) Daniel L. C. Costa et al.   JOURNAL OF CLINICAL PSYCHIATRY

N-acetylcysteine prevents the development of gastritis induced by Helicobacter pylori infection

(2017) Sungil Jang et al.   JOURNAL OF MICROBIOLOGY

Pilot study demonstrating metabolic and anti-proliferative effects of in vivo anti-oxidant supplementation with N-Acetylcysteine in Breast Cancer

(2017) Daniel Monti et al.   SEMINARS IN ONCOLOGY

N-acetylcysteine augmentation therapy for moderate-to-severe obsessive-compulsive disorder: randomized, double-blind, placebo-controlled trial

(2016) K. Paydary et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

What Future Role Might N-Acetyl-Cysteine Have in the Treatment of Obsessive Compulsive and Grooming Disorders?

(2016) Louise Smith et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

The antioxidant N-Acetylcysteine does not improve glucose tolerance or β-cell function in type 2 diabetes

(2016) Magdalena A. Szkudlinska et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Fetal and Neonatal Effects of N-Acetylcysteine When Used for Neuroprotection in Maternal Chorioamnionitis

(2016) Dorothea D. Jenkins et al.   JOURNAL OF PEDIATRICS

N-acetyl-cysteine attenuates neuropathic pain by suppressing matrix metalloproteinases

(2016) Jiajie Li et al.   PAIN

Antioxidant Carbocysteine Treatment in Obstructive Sleep Apnea Syndrome: A Randomized Clinical Trial

(2016) Kang Wu et al.   PLoS One

The effect of N-acetylcysteine on biofilms: Implications for the treatment of respiratory tract infections

(2016) Francesco Blasi et al.   RESPIRATORY MEDICINE

The Effects of Ascorbate, N-Acetylcysteine, and Resveratrol on Fibroblasts from Patients with Mitochondrial Disorders

(2016) Liza Douiev et al.   Journal of Clinical Medicine

Nail-Biting Stuff? The Effect of N-acetyl Cysteine on Nail-Biting

(2016) Michael Berk et al.   CNS SPECTRUMS

N-Acetyl Cysteine Depletes Reactive Oxygen Species and Prevents Dental Monomer-Induced Intrinsic Mitochondrial Apoptosis In Vitro in Human Dental Pulp Cells

(2016) Yang Jiao et al.   PLoS One

Oral N-acetylcysteine reduces plasma homocysteine concentrations regardless of lipid or smoking status

(2015) Wulf Hildebrandt et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Long-term treatment with oral N-acetylcysteine: Affects lung function but not sputum inflammation in cystic fibrosis subjects. A phase II randomized placebo-controlled trial

(2015) C. Conrad et al.   Journal of Cystic Fibrosis

Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review

(2015) Deepmala et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Efficacy and safety of acetylcysteine in “non-acetaminophen” acute liver failure: A meta-analysis of prospective clinical trials

(2015) Jinhua Hu et al.   Clinics and Research in Hepatology and Gastroenterology

N-acetylcysteine in COPD: why, how, and when?

(2015) Claudio M. Sanguinetti   MULTIDISCIPLINARY RESPIRATORY MEDICINE

Antioxidant therapy for treatment of inflammatory bowel disease: Does it work?

(2015) Fabiana Andréa Moura et al.   Redox Biology

Mycetismus: a review

(2015) Michael R. Smith et al.   Gastroenterology Report

Mechanisms of Fatal Cardiotoxicity following High-Dose Cyclophosphamide Therapy and a Method for Its Prevention

(2015) Takuro Nishikawa et al.   PLoS One

Effect of N-acetylcysteine administration on the expression and activities of antioxidant enzymes and the malondialdehyde level in the blood of lead-exposed workers

(2014) Sławomir Kasperczyk et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

N-acetylcysteine chemoprotection without decreased cisplatin antitumor efficacy in pediatric tumor models

(2014) Leslie L. Muldoon et al.   JOURNAL OF NEURO-ONCOLOGY

N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action

(2014) Olivia Dean et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

N-acetylcysteine improves established monocrotaline-induced pulmonary hypertension in rats

(2014) Marie-Camille Chaumais et al.   RESPIRATORY RESEARCH

Antioxidants Accelerate Lung Cancer Progression in Mice

(2014) V. I. Sayin et al.   Science Translational Medicine

ROS inhibitorN-acetyl-L-cysteine antagonizes the activity of proteasome inhibitors

(2013) Marianna Halasi et al.   BIOCHEMICAL JOURNAL

N-acetylcysteine exerts therapeutic action in a rat model of allergic rhinitis

(2013) George V. Guibas et al.   International Forum of Allergy & Rhinology

N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: A randomized, double-blind, placebo-controlled trial

(2012) Zhi-Wei Lai et al.   ARTHRITIS AND RHEUMATISM

Prednisone, Azathioprine, andN-Acetylcysteine for Pulmonary Fibrosis

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

N-acetylcysteine expresses powerful anti-inflammatory and antioxidant activities resulting in complete improvement of acetic acid-induced colitis in rats

(2012) Suleyman Uraz et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

N-acetylcysteine (NAC) diminishes the severity of PCB 126-induced fatty liver in male rodents

(2012) Ian K. Lai et al.   TOXICOLOGY

N-Acetylcysteine Amide (NACA) Prevents Retinal Degeneration by Up-Regulating Reduced Glutathione Production and Reversing Lipid Peroxidation

(2011) Andrew M. Schimel et al.   AMERICAN JOURNAL OF PATHOLOGY

N-acetyl-l-cysteine (NAC) inhibit mucin synthesis and pro-inflammatory mediators in alveolar type II epithelial cells infected with influenza virus A and B and with respiratory syncytial virus (RSV)

(2011) Manuel Mata et al.   BIOCHEMICAL PHARMACOLOGY

The Effect of N-Acetylcysteine in the Nucleus Accumbens on Neurotransmission and Relapse to Cocaine

(2011) Yonatan M. Kupchik et al.   BIOLOGICAL PSYCHIATRY

The Potential Role of N-Acetylcysteine for the Treatment of Helicobacter pylori

(2011) Kian Makipour et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Effect of antioxidant N-acetylcysteine on diabetic retinopathy and expression of VEGF and ICAM-1 from retinal blood vessels of diabetic rats

(2011) Yuan Zhu et al.   MOLECULAR BIOLOGY REPORTS

N-acetylcysteine as a mitochondrial enhancer: a new class of psychoactive drugs?

(2011) Gabriel Rodrigo Fries et al.   REVISTA BRASILEIRA DE PSIQUIATRIA

Using glutamate homeostasis as a target for treating addictive disorders

(2010) Kathryn J. Reissner et al.   BEHAVIOURAL PHARMACOLOGY

Lower levels of glutathione in the brains of secondary progressive multiple sclerosis patients measured by 1H magnetic resonance chemical shift imaging at 3 T

(2010) I-Y Choi et al.   Multiple Sclerosis Journal

N-acetyl cysteine for treatment of recurrent unexplained pregnancy loss

(2010) Ahmed F Amin et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Suppression of human prostate cancer PC-3 cell growth by N-acetylcysteine involves over-expression of Cyr61

(2010) Yoon-Jin Lee et al.   TOXICOLOGY IN VITRO

N-acetyl cysteine enhances imatinib-induced apoptosis of Bcr-Abl+ cells by endothelial nitric oxide synthase-mediated production of nitric oxide

(2009) Srabanti Rakshit et al.   APOPTOSIS

N-Acetylcysteine, a Glutamate Modulator, in the Treatment of Trichotillomania

(2009) Jon E. Grant et al.   ARCHIVES OF GENERAL PSYCHIATRY

N-acetyl-l-cysteine (NAC) inhibits virus replication and expression of pro-inflammatory molecules in A549 cells infected with highly pathogenic H5N1 influenza A virus

(2009) Janina Geiler et al.   BIOCHEMICAL PHARMACOLOGY

Role of N-acetylcysteine in adults with non-acetaminophen-induced acute liver failure in a center without the facility of liver transplantation

(2009) Khalid Mumtaz et al.   Hepatology International

Topical N-acetyl cysteine (NAC) Reduces Late Phase Nasal Symptoms Following Ragweed Challenge

(2009) C.J. Lane et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Retinal Oxidative Stress Induced by Intraocular Hypertension in Rats May be Ameliorated by Brimonidine Treatment and N-acetyl Cysteine Supplementation

(2009) Gokhan Ozdemir et al.   JOURNAL OF GLAUCOMA

Effects of N-acetylcysteine on Semen Parameters and Oxidative/Antioxidant Status

(2009) Halil Ciftci et al.   UROLOGY

N-Acetyl Cysteine for Depressive Symptoms in Bipolar Disorder—A Double-Blind Randomized Placebo-Controlled Trial

(2008) Michael Berk et al.   BIOLOGICAL PSYCHIATRY

Long-Term N-Acetylcysteine and L-Arginine Administration Reduces Endothelial Activation and Systolic Blood Pressure in Hypertensive Patients With Type 2 Diabetes

(2008) V. Martina et al.   DIABETES CARE

The glutathione precursor N-acetylcysteine improves immune function in postmenopausal women

(2008) L ARRANZ et al.   FREE RADICAL BIOLOGY AND MEDICINE

Efficacy of Selenium and/or N-Acetyl-Cysteine for Improving Semen Parameters in Infertile Men: A Double-Blind, Placebo Controlled, Randomized Study

(2008) Mohammad Reza Safarinejad et al.   JOURNAL OF UROLOGY

N-Acetylcysteine enhances the lung cancer inhibitory effect of epigallocatechin-3-gallate and forms a new adduct

(2007) Joshua D. Lambert et al.   FREE RADICAL BIOLOGY AND MEDICINE