N-ArylacylO-sulfonated aminoglycosides as novel inhibitors of human neutrophil elastase, cathepsin G and proteinase 3

Roles for proteinases in the pathogenesis of chronic obstructive pulmonary disease

(2016) Caroline Owen   International Journal of Chronic Obstructive Pulmonary Disease

Synthesis and pharmacological characterization of 2-aminobenzaldehyde oxime analogs as dual inhibitors of neutrophil elastase and proteinase 3

(2015) Tsong-Long Hwang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Unopposed Cathepsin G, Neutrophil Elastase, and Proteinase 3 Cause Severe Lung Damage and Emphysema

(2014) Nicolas Guyot et al.   AMERICAN JOURNAL OF PATHOLOGY

Sulfated Caffeic Acid Dehydropolymer Attenuates Elastase and Cigarette Smoke Extract–induced Emphysema in Rats: Sustained Activity and a Need of Pulmonary Delivery

(2014) Bhawana Saluja et al.   LUNG

Efficacy of Low Molecular Weight Heparin in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease Receiving Ventilatory Support

(2013) Yongbing Qian et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Selective Inhibition of Bacterial and Human Topoisomerases by N-Arylacyl O-Sulfonated Aminoglycoside Derivatives

(2013) Amanda M. Fenner et al.   ACS Medicinal Chemistry Letters

SLPI and trappin-2 as therapeutic agents to target airway serine proteases in inflammatory lung diseases: current and future directions

(2012) Marie-Louise Zani et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Novel low molecular weight lignins as potential anti-emphysema agents: In vitro triple inhibitory activity against elastase, oxidation and inflammation

(2012) Bhawana Saluja et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Sulfated, low molecular weight lignins inhibit a select group of heparin-binding serine proteases

(2011) Brian L. Henry et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Synthesis, separation, and characterization of amphiphilic sulfated oligosaccharides enabled by reversed-phase ion pairing LC and LC–MS methods

(2011) Amanda M. Fenner et al.   CARBOHYDRATE RESEARCH

Cathepsin G and Neutrophil Elastase Play Critical and Nonredundant Roles in Lung-Protective Immunity against Streptococcus pneumoniae in Mice

(2011) Ines Hahn et al.   INFECTION AND IMMUNITY

Interaction of Serine Proteases from Polymorphonuclear Leucocytes with the Cell Surface and Heparin

(2011) Jana Fleddermann et al.   INFLAMMATION

Targeting COPD: advances on low-molecular-weight inhibitors of human neutrophil elastase

(2011) Susana D. Lucas et al.   MEDICINAL RESEARCH REVIEWS

Extracellular Matrix Degradation and Remodeling in Development and Disease

(2011) P. Lu et al.   Cold Spring Harbor Perspectives in Biology

Infection as a comorbidity of COPD

(2010) S. Sethi   EUROPEAN RESPIRATORY JOURNAL

Structures of human proteinase 3 and neutrophil elastase - so similar yet so different

(2010) Eric Hajjar et al.   FEBS Journal

Tailor-made inflammation: how neutrophil serine proteases modulate the inflammatory response

(2010) Kai Kessenbrock et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Emerging principles in protease-based drug discovery

(2010) Marcin Drag et al.   NATURE REVIEWS DRUG DISCOVERY

Neutrophil Elastase, Proteinase 3, and Cathepsin G as Therapeutic Targets in Human Diseases

(2010) B. Korkmaz et al.   PHARMACOLOGICAL REVIEWS

Alpha-1-proteinase inhibitor is a heparin binding serpin: Molecular interactions with the Lys rich cluster of helix-F domain

(2008) Vivek Kumar Gupta et al.   BIOCHIMIE

Emerging Pharmacotherapies for COPD

(2008) Peter J. Barnes   CHEST

Neutrophil elastase, proteinase 3 and cathepsin G: Physicochemical properties, activity and physiopathological functions

(2007) Brice Korkmaz et al.   BIOCHIMIE