Hypoxia‐stimulated ATM activation regulates autophagy‐associated exosome release from cancer‐associated fibroblasts to promote cancer cell invasion

Myocardial ischemia‐reperfusion induced cardiac extracellular vesicles harbour proinflammatory features and aggravate heart injury

(2021) Xinyu Ge et al.   Journal of Extracellular Vesicles

FAK signaling in cancer-associated fibroblasts promotes breast cancer cell migration and metastasis by exosomal miRNAs-mediated intercellular communication

(2020) Hsin-Jung Wu et al.   ONCOGENE

UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors

(2019) Ron D. Jachimowicz et al.   CELL

Oxidized ATM protein kinase is a new signal transduction player that regulates glycolysis in CAFs as well as tumor growth and metastasis

(2019) Álvaro Marín-Hernández et al.   EBioMedicine

Oxidized ATM-mediated glycolysis enhancement in breast cancer-associated fibroblasts contributes to tumor invasion through lactate as metabolic coupling

(2019) Kexin Sun et al.   EBioMedicine

Multifaceted roles of ATM in autophagy: From nonselective autophagy to selective autophagy

(2019) Nan Liang et al.   CELL BIOCHEMISTRY AND FUNCTION

Mechanical Stress-Dependent Autophagy Component Release via Extracellular Nanovesicles in Tumor Cells

(2019) Kaizhe Wang et al.   ACS Nano

Cancer-associated fibroblasts as abettors of tumor progression at the crossroads of EMT and therapy resistance

(2019) Micol Eleonora Fiori et al.   Molecular Cancer

FOXO3 directly regulates an autophagy network to functionally regulate proteostasis in adult neural stem cells

(2019) Amanda J. Audesse et al.   PLoS Genetics

Autocrine TGF-β1/miR-200s/miR-221/DNMT3B regulatory loop maintains CAF status to fuel breast cancer cell proliferation

(2019) Xi Tang et al.   CANCER LETTERS

NF-κB/Rel Transcription Factors in Pancreatic Cancer: Focusing on RelA, c-Rel, and RelB

(2019) Derya Kabacaoglu et al.   Cancers

The stromal loss of miR-4516 promotes the FOSL1-dependent proliferation and malignancy of triple negative breast cancer

(2019) Ji Eun Kim et al.   CANCER LETTERS

Cancer-derived exosomes trigger endothelial to mesenchymal transition followed by the induction of cancer-associated fibroblasts

(2018) Ju Hun Yeon et al.   Acta Biomaterialia

Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

(2018) Mario Mauthe et al.   Autophagy

Autophagy regulates exosomal release of prions in neuronal cells

(2018) Basant A. Abdulrahman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Progranulin Gene Therapy Improves Lysosomal Dysfunction and Microglial Pathology Associated with Frontotemporal Dementia and Neuronal Ceroid Lipofuscinosis

(2018) Andrew E. Arrant et al.   JOURNAL OF NEUROSCIENCE

Integrated omics profiling identifies hypoxia-regulated genes in HCT116 colon cancer cells

(2018) Jeng-Ting Chen et al.   Journal of Proteomics

Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells

(2018) Wei Yan et al.   NATURE CELL BIOLOGY

Ataxia-Telangiectasia Mutated Kinase in the Control of Oxidative Stress, Mitochondria, and Autophagy in Cancer: A Maestro With a Large Orchestra

(2018) Venturina Stagni et al.   Frontiers in Oncology

Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis

(2018) Zhicheng Zeng et al.   Nature Communications

Cancer-associated fibroblast (CAF)-derived IL32 promotes breast cancer cell invasion and metastasis via integrin β3–p38 MAPK signalling

(2018) Siyang Wen et al.   CANCER LETTERS

Targeting the Myofibroblastic Cancer-Associated Fibroblast Phenotype Through Inhibition of NOX4

(2017) Christopher J Hanley et al.   JNCI-Journal of the National Cancer Institute

Chemical screening identifies ATM as a target for alleviating senescence

(2017) Hyun Tae Kang et al.   Nature Chemical Biology

Secretory carrier membrane protein 5 is an autophagy inhibitor that promotes the secretion of α-synuclein via exosome

(2017) Yi Yang et al.   PLoS One

MiR-205/YAP1 in Activated Fibroblasts of Breast Tumor Promotes VEGF-independent Angiogenesis through STAT3 Signaling

(2017) Yan-e Du et al.   Theranostics

Targeting the Myofibroblastic Cancer-Associated Fibroblast Phenotype Through Inhibition of NOX4

(2017) Christopher J Hanley et al.   JNCI-Journal of the National Cancer Institute

ExoCarta: A Web-Based Compendium of Exosomal Cargo

(2016) Shivakumar Keerthikumar et al.   JOURNAL OF MOLECULAR BIOLOGY

Cytoplasmic GPER translocation in cancer-associated fibroblasts mediates cAMP/PKA/CREB/glycolytic axis to confer tumor cells with multidrug resistance

(2016) T Yu et al.   ONCOGENE

Cancer-associated fibroblast exosomes regulate survival and proliferation of pancreatic cancer cells

(2016) K E Richards et al.   ONCOGENE

Autophagy inhibits endothelial progenitor cells migration via the regulation of MMP2, MMP9 and uPA under normoxia condition

(2015) Wen-Dong Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oxidized ATM promotes abnormal proliferation of breast CAFs through maintaining intracellular redox homeostasis and activating the PI3K-AKT, MEK-ERK, and Wnt-β-catenin signaling pathways

(2015) Shifu Tang et al.   CELL CYCLE

Stromal miR-200s contribute to breast cancer cell invasion through CAF activation and ECM remodeling

(2015) X Tang et al.   CELL DEATH AND DIFFERENTIATION

The adhesion G protein-coupled receptor G2 (ADGRG2/GPR64) constitutively activates SRE and NFκB and is involved in cell adhesion and migration

(2015) Miriam C. Peeters et al.   CELLULAR SIGNALLING

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Bnip3 Binds and Activates p300: Possible Role in Cardiac Transcription and Myocyte Morphology

(2015) John W. Thompson et al.   PLoS One

V-ATPase: a master effector of E2F1-mediated lysosomal trafficking, mTORC1 activation and autophagy

(2015) Nathalie Meo-Evoli et al.   Oncotarget

ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1

(2014) Peijing Zhang et al.   NATURE CELL BIOLOGY

Exosomes and Autophagy: Coordinated Mechanisms for the Maintenance of Cellular Fitness

(2014) Francesc Baixauli et al.   Frontiers in Immunology

The ATM protein kinase: regulating the cellular response to genotoxic stress and more

(2013) Yosef Shiloh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Bleomycin Induces Molecular Changes Directly Relevant to Idiopathic Pulmonary Fibrosis: A Model for “Active” Disease

(2013) Ruoqi Peng et al.   PLoS One

Wip1-Dependent Regulation of Autophagy, Obesity, and Atherosclerosis

(2012) Xavier Le Guezennec et al.   Cell Metabolism

Modulation of Serines 17 and 24 in the LC3-interacting Region of Bnip3 Determines Pro-survival MitophagyversusApoptosis

(2012) Yanyan Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mystery of DNA repair: the role of the MRN complex and ATM kinase in DNA damage repair

(2010) Kamila Czornak et al.   JOURNAL OF APPLIED GENETICS

Site-specific Phosphorylation Dynamics of the Nuclear Proteome during the DNA Damage Response

(2010) Martin V. Bennetzen et al.   MOLECULAR & CELLULAR PROTEOMICS

ATM Activation by Oxidative Stress

(2010) Z. Guo et al.   SCIENCE

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

ATM protein kinase mediates full activation of Akt and regulates glucose transporter 4 translocation by insulin in muscle cells

(2008) Marie-Jo Halaby et al.   CELLULAR SIGNALLING

ATM Activation and Signaling under Hypoxic Conditions

(2008) Z. Bencokova et al.   MOLECULAR AND CELLULAR BIOLOGY

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH