Article
Cardiac & Cardiovascular Systems
Punashi Dutta, Karthik M. Kodigepalli, Stephanie LaHaye, J. Will Thompson, Sarah Rains, Casey Nagel, Kaitlyn Thatcher, Robert B. Hinton, Joy Lincoln
Summary: The study demonstrates the potential benefits of repurposing the selective XPO1 inhibitor drug KPT-330 for the treatment of CAVD. By inhibiting specific transcription factors and regulating the Wnt signaling pathway, KPT-330 shows promise in preventing and treating CAVD.
CIRCULATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Daniel Tortolani, Camilla Di Meo, Sara Standoli, Francesca Ciaramellano, Salam Kadhim, Eric Hsu, Cinzia Rapino, Mauro Maccarrone
Summary: Rare cannabis-derived phytocannabinoids (pCBs) have therapeutic potential in skin disorders and their anti-inflammatory effects were investigated in this study. The experiment involved using lipopolysaccharide (LPS) to induce inflammation in human keratinocytes (HaCaT cells) and measuring the levels of pro-inflammatory interleukins. The results showed that pCBs significantly reduced the release of pro-inflammatory interleukins and modulated MAPK signaling, suggesting their potential as a treatment for inflammation-related skin pathologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Yuhan Su, Tianyu Tao, Xiuxing Liu, Wenru Su
Summary: This review summarizes the diverse roles of the JAK-STAT signaling pathway in ocular homeostasis and non-infectious uveitis (NIU) pathology, and discusses the safety and efficacy of JAK inhibitors for treating NIU and potential approaches for treatment optimization.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Rachael L. Philips, Yuxin Wang, HyeonJoo Cheon, Yuka Kanno, Massimo Gadina, Vittorio Sartorelli, Curt M. Horvath, James E. Darnell, George R. Stark, John J. O'Shea
Summary: The discovery of the JAK-STAT pathway reveals a paradigm in cell signaling and provides important research perspectives for human diseases.
Article
Multidisciplinary Sciences
Fangyu Song, Wenshuo Zhang, Xiaohui Li, Xiaoqing Chen, Xuejun Yuan, Mingjin Jiang, Yunhe Zhao, Qingxin Liu, Zizhang Zhou
Summary: The main cause of high mortality in cancer patients is tumor metastasis, and exploring the underlying mechanism of tumor metastasis is important for clinical treatments. This study identifies the transcription factor Apt/FSBP as a suppressor for tumor metastasis, providing it as a potential drug target for tumor treatment.
Review
Pharmacology & Pharmacy
Natalie C. Sondermann, Sonja Fassbender, Frederick Hartung, Anna M. Hatala, Katharina M. Rolfes, Christoph F. A. Vogel, Thomas Haarmann-Stemmann
Summary: The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that plays a critical role in the pathogenesis of various diseases. AHR can interact with other transcription factors and signaling molecules to regulate gene expression and associated physiological or pathophysiological functions. Understanding the non-canonical functions of AHR is important for disease prevention and treatment.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Oncology
Jiuhui Xu, Chenglong Chen, Kunkun Sun, Qianyu Shi, Boyang Wang, Yi Huang, Tingting Ren, Xiaodong Tang
Summary: This study found that interleukin-6 (IL-6) and its downstream pathway STAT3 were activated in anlotinib-resistant osteosarcoma. Tocilizumab, an anti-IL-6 receptor drug, can block tumor progression in anlotinib-resistant OS cells by inhibiting STAT3 expression. Combination treatment with anlotinib enhances these effects. IL-6 is highly expressed in osteosarcoma patients and is associated with poor prognosis.
FRONTIERS IN ONCOLOGY
(2023)
Review
Immunology
I-Hsin Huang, Wen-Hung Chung, Po-Chien Wu, Chun-Bing Chen
Summary: Atopic dermatitis is a chronic, inflammatory, pruritic skin disease that significantly affects patients' quality of life. The JAK-STAT pathway plays a crucial role in the pathogenesis of AD, and targeting this pathway may alleviate inflammation and itchiness. Topical and oral JAK inhibitors offer promising therapeutic options for AD treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nicholas K. K. Tonks
Summary: In October 2020, a celebration for Eddy Fischer's 100th birthday was held via ZOOM due to COVID restrictions. Eddy Fischer, along with Ed Krebs, made significant contributions to the field of signal transduction through their discovery of reversible protein phosphorylation. This work has had a profound impact on the biotechnology industry and the treatment of various cancers.
Article
Microbiology
Nicole E. Minton, Dusanka Djoric, Jaime Little, Christopher J. Kristich
Summary: Enterococci are opportunistic pathogens that are difficult to treat due to their resistance to commonly used antibiotics. This study reveals the role of a protein called GpsB in signaling and cephalosporin resistance in these bacteria.
JOURNAL OF BACTERIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mai Tanaka, Dietmar W. Siemann
Summary: Dysregulated signaling pathways in cancer cells and the tumor microenvironment, including the Axl and Gas6 pathways, have led to the development of therapeutic agents targeting the Gas6/Axl pathway. Promising results have been observed in both preclinical and clinical settings, indicating potential clinical efficacy of targeting Gas6 and Axl.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Plant Sciences
Laura Medina-Puche, Rosa Lozano-Duran
Summary: Communication between the plasma membrane and organelles is crucial for cells to respond and adapt to changing conditions. Recently, there has been increasing interest in understanding the mechanisms of communication between these cellular components.
CURRENT OPINION IN PLANT BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ting Niu, Zhiying Wei, Jiao Fu, Shu Chen, Ru Wang, Yuya Wang, Ruihe Zheng
Summary: Venlafaxine can slow down the growth and induce apoptosis of melanoma cells through the Nur77-dependent pathway. Animal experiments also showed that venlafaxine effectively inhibited the growth of melanoma cells in nude mice. These results suggest that venlafaxine may be a potential therapeutic drug for melanoma.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cell Biology
Juanjuan Xiao, Lu Zhang, Huijun Yi, Ling Zou, Jianmei Mo, Feng Xue, Jinhua Zheng, Yingze Huang, Hui Lu, Hansheng Wu, Peipei Xue, Xin Zhang, Lifei He, Zhaoxin Li, Shigui Pang, Guibin Qiao, Qiuhong Duan, Feng Zhu
Summary: This study reveals the role of T-LAK cell-oriented protein kinase (TOPK) in anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC). The researchers found that TOPK is highly expressed in ALK-positive NSCLC and identified ALK as an upstream kinase of TOPK. Moreover, they showed that inhibiting TOPK enhances tumor sensitivity to an ALK inhibitor, and the combination of alectinib and a TOPK inhibitor suppresses tumor growth and promotes apoptosis of ALK-positive NSCLC cells.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Xiaojie Tian, Mingliang He, Enyang Mei, Baowen Zhang, Jiaqi Tang, Min Xu, Jiali Liu, Xiufeng Li, Zhenyu Wang, Wenqiang Tang, Qingjie Guan, Qingyun Bu
Summary: The study reveals the crosstalk between WRKY53, BR signaling, and the MAPK pathway in regulating plant architecture and seed size. GSK2 plays a crucial role in this interplay by phosphorylating WRKY53 and MAPKK4. The findings highlight the complex regulatory mechanisms involved in controlling rice yield.
Article
Biochemistry & Molecular Biology
Ruth Maron, Bilha Schechter, Nishanth Belugali Nataraj, Soma Ghosh, Donatella Romaniello, Ilaria Marrocco, Ashish Noronha, Silvia Carvalho, Yosef Yarden, Michael Sela
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Cell Biology
Ilaria Marrocco, F. Abio Altieri, Lisabetta Rubini, Giuliano Paglia, Silvia Chichiarelli, Flavia Giamogante, Alberto Macone, Giacomo Perugia, Fabio Massimo Magliocca, Aymone Gurtner, Bruno Maras, Rino Ragno, Lexandros Patsilinakos, Roberto Manganaro, Margherita Eufemi
Article
Oncology
Donatella Romaniello, Ilaria Marrocco, Nishanth Belugali Nataraj, Irene Ferrer, Diana Drago-Garcia, Itay Vaknin, Roni Oren, Moshit Lindzen, Soma Ghosh, Matthew Kreitman, Jeanette Clarissa Kittel, Nadege Gaborit, Gretchen Bergado Baez, Belinda Sanchez, Raya Eilam, Eli Pikarsky, Luis Paz-Ares, Yosef Yarden
Article
Medicine, Research & Experimental
Ilaria Marrocco, Donatella Romaniello, Itay Vaknin, Diana Drago-Garcia, Roni Oren, Mary Luz Uribe, Nishanth Belugali Nataraj, Soma Ghosh, Raya Eilam, Tomer-Meir Salame, Moshit Lindzen, Yosef Yarden
Summary: The study suggests that combination therapy of TKIs and antibodies in lung cancer patients can prevent the emergence of resistance more effectively compared to monotherapy.
EMBO MOLECULAR MEDICINE
(2021)
Article
Oncology
Yuya Haga, Ilaria Marrocco, Ashish Noronha, Mary Luz Uribe, Nishanth Belugali Nataraj, Arunachalam Sekar, Diana Drago-Garcia, Simone Borgoni, Moshit Lindzen, Suvendu Giri, Stefan Wiemann, Yasuo Tsutsumi, Yosef Yarden
Summary: This study reveals an unconventional mechanism of resistance to dacomitinib in lung cancer cells and uncovers a previously unknown step of resistance acquisition. The resistant cells did not acquire secondary mutations in EGFR but displayed characteristics of epithelial-mesenchymal transition. Interestingly, when implanted in animals, the resistant cells reverted to a dacomitinib-sensitive state, but regained resistance when cultured in vitro.
Article
Biochemistry & Molecular Biology
Daniela Ricci, Stephen Tutton, Ilaria Marrocco, Mingjie Ying, Daniel Blumenthal, Daniela Eletto, Jade Vargas, Sarah Boyle, Hossein Fazelinia, Lei Qian, Krishna Suresh, Deanne Taylor, James C. Paton, Adrienne W. Paton, Chih-Hang Anthony Tang, Chih-Chi Andrew Hu, Ravi Radhakrishnan, Tali Gidalevitz, Yair Argon
Summary: The unfolded protein response is crucial for maintaining homeostasis and its dysregulation can lead to diseases like diabetes and cancer. IRE1 alpha is a key transducer in detecting endoplasmic reticulum stress, but gaps remain in understanding how this stress detection leads to molecular outcomes. Helix aK in IRE1 alpha plays a vital role in transmitting critical conformational changes in response to stress, affecting oligomerization, kinase activity, and RNase activity differently. Specific residues in position 827 of IRE1 alpha specify distinct conformations and mutations can impact its function, highlighting the importance of aK helix in the activation of IRE1 alpha.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Nishanth Belugali Nataraj, Ilaria Marrocco, Yosef Yarden
Summary: Cancer is initiated by specific genetic aberrations, leading to a multi-step metastatic process involving vascular dissemination. While mutagenesis establishes primary tumors, reversible epigenetic processes underlie micro-metastases. Understanding the complexity of metastasis, particularly the roles of growth factors, is crucial for developing anti-metastasis interventions.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2021)
Article
Biochemical Research Methods
Mary Luz Uribe, Jose Martin-Nieto, Cristina Quereda, Marcos Rubio-Fernandez, Jesus Cruces, George M. C. Janssen, Arnoud H. de Ru, Peter A. van Veelen, Paul J. Hensbergen
Summary: Mutations in the POMT1 gene lead to low glycosylation of protein α-DG, frequently observed in rare muscular dystrophies. Study on Pomt1 cKO mice reveals proteomic changes and structural alterations in photoreceptor cells. Besides the impaired α-DG glycosylation, morphological alterations related to an understudied POMT1 substrate, BBSome proteins, and retinal stress markers are also observed.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Mary L. Uribe, Maik Dahlhoff, Rajbir N. Batra, Nishanth B. Nataraj, Yuya Haga, Diana Drago-Garcia, Ilaria Marrocco, Arunachalam Sekar, Soma Ghosh, Itay Vaknin, Sacha Lebon, Lior Kramarski, Yasuo Tsutsumi, Inpyo Choi, Oscar M. Rueda, Carlos Caldas, Yosef Yarden
Summary: Unlike early transcriptional responses to mitogens, the later events in the response to epidermal growth factor (EGF) are less well understood. This study identified delayed down-regulated genes (DDGs) in mammary cells after prolonged EGF treatment, showing that some DDGs may act as tumor suppressors. The transcription factor TSHZ2, encoded by a DDG, inhibits tumor growth and metastasis and plays a role in cell cycle regulation.
Article
Biochemistry & Molecular Biology
Daniel Di Risola, Daniela Ricci, Ilaria Marrocco, Flavia Giamogante, Maddalena Grieco, Antonio Francioso, Aldrin Vasco-Vidal, Patrizia Mancini, Gianni Colotti, Luciana Mosca, Fabio Altieri
Summary: This study reveals the interaction between Aβ and ERp57, and demonstrates that ERp57 can counteract the toxicity of Aβ, restore cellular viability, and potentially serve as a therapeutic tool for Alzheimer's disease.
JOURNAL OF NEUROCHEMISTRY
(2022)