Dual PD-L1 and TGF-b blockade in patients with recurrent respiratory papillomatosis

TGFβ1 neutralization displays therapeutic efficacy through both an immunomodulatory and a non-immune tumor-intrinsic mechanism

(2021) Stefania Canè et al.   Journal for ImmunoTherapy of Cancer

SuperFreq: Integrated mutation detection and clonal tracking in cancer

(2020) Christoffer Flensburg et al.   PLoS Computational Biology

Bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in advanced squamous cell carcinoma of the head and neck: results from a phase I cohort

(2020) Byoung Chul Cho et al.   Journal for ImmunoTherapy of Cancer

Bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with human papillomavirus-associated malignancies

(2020) Julius Strauss et al.   Journal for ImmunoTherapy of Cancer

Transforming Growth Factor-β Signaling in Immunity and Cancer

(2019) Eduard Batlle et al.   IMMUNITY

Safety and clinical activity of PD-L1 blockade in patients with aggressive recurrent respiratory papillomatosis

(2019) Clint T. Allen et al.   Journal for ImmunoTherapy of Cancer

Cancer-Associated Fibroblasts Build and Secure the Tumor Microenvironment

(2019) Tianyi Liu et al.   Frontiers in Cell and Developmental Biology

The outcome of TGFβ antagonism in metastatic breast cancer models in vivo reflects a complex balance between tumor-suppressive and pro-progression activities of TGFβ

(2019) Yuan Yang et al.   CLINICAL CANCER RESEARCH

TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis

(2018) Daniele V. F. Tauriello et al.   NATURE

Strelka2: fast and accurate calling of germline and somatic variants

(2018) Sangtae Kim et al.   NATURE METHODS

Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β

(2018) Yan Lan et al.   Science Translational Medicine

Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade

(2018) Rikke B. Holmgaard et al.   Journal for ImmunoTherapy of Cancer

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

(2018) Sanjeev Mariathasan et al.   NATURE

A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily

(2018) Anil Korkut et al.   Cell Systems

Maftools: efficient and comprehensive analysis of somatic variants in cancer

(2018) Anand Mayakonda et al.   GENOME RESEARCH

QuPath: Open source software for digital pathology image analysis

(2017) Peter Bankhead et al.   Scientific Reports

TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway

(2016) Sébastien Viel et al.   Science Signaling

TGF-β Family Signaling in the Control of Cell Proliferation and Survival

(2016) Yun Zhang et al.   Cold Spring Harbor Perspectives in Biology

TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway

(2016) Sébastien Viel et al.   Science Signaling

Manta: rapid detection of structural variants and indels for germline and cancer sequencing applications

(2015) Xiaoyu Chen et al.   BIOINFORMATICS

Cutaneous keratoacanthomas/squamous cell carcinomas associated with neutralization of transforming growth factor β by the monoclonal antibody fresolimumab (GC1008)

(2015) Mario E. Lacouture et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Comprehensive genomic characterization of head and neck squamous cell carcinomas

(2015)   NATURE

TGF  Receptor 1: An Immune Susceptibility Gene in HPV-Associated Cancer

(2014) C. Levovitz et al.   CANCER RESEARCH

TGF- -induced epithelial-to-mesenchymal transition proceeds through stepwise activation of multiple feedback loops

(2014) J. Zhang et al.   Science Signaling

Immune Suppression in Premalignant Respiratory Papillomas: Enriched Functional CD4+Foxp3+ Regulatory T Cells and PD-1/PD-L1/L2 Expression

(2012) L. J. Hatam et al.   CLINICAL CANCER RESEARCH

LoFreq: a sequence-quality aware, ultra-sensitive variant caller for uncovering cell-population heterogeneity from high-throughput sequencing datasets

(2012) Andreas Wilm et al.   NUCLEIC ACIDS RESEARCH

Multiple self-healing squamous epithelioma is caused by a disease-specific spectrum of mutations in TGFBR1

(2011) David R Goudie et al.   NATURE GENETICS

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Attenuated Transforming Growth Factor   Signaling Promotes Nuclear Factor- B Activation in Head and Neck Cancer

(2009) J. Cohen et al.   CANCER RESEARCH