Redox Properties of Small Molecules Essential for Multiple Reactivities with Pathological Factors in Alzheimer's Disease

Landmark Alzheimer’s drug approval confounds research community

(2021) Asher Mullard   NATURE

Alzheimer's drug approved despite murky results

(2021) Kelly Servick   SCIENCE

Minimalistic Principles for Designing Small Molecules with Multiple Reactivities against Pathological Factors in Dementia

(2020) Mingeun Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Key Physicochemical and Biological Factors of the Phase Behavior of Tau

(2020) Geewoo Nam et al.   Chem

Singlet Molecular Oxygen Reactions with Nucleic Acids, Lipids, and Proteins

(2019) Paolo Di Mascio et al.   CHEMICAL REVIEWS

Intertwined Pathologies of Amyloid-β and Metal Ions in Alzheimer’s Disease: Metal–Amyloid-β

(2019) Geewoo Nam et al.   CHEMISTRY LETTERS

Development of novel carbazole derivatives with effective multifunctional action against Alzheimer’s diseases: Design, synthesis, in silico, in vitro and in vivo investigation

(2019) Chandra Bhushan Mishra et al.   BIOORGANIC CHEMISTRY

Electrochemistry of Alzheimer Disease Amyloid Beta Peptides

(2018) Ana-Maria Chiorcea-Paquim et al.   CURRENT MEDICINAL CHEMISTRY

Alzheimer's Disease: A Systemic Review of Substantial Therapeutic Targets and the Leading Multi-functional Molecules

(2018) Tarana Umar et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

A review on flavonoid-based scaffolds as multi-target-directed ligands (MTDLs) for Alzheimer's disease

(2018) Leili Jalili-Baleh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

(2018) C. Cheignon et al.   Redox Biology

Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis in the Last Decade

(2018) Masha G. Savelieff et al.   CHEMICAL REVIEWS

Strategies Employing Transition Metal Complexes To Modulate Amyloid-β Aggregation

(2018) Jong-Min Suh et al.   INORGANIC CHEMISTRY

Fibril structure of amyloid-β(1–42) by cryo–electron microscopy

(2017) Lothar Gremer et al.   SCIENCE

Multi-target-directed phenol–triazole ligands as therapeutic agents for Alzheimer's disease

(2017) Michael R. Jones et al.   Chemical Science

Vascular and Metabolic Factors in Alzheimer’s Disease and Related Dementias: Introduction

(2016) Costantino Iadecola   CELLULAR AND MOLECULAR NEUROBIOLOGY

Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer’s disease

(2016) Michael W. Beck et al.   Nature Communications

Tools of the Trade: Investigations into Design Strategies of Small Molecules to Target Components in Alzheimer's Disease

(2015) Jeffrey S. Derrick et al.   CHEMBIOCHEM

A Redox-Active, Compact Molecule for Cross-Linking Amyloidogenic Peptides into Nontoxic, Off-Pathway Aggregates: In Vitro and In Vivo Efficacy and Molecular Mechanisms

(2015) Jeffrey S. Derrick et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A rationally designed small molecule for identifying an in vivo link between metal–amyloid-β complexes and the pathogenesis of Alzheimer's disease

(2015) Michael W. Beck et al.   Chemical Science

Electrochemical evaluation of Abelson tyrosine-protein kinase 1 activity and inhibition by imatinib mesylate and danusertib

(2014) Victor C. Diculescu et al.   ANALYTICA CHIMICA ACTA

Biological metals and metal-targeting compounds in major neurodegenerative diseases

(2014) Kevin J. Barnham et al.   CHEMICAL SOCIETY REVIEWS

Multifunctional compounds: Smart molecules for multifactorial diseases

(2014) Yogita Bansal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Bimodal-hybrid heterocyclic amine targeting oxidative pathways and copper mis-regulation in Alzheimer's disease

(2014) Paulina Gonzalez et al.   Metallomics

Spreading of amyloid-β peptides via neuritic cell-to-cell transfer is dependent on insufficient cellular clearance

(2014) Jakob Domert et al.   NEUROBIOLOGY OF DISEASE

Soluble Aβ Oligomers Are Rapidly Sequestered from Brain ISF In Vivo and Bind GM1 Ganglioside on Cellular Membranes

(2014) Soyon Hong et al.   NEURON

Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases

(2014) Asima Bhattacharyya et al.   PHYSIOLOGICAL REVIEWS

Untangling Amyloid-β, Tau, and Metals in Alzheimer’s Disease

(2013) Masha G. Savelieff et al.   ACS Chemical Biology

Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue

(2013) Jun-Xia Lu et al.   CELL

Role of Metal Ions in the Self-assembly of the Alzheimer’s Amyloid-β Peptide

(2013) Peter Faller et al.   INORGANIC CHEMISTRY

Rational Design of a Structural Framework with Potential Use to Develop Chemical Reagents That Target and Modulate Multiple Facets of Alzheimer’s Disease

(2013) Sanghyun Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Proliferation of amyloid- 42 aggregates occurs through a secondary nucleation mechanism

(2013) S. I. A. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An N-Heterocyclic Amine Chelate Capable of Antioxidant Capacity and Amyloid Disaggregation

(2012) Kimberly M. Lincoln et al.   ACS Chemical Neuroscience

Peptide methionine sulfoxide reductase A (MsrA): Direct electrochemical oxidation on carbon electrodes

(2012) T.A. Enache et al.   BIOELECTROCHEMISTRY

Two-Step Mechanism of Membrane Disruption by Aβ through Membrane Fragmentation and Pore Formation

(2012) Michele F.M. Sciacca et al.   BIOPHYSICAL JOURNAL

The Amyloid Beta Peptide: A Chemist’s Perspective. Role in Alzheimer’s and Fibrillization

(2012) I. W. Hamley   CHEMICAL REVIEWS

Bioinorganic Chemistry of Alzheimer’s Disease

(2012) Kasper P. Kepp   CHEMICAL REVIEWS

Metal-associated amyloid-β species in Alzheimer's disease

(2012) Amit S Pithadia et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

(2012) Ji Won Um et al.   NATURE NEUROSCIENCE

Metal dyshomeostasis and oxidative stress in Alzheimer’s disease

(2012) Mark A. Greenough et al.   NEUROCHEMISTRY INTERNATIONAL

A partially folded structure of amyloid-beta(1–40) in an aqueous environment

(2011) Subramanian Vivekanandan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Boron doped diamond and glassy carbon electrodes comparative study of the oxidation behaviour of cysteine and methionine

(2011) T.A. Enache et al.   BIOELECTROCHEMISTRY

Misfolded proteins in Alzheimer's disease and type II diabetes

(2011) Alaina S. DeToma et al.   CHEMICAL SOCIETY REVIEWS

Cu(II) Mediates Kinetically Distinct, Non-amyloidogenic Aggregation of Amyloid-β Peptides

(2011) Jeppe T. Pedersen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phenol and para-substituted phenols electrochemical oxidation pathways

(2011) Teodor Adrian Enache et al.   JOURNAL OF ELECTROANALYTICAL CHEMISTRY

Intraneuronal amyloid β oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo

(2011) Tomohiro Umeda et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Chemistry and biology of reactive oxygen species in signaling or stress responses

(2011) Bryan C Dickinson et al.   Nature Chemical Biology

The Revitalized Tau Hypothesis on Alzheimer's Disease

(2010) Ricardo B. Maccioni et al.   ARCHIVES OF MEDICAL RESEARCH

Polymorphism in Alzheimer Aβ Amyloid Organization Reflects Conformational Selection in a Rugged Energy Landscape

(2010) Yifat Miller et al.   CHEMICAL REVIEWS

A Prochelator Activated by β-Secretase Inhibits Aβ Aggregation and Suppresses Copper-Induced Reactive Oxygen Species Formation

(2010) Drew S. Folk et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metals, oxidative stress and neurodegenerative disorders

(2010) Klaudia Jomova et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Design of small molecules that target metal-A  species and regulate metal-induced A  aggregation and neurotoxicity

(2010) J.-S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer's Disease: From Pathology to Therapeutic Approaches

(2009) Roland Jakob-Roetne et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Small Molecule Modulators of Copper-Induced Aβ Aggregation

(2009) Sarmad S. Hindo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metals in Neurobiology: Probing Their Chemistry and Biology with Molecular Imaging

(2008) Emily L. Que et al.   CHEMICAL REVIEWS

Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-β peptide

(2008) Peter Faller et al.   DALTON TRANSACTIONS

Zinc-Amyloid β Interactions on a Millisecond Time-Scale Stabilize Non-fibrillar Alzheimer-Related Species

(2008) Dror Noy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Therapeutics for Alzheimer’s disease based on the metal hypothesis

(2008) Ashley I. Bush et al.   Neurotherapeutics