Molecular Regulation of Paused Pluripotency in Early Mammalian Embryos and Stem Cells

An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence

(2021) Eugen Dhimolea et al.   CANCER CELL

Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy

(2021) Sumaiyah K. Rehman et al.   CELL

Chemotherapy induces senescence-like resilient cells capable of initiating AML recurrence

(2021) Cihangir Duy et al.   Cancer Discovery

FAK regulates IL-33 expression by controlling chromatin accessibility at c-Jun motifs

(2021) Billie G. C. Griffith et al.   Scientific Reports

Lipid droplets in mammalian eggs are utilized during embryonic diapause

(2021) Roberta Arena et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Control over mTOR-Dependent Diapause-like State

(2020) Abdiasis M. Hussein et al.   DEVELOPMENTAL CELL

Vertebrate diapause preserves organisms long term through Polycomb complex members

(2020) Chi-Kuo Hu et al.   SCIENCE

In vitro capture and characterization of embryonic rosette-stage pluripotency between naive and primed states

(2020) Alex Neagu et al.   NATURE CELL BIOLOGY

Metabolic characterization of a paused-like pluripotent state

(2020) Maria Inês Sousa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Histone Acetyltransferase MOF Blocks Acquisition of Quiescence in Ground-State ESCs through Activating Fatty Acid Oxidation

(2020) Le Tran Phuc Khoa et al.   Cell Stem Cell

mRNAs, proteins and the emerging principles of gene expression control

(2020) Christopher Buccitelli et al.   NATURE REVIEWS GENETICS

Embryonic diapause in roe deer: A model to unravel embryo-maternal communication during pre-implantation development in wildlife and livestock species

(2020) V.A. van der Weijden et al.   THERIOGENOLOGY

Initiation of a conserved trophectoderm program in human, cow and mouse embryos

(2020) Claudia Gerri et al.   NATURE

Let-7 derived from endometrial extracellular vesicles is an important inducer of embryonic diapause in mice

(2020) W. M. Liu et al.   Science Advances

Capture of Mouse and Human Stem Cells with Features of Formative Pluripotency

(2020) Masaki Kinoshita et al.   Cell Stem Cell

HYPOXIA AND REPRODUCTIVE HEALTH: Hypoxic regulation of preimplantation embryos: lessons from human embryonic stem cells

(2020) Franchesca D Houghton   REPRODUCTION

Distinct dormancy progression depending on embryonic regions during mouse embryonic diapause†

(2019) Chizuru Kamemizu et al.   BIOLOGY OF REPRODUCTION

Uterine fluid proteome changes during diapause and resumption of embryo development in roe deer (Capreolus capreolus)

(2019) V A van der Weijden et al.   REPRODUCTION

FoxO transcription factors 1 regulate mouse preimplantation embryo development

(2019) Nilay Kuscu et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Dormant disseminated tumor cells and cancer stem/progenitor-like cells: Similarities and opportunities

(2019) Omri Hen et al.   SEMINARS IN CANCER BIOLOGY

Cell cycle dynamics during diapause entry and exit in an annual killifish revealed by FUCCI technology

(2019) Luca Dolfi et al.   EvoDevo

The Transcriptionally Permissive Chromatin State of Embryonic Stem Cells Is Acutely Tuned to Translational Output

(2018) Aydan Bulut-Karslioglu et al.   Cell Stem Cell

Mammalian embryo comparison identifies novel pluripotency genes associated with the naïve or primed state

(2018) Andreia S. Bernardo et al.   Biology Open

Regulation of microRNA biogenesis and its crosstalk with other cellular pathways

(2018) Thomas Treiber et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Prospects for the Use of Induced Pluripotent Stem Cells (iPSC) in Animal Conservation and Environmental Protection

(2018) Morgan M. Stanton et al.   Stem Cells Translational Medicine

The Nature of Actin-Family Proteins in Chromatin-Modifying Complexes

(2018) Naeh L. Klages-Mundt et al.   Frontiers in Genetics

Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation

(2018) Jacob O'Brien et al.   Frontiers in Endocrinology

Single cell transcriptome analysis of human, marmoset and mouse embryos reveals common and divergent features of preimplantation development

(2018) Thorsten Boroviak et al.   DEVELOPMENT

Evidence that microRNAs are part of the molecular toolkit regulating adult reproductive diapause in the mosquito, Culex pipiens

(2018) Megan E. Meuti et al.   PLoS One

Pan-cancer characterisation of microRNA across cancer hallmarks reveals microRNA-mediated downregulation of tumour suppressors

(2018) Andrew Dhawan et al.   Nature Communications

Differentially expressed microRNAs in diapausing versus HCl-treated Bombyx embryos

(2017) Wentao Fan et al.   PLoS One

Physiological importance of polyamines

(2017) Yasser Y. Lenis et al.   ZYGOTE

Gene expression analysis of bovine embryonic disc, trophoblast and parietal hypoblast at the start of gastrulation

(2017) Peter L. Pfeffer et al.   ZYGOTE

Differences between germline and somatic mutation rates in humans and mice

(2017) Brandon Milholland et al.   Nature Communications

DAF-16/FOXO Transcription Factor in Aging and Longevity

(2017) Xiaojuan Sun et al.   Frontiers in Pharmacology

Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause

(2016) Roberta Scognamiglio et al.   CELL

Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos

(2016) Sophie Petropoulos et al.   CELL

Inhibition of mTOR induces a paused pluripotent state

(2016) Aydan Bulut-Karslioglu et al.   NATURE

The lipolysis pathway sustains normal and transformed stem cells in adult Drosophila

(2016) Shree Ram Singh et al.   NATURE

The landscape of accessible chromatin in mammalian preimplantation embryos

(2016) Jingyi Wu et al.   NATURE

A developmental coordinate of pluripotency among mice, monkeys and humans

(2016) Tomonori Nakamura et al.   NATURE

CNOT3-Dependent mRNA Deadenylation Safeguards the Pluripotent State

(2016) Xiaofeng Zheng et al.   Stem Cell Reports

Mucin-Inspired Thermoresponsive Synthetic Hydrogels Induce Stasis in Human Pluripotent Stem Cells and Human Embryos

(2016) Irene Canton et al.   ACS Central Science

Uterine glands impact uterine receptivity, luminal fluid homeostasis and blastocyst implantation

(2016) Andrew M. Kelleher et al.   Scientific Reports

mTOR is necessary for proper satellite cell activity and skeletal muscle regeneration

(2015) Pengpeng Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Comparison of American mink embryonic stem and induced pluripotent stem cell transcriptomes

(2015) Aleksei G Menzorov et al.   BMC GENOMICS

Circulating microRNAs as novel prognosis biomarkers for head and neck squamous cell carcinoma

(2015) Bo Hou et al.   CANCER BIOLOGY & THERAPY

Defining the three cell lineages of the human blastocyst by single-cell RNA-seq

(2015) P. Blakeley et al.   DEVELOPMENT

Lineage-Specific Profiling Delineates the Emergence and Progression of Naive Pluripotency in Mammalian Embryogenesis

(2015) Thorsten Boroviak et al.   DEVELOPMENTAL CELL

Extreme tolerance and developmental buffering of UV-C induced DNA damage in embryos of the annual killifishAustrofundulus limnaeus

(2015) Josiah T. Wagner et al.   Journal of Experimental Zoology Part A-Ecological Genetics and Physiology

Morphological and Gene Expression Changes in Cattle Embryos from Hatched Blastocyst to Early Gastrulation Stages after Transfer of In Vitro Produced Embryos

(2015) Jessica van Leeuwen et al.   PLoS One

Caenorhabditis elegansmicroRNAs of thelet-7family act in innate immune response circuits and confer robust developmental timing against pathogen stress

(2015) Zhiji Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integral Proteomic Analysis of Blastocysts Reveals Key Molecular Machinery Governing Embryonic Diapause and Reactivation for Implantation in Mice1

(2014) Zheng Fu et al.   BIOLOGY OF REPRODUCTION

mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert

(2014) Joseph T. Rodgers et al.   NATURE

Amino Acids in the Uterine Luminal Fluid Reflects the Temporal Changes in Transporter Expression in the Endometrium and Conceptus during Early Pregnancy in Cattle

(2014) Niamh Forde et al.   PLoS One

The Dynamics of Morphogenesis in the Early Mouse Embryo

(2014) Jaime A. Rivera-Pérez et al.   Cold Spring Harbor Perspectives in Biology

Arginine, Leucine, and Glutamine Stimulate Proliferation of Porcine Trophectoderm Cells Through the MTOR-RPS6K-RPS6-EIF4EBP1 Signal Transduction Pathway1

(2013) Jinyoung Kim et al.   BIOLOGY OF REPRODUCTION

Early cell lineage specification in a marsupial: a case for diverse mechanisms among mammals

(2013) S. Frankenberg et al.   DEVELOPMENT

Daily prolactin pulse inhibits the corpus luteum during lactational quiescence in the marsupial, Macropus eugenii

(2013) L. A. Hinds et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

A new role for muscle segment homeobox genes in mammalian embryonic diapause

(2013) J. Cha et al.   Open Biology

Hsp90 Globally Targets Paused RNA Polymerase to Regulate Gene Expression in Response to Environmental Stimuli

(2012) Ritwick Sawarkar et al.   CELL

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Metaboloepigenetics: Interrelationships between energy metabolism and epigenetic control of gene expression

(2012) Dallas R. Donohoe et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Embryonic Diapause Is Conserved across Mammals

(2012) Grazyna E. Ptak et al.   PLoS One

Involvement of microRNA Lethal-7a in the Regulation of Embryo Implantation in Mice

(2012) Wei-Min Liu et al.   PLoS One

Embryonic Diapause: Advances in Understanding the Enigma of Seasonal Delayed Implantation

(2012) BD Murphy   REPRODUCTION IN DOMESTIC ANIMALS

Uterine signaling at the emergence of the embryo from obligate diapause

(2011) Pavine L. C. Lefèvre et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Control of the Embryonic Stem Cell State

(2011) Richard A. Young   CELL

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Conditional Deletion of MSX Homeobox Genes in the Uterus Inhibits Blastocyst Implantation by Altering Uterine Receptivity

(2011) Takiko Daikoku et al.   DEVELOPMENTAL CELL

Polyamines Are Implicated in the Emergence of the Embryo from Obligate Diapause

(2011) Pavine L. C. Lefèvre et al.   ENDOCRINOLOGY

Autophagy Regulates Embryonic Survival During Delayed Implantation

(2011) Jong-Eun Lee et al.   ENDOCRINOLOGY

The association of maternal factors with delayed implantation and the initial rise of urinary human chorionic gonadotrophin

(2011) A. M. Z. Jukic et al.   HUMAN REPRODUCTION

Global quantification of mammalian gene expression control

(2011) Björn Schwanhäusser et al.   NATURE

FOXO1 is an essential regulator of pluripotency in human embryonic stem cells

(2011) Xin Zhang et al.   NATURE CELL BIOLOGY

Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells

(2011) Derk ten Berge et al.   NATURE CELL BIOLOGY

Hematopoietic stem cell function requires 12/15-lipoxygenase-dependent fatty acid metabolism

(2010) M. Kinder et al.   BLOOD

Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice

(2009) M. G. Kharas et al.   BLOOD

Select Nutrients in the Ovine Uterine Lumen. I. Amino Acids, Glucose, and Ions in Uterine Lumenal Flushings of Cyclic and Pregnant Ewes1

(2008) Haijun Gao et al.   BIOLOGY OF REPRODUCTION

Wnt Signaling Mediates Self-Organization and Axis Formation in Embryoid Bodies

(2008) Derk ten Berge et al.   Cell Stem Cell

Parameters influencing derivation of embryonic stem cells from murine embryos

(2008) Laura Batlle-Morera et al.   GENESIS

The ground state of embryonic stem cell self-renewal

(2008) Qi-Long Ying et al.   NATURE