期刊
GREEN CHEMISTRY
卷 18, 期 24, 页码 6630-6636出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6gc02556k
关键词
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资金
- Scientific Council of the President of the Russian Federation [MK-3228.2015.3]
- Saint Petersburg State University [12.50.1190.2014, 12.37.214.2016]
- Russian Foundation for Basic Research [15-33-50913 mol_nr]
A novel solvent-and halide-free atom-economical synthesis of practically useful pyridine-2-yl substituted ureas utilizes easily accessible or commercially available pyridine N-oxides (PyO) and dialkylcyanamides. The observed C-H functionalization of PyO is suitable for the good-to-high yielding synthesis of a wide range of pyridine-2-yl substituted ureas featuring electron donating and electron withdrawing, sensitive, or even fugitive functional groups at any position of the pyridine ring (63-92%; 19 examples). In the cases of 3-substituted PyO, the C-H functionalization occurs regioselectively providing a route for facile generation of ureas bearing a 5-substituted pyridine-2-yl moiety.
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