Article
Immunology
Daniel Villalba Lopez, Fatima A. H. Al-Jaberi, Anders Woetmann, Niels Odum, Charlotte Menne Bonefeld, Martin Kongsbak-Wismann, Carsten Geisler
Summary: The active form of vitamin D-3, 1,25(OH)(2)D-3, has a significant impact on T cell effector function. However, vitamin D binding protein (DBP) can hinder its effectiveness. Recent research shows that in highly inflammatory conditions, M1 macrophages can produce sufficient levels of 1,25(OH)(2)D-3 to suppress T cell-mediated inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Nutrition & Dietetics
Tafirenyika Gwenzi, Anna Zhu, Petra Schrotz-King, Ben Schoettker, Michael Hoffmeister, Hermann Brenner
Summary: This systematic review and meta-analysis evaluated the effects of vitamin D3 supplementation on serum inflammatory biomarkers among patients with cancer or pre-cancerous lesions. The study found that vitamin D3 supplementation significantly reduced TNF-a levels and may have a suppressive effect on tumor-promoting inflammatory response in patients with cancer or pre-cancerous lesions.
CLINICAL NUTRITION
(2023)
Review
Nutrition & Dietetics
Fei Cai, Cheng Hu, Chan-Juan Chen, Yuan-Ping Han, Zi-Qi Lin, Li-Hui Deng, Qing Xia
Summary: Vitamin D metabolic disorder is implicated in both acute and chronic pancreatitis, with studies showing its anti-inflammatory and anti-fibrotic effects through binding with VDR. Further research is needed to establish the protective role of vitamin D in pancreatitis, but current evidence suggests that assessing and supplementing vitamin D levels are important strategies for management.
Article
Pharmacology & Pharmacy
Tareq Saleh, Valerie J. Carpenter
Summary: Senescence is a vital cell state that can be triggered by replicative exhaustion or oncogene hyperactivation, and senolytics are emerging drugs capable of selectively eliminating senescent cells. Evidence suggests that targeting oncogene-induced senescent cells with senolytics may provide a novel and less invasive approach to treat premalignant lesions and hinder their progression to cancer.
MOLECULAR PHARMACOLOGY
(2021)
Article
Engineering, Environmental
Yun Peng, Lei Li, Pingjin Yang, Hengyi Liu, Wenjie Ye, Zhirong Xue, Xuya Peng, Xiaoming Wang
Summary: This study identified the key microorganisms and metabolic links causing instability during endogenous ammonia accumulation in anaerobic digestion. It revealed the important role of mixed acid fermentation and methanogenesis in the performance of methane production and provided new insights for addressing ammonia inhibition in nitrogen-rich organic waste treatment.
Article
Geriatrics & Gerontology
Hai Pham, Mary Waterhouse, Sabbir Rahman, Catherine Baxter, Briony Duarte Romero, Donald S. A. McLeod, Bruce K. Armstrong, Peter R. Ebeling, Dallas R. English, Gunter Hartel, Michael G. Kimlin, Rachel L. O'Connell, Jolieke C. van der Pols, Alison J. Venn, Penelope M. Webb, David C. Whiteman, Osvaldo P. Almeida, Rachel E. Neale
Summary: A randomized controlled trial found that monthly bolus doses of vitamin D supplementation for 5 years did not improve cognitive function in older adults.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Cell Biology
Lulu Sun, Xindan Kang, Chong Wang, Rui Wang, Guizhu Yang, Wen Jiang, Qi Wu, Yujue Wang, Yaping Wu, Jiamin Gao, Lan Chen, Jie Zhang, Zhen Tian, Guopei Zhu, Shuyang Sun
Summary: This study analyzed oral mucosal biopsies from 9 individuals with very early-stage OSCC, adjacent precancerous lesions, and normal regions. It revealed altered gene expression profiles, distinct cell subclusters, and immune regulation surrounding precancerous lesions, all of which contribute to OSCC initiation.
Article
Chemistry, Applied
Tiffany Antoine, Asma El Aoud, Katherine Alvarado-Ramos, Charlotte Halimi, Donato Vairo, Stephane George, Emmanuelle Reboul
Summary: In vitro and in vivo experiments confirm that compounds in pulses and meat can decrease the bioavailability and intestinal content of vitamin D and K.
Article
Immunology
Zhengqi Li, Lizhou Dou, Yueming Zhang, Shun He, Deli Zhao, Changqing Hao, Guohui Song, Wei Zhang, Yong Liu, Guiqi Wang
Summary: Important evidence suggests that the microbiota plays a key role in esophageal squamous cell carcinoma (ESCC). The study found that with disease progression, the alpha diversity of microbiota in saliva and cell brush samples decreased, and specific bacteria were identified as potential biomarkers. Further research could focus on the functional roles of these characteristic bacteria in ESCC.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Nutrition & Dietetics
Takashi Ogasawara, Yasuhisa Tajima, Naoto Nakamura, Hiroki Kanasaki, Wataru Matsuyama, Mitsuru Niwa, Yuichi Ozawa, Masayuki Sugiura, Masahito Ogiku, Jun Sato
Summary: This study aimed to evaluate the efficacy of 1-hydroxy-vitamin D in COVID-19 patients. The results showed that patients treated with 1-hydroxy-vitamin D had a significantly lower proportion of needing respiratory support and in-hospital mortality compared to the control group.
CLINICAL NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Karina Piatek, Andrzej Kutner, Dan Cacsire Castillo-Tong, Teresa Manhardt, Nadja Kupper, Urszula Nowak, Michal Chodynski, Ewa Marcinkowska, Enikoe Kallay, Martin Schepelmann
Summary: This study found that newly developed low calcemic vitamin D analogs (an1,25Ds) can be used as anticancer agents in ovarian cancer cells, with PRI-5202 showing the best efficacy. The potency of these analogs and their ability to increase CYP24A1 expression in HGSOC cell lines were dependent on the cell line and chemical structure, suggesting that further optimization of the analogs' structure may lead to new treatment options for ovarian cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Chun Zhou, Panpan He, Ziliang Ye, Yuanyuan Zhang, Yanjun Zhang, Sisi Yang, Qimeng Wu, Mengyi Liu, Jing Nie, Xianhui Qin
Summary: The study found an inverse association between serum vitamin D levels and new-onset chronic kidney disease in participants with diabetes. However, this association was not observed in participants without diabetes.
Article
Medicine, General & Internal
Aslam Shiraz, Nagayasu Egawa, Daniel M. Pelt, Robin Crawford, Adeline K. Nicholas, Veronika Romashova, Peter Sasieni, Heather Griffin, John Doorbar
Summary: A triage test that generates molecular maps of the cervical surface has been developed to improve the detection rate of high-grade disease. The spatial molecular mapping showed a sensitivity of 90% for detecting high-grade disease and AI-based analysis could aid in disease detection through automated flagging of biomarker-positive cells.
Review
Medicine, General & Internal
Davaasambuu Ganmaa, Davaasambuu Enkhmaa, Erdenebileg Nasantogtokh, Surenmaa Sukhbaatar, Khash-Erdene Tumur-Ochir, J. E. Manson
Summary: Current evidence from RCTs and meta-analyses of RCTs is inconsistent regarding the effects of vitamin D supplementation on respiratory infections and chronic diseases. Individuals most likely to benefit are those with baseline VDD or with selected high-risk conditions.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Hai Pham, Mary Waterhouse, Sabbir Rahman, Catherine Baxter, Briony Duarte Romero, Donald S. A. McLeod, Peter R. Ebeling, Dallas R. English, Gunter Hartel, Rachel L. O'Connell, Jolieke C. Van der Pols, Alison J. Venn, Penelope M. Webb, David C. Whiteman, Flavia Huygens, Rachel E. Neale
Summary: Observational studies suggest a link between vitamin D and gut microbiome composition, but randomized controlled trials of vitamin D supplementation have shown little evidence. This study analyzed data from the D-Health Trial and found that monthly doses of 60,000 IU of vitamin D-3 for 5 years did not alter the composition of the gut microbiome in older Australians.
Article
Oncology
Justine Gantzer, Guillaume Davidson, Bujamin Vokshi, Noelle Weingertner, Antoine Bougouin, Marco Moreira, Veronique Lindner, Guillaume Lacroix, Celine Mascaux, Marie-Pierre Chenard, Francois Bertucci, Irwin Davidson, Jean-Emmanuel Kurtz, Catherine Sautes-Fridman, Wolf H. Fridman, Gabriel G. Malouf
Summary: Thoracic SMARCA4-deficient undifferentiated tumors (SMARCA4-UT) mainly have an immune desert tumor microenvironment (TME) and limited efficacy to immune checkpoint inhibitors (ICI). The TME of SMARCA4-driven tumors varies according to the cell of origin.
Article
Multidisciplinary Sciences
Mohamed A. Abu El Maaty, Julie Terzic, Celine Keime, Daniela Rovito, Regis Lutzing, Darya Yanushko, Maxime Parisotto, Elise Grelet, Izzie Jacques Namer, Veronique Lindner, Gilles Laverny, Daniel Metzger
Summary: This study reveals the role of hypoxia-inducible factor 1 alpha (HIF1A) in promoting the malignant progression of prostatic intraepithelial neoplasia (PIN). It shows that early PINs are hypoxic and that luminal HIF1A enhances this hypoxic environment, leading to impaired immune surveillance and the emergence of cells overexpressing Transglutaminase 2 (TGM2) with impaired androgen signaling. Elevated TGM2 levels are associated with shortened progression-free survival in patients with prostate cancer. Furthermore, pharmacologically inhibiting HIF1A impairs cell proliferation and induces apoptosis in PINs. These findings highlight HIF1A as a potential target for PCa prevention and TGM2 as a promising prognostic biomarker for early relapse after prostatectomy.
Article
Medicine, Research & Experimental
Julie Terzic, Mohamed A. Abu el Maaty, Regis Lutzing, Alexandre Vincent, Rana El Bizri, Matthieu Jung, Celine Keime, Daniel Metzger
Summary: Androgen deprivation therapy is a key treatment for prostate cancer, but some cases develop into castration-resistant prostate cancer (CRPC). In this study, it was found that the major luminal cell population in CRPC is castration-resistant, with enhanced expression of inflammation and stemness markers. Additionally, hypoxia-inducible factor 1 (HIF1) signaling, which promotes malignant progression, is further activated. Inhibition of HIF1A enhances the sensitivity of Pten-deficient prostatic tumors to castration and induces apoptotic signaling in human CRPC cell lines.
EMBO MOLECULAR MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Ariane Zaloszyc, Julie Bernardor, Justine Bacchetta, Gilles Laverny, Claus Peter Schmitt
Summary: Patients with chronic kidney disease (CKD) suffer from mineral and bone disorders (CKD-MBD), which have a negative impact on their survival and quality of life. Mouse models are crucial for understanding the underlying pathophysiology and identifying new therapeutic approaches. Different methods can be used to induce CKD in mice, leading to a wide range of bone diseases similar to human CKD-MBD. These mouse models provide valuable insights into the specific mechanisms, bone properties, and potential therapies for CKD-MBD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Jing-Jing Zhang, Qi-Jie Xu, Claudia Schmidt, Mohamed A. Abu el Maaty, Jinglin Song, Chunqiu Yu, Jun Zhou, Kang Han, Hao Sun, Angela Casini, Ingo Ott, Stefan Woelfl
Summary: Targeting lipid, carbohydrate, and nucleotide metabolism pathways has recently been proven as a promising option for the treatment of triple-negative breast cancer (TNBC). In this study, a multimodal anticancer platinum(II) complex, Pt(II)caffeine, was developed, which simultaneously damages mitochondria, inhibits metabolic pathways, and promotes autophagy, resulting in strong suppression of TNBC cell proliferation both in vitro and in vivo. These findings highlight the potential of Pt(II)caffeine as a metallodrug to overcome the metabolic heterogeneity of TNBC.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Geriatrics & Gerontology
Kamar Ghaibour, Melanie Schuh, Sirine Souali-Crespo, Celine Chambon, Anouk Charlot, Joe Rizk, Daniela Rovito, Anna-Isavella Rerra, Qingshuang Cai, Nadia Messaddeq, Joffrey Zoll, Delphine Duteil, Daniel Metzger
Summary: Disrupting the androgen/androgen receptor axis impairs glycolytic activity and promotes the development of type 2 diabetes in male mice, but not in females. It also leads to oxidative stress and necrosis in muscle fibers.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Neurosciences
Quentin Raas, Ali Tawbeh, Mounia Tahri-Joutey, Catherine Gondcaille, Celine Keime, Romain Kaiser, Doriane Trompier, Boubker Nasser, Valerio Leoni, Emma Bellanger, Maud Boussand, Yannick Hamon, Alexandre Benani, Francesca Di Cara, Caroline Truntzer, Mustapha Cherkaoui-Malki, Pierre Andreoletti, Stephane Savary
Summary: Microglial cells play crucial roles in maintaining brain homeostasis. In X-ALD, microglial defect may occur before myelin degradation and contribute to the neurodegenerative process. Therefore, understanding the underlying mechanisms of microglial dysfunction is important for the pathogenesis of peroxisomal disorders.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Hamid Merdji, Justine Gantzer, Laurent Bonello, Nicolas Lamblin, Francois Roubille, Bruno Levy, Sebastien Champion, Pascal Lim, Francis Schneider, Alain Cariou, Hadi Khachab, Jeremy Bourenne, Marie-France Seronde, Guillaume Schurtz, Brahim Harbaoui, Gerald Vanzetto, Charlotte Quentin, Anais Curtiaud, Jean-Emmanuel Kurtz, Nicolas Combaret, Benjamin Marchandot, Benoit Lattuca, Caroline Biendel, Guillaume Leurent, Vincent Bataille, Edouard Gerbaud, Etienne Puymirat, Eric Bonnefoy, Nadia Aissaoui, Clement Delmas
Summary: This study aimed to investigate the characteristics, management, and outcomes of patients with active cancer admitted for cardiogenic shock. The results showed that patients with active cancer had different in-hospital management and a significantly higher 1-year mortality rate compared to those without active cancer.
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2023)
Article
Gastroenterology & Hepatology
Florence Blot, Justine Marchix, Miriam Ejarque, Sara Jimenez, Aline Meunier, Celine Keime, Camille Trottier, Mikael Croyal, Celine Lapp, Maxime M. Mahe, Adele De Arcangelis, Gerard Gradwohl
Summary: EECs play a crucial role in regulating energy homeostasis by sensing luminal nutrients and microbial metabolites. The absence of EECs in healthy adult mice leads to weight loss, impaired lipid absorption and metabolism, and altered gut microbiota composition.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Clinical Neurology
Chiara Dionisi, Marine Chazalon, Myriam Rai, Celine Keime, Virginie Imbault, David Communi, Helene Puccio, Serge N. Schiffmann, Massimo Pandolfo
Summary: This study characterizes the abnormalities in neurons of Friedreich ataxia, demonstrating impaired cytoskeleton organization, neurite extension, synaptic plasticity, and altered electrophysiological profiles. Despite restoration of FXN expression, isogenic control neurons still exhibit characteristics of Friedreich ataxia neurons.
BRAIN COMMUNICATIONS
(2022)
Article
Cell Biology
Anna Niewiadomska-Cimicka, Antoine Hache, Stephanie Le Gras, Celine Keime, Tao Ye, Aurelie Eisenmann, Imen Harichane, Michel J. J. Roux, Nadia Messaddeq, Emmanuelle Clerin, Thierry Leveillard, Yvon Trottier
Summary: SCA7 leads to reduced active transcription marks at gene promoters in the retina, with a preferential downregulation of highly expressed photoreceptor genes. The affected photoreceptor genes show altered histone acetylation, enhancer-related non-coding RNA expression, and increased RNA polymerase II pausing, suggesting impaired superenhancer-related features in SCA7.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)