Article
Nutrition & Dietetics
Jose Riezu-Boj, Miguel Barajas, Tania Perez-Sanchez, Maria J. Pajares, Miriam Arana, Fermin Milagro, Raquel Urtasun
Summary: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease, and modulating the gut microbiota may be a promising therapeutic approach. This study found that the Lactiplantibacillus plantarum strain DSM20174 (L.p. DSM20174) can prevent NAFLD progression, improve metabolic balance, and reduce inflammation.
Review
Food Science & Technology
Amin Gasmi, Geir Bjorklund, Pavan Kumar Mujawdiya, Yuliya Semenova, Alexandru Dosa, Salva Piscopo, Joeri J. Pen, Asma Gasmi Benahmed, Daniel-Ovidiu Costea
Summary: Gut microbes play a crucial role in bariatric surgery outcomes, as they can be altered by the surgery and have beneficial effects on therapeutic results.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biology
Martial Marbouty, Agnes Thierry, Gael A. Millot, Romain Koszul
Summary: The study applied metagenomic Hi-C approach to analyze healthy human gut samples, revealing a large infection network of bacteriophages in the gut microbiota, with over 6000 interactions identified. Results showed that 5% of the phages may be actively replicating, and 17 members of the crAss-like phage family were successfully identified with their bacterial hosts.
Review
Nutrition & Dietetics
Qi Zhang, Wenmin Xing, Qiao Wang, Zhan Tang, Yazhen Wang, Wenyan Gao
Summary: The increasing prevalence of non-alcoholic fatty liver disease (NAFLD) has become a significant healthcare burden worldwide. Recent investigations have shown that the gut microbiota plays a crucial role in the progression of NAFLD through the gut-liver axis or gut-brain-liver axis. The composition of the microbiota can be influenced by various factors, including dietary style, nutritional supplements, or exercise. Additionally, microbiota metabolites can impact mitochondrial function and inflammatory response, which are important factors in NAFLD.
FRONTIERS IN NUTRITION
(2022)
Article
Microbiology
Haripriya Gupta, Sung Hun Kim, Seul Ki Kim, Sang Hak Han, Hak Cheol Kwon, Ki Tae Suk
Summary: This study investigated the effects of probiotic treatment on alcoholic hepatitis patients by restoring gut microbial balance. The results showed that probiotics improved liver function, decreased lipopolysaccharide levels, and modulated the composition of gut microbiota.
Article
Gastroenterology & Hepatology
Gang Fan, Feng Cao, Tingting Kuang, Huan Yi, Chengcheng Zhao, Lijie Wang, Jiayan Peng, Zhenhua Zhuang, Tong Xu, Yuting Luo, Yuchen Xie, Hongying Li, Kun Zhang, Yujiao Zeng, Xiyu Zhang, Sihan Peng, Xianliang Qiu, Dongqi Zhou, Huan Liang, Bin Yang, Jian Kang, Ya Liu, Yi Zhang
Summary: The gut virome in patients with T2D and its complication DN is significantly altered, with decreased viral richness and diversity. Specific viral species are found to be altered in T2D and DN patients, while multiple viral functions and viral-bacterial interactions are disrupted. The combined use of gut viral and bacterial markers shows great diagnostic potential for T2D and DN.
Article
Multidisciplinary Sciences
Leen Beller, Ward Deboutte, Sara Vieira-Silva, Gwen Falony, Raul Yhossef Tito, Leen Rymenans, Claude Kwe Yinda, Bert Vanmechelen, Lore Van Espen, Daan Jansen, Chenyan Shi, Mark Zeller, Piet Maes, Karoline Faust, Marc Van Ranst, Jeroen Raes, Jelle Matthijnssens
Summary: This study analyzed the virome and 16/18S gene data from 304 fecal samples of eight infants. The findings show that the gut virome is mainly composed of bacteriophages, which rapidly increase in abundance within the first few weeks after birth. The majority of phages are individual-specific, but there are also some common phages among infants. Bacterial hosts could be predicted for most of the phages, mainly infecting Firmicutes. Additionally, clinically asymptomatic eukaryotic viruses were detected, with an increase in infection rate after day-care entrance.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Health Care Sciences & Services
Hui-Ju Tsai, Yi-Chun Tsai, Wei-Wen Hung, Wei-Chun Hung, Chen-Chia Chang, Chia-Yen Dai
Summary: This study found a positive correlation between the abundance of Firmicutes phylum and the severity of NAFLD in T2D patients. The gut microbiota, specifically Firmicutes, could potentially serve as a predictor for NAFLD severity in T2D patients.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Environmental Sciences
Amr El-Sayed, Lotfi Aleya, Mohamed Kamel
Summary: The microbiome refers to the community of microorganisms living inside human/animal bodies or on their skin, including trillions of commensals, symbiotics, and even pathogenic microorganisms. It has a significant impact on health and disease, influencing the development of conditions like cancer, metabolic disorders, cardiovascular diseases, and even psychological disorders. Recent studies have highlighted its dynamic nature and its potential role in the prevention and treatment of various health disorders.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Nutrition & Dietetics
Riley L. Hughes, William H. Horn, Peter Finnegan, John W. Newman, Maria L. Marco, Nancy L. Keim, Mary E. Kable
Summary: The study found that consumption of RS2-enriched wheat leads to reduced postprandial glycemia, altered gut microbiota composition, and increased fermentation activity.
Article
Chemistry, Multidisciplinary
Christina Schubert, Sabina Fischer, Kathrin Dorsch, Lutz Tessmer, Joerg Hinrichs, Zeynep Atamer
Summary: There is a bidirectional interaction between the gut microbiota and human health. Researchers have investigated an encapsulation method using alginate, calcium ions, and milk proteins to protect bacteriophages and release them in the gut. By inserting the capsules into food matrices, probiotics can be consumed along with the bacteriophages to repopulate the gut and contribute to better health.
APPLIED SCIENCES-BASEL
(2022)
Review
Biochemistry & Molecular Biology
Natalia Vallianou, Gerasimos Socrates Christodoulatos, Irene Karampela, Dimitrios Tsilingiris, Faidon Magkos, Theodora Stratigou, Dimitris Kounatidis, Maria Dalamaga
Summary: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, often starting as a benign liver fat accumulation that can progress to non-alcoholic steatohepatitis (NASH) and increase the risk of cirrhosis and hepatocellular carcinoma (HCC). Recent studies have highlighted the role of gut dysbiosis, which can lead to increased gut permeability and the release of toxic bacterial products and proinflammatory cytokines, causing and sustaining inflammation. The composition of the gut microbiota and various metabolites may vary during different stages of NAFLD and among population groups, and further research is needed to determine the causal relationship between gut microbiota profiles and NAFLD in patients. Additionally, multiple metabolites may contribute to the pathogenesis of NAFLD.
Article
Microbiology
Felix Broecker, Karin Moelling
Summary: Viral infections and changes in intestinal microbiota composition have been linked to cancer, with the success of cancer immunotherapy being correlated with patients' gut microbial composition. Fecal microbiota transplantation (FMT) can convert some non-responders to responders, and phages may increase immunotherapy response by inducing T cells cross-reacting with cancer antigens. Modulating phage populations might offer a new approach to enhance immunotherapy responsiveness.
Article
Microbiology
Stephen Nayfach, David Paez-Espino, Lee Call, Soo Jen Low, Hila Sberro, Natalia N. Ivanova, Amy D. Proal, Michael A. Fischbach, Ami S. Bhatt, Philip Hugenholtz, Nikos C. Kyrpides
Summary: By mining deposited human stool metagenomes, nearly 190,000 draft-quality DNA virus genomes were recovered to create the Metagenomic Gut Virus catalogue, improving virus detection in stool metagenomes and revealing diverse retroelements with potential involvement in the molecular arms race between phages and their bacterial hosts.
NATURE MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Ting Liu, Gongjin Lan, K. Anton Feenstra, Zhisheng Huang, Jaap Heringa
Summary: Scientific publications provide biological relationships, but are not easy to integrate and query. Existing databases are well-structured for analysis, but lack comprehensive biological knowledge. We developed a method to construct a comprehensive knowledge graph by combining these two resources, and applied it to study the relationships between pre-/probiotics and microbiota-gut-brain axis diseases.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Rocco Barazzoni, Stephan C. Bischoff, Luca Busetto, Tommy Cederholm, Michael Chourdakis, Cristina Cuerda, Nathalie Delzenne, Laurence Genton, Stephane Schneider, Pierre Singer, Yves Boirie
Summary: The COVID-19 pandemics has created unprecedented challenges and threats to patients and healthcare systems worldwide. Acute respiratory complications are a major cause of morbidity and mortality in COVID-19 patients. Obesity and undernutrition-malnutrition have emerged as strong predictors of severe COVID-19 outcomes. Obesity-related excessive body fat may lead to respiratory, metabolic and immune derangements, increasing the risk of COVID-19 complications. Moreover, obesity is commonly associated with micronutrient deficiencies that directly influence immune function and infection risk. Lockdown measures can worsen eating behaviors, sedentarity, and body weight regulation, leading to further metabolic complications and non-communicable disease risk associated with obesity.
CLINICAL NUTRITION
(2022)
Article
Gastroenterology & Hepatology
Tiphaine Le Roy, Emilie Moens de Hase, Matthias Van Hul, Adrien Paquot, Rudy Pelicaen, Marion Regnier, Clara Depommier, Celine Druart, Amandine Everard, Dominique Maiter, Nathalie M. Delzenne, Laure B. Bindels, Marie de Barsy, Audrey Loumaye, Michel P. Hermans, Jean-Paul Thissen, Sara Vieira-Silva, Gwen Falony, Jeroen Raes, Giulio G. Muccioli, Patrice D. Cani
Summary: The study found that the newly identified bacterium was detected in 62.7%-69.8% of the healthy population. In obese individuals with metabolic syndrome, the abundance of Dysosmobacter genus was negatively correlated with body mass index, fasting glucose, and glycated hemoglobin. In mice, supplementation with live D. welbionis J115T partially counteracted diet-induced obesity, fat mass gain, insulin resistance, and white adipose tissue inflammation.
Article
Nutrition & Dietetics
Quentin Leyrolle, Renata Cserjesi, Romane Demeure, Audrey M. Neyrinck, Camille Amadieu, Julie Rodriguez, Olli Kaerkkaeinen, Kati Hanhineva, Nicolas Paquot, Miriam Cnop, Patrice D. Cani, Jean-Paul Thissen, Laure B. Bindels, Olivier Klein, Olivier Luminet, Nathalie M. Delzenne
Summary: This study evaluated the potential links between serum metabolomics and gut microbiome, and mood disturbances in obese patients. The findings revealed altered levels of microbiota-derived metabolites in obese subjects with mood disturbances, suggesting new targets for tackling mood disorders in this context.
Article
Gastroenterology & Hepatology
Camille Amadieu, Valentin Coste, Audrey M. Neyrinck, Victoria Thijssen, Quentin Leyrolle, Laure B. Bindels, Hubert Piessevaux, Peter Starkel, Philippe de Timary, Nathalie M. Delzenne, Sophie Leclercq
Summary: This study aims to evaluate the effects of supplementing alcohol-dependent patients with prebiotic fiber on gut microbiota and patient behavior. The results showed that prebiotics can modulate gut microbiota and improve social behavior, but had limited effects on other psychological and biological parameters.
Article
Medicine, General & Internal
Julie Rodriguez, Audrey M. Neyrinck, Maxime Van Kerckhoven, Marco A. Gianfrancesco, Edith Renguet, Luc Bertrand, Patrice D. Cani, Nicolas Lanthier, Miriam Cnop, Nicolas Paquot, Jean-Paul Thissen, Laure B. Bindels, Nathalie M. Delzenne
Summary: This study confirms that increasing physical activity can enhance the metabolic benefits of prebiotic supplementation on the gut microbiota, leading to clinical improvements in obese patients such as decreased BMI, lower liver enzymes and cholesterol levels, and improved glucose tolerance.
Article
Biochemistry & Molecular Biology
Anne Abot, Amandine Brochot, Nicolas Pomie, Eve Wemelle, Celine Druart, Marion Regnier, Nathalie M. Delzenne, Willem M. de Vos, Claude Knauf, Patrice D. Cani
Summary: In this study, the effects of Camu-Camu extract on obesity and associated disorders were evaluated. It was found that low doses of Camu-Camu extract improved glucose and lipid homeostasis and increased the abundance of Akkermansia muciniphila. High doses of Camu-Camu extract prevented excessive body weight gain, fat mass gain, and hepatic steatosis. These findings suggest that plant extracts, particularly Camu-Camu extract, may be beneficial in weight management and glucose homeostasis.
Article
Cell Biology
Radu Bachmann, Matthias Van Hul, Pamela Baldin, Daniel Leonard, Nathalie M. Delzenne, Clara Belzer, Janneke P. Ouwerkerk, Dirk Repsilber, Ignacio Rangel, Alex Kartheuser, Robert Jan Brummer, Willem M. De Vos, Patrice D. Cani
Summary: Akkermansia muciniphila pretreatment reduces mortality and severity of peritonitis following colonic leakage. This effect is associated with improved wound healing and increased IL22 production, but not changes in mucus layer thickness or genes involved in cell renewal, proliferation, or differentiation. MyD88 in intestinal cells is required for these effects. Additionally, colonic administration of A. muciniphila in healthy humans leads to changes in gene expression related to immune pathways.
Article
Cell Biology
Francesco Suriano, Claudia Manca, Nicolas Flamand, Matthias Van Hul, Nathalie M. Delzenne, Cristoforo Silvestri, Patrice D. Cani, Vincenzo Di Marzo
Summary: This study characterized the profile of endocannabinoidome and oxylipins in the intestines of obese and diabetic mice, and found correlations between these mediators and intestinal inflammation and gut microbiota composition. The results suggest that the altered eCBome and oxylipin signaling may contribute to obesity and diabetes-induced gut dysbiosis and inflammation.
Editorial Material
Nutrition & Dietetics
Nathalie Delzenne, Nicolaas E. Deutz, Dileep N. Lobo, George Grimble
Summary: In this education paper, advice is given on successful scientific grant writing. The paper emphasizes the importance of defining research hypothesis, fulfilling technical aspects, and understanding the requirements before writing the proposal. It also highlights the need to develop a timeline, create an attractive summary, and set SMART research objectives. Additionally, the paper emphasizes the importance of making the proposal understandable to non-experts while providing sufficient details for experts.
CLINICAL NUTRITION ESPEN
(2023)
Article
Nutrition & Dietetics
Sarah A. Potgens, Sophie Lecop, Violaine Havelange, Fuyong Li, Audrey M. Neyrinck, Nathalie Neveux, Johan Maertens, Jens Walter, Helene Schoemans, Nathalie M. Delzenne, Laure B. Bindels
Summary: In this study, the researchers investigated the changes in gut microbiota induced by intensive therapy in acute myeloid leukaemia (AML) patients. They found that the therapy temporarily impaired the gut barrier function and led to long-lasting alterations in the composition and metabolic activity of the gut microbiota, which were associated with weight loss.
CLINICAL NUTRITION
(2023)
Article
Endocrinology & Metabolism
Emilie Moens de Hase, Audrey M. Neyrinck, Julie Rodriguez, Miriam Cnop, Nicolas Paquot, Jean-Paul Thissen, Yining Xu, Ana Beloqui, Laure B. Bindels, Nathalie M. Delzenne, Matthias Van Hul, Patrice D. Cani
Summary: This study investigated the association between the abundance of Dysosmobacter welbionis and metabolic health in individuals with obesity and diabetes, as well as the influence of metformin treatment and prebiotic intervention. The findings suggest that Dysosmobacter welbionis abundance is influenced by metformin treatment and is associated with liver health and glucose metabolism in individuals with obesity and diabetes. This highlights the potential role of Dysosmobacter welbionis in metabolic health.
Article
Biochemistry & Molecular Biology
Emilie Moens de Hase, Camille Petitfils, Mireille Alhouayek, Clara Depommier, Pauline Le Faouder, Nathalie M. Delzenne, Matthias Van Hul, Giulio G. Muccioli, Nicolas Cenac, Patrice D. Cani
Summary: The newly identified bacterium D. welbionis J115(T) improves host metabolism in high-fat diet-fed mice through the production of bioactive lipids. These metabolic effects are associated with a whitening of brown adipose tissue and upregulation of genes related to PPAR-γ agonists.
JOURNAL OF LIPID RESEARCH
(2023)
Article
Nutrition & Dietetics
Nicolaas E. Deutz, Nathalie Delzenne, George Grimble, Dileep N. Lobo
Summary: Publishing a scientific paper is a challenging process that depends on the quality of study design, research questions, clear primary endpoints, and data from a large population. Before submission, it is important to meet ethical requirements, register in public databases, and declare any conflicts of interest. The structure of the manuscript includes sections for introduction, materials and methods, results, discussion, and an abstract that summarizes all aspects concisely. The publication process involves editors, reviewers, and publishers, with the initial impression being crucial for review. Thoughtful responses to reviewers' feedback are necessary for revisions. The goal is acceptance and publication of the paper.
CLINICAL NUTRITION ESPEN
(2023)
Article
Nutrition & Dietetics
George Grimble, Dileep N. Lobo, Nathalie Delzenne, Nicolaas E. Deutz
Summary: When presenting a paper, it is important to tailor your presentation to the audience's knowledge level and the title and abstract you submitted. Keep the talk simple and avoid complexity. Stick to the scheduled time and present the information in a concise manner. Make sure your slides are clear and informative, readable from a distance. Practice the talk beforehand, preferably with colleagues, and be prepared to make any necessary changes. Familiarize yourself with the content so you can relax and enjoy the experience.
CLINICAL NUTRITION ESPEN
(2023)
Article
Nutrition & Dietetics
Dileep N. Lobo, George Grimble, Nathalie Delzenne, Nicolaas E. Deutz
Summary: There are potential pitfalls in the publication process that researchers may encounter, whether knowingly or unknowingly. Disregarding publication governance can be risky and harm the reputation of authors and co-authors, even if the errors are unintentional. This article highlights these pitfalls, introduces relevant rules in research and publishing, and guides readers on how to avoid stumbling on the path to publication.
CLINICAL NUTRITION ESPEN
(2023)
