Of bats and men: Immunomodulatory treatment options for COVID-19 guided by the immunopathology of SARS-CoV-2 infection
出版年份 2021 全文链接
标题
Of bats and men: Immunomodulatory treatment options for COVID-19 guided by the immunopathology of SARS-CoV-2 infection
作者
关键词
-
出版物
Science Immunology
Volume 6, Issue 63, Pages -
出版商
American Association for the Advancement of Science (AAAS)
发表日期
2021-09-18
DOI
10.1126/sciimmunol.abd0205
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Evolution of antibody immunity to SARS-CoV-2
- (2021) Christian Gaebler et al. NATURE
- ACE2 expression is elevated in airway epithelial cells from older and male healthy individuals but reduced in asthma
- (2021) Peter A.B. Wark et al. RESPIROLOGY
- Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection
- (2021) Jennifer M. Dan et al. SCIENCE
- SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques
- (2021) Yashavanth Shaan Lakshmanappa et al. Nature Communications
- Repurposing Approved Drugs for Guiding COVID-19 Prophylaxis: A Systematic Review
- (2021) Bruno Silva Andrade et al. Frontiers in Pharmacology
- Nucleic Acid-Sensing Pathways During SARS-CoV-2 Infection: Expectations versus Reality
- (2021) Bushra Mdkhana et al. Journal of Inflammation Research
- Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics
- (2021) Christoph Muus et al. NATURE MEDICINE
- Discrete SARS-CoV-2 antibody titers track with functional humoral stability
- (2021) Yannic C. Bartsch et al. Nature Communications
- Innate cell profiles during the acute and convalescent phase of SARS-CoV-2 infection in children
- (2021) Melanie R. Neeland et al. Nature Communications
- Prolonged evolution of the human B cell response to SARS-CoV-2 infection
- (2021) Mrunal Sakharkar et al. Science Immunology
- SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies
- (2021) Markus Hoffmann et al. CELL
- SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, multicentre, prospective cohort study (SIREN)
- (2021) Victoria Jane Hall et al. LANCET
- Functional landscape of SARS-CoV-2 cellular restriction
- (2021) Laura Martin-Sancho et al. MOLECULAR CELL
- Increased mortality in community-tested cases of SARS-CoV-2 lineage B.1.1.7
- (2021) Nicholas G. Davies et al. NATURE
- TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines
- (2021) Min Zheng et al. NATURE IMMUNOLOGY
- Post-acute COVID-19 syndrome
- (2021) Ani Nalbandian et al. NATURE MEDICINE
- New SARS-CoV-2 Variants — Clinical, Public Health, and Vaccine Implications
- (2021) Salim S. Abdool Karim et al. NEW ENGLAND JOURNAL OF MEDICINE
- SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes
- (2021) Yize Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Anakinra in hospitalized non-intubated patients with coronavirus disease 2019: a systematic review and meta-analysis
- (2021) Fotios Barkas et al. RHEUMATOLOGY
- X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease
- (2021) Sebastian Günther et al. SCIENCE
- The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates
- (2021) Bryan E. Jones et al. Science Translational Medicine
- Exposure to SARS-CoV-2 generates T-cell memory in the absence of a detectable viral infection
- (2021) Zhongfang Wang et al. Nature Communications
- The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets
- (2021) Thomas P. Peacock et al. Nature Microbiology
- A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection
- (2021) Fiachra Humphries et al. Science Immunology
- Pharmacological activation of STING blocks SARS-CoV-2 infection
- (2021) Minghua Li et al. Science Immunology
- SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation
- (2021) Bingyu Yan et al. Science Immunology
- Novel Canine Coronavirus Isolated from a Hospitalized Pneumonia Patient, East Malaysia
- (2021) Anastasia N Vlasova et al. CLINICAL INFECTIOUS DISEASES
- Clinical and virological features of SARS-CoV-2 variants of concern: a retrospective cohort study comparing B.1.1.7 (Alpha), B.1.315 (Beta), and B.1.617.2 (Delta)
- (2021) Sean Wei Xiang Ong et al. CLINICAL INFECTIOUS DISEASES
- Rapid spread of the SARS-CoV-2 Delta variant in some French regions, June 2021
- (2021) Samuel Alizon et al. Eurosurveillance
- Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization
- (2021) Delphine Planas et al. NATURE
- Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) Variant
- (2021) Jamie Lopez Bernal et al. NEW ENGLAND JOURNAL OF MEDICINE
- Tofacitinib in Patients Hospitalized with Covid-19 Pneumonia
- (2021) Patrícia O. Guimarães et al. NEW ENGLAND JOURNAL OF MEDICINE
- The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-Ι
- (2021) Yiwen Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation
- (2021) Pan Pan et al. Nature Communications
- Delta variant: What is happening with transmission, hospital admissions, and restrictions?
- (2021) Elisabeth Mahase BMJ-British Medical Journal
- RIG-I-Like Receptor-Mediated Recognition of Viral Genomic RNA of Severe Acute Respiratory Syndrome Coronavirus-2 and Viral Escape From the Host Innate Immune Responses
- (2021) Takahisa Kouwaki et al. Frontiers in Immunology
- Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China
- (2020) Zunyou Wu et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding
- (2020) Roujian Lu et al. LANCET
- Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
- (2020) Chaolin Huang et al. LANCET
- Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19
- (2020) Daniel Blanco-Melo et al. CELL
- Host-Viral Infection Maps Reveal Signatures of Severe COVID-19 Patients
- (2020) Pierre Bost et al. CELL
- Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein
- (2020) Alexandra C. Walls et al. CELL
- Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients
- (2020) Zhuo Zhou et al. Cell Host & Microbe
- COVID ‐19: lambda interferon against viral load and hyperinflammation
- (2020) Evangelos Andreakos et al. EMBO Molecular Medicine
- Inhaled corticosteroids and COVID-19: a systematic review and clinical perspective
- (2020) David M.G. Halpin et al. EUROPEAN RESPIRATORY JOURNAL
- The effect of corticosteroid treatment on patients with coronavirus infection: a systematic review and meta-analysis
- (2020) Zhenwei Yang et al. JOURNAL OF INFECTION
- Interferon-Induced Transmembrane Protein 3 Genetic Variant rs12252-C Associated With Disease Severity in Coronavirus Disease 2019
- (2020) Yonghong Zhang et al. JOURNAL OF INFECTIOUS DISEASES
- Elevated Interleukin‐6 and Severe COVID‐19: A Meta‐Analysis
- (2020) Muhammad Aziz et al. JOURNAL OF MEDICAL VIROLOGY
- Kawasaki-like disease: emerging complication during the COVID-19 pandemic
- (2020) Russell M Viner et al. LANCET
- Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial
- (2020) Yeming Wang et al. LANCET
- Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
- (2020) Fei Zhou et al. LANCET
- Extreme Genomic CpG Deficiency in SARS-CoV-2 and Evasion of Host Antiviral Defense
- (2020) Xuhua Xia MOLECULAR BIOLOGY AND EVOLUTION
- A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
- (2020) David E. Gordon et al. NATURE
- Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19
- (2020) Mingfeng Liao et al. NATURE MEDICINE
- Severe Covid-19
- (2020) David A. Berlin et al. NEW ENGLAND JOURNAL OF MEDICINE
- Remdesivir for the Treatment of Covid-19 — Preliminary Report
- (2020) John H. Beigel et al. NEW ENGLAND JOURNAL OF MEDICINE
- Mild depolarization of the inner mitochondrial membrane is a crucial component of an anti-aging program
- (2020) Mikhail Y. Vyssokikh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: a report of five cases
- (2020) Cynthia Magro et al. Translational Research
- Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, China, January-March 2020: retrospective cohort study
- (2020) Shufa Zheng et al. BMJ-British Medical Journal
- Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China
- (2020) Chaomin Wu et al. JAMA Internal Medicine
- Egyptian Rousette IFN-ω Subtypes Elicit Distinct Antiviral Effects and Transcriptional Responses in Conspecific Cells
- (2020) Stephanie S. Pavlovich et al. Frontiers in Immunology
- Vertical Transmission of COVID-19: A Systematic Review and Meta-analysis
- (2020) Alexander Kotlyar et al. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Severe COVID-19 is marked by a dysregulated myeloid cell compartment
- (2020) Jonas Schulte-Schrepping et al. CELL
- Retrospective Multicenter Cohort Study Shows Early Interferon Therapy Is Associated with Favorable Clinical Responses in COVID-19 Patients
- (2020) Nan Wang et al. Cell Host & Microbe
- Pharmaco-Immunomodulatory Therapy in COVID-19
- (2020) John G. Rizk et al. DRUGS
- Next-Generation Sequencing of T and B Cell Receptor Repertoires from COVID-19 Patients Showed Signatures Associated with Severity of Disease
- (2020) Christoph Schultheiß et al. IMMUNITY
- A minimal common outcome measure set for COVID-19 clinical research
- (2020) John C Marshall et al. LANCET INFECTIOUS DISEASES
- Comparing SARS-CoV-2 with SARS-CoV and influenza pandemics
- (2020) Eskild Petersen et al. LANCET INFECTIOUS DISEASES
- Coronavirus RNA proofreading: molecular basis and therapeutic targeting
- (2020) Fran Robson et al. MOLECULAR CELL
- IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy
- (2020) Ting Zhou et al. NATURE
- Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2
- (2020) Brandi N. Williamson et al. NATURE
- Longitudinal analyses reveal immunological misfiring in severe COVID-19
- (2020) Carolina Lucas et al. NATURE
- Single-cell landscape of immunological responses in patients with COVID-19
- (2020) Ji-Yuan Zhang et al. NATURE IMMUNOLOGY
- Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report
- (2020) NEW ENGLAND JOURNAL OF MEDICINE
- Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications
- (2020) Divij Mathew et al. SCIENCE
- Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients
- (2020) Jérôme Hadjadj et al. SCIENCE
- Asymptomatic SARS-CoV-2 infection: the tip or the iceberg?
- (2020) Alexander J Keeley et al. THORAX
- The FDA-approved gold drug auranofin inhibits novel coronavirus (SARS-COV-2) replication and attenuates inflammation in human cells
- (2020) Hussin A. Rothan et al. VIROLOGY
- Evolutionary origins of the SARS-CoV-2 sarbecovirus lineage responsible for the COVID-19 pandemic
- (2020) Maciej F. Boni et al. Nature Microbiology
- Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19
- (2020) Jeong Seok Lee et al. Science Immunology
- Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19
- (2020) Naoki Kaneko et al. CELL
- Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity
- (2020) Carolyn Rydyznski Moderbacher et al. CELL
- Coronavirus Disease 2019 (COVID-19) Re-infection by a Phylogenetically Distinct Severe Acute Respiratory Syndrome Coronavirus 2 Strain Confirmed by Whole Genome Sequencing
- (2020) Kelvin Kai-Wang To et al. CLINICAL INFECTIOUS DISEASES
- A Novel Bat Coronavirus Closely Related to SARS-CoV-2 Contains Natural Insertions at the S1/S2 Cleavage Site of the Spike Protein
- (2020) Hong Zhou et al. CURRENT BIOLOGY
- Long-term Health Consequences of COVID-19
- (2020) Carlos del Rio et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19
- (2020) et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19
- (2020) Christoph D. Spinner et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Neutrophil extracellular traps infiltrate the lung airway, interstitial, and vascular compartments in severe COVID-19
- (2020) Coraline Radermecker et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Animal and translational models of SARS-CoV-2 infection and COVID-19
- (2020) M. D. Johansen et al. Mucosal Immunology
- Interferons and viruses induce a novel truncated ACE2 isoform and not the full-length SARS-CoV-2 receptor
- (2020) Olusegun O. Onabajo et al. NATURE GENETICS
- An inflammatory cytokine signature predicts COVID-19 severity and survival
- (2020) Diane Marie Del Valle et al. NATURE MEDICINE
- Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients
- (2020) Jan C. Holter et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans
- (2020) Prabhu S. Arunachalam et al. SCIENCE
- Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity
- (2020) Ludovico Cantuti-Castelvetri et al. SCIENCE
- Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity
- (2020) Ellen Shrock et al. SCIENCE
- Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
- (2020) Qian Zhang et al. SCIENCE
- Autoantibodies against type I IFNs in patients with life-threatening COVID-19
- (2020) Paul Bastard et al. SCIENCE
- Two distinct immunopathological profiles in autopsy lungs of COVID-19
- (2020) Ronny Nienhold et al. Nature Communications
- Evasion of Type I Interferon by SARS-CoV-2
- (2020) Hongjie Xia et al. Cell Reports
- Covid-19: Perspectives on Innate Immune Evasion
- (2020) Nima Taefehshokr et al. Frontiers in Immunology
- Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19
- (2020) Elizabeth R. Mann et al. Science Immunology
- PD-1-Expressing SARS-CoV-2-Specific CD8+ T Cells Are Not Exhausted, but Functional in Patients with COVID-19
- (2020) Min-Seok Rha et al. IMMUNITY
- Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients
- (2020) Tamara S. Rodrigues et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Genetic mechanisms of critical illness in Covid-19
- (2020) Erola Pairo-Castineira et al. NATURE
- Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison
- (2020) Ioanna-Evdokia Galani et al. NATURE IMMUNOLOGY
- Repurposed Antiviral Drugs for Covid-19 — Interim WHO Solidarity Trial Results
- (2020) NEW ENGLAND JOURNAL OF MEDICINE
- REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19
- (2020) David M. Weinreich et al. NEW ENGLAND JOURNAL OF MEDICINE
- Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers
- (2020) Sheila F. Lumley et al. NEW ENGLAND JOURNAL OF MEDICINE
- Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19
- (2020) Andre C. Kalil et al. NEW ENGLAND JOURNAL OF MEDICINE
- Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: a randomised, double-blind, placebo-controlled, phase 2 trial
- (2020) Phillip D Monk et al. Lancet Respiratory Medicine
- Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host
- (2019) Matae Ahn et al. Nature Microbiology
- A metaanalysis of bat phylogenetics and positive selection based on genomes and transcriptomes from 18 species
- (2019) John A. Hawkins et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Peptide presentation by bat MHC class I provides new insight into the antiviral immunity of bats
- (2019) Dan Lu et al. PLOS BIOLOGY
- Corticosteroid Therapy for Critically Ill Patients with Middle East Respiratory Syndrome
- (2018) Yaseen M. Arabi et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- The Egyptian Rousette Genome Reveals Unexpected Features of Bat Antiviral Immunity
- (2018) Stephanie S. Pavlovich et al. CELL
- Dampened STING-Dependent Interferon Activation in Bats
- (2018) Jiazheng Xie et al. Cell Host & Microbe
- Longitudinal study of age-specific pattern of coronavirus infection in Lyle’s flying fox (Pteropus lylei) in Thailand
- (2018) Supaporn Wacharapluesadee et al. Virology Journal
- Blockade of the C5a–C5aR axis alleviates lung damage in hDPP4-transgenic mice infected with MERS-CoV
- (2018) Yuting Jiang et al. Emerging Microbes & Infections
- Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis
- (2018) Lisa E. Gralinski et al. mBio
- Inflammasomes in the lung
- (2017) James W. Pinkerton et al. MOLECULAR IMMUNOLOGY
- Host and viral traits predict zoonotic spillover from mammals
- (2017) Kevin J. Olival et al. NATURE
- IFNAR2-dependent gene expression profile induced by IFN-α in Pteropus alecto bat cells and impact of IFNAR2 knockout on virus infection
- (2017) Qian Zhang et al. PLoS One
- Transcriptomic Signatures of Tacaribe Virus-Infected Jamaican Fruit Bats
- (2017) Diana L. Gerrard et al. mSphere
- Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome
- (2016) Bita Shakoory et al. CRITICAL CARE MEDICINE
- Antioxidant Defenses in the Brains of Bats during Hibernation
- (2016) Qiuyuan Yin et al. PLoS One
- No fever and leucocytosis in response to a lipopolysaccharide challenge in an insectivorous bat
- (2015) Sebastian Stockmaier et al. Biology Letters
- Interferon-λ: Immune Functions at Barrier Surfaces and Beyond
- (2015) Helen M. Lazear et al. IMMUNITY
- Brief Report: Interleukin-38 Exerts Antiinflammatory Functions and Is Associated With Disease Activity in Systemic Lupus Erythematosus
- (2015) Ina Rudloff et al. Arthritis & Rheumatology
- Metabolic Regulation of Immune Responses
- (2014) Kirthana Ganeshan et al. Annual Review of Immunology
- Comparative Analysis of Bat Genomes Provides Insight into the Evolution of Flight and Immunity
- (2012) G. Zhang et al. SCIENCE
- Protection from RNA and DNA Viruses by IL-32
- (2011) Jarod A. Zepp et al. JOURNAL OF IMMUNOLOGY
- Type III IFN Receptor Expression and Functional Characterisation in the Pteropid Bat, Pteropus alecto
- (2011) Peng Zhou et al. PLoS One
- IL-37 is a fundamental inhibitor of innate immunity
- (2010) Marcel F Nold et al. NATURE IMMUNOLOGY
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