Targeting COPD: advances on low-molecular-weight inhibitors of human neutrophil elastase

Dual function inhibitors of relevance to chronic obstructive pulmonary disease

(2010) Dengfeng Dou et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Advances in the Chemistry of Saccharins: From Synthetic Novelties Towards Biologically Active Compounds

(2010) Z. Jakopin et al.   CURRENT MEDICINAL CHEMISTRY

Inhibitors of human neutrophil elastase based on a highly functionalized N-amino-4-imidazolidinone scaffold

(2010) Guijia He et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Effect of Neutrophil Elastase Inhibitor (Sivelestat Sodium) in the Treatment of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS): A Systematic Review and Meta-Analysis

(2010) Kentaro Iwata et al.   INTERNAL MEDICINE

Serine proteases of the human immune system in health and disease

(2010) Kirstin M. Heutinck et al.   MOLECULAR IMMUNOLOGY

Development of a highly water-soluble peptide-based human neutrophil elastase inhibitor; AE-3763 for treatment of acute organ injury

(2009) Yasunao Inoue et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Mechanism-based inhibitors of serine proteases with high selectivity through optimization of S′ subsite binding

(2009) Yi Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and optimization of 2-pyridin-3-yl-benzo[d][1,3]oxazin-4-one based inhibitors of human neutrophil elastase

(2009) Kevin R. Shreder et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Proteases and antiproteases in chronic neutrophilic lung disease - relevance to drug discovery

(2009) Catherine M Greene et al.   BRITISH JOURNAL OF PHARMACOLOGY

Proteinases involved in matrix turnover during cartilage and bone breakdown

(2009) Tim E. Cawston et al.   CELL AND TISSUE RESEARCH

Inhibition of Human Leukocyte Elastase by Brunsvicamides A-C: Cyanobacterial Cyclic Peptides

(2009) Mihiret T. Sisay et al.   ChemMedChem

An Update on the Synthesis of β-Lactams

(2009) M. Aranda et al.   CURRENT ORGANIC SYNTHESIS

Contribution of methylated exudate flavonoids to the anti-inflammatory activity of Grindelia robusta

(2009) Liselotte Krenn et al.   FITOTERAPIA

4-Oxo-β-lactams (Azetidine-2,4-diones) Are Potent and Selective Inhibitors of Human Leukocyte Elastase

(2009) Jalmira Mulchande et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molassamide, a Depsipeptide Serine Protease Inhibitor from the Marine CyanobacteriumDichothrix utahensis†

(2009) Sarath P. Gunasekera et al.   JOURNAL OF NATURAL PRODUCTS

Cleavage of Four Carbon−Carbon Bonds during Biosynthesis of the Griseorhodin A Spiroketal Pharmacophore

(2009) Zeynep Yunt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

2-Amino- and 2-Alkylthio-4H-3,1-benzothiazin-4-ones: Synthesis, Interconversion and Enzyme Inhibitory Activities

(2009) Hans-Georg Häcker et al.   MOLECULES

N,N′-Linked 1,2-benzisothiazol-3(2H)-one 1,1-dioxides: synthesis, biological activity, and derived radicals

(2009) Valeria M. Zakharova et al.   TETRAHEDRON

Synthesis and elastase-inhibiting activity of 2-pyridinyl-isothiazol-3(2H)-one 1,1-dioxides

(2008) Alexander Eilfeld et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure–activity relationship analysis of N-benzoylpyrazoles for elastase inhibitory activity: A simplified approach using atom pair descriptors

(2008) Andrei I. Khlebnikov et al.   BIOORGANIC & MEDICINAL CHEMISTRY

New Peptolides from the CyanobacteriumNostoc insulareas Selective and Potent Inhibitors of Human Leukocyte Elastase

(2008) Christian Mehner et al.   CHEMBIOCHEM

Proteases and cystic fibrosis

(2008) J VOYNOW et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Azetidine-2,4-diones (4-Oxo-β-lactams) as Scaffolds for Designing Elastase Inhibitors

(2008) Jalmira Mulchande et al.   JOURNAL OF MEDICINAL CHEMISTRY

X-ray Snapshot of the Mechanism of Inactivation of Human Neutrophil Elastase by 1,2,5-Thiadiazolidin-3-one 1,1-Dioxide Derivatives†

(2008) Weijun Huang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel Beta-Lactam Antibiotics Derivatives: Their New Applications as Gene Reporters, Antitumor Prodrugs and Enzyme Inhibitors

(2008) Bengang Xing et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

β-Lactam derivatives as enzyme inhibitors: halogenated β-lactams and related compounds

(2008) Ali Elriati et al.   MONATSHEFTE FUR CHEMIE

Attacking the multi-tiered proteolytic pathology of COPD: New insights from basic and translational studies

(2008) Uros V. Djekic et al.   PHARMACOLOGY & THERAPEUTICS

Neutrophil elastase, proteinase 3 and cathepsin G: Physicochemical properties, activity and physiopathological functions

(2007) Brice Korkmaz et al.   BIOCHIMIE

Inhibitors of proteases and amide hydrolases that employ an α-ketoheterocycle as a key enabling functionality

(2007) Bruce E. Maryanoff et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Bornyl (3,4,5-trihydroxy)-cinnamate - An optimized human neutrophil elastase inhibitor designed by free energy calculations

(2007) Thomas Steinbrecher et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Neutrophil serine proteases fine-tune the inflammatory response

(2007) C PHAM   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY