SCD2-mediated monounsaturated fatty acid metabolism regulates cGAS-STING-dependent type I IFN responses in CD4+ T cells

CHOPCHOP v3: expanding the CRISPR web toolbox beyond genome editing

(2019) Kornel Labun et al.   NUCLEIC ACIDS RESEARCH

A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription

(2019) Ekaterini Platanitis et al.   Nature Communications

Compartmentalized Synthesis of Triacylglycerol at the Inner Nuclear Membrane Regulates Nuclear Organization

(2019) Antonio D. Barbosa et al.   DEVELOPMENTAL CELL

Lipid Droplets as Immune Modulators in Myeloid Cells

(2018) Martijn H. den Brok et al.   TRENDS IN IMMUNOLOGY

Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling

(2018) Anne Louise Hansen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DUSP10 constrains innate IL-33-mediated cytokine production in ST2hi memory-type pathogenic Th2 cells

(2018) Takeshi Yamamoto et al.   Nature Communications

Sequence-Specific Sensing of Nucleic Acids

(2017) Nicolas Vabret et al.   TRENDS IN IMMUNOLOGY

Crosstalk between Cytoplasmic RIG-I and STING Sensing Pathways

(2017) Alessandra Zevini et al.   TRENDS IN IMMUNOLOGY

Type 1 Interferons Induce Changes in Core Metabolism that Are Critical for Immune Function

(2016) Duojiao Wu et al.   IMMUNITY

Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells

(2016) Mulki Angela et al.   Nature Communications

Activation of STING requires palmitoylation at the Golgi

(2016) Kojiro Mukai et al.   Nature Communications

Functional organization of the HIV lipid envelope

(2016) Nerea Huarte et al.   Scientific Reports

HIV Triggers a cGAS-Dependent, Vpu- and Vpr-Regulated Type I Interferon Response in CD4 + T Cells

(2016) Jolien Vermeire et al.   Cell Reports

Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling

(2015) Autumn G. York et al.   CELL

Expanding Roles for Lipid Droplets

(2015) Michael A. Welte   CURRENT BIOLOGY

Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine

(2015) Aiden Haghikia et al.   IMMUNITY

T cell metabolism drives immunity

(2015) Michael D. Buck et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Obesity Drives Th17 Cell Differentiation by Inducing the Lipid Metabolic Kinase, ACC1

(2015) Yusuke Endo et al.   Cell Reports

Fatty Acid Elongase 7 Catalyzes Lipidome Remodeling Essential for Human Cytomegalovirus Replication

(2015) John G. Purdy et al.   Cell Reports

Type I Interferon Protects Antiviral CD8+ T Cells from NK Cell Cytotoxicity

(2014) Haifeng C. Xu et al.   IMMUNITY

Type I Interferons Protect T Cells against NK Cell Attack Mediated by the Activating Receptor NCR1

(2014) Josh Crouse et al.   IMMUNITY

Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development

(2014) David O’Sullivan et al.   IMMUNITY

25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon

(2014) A. Reboldi et al.   SCIENCE

The Lipid Mediator Protectin D1 Inhibits Influenza Virus Replication and Improves Severe Influenza

(2013) Masayuki Morita et al.   CELL

Lipids in Innate Antiviral Defense

(2013) John W. Schoggins et al.   Cell Host & Microbe

Interferon-Inducible Cholesterol-25-Hydroxylase Broadly Inhibits Viral Entry by Production of 25-Hydroxycholesterol

(2012) Su-Yang Liu et al.   IMMUNITY

The Transcription Factor STAT-1 Couples Macrophage Synthesis of 25-Hydroxycholesterol to the Interferon Antiviral Response

(2012) Mathieu Blanc et al.   IMMUNITY

Contribution of a TANK-Binding Kinase 1-Interferon (IFN) Regulatory Factor 7 Pathway to IFN- -Induced Gene Expression

(2012) M. Farlik et al.   MOLECULAR AND CELLULAR BIOLOGY

A FOXO3–IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses

(2012) Vladimir Litvak et al.   NATURE

Memory B cells in the lung participate in protective humoral immune responses to pulmonary influenza virus reinfection

(2012) T. Onodera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development

(2011) Gerritje J.W. van der Windt et al.   IMMUNITY

Multifaceted roles for lipids in viral infection

(2011) Nicholas S. Heaton et al.   TRENDS IN MICROBIOLOGY

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols