Article
Biochemistry & Molecular Biology
Leila Shakerian, Hanieh Kolahdooz, Mitra Garousi, Vahideh Keyvani, Ramiar Kamal Kheder, Tola Abdulsattar Faraj, Esmaeil Yazdanpanah, Seyed-Alireza Esmaeili
Summary: Interleukin-33 (IL-33) is a cytokine that plays an ambivalent role in autoimmune diseases. It signals through the ST2 receptor and induces cytokine production in various cell types. IL-33 has been implicated in inflammatory disorders and immune-mediated diseases, but its role can vary depending on the specific condition. This review discusses the studies on IL-33/ST2 axis in autoimmune diseases and explores its potential as a pathogenic or protective cytokine.
Article
Immunology
Melvin Zhang, Jennifer L. Duffen, Karl H. Nocka, Marion T. Kasaian
Summary: IL-13 regulates the activity of IL-33 by modulating the transmembrane and soluble forms of ST2, impacting the responsiveness to IL-33. IL-13-deficient mice showed exacerbated effects following IL-33 administration, highlighting the important regulatory role of IL-13 on IL-33.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Mengying Xie, Mingying Zhang, Mengyuan Dai, Shan Yue, Zhao Li, Ju Qiu, Chenqi Lu, Wei Xu
Summary: This study characterized a population of IL-7R alpha+IL-18R alpha(+) ILC progenitors in mouse bone marrow with multi-ILC lineage potential. Single-cell gene expression analysis revealed the heterogeneity of this population and identified several subpopulations with specific ILC subset-biased gene expression profiles. The role of IL-18 signaling in the regulation of IL-18R alpha(+) ILC progenitors and ILC development was found to be limited.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Corine Glineur, Ines Leleu, Sylviane Pied
Summary: Interleukin-33 (IL-33) plays a critical role in cerebral malaria and its signaling pathway may affect the permeability of brain and cerebrospinal barriers. IL-33 serum levels are higher in children with severe Plasmodium falciparum malaria and correlate with parasite load.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Elizabeth England, D. Gareth Rees, Ian Christopher Scott, Sara Carmen, Denice T. Y. Chan, Catherine Chaillan E. Huntington, Kirsty F. Houslay, Teodor Erngren, Mark Penney, Jayesh B. Majithiya, Laura Rapley, Dorothy A. Sims, Claire Hollins, Elizabeth C. Hinchy, Martin D. Strain, Benjamin P. Kemp, Dominic J. Corkill, Richard D. May, Katherine A. Vousden, Robin J. Butler, Tomas Mustelin, Tristan J. Vaughan, David C. Lowe, Caroline Colley, E. Suzanne Cohen
Summary: This study identified a drug called tozorakimab, a monoclonal antibody that inhibits interleukin-33 through different signaling pathways. It effectively reduces inflammation and epithelial dysfunction.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Mengxiang Zhao, Yijia He, Nisha Zhu, Yuxian Song, Qingang Hu, Zhiyong Wang, Yanhong Ni, Liang Ding
Summary: This study found that IL-33/ST2 signaling pathway can enhance PD-L1-mediated immune escape, and ST2 high-expression OSCC patients may benefit from anti-PD-1/L1 therapy.
BRITISH JOURNAL OF CANCER
(2023)
Review
Biochemistry & Molecular Biology
Punniyakoti Veeraveedu Thanikachalam, Srinivasan Ramamurthy, Poojitha Mallapu, Sudhir Rama Varma, Jayaraj Narayanan, Mohammed A. S. Abourehab, Prashant Kesharwani
Summary: IL-33 is a cytokine that belongs to the IL-1 family and promotes the production of Th2 cytokines by binding with ST2L and IL-1RAcP. It has demonstrated protective effects against cardiovascular diseases by inducing Th2 cytokines and promoting alternative activating M2 polarization. However, the soluble decoy form of ST2 mitigates its effects, exacerbating cardiovascular diseases. IL-33 also plays a significant role in the development of asthma, arthritis, atopic dermatitis, and anaphylaxis. This review aims to explore the protective role of IL-33 against cardiovascular diseases and the potential of serum soluble ST2 as a diagnostic biomarker for these diseases. Therefore, IL-33 holds promise as a potential therapeutic target for cardiovascular diseases.
CYTOKINE & GROWTH FACTOR REVIEWS
(2023)
Article
Respiratory System
Qiong Huang, Chen Duo Li, Yi Ran Yang, Xiao Feng Qin, Jing Jing Wang, Xin Zhang, Xiao Nan Du, Xia Yang, Ying Wang, Lun Li, Mi Mu, Zhe Lv, Ye Cui, Kewu Huang, Chris J. Corrigan, Wei Wang, Sun Ying
Summary: The study investigated the role of the IL-33/ST2 axis in cigarette smoke-induced airway remodeling in COPD. It was found that cigarette smoke exposure leads to remodeling changes in multiple organs. Blocking IL-33/ST2 signaling can inhibit fibroblast proliferation and protein synthesis in the airways.
Article
Immunology
Enrique Olguin-Martinez, Ofelia Munoz-Paleta, Blanca E. Ruiz-Medina, Jose Luis Ramos-Balderas, Ileana Licona-Limon, Paula Licona-Limon
Summary: This study reveals the heterogeneity of ILC2 subsets based on the expression of IL-9 and ST2 in mice infected with N. brasiliensis. Through in vitro experiments, the researchers identified IL-33 as a key factor for increasing IL-9 expression in ILC2s. Additionally, they found that the PKA pathway acts as a dual regulator of ILC2 cells, enhancing IL-9 production and affecting proliferation and marker expression. These findings emphasize the importance of distinguishing ILC2 subsets and understanding their activation mechanisms for therapeutic purposes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Irina G. Luzina, Virginia Lockatell, Jean-Paul Courneya, Zhongcheng Mei, Rita Fishelevich, Pavel Kopach, Edward M. Pickering, Phillip H. Kang, Alexander S. Krupnick, Nevins W. Todd, Stefanie N. Vogel, Sergei P. Atamas
Summary: Mature IL-33 (MIL33) through ST2 receptor regulates fibrosis. However, the precursor full-length IL-33 (FLIL33) may have a different function and act independently of ST2. Genetic deletion of IL-33 or ST2, as well as Cre-induced IL-33 deficiency, attenuates pulmonary fibrosis. Adenovirus-mediated delivery of FLIL33, but not MIL33, enhances the profibrotic effect of bleomycin without inducing Th2 phenotype. FLIL33 may contribute to fibrosis in an ST2-independent, Th2-independent, non-transcriptomic fashion, suggesting potential efficacy of targeting both FLIL33 and MIL33 in pulmonary fibrosis patients.
CELLULAR IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chih-Feng Kuo, Wei-Yu Chen, Hai-Han Yu, Yu-Hsuan Tsai, Ya-Chu Chang, Chih-Peng Chang, Nina Tsao
Summary: The IL-33/ST2 axis was found to provide protective effect against Group A Streptococcus infection by enhancing innate immunity through promoting neutrophil migration and bactericidal activity. The absence of IL-33/ST2 axis led to increased mortality, more severe skin lesions, and higher bacterial loads in infected mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Zexi Jia, Mengtian Guo, Xintong Ge, Fanglian Chen, Ping Lei
Summary: IL-33 is a cytokine that is passively produced in response to tissue damage or cell necrosis. It interacts with the ST2 receptor to produce pro-inflammatory cytokines and plays a crucial role in immune regulation and neurodegenerative diseases.
Article
Immunology
ChunYan Yuan
Summary: IL-33 is a cytokine that modulates inflammation and immune responses, primarily associated with the development of Th2 immunological responses. It has been shown to be elevated in various autoimmune disorders, suggesting a role in inducing autoimmunity and inflammatory damage. The IL-33/ST2 axis holds promising potential as a therapeutic target for autoimmune disease treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Allergy
Yuying Huang, Xuezhen Li, Lin Zhu, Chunrong Huang, Wen Chen, Zhiyang Ling, SongLing Zhu, Xintong Feng, Chunyan Yi, Wangpeng Gu, Chenghua Yan, Jing Wang, Liyan Ma, Xiao Su, Ranran Dai, Guochao Shi, Bing Sun, Yaguang Zhang
Summary: The study discovered that by inhibiting thrombin, the maturation of IL-33 can be regulated, thus impacting ILC2s cells and treating lung inflammation.
Review
Pharmacology & Pharmacy
Wenran Li, Mengqi Liu, Ming Chu
Summary: The IL-33/ST2 axis plays a crucial role in the pathogenesis of allergic diseases and shows promise in allergy treatment. Targeting regulation of IL-33 and ST2 or molecules involved in the signal transduction can block IL-33/ST2 activity.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Kenta Shinoda, Andrea Choe, Kiyoshi Hirahara, Masahiro Kiuchi, Kota Kokubo, Tomomi Ichikawa, Jason S. Hoki, Akane S. Suzuki, Neelanjan Bose, Judith A. Appleton, Raffi Aroian, Frank C. Schroeder, Paul W. Sternberg, Toshinori Nakayama
Summary: Mounting evidence suggests that nematode infection may help protect against immune disorders. Nanogram quantities of a family of nematode pheromones called ascarosides, when administered, were found to modulate the pulmonary immune response and reduce asthma severity in mice. Ascr#7, one of the ascarosides, suppressed the production of IL-33 and reduced the number of pathogenic Th2 cells and ILC2s in the lung, indicating its potential as a treatment strategy for allergic diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Ken Wakai, Kazuhiko Azuma, Chiaki Iwamura, Maihulan Maimaiti, Kosuke Mikami, Kei Yoneda, Shinichi Sakamoto, Sanae Ikehara, Takashi Yamaguchi, Kiyoshi Hirahara, Tomohiko Ichikawa, Toshinori Nakayama, Yuzuru Ikehara
Summary: In bronchial asthma patients, mucous cell metaplasia (MCM) and fibrosis occur in the bronchial epithelium and interstitium, respectively. This study developed a method to evaluate pathological remodeling in asthma and investigate the molecular mechanisms using chemical staining and scanning electron microscopy.
SCIENTIFIC REPORTS
(2022)
Article
Health Care Sciences & Services
Kazuhisa Tanaka, Takahiro Nakajima, Terunaga Inage, Yuichi Sakairi, Hidemi Suzuki, Ichiro Yoshino
Summary: Transbronchoscopic laser ablation using a diode laser system with a non-contact probe is safe and effective for treating central airway lesions, including both neoplastic and non-neoplastic causes. Patients underwent an average of 1.36 to 3.82 treatments, with an average total energy of 1,936 J, and no major complications were reported with this therapy.
ANNALS OF PALLIATIVE MEDICINE
(2022)
Article
Allergy
Tomohisa Iinuma, Masahiro Kiuchi, Kiyoshi Hirahara, Junya Kurita, Kota Kokubo, Hiroyuki Yagyu, Riyo Yoneda, Tomoyuki Arai, Yuri Sonobe, Masaki Fukuyo, Atsushi Kaneda, Syuji Yonekura, Toshinori Nakayama, Yoshitaka Okamoto, Toyoyuki Hanazawa
Summary: This study comprehensively investigated the role and changes of antigen-specific T cells in Japanese cedar pollinosis patients before and after sublingual immunotherapy (SLIT). The results revealed that SLIT led to clonal expansion and differentiation of T(H)2 cells, as well as differentiation of trans-type T(H)2 cells into regulatory T cells. The study also identified musculin (MSC) as a potential biomarker of SLIT for allergic rhinitis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Chiaki Iwamura, Kiyoshi Hirahara, Masahiro Kiuchi, Sanae Ikehara, Kazuhiko Azuma, Tadanaga Shimada, Sachiko Kuriyama, Syota Ohki, Emiri Yamamoto, Yosuke Inaba, Yuki Shiko, Ami Aoki, Kota Kokubo, Rui Hirasawa, Takahisa Hishiya, Kaori Tsuji, Tetsutaro Nagaoka, Satoru Ishkawa, Akira Kojima, Haruki Mito, Ryota Hase, Yasunori Kasahara, Naohide Kuriyama, Tetsuya Tsukamoto, Sukeyuki Nakamura, Takashi Urushibara, Satoru Kaneda, Seiichiro Sakao, Minoru Tobiume, Yoshio Suzuki, Mitsuhiro Tsujiwaki, Terufumi Kubo, Tadashi Hasegawa, Hiroshi Nakase, Osamu Nishida, Kazuhisa Takahashi, Komei Baba, Yoko Iizumi, Toshiya Okazaki, Motoko Y. Kimura, Ichiro Yoshino, Hidetoshi Igari, Hiroshi Nakajima, Takuji Suzuki, Hideki Hanaoka, Taka-aki Nakada, Yuzuru Ikehara, Koutaro Yokote, Toshinori Nakayama
Summary: This study investigates the pathogenesis of vasculitis and immunothrombosis in COVID-19, finding that SARS-CoV-2 accumulates in pulmonary vessels and causes vasculitis and microthrombi formation. The amount of plasma Myl9 is correlated with disease severity, and measuring plasma Myl9 together with other markers allows for a more accurate prediction of disease severity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Yuki Ito, Takahiro Nakajima, Terunaga Inage, Takeshi Otsuka, Yuki Sata, Kazuhisa Tanaka, Yuichi Sakairi, Hidemi Suzuki, Ichiro Yoshino
Summary: Endobronchial ultrasound-guided transbronchial aspiration is a minimally invasive and accurate method for the diagnosis of lymph node metastasis in lung cancer. This study investigated the feasibility of computer-aided diagnosis using deep learning technology for the prediction of nodal metastasis in lung cancer. The results showed that computer-aided diagnosis can improve diagnostic efficiency and reduce invasiveness of the procedure.
Article
Immunology
Toshio Kanno, Keisuke Miyako, Takahiro Nakajima, Satoru Yokoyama, Shigemi Sasamoto, Hikari K. Asou, Osamu Ohara, Toshinori Nakayama, Yusuke Endo
Summary: This study reveals that the decrease in monounsaturated fatty acid caused by the genetic deletion of Scd2 can activate IRF3 and induce the nuclear translocation of IRF9, leading to the production of type I interferon in CD4(+) Th1 cells. Furthermore, IRF9 selectively regulates autoimmunity-related genes in sgScd2 Th1 cells. These findings provide novel insights into the connection between fatty acid metabolism and immune response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Toshio Kanno, Ryo Konno, Keisuke Miyako, Takahiro Nakajima, Satoru Yokoyama, Shigemi Sasamoto, Hikari K. Asou, Junichiro Ohzeki, Yusuke Kawashima, Yoshinori Hasegawa, Osamu Ohara, Yusuke Endo
Summary: Functionally distinct CD4(+) helper T cell subsets, including Th1, Th2, Th17, and Treg, play a pivotal role in acquired immunity regulation. This study characterized the proteogenomic signatures of differentiation to each Th cell subset and revealed that T cell receptor activation and specific cytokine treatments have unique effects on transcript and protein profiles. The comprehensive proteogenomic dataset obtained in this study provides crucial insights into the molecular mechanisms underlying effector Th cell differentiation.
Article
Multidisciplinary Sciences
Kota Kokubo, Kiyoshi Hirahara, Masahiro Kiuchi, Kaori Tsuji, Yuki Shimada, Yuri Sonobe, Rie Shinmi, Takahisa Hishiya, Chiaki Iwamura, Atsushi Onodera, Toshinori Nakayama
Summary: CD4(+) memory T cells play a vital role in long-lasting protective immunity and the pathophysiology of chronic inflammation. However, the mechanisms controlling redox metabolism in memory T cell formation are still unclear. This study reveals that Thioredoxin-interacting protein (Txnip) regulates apoptosis and scavenges reactive oxygen species (ROS) through the Nrf2-Biliverdin reductase B pathway, thereby influencing chronic airway inflammation in the lung. The Txnip-Nrf2-Blvrb axis could be a potential therapeutic target for chronic inflammatory diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Respiratory System
Huda Asif, Franck F. Rahaghi, Akihiro Ohsumi, Julie Philley, Amir Emtiazjoo, Takashi Hirama, Arthur W. Baker, Chin-Chung Shu, Fernanda Silveira, Vincent Poulin, Pete Rizzuto, Miki Nagao, Pierre-Regis Burgel, Steve Hays, Timothy Aksamit, Takeshi Kawasaki, Charles Dela Cruz, Stefano Aliberti, Takahiro Nakajima, Stephen Ruoss, Theodore K. Marras, Gregory Snell, Kevin Winthrop, Mehdi Mirsaeidi
Summary: This study provides essential recommendations for the management of nontuberculous mycobacterial infections in lung transplant candidates. The recommendations cover screening methods, contraindications for surgery, and treatment options. These recommendations can serve as expert opinions for clinicians until more evidence-based contributions are available.
Article
Allergy
Kwok Ho Yip, Jessica Chao, Carl Coolen, Harshita Pant, Anita Kral, William Smith, Quenten Schwarz, Michele A. Grimbaldeston, Stuart Pitson, Angel F. Lopez, Joanna Woodcock, Damon J. Tumes
Summary: This study found that 14-3-3z protein plays a positive regulatory role in IgE-dependent activation of mast cells (MCs). It suggests that targeting this pathway could be a potential treatment for MC-mediated inflammatory diseases.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Urology & Nephrology
Yuki Sato, Karina Silina, Maries van den Broek, Kiyoshi Hirahara, Motoko Yanagita
Summary: Tertiary lymphoid structures (TLSs) are ectopic lymphoid tissues that drive antigen-specific immune responses at sites of chronic inflammation. Their presence correlates with disease course, with favorable outcomes in cancer and infection, but more severe disease in autoimmune and chronic inflammatory diseases. However, the mechanisms underlying these associations are still unclear.
NATURE REVIEWS NEPHROLOGY
(2023)
Article
Oncology
Ryo Koyama-Nasu, Motoko Y. Kimura, Masahiro Kiuchi, Ami Aoki, Yangsong Wang, Yukiyoshi Mita, Ichita Hasegawa, Yukihiro Endo, Atsushi Onodera, Kiyoshi Hirahara, Shinichiro Motohashi, Toshinori Nakayama
Summary: This study reveals that CD69 regulates the differentiation process of tumor-specific CD8+ T cells through controlling the expression of transcription factor TOX. Lack of CD69 promotes the generation of functional terminally differentiated CD8+ T cells. Combined use of anti-CD69 and anti-PD-1 shows efficient antitumor effect.
CANCER IMMUNOLOGY RESEARCH
(2023)
Article
Health Care Sciences & Services
Kota Ohashi, Hidemi Suzuki, Yuki Sata, Kazuhisa Tanaka, Takayoshi Yamamoto, Yuichi Sakairi, Hironobu Wada, Takahiro Nakajima, Natsuko Nozaki-Taguchi, Shiroh Isono, Yuki Shiko, Yohei Kawasaki, Ichiro Yoshino
Summary: This study aimed to identify the factors associated with postoperative pain, quality of life, and development of chronic pain after lung cancer surgery. The results showed that individual pain sensation threshold and fentanyl sensitivity were not significantly associated with postoperative pain scores, quality of life scores, or the incidence of post-thoracotomy pain syndrome.
ANNALS OF PALLIATIVE MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Huitao Wang, Kohei Shikano, Takahiro Nakajima, Yukihiro Nomura, Toshiya Nakaguchi
Summary: Lung cancer is the second most common cancer with a low survival rate. Endobronchial ultrasonography (EBUS) images have been increasingly used in diagnosing lung cancer due to their real-time performance and no radiation. This research aims to develop a computer-aided diagnosis (CAD) system for differentiating benign and malignant peripheral pulmonary lesions (PPLs). The experimental results show that the developed CAD system has the potential ability to diagnose PPLs using EBUS images based on Deep Learning.
APPLIED SCIENCES-BASEL
(2023)