Protein asparagine deamidation prediction based on structures with machine learning methods

Classification evaluation

(2016) Jake Lever et al.   NATURE METHODS

Building Predictive Models inRUsing thecaretPackage

(2015) Max Kuhn   Journal of Statistical Software

Prediction of Spontaneous Protein Deamidation from Sequence-Derived Secondary Structure and Intrinsic Disorder

(2015) J. Ramiro Lorenzo et al.   PLoS One

Structure-Based Prediction of Asparagine and Aspartate Degradation Sites in Antibody Variable Regions

(2014) Jasmin F. Sydow et al.   PLoS One

In silico selection of therapeutic antibodies for development: Viscosity, clearance, and chemical stability

(2014) Vikas K. Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative Analysis of Deamidation and Isomerization in β2-Microglobulin by 18O Labeling

(2012) Masafumi Fukuda et al.   ANALYTICAL CHEMISTRY

Conformational Variation Revealed by the Crystal Structure of Rnase U2A Complexed with Ca Ion and 2´-Adenylic Acid at 1.03 Å Resolution

(2012) Shuji Noguchi   PROTEIN AND PEPTIDE LETTERS

Characterization of deamidation of barstar using electrospray ionization quadrupole time-of-flight mass spectrometry, which stabilizes an equilibrium unfolding intermediate

(2012) Santosh Kumar Jha et al.   PROTEIN SCIENCE

Structural changes induced by the deamidation and isomerization of asparagine revealed by the crystal structure of Ustilago sphaerogena ribonuclease U2B

(2010) Shuji Noguchi   BIOPOLYMERS

Identification and characterization of asparagine deamidation in the light chain CDR1 of a humanized IgG1 antibody

(2009) Josef Vlasak et al.   ANALYTICAL BIOCHEMISTRY

Isomerization in the CDR2 of a monoclonal antibody: Binding analysis and factors that influence the isomerization rate

(2009) Lawrence W. Dick et al.   BIOTECHNOLOGY AND BIOENGINEERING

Effect of protein structure on deamidation rate in the Fc fragment of an IgG1 monoclonal antibody

(2009) Sandipan Sinha et al.   PROTEIN SCIENCE

Structural and Functional Roles of Deamidation and/or Truncation of N- or C-Termini in Human αA-Crystallin†

(2008) Jose M. Chaves et al.   BIOCHEMISTRY