Machine learning prediction of methionine and tryptophan photooxidation susceptibility
出版年份 2021 全文链接
标题
Machine learning prediction of methionine and tryptophan photooxidation susceptibility
作者
关键词
oxidation, photostability, machine learning, prediction, developability, stability, drug development, therapeutic protein, antibody, mab
出版物
Molecular Therapy-Methods & Clinical Development
Volume 21, Issue -, Pages 466-477
出版商
Elsevier BV
发表日期
2021-04-01
DOI
10.1016/j.omtm.2021.03.023
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Selective Tryptophan Oxidation of Monoclonal Antibodies: Oxidative Stress and Modeling Prediction
- (2019) Jorge Alexander Pavon et al. ANALYTICAL CHEMISTRY
- Probing the Tryptophan Environment in Therapeutic Proteins: Implications for Higher Order Structure upon Tryptophan Oxidation
- (2019) Gregory V. Barnett et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Singlet Molecular Oxygen Reactions with Nucleic Acids, Lipids, and Proteins
- (2019) Paolo Di Mascio et al. CHEMICAL REVIEWS
- Susceptibility of protein therapeutics to spontaneous chemical modifications by oxidation, cyclization, and elimination reactions
- (2019) Luigi Grassi et al. AMINO ACIDS
- Charge and hydrophobicity are key features in sequence-trained machine learning models for predicting the biophysical properties of clinical-stage antibodies
- (2019) Max Hebditch et al. PeerJ
- Machine Learning Enables Accurate Prediction of Asparagine Deamidation Probability and Rate
- (2019) Jared A. Delmar et al. Molecular Therapy-Methods & Clinical Development
- Prediction of the Hydrogen Peroxide–Induced Methionine Oxidation Propensity in Monoclonal Antibodies
- (2018) Neeraj J. Agrawal et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Prediction of methionine oxidation risk in monoclonal antibodies using a machine learning method
- (2018) Kannan Sankar et al. mAbs
- Mitigation of Oxidation in Therapeutic Antibody Formulations: a Biochemical Efficacy and Safety Evaluation of N-Acetyl-Tryptophan and L-Methionine
- (2018) Michelle Z. Dion et al. PHARMACEUTICAL RESEARCH
- Rapid assessment of oxidation via middle-down LCMS correlates with methionine side-chain solvent-accessible surface area for 121 clinical stage monoclonal antibodies
- (2017) Rong Yang et al. mAbs
- Forced degradation of recombinant monoclonal antibodies: A practical guide
- (2017) Christine Nowak et al. mAbs
- Type I and Type II Photosensitized Oxidation Reactions: Guidelines and Mechanistic Pathways
- (2017) Maurício S. Baptista et al. PHOTOCHEMISTRY AND PHOTOBIOLOGY
- Protein asparagine deamidation prediction based on structures with machine learning methods
- (2017) Lei Jia et al. PLoS One
- Isomerization and Oxidation in the Complementarity-Determining Regions of a Monoclonal Antibody: A Study of the Modification–Structure–Function Correlations by Hydrogen–Deuterium Exchange Mass Spectrometry
- (2016) Yuetian Yan et al. ANALYTICAL CHEMISTRY
- Oxidation in the complementarity-determining regions differentially influences the properties of therapeutic antibodies
- (2016) Tetyana Dashivets et al. mAbs
- Modeling the Oxidation of Methionine Residues by Peroxides in Proteins
- (2015) Naresh Chennamsetty et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Effect of Individual Fc Methionine Oxidation on FcRn Binding: Met252 Oxidation Impairs FcRn Binding More Profoundly than Met428 Oxidation
- (2015) Xuan Gao et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Developability Assessment During the Selection of Novel Therapeutic Antibodies
- (2015) Alexander Jarasch et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Mechanistic and Kinetic Study of Singlet O2 Oxidation of Methionine by On-Line Electrospray Ionization Mass Spectrometry
- (2015) Fangwei Liu et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Aggregation risk prediction for antibodies and its application to biotherapeutic development
- (2015) Olga Obrezanova et al. mAbs
- Hole hopping through tyrosine/tryptophan chains protects proteins from oxidative damage
- (2015) Harry B. Gray et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Sulphur Atoms from Methionines Interacting with Aromatic Residues Are Less Prone to Oxidation
- (2015) Juan C. Aledo et al. Scientific Reports
- Assessment of chemical modifications of sites in the CDRs of recombinant antibodies
- (2014) Markus Haberger et al. mAbs
- In silico selection of therapeutic antibodies for development: Viscosity, clearance, and chemical stability
- (2014) Vikas K. Sharma et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Antibody structure determination using a combination of homology modeling, energy-based refinement, and loop prediction
- (2014) Kai Zhu et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Influence of methionine oxidation on the aggregation of recombinant human growth hormone
- (2013) Filippo Mulinacci et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Oxidation of Therapeutic Proteins and Peptides: Structural and Biological Consequences
- (2013) Riccardo Torosantucci et al. PHARMACEUTICAL RESEARCH
- Quality attributes of recombinant therapeutic proteins: An assessment of impact on safety and efficacy as part of a quality by design development approach
- (2012) Alex Eon-Duval et al. BIOTECHNOLOGY PROGRESS
- Reaction of Singlet Oxygen with Tryptophan in Proteins: A Pronounced Effect of the Local Environment on the Reaction Rate
- (2012) Rasmus Lybech Jensen et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Immunogenicity of different stressed IgG monoclonal antibody formulations in immune tolerant transgenic mice
- (2012) Vasco Filipe et al. mAbs
- Oxidation of Human Growth Hormone by Oxygen-Centered Radicals: Formation of Leu-101 Hydroperoxide and Tyr-103 Oxidation Products
- (2012) Daniel Steinmann et al. MOLECULAR PHARMACEUTICS
- Role of Surface Exposed Tryptophan as Substrate Generators for the Antibody Catalyzed Water Oxidation Pathway
- (2012) Alavattam Sreedhara et al. MOLECULAR PHARMACEUTICS
- Chemical Modifications in Aggregates of Recombinant Human Insulin Induced by Metal-Catalyzed Oxidation: Covalent Cross-Linking via Michael Addition to Tyrosine Oxidation Products
- (2012) Riccardo Torosantucci et al. PHARMACEUTICAL RESEARCH
- Classification and Characterization of Therapeutic Antibody Aggregates
- (2011) Marisa K. Joubert et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Chemical Modifications in Therapeutic Protein Aggregates Generated under Different Stress Conditions
- (2011) Quanzhou Luo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Stabilization of a monoclonal antibody during purification and formulation by addition of basic amino acid excipients
- (2011) Robert J Falconer et al. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
- Plain and Mono-pegylated Recombinant Human Insulin Exhibit Similar Stress-Induced Aggregation Profiles
- (2011) Riccardo Torosantucci et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Photosensitizers Form in Histidine Buffer and Mediate the Photodegradation of a Monoclonal Antibody
- (2011) Steven D. Stroop et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Redox Proteomics of Protein-bound Methionine Oxidation
- (2011) Bart Ghesquière et al. MOLECULAR & CELLULAR PROTEOMICS
- Impact of methionine oxidation in human IgG1 Fc on serum half-life of monoclonal antibodies
- (2011) Weirong Wang et al. MOLECULAR IMMUNOLOGY
- Site-Specific Tryptophan Oxidation Induced by Autocatalytic Reaction of Polysorbate 20 in Protein Formulation
- (2011) Xanthe M. Lam et al. PHARMACEUTICAL RESEARCH
- Photo-oxidation of proteins
- (2011) David I. Pattison et al. PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
- Identification of Potential Sites for Tryptophan Oxidation in Recombinant Antibodies Using tert-Butylhydroperoxide and Quantitative LC-MS
- (2011) Miriam Hensel et al. PLoS One
- Separation of post-translational modifications in monoclonal antibodies by exploiting subtle conformational changes under mildly acidic conditions
- (2010) Shiyi Wang et al. JOURNAL OF CHROMATOGRAPHY A
- Stability of Human Growth Hormone: Influence of Methionine Oxidation on Thermal Folding
- (2010) Filippo Mulinacci et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Assessing monoclonal antibody product quality attribute criticality through clinical studies
- (2010) Andrew M. Goetze et al. mAbs
- Singlet-oxygen-mediated amino acid and protein oxidation: Formation of tryptophan peroxides and decomposition products
- (2009) Michelle Gracanin et al. FREE RADICAL BIOLOGY AND MEDICINE
- Immunological detection of N-formylkynurenine in oxidized proteins
- (2009) Marilyn Ehrenshaft et al. FREE RADICAL BIOLOGY AND MEDICINE
- Impact of methionine oxidation on the binding of human IgG1 to FcRn and Fcγ receptors
- (2009) Andrea Bertolotti-Ciarlet et al. MOLECULAR IMMUNOLOGY
- Methionine oxidation in human IgG2 Fc decreases binding affinities to protein A and FcRn
- (2009) Hai Pan et al. PROTEIN SCIENCE
- Structure and Stability Changes of Human IgG1 Fc as a Consequence of Methionine Oxidation
- (2008) Dingjiang Liu et al. BIOCHEMISTRY
- Characterization of the photodegradation of a human IgG1 monoclonal antibody formulated as a high-concentration liquid dosage form
- (2008) Pei Qi et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Mass spectrometry analysis of photo-induced methionine oxidation of a recombinant human monoclonal antibody
- (2008) Hongcheng Liu et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search