Article
Nutrition & Dietetics
Nives Bogataj Jontez, Sasa Kenig, Karin Sik Novak, Ana Petelin, Zala Jenko Praznikar, Nina Mohorko
Summary: This study compared the dietary patterns of individuals following LCHF, vegan, vegetarian, and omnivorous diets. The results showed that compared to other groups, the LCHF group had higher intakes of saturated fats, cholesterol, and animal proteins, while the intakes of sugars and dietary fibers were lower. The levels of total and LDL cholesterol were significantly higher in the LCHF group. Thus, it is recommended to select healthy fat sources, increase dietary fiber intake, and partially replace animal sources with plant sources in the LCHF diet.
FRONTIERS IN NUTRITION
(2023)
Article
Nutrition & Dietetics
Chengxiang Hu, Rong Huang, Runhong Li, Ning Ning, Yue He, Jiaqi Zhang, Yingxin Wang, Yanan Ma, Lina Jin
Summary: This study found that healthy low-carbohydrate diet (LCD) and low-fat diet (LFD) can protect against metabolic-dysfunction-associated fatty liver disease (MAFLD), while unhealthy LFD can increase the risk of MAFLD. Both the quantity and quality of macronutrients have significant influences on MAFLD.
Review
Nutrition & Dietetics
Hamed Kord Varkaneh, Faezeh Poursoleiman, Mohammad Khaldoun Al Masri, Kamar Allayl Alras, Yamen Shayah, Mohd Diya Masmoum, Fulwah Abdulaziz Alangari, Abd Alfatah Alras, Giulia Rinaldi, Andrew S. S. Day, Azita Hekmatdoost, Ahmed Abu-Zaid, Emad Kutbi
Summary: There is currently no consensus on the most beneficial dietary intervention for non-alcoholic fatty liver disease (NAFLD) patients, and there is also a lack of consensus on the definition of different restrictive diets and the recommended percentage of macronutrient restriction. Regardless of the fat and carbohydrate composition, low calorie diets are effective in reducing liver enzymes. All calorie restrictive dietary interventions are beneficial for reducing weight, liver fat content, and liver enzymes in individuals with NAFLD.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Henrik Hagstrom, Linda Nystrom Hagfors, Anna Tellstrom, Rikard Hedelin, Krister Lindmark
Summary: This study aimed to evaluate the dietary intake of individuals adhering to a low carbohydrate high fat (LCHF) diet. The results showed that this diet had low carbohydrate and fiber intake, while high intake of saturated fats and cholesterol.
Article
Nutrition & Dietetics
Sisi Yan, Sha Liu, Jianyu Qu, Xiaowen Li, Jiahao Hu, Linyu Zhang, Xiangyan Liu, Xin Li, Xianglin Wang, Lixin Wen, Ji Wang
Summary: This study found that a mixture of lard and soybean oil can reduce the occurrence of NAFLD and improve related indicators. The mixed oil acts through mechanisms such as reducing fatty acid transportation, inhibiting oxidative phosphorylation, and alleviating inflammation.
Review
Biochemistry & Molecular Biology
Dena Nuwaylati, Basmah Eldakhakhny, Abdulhadi Bima, Hussein Sakr, Ayman Elsamanoudy
Summary: Insulin resistance plays a role in the pathogenesis of many diseases, and the ketogenic diet has been proven as an effective treatment for various insulin resistance-related disorders. However, the safety of the ketogenic diet is still debatable, and attention should be given to the opportunities and challenges associated with its implementation.
Article
Radiology, Nuclear Medicine & Medical Imaging
Riccardo De Robertis, Flavio Spoto, Daniele Autelitano, Daniela Guagenti, Antonia Olivieri, Piero Zanutto, Greta Incarbone, Mirko D'Onofrio
Summary: This study compared the efficacy of ultrasound (US) and US-derived fat fraction (UDFF) with magnetic resonance proton density fat fraction (MRI-PDFF) in detecting hepatic steatosis and quantifying liver fat content. The results showed that UDFF can reliably quantify liver fat content and improve the diagnostic value of US for detecting hepatic steatosis.
Article
Medicine, General & Internal
Yimin Zhao, Yueying Li, Wenxiu Wang, Zimin Song, Zhenhuang Zhuang, Duo Li, Lu Qi, Tao Huang
Summary: This study aimed to investigate the long-term associations between low-carbohydrate diets (LCDs) and low-fat diets (LFDs) and mortality among middle-aged and older individuals. The results showed that higher scores of overall LCD and unhealthy LCD were associated with increased risks of total and cause-specific mortality, while a healthy LCD was associated with slightly lower total mortality. On the other hand, the highest score of a healthy LFD was associated with significantly lower total, cardiovascular, and cancer mortality. These findings highlight the importance of maintaining a healthy LFD with less saturated fat in preventing all-cause and cause-specific mortality among middle-aged and older individuals.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Nutrition & Dietetics
David S. Ludwig, Frank B. Hu, Alice H. Lichtenstein, Walter C. Willett
Summary: Worldwide dietary guidelines in the late 20th century promoted a low-fat diet based on the belief that dietary fat causes excess weight gain. However, recent high-quality evidence refutes this association. Substituting carbohydrates for unsaturated fat may increase insulin resistance and cardiometabolic disease, particularly in populations with prevalent insulin resistance. Therefore, the recent WHO recommendation to limit dietary fat to <= 30% seems ill advised and should be reconsidered.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Environmental Sciences
Xiwei He, Jinhong Jiang, Xu-Xiang Zhang
Summary: This study investigates the impact of chronic exposure to low-dose PFHxS on NAFLD and metabolic functions. The results showed that PFHxS exposure significantly promoted obesity and metabolic syndrome, aggravated NAFLD symptoms, and caused gut dysbiosis as well as alterations in key genes. These findings suggest that environmental PFHxS exposure is an important risk factor for metabolic diseases, especially among obese individuals.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Nutrition & Dietetics
Philip J. Prins, Timothy D. Noakes, Alex Buga, Dominic P. D'Agostino, Jeff S. Volek, Jeffrey D. Buxton, Kara Heckman, Dalton W. Jones, Naomi E. Tobias, Holly M. Grose, Anna K. Jenkins, Kelli T. Jancay, Andrew P. Koutnik
Summary: Recent research challenges the notion that high carbohydrate, low fat (HCLF) diets are superior for athletic performance and highlights the potential health benefits of low carbohydrate, high fat (LCHF) diets. In this study, highly trained competitive middle-aged athletes followed either a HCLF or LCHF diet for 31 days and found that there were no significant differences in performance, body composition, or metabolic markers between the two groups. However, the LCHF diet resulted in higher rates of fat oxidation and improved glycemic control, especially in individuals at risk for diabetes.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Marija Pinteric, Iva I. Podgorski, Marijana Popovic Hadzija, Ivana Tartaro Bujak, Ana Tadijan, Tihomir Balog, Sandra Sobocanec
Summary: This study found that high fat diet can lead to weight gain, increased expression of NAFLD and oxidative stress-inducing genes, and impaired response of antioxidative system in mice with ovariectomy and Sirt3 depletion. Ovariectomy increases Sirt3 and fatty acid synthesis, maintains mitochondrial function, and decreases levels of lipid hydroperoxides, providing protection against harmful effects of high fat diet.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Parker N. Hyde, Teryn N. Sapper, Richard A. LaFountain, Madison L. Kackley, Alex Buga, Brandon Fell, Christopher D. Crabtree, Stephen D. Phinney, Vincent J. Miller, Sarah M. King, Ronald M. Krauss, William J. Kraemer, Jeff S. Volek
Summary: This study compared the effects of palm stearin and butter consumption on circulating cholesterol levels in healthy subjects on low-carbohydrate/high-fat and high-carbohydrate/low-fat diets. The results showed that butter led to higher LDL cholesterol levels compared to palm stearin, regardless of the background dietary variations, primarily due to larger cholesterol-rich LDL particles.
Article
Biochemistry & Molecular Biology
Oluwanifemi Esther Bolatimi, Kimberly Z. Head, Jianzhu Luo, Tyler C. Gripshover, Qian Lin, Ngozi V. Adiele, Walter H. Watson, Caitlin Wilkerson, Lu Cai, Matthew C. Cave, Jamie L. Young
Summary: The pathogenesis of NAFLD is associated with zinc deficiency. Zinc supplementation does not have therapeutic effects on established NAFLD. Our study suggests that 8-week zinc supplementation cannot reverse established NAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Pernille H. Hellmann, Jonatan Bagger, Katrine R. Carlander, Julie Forman, Elizaveta Chabanova, Jens S. Svenningsen, Jens J. Holst, Matthew P. Gillum, Tina Vilsboll, Filip K. Knop
Summary: Curcumin treatment did not significantly affect hepatic fat content in obese individuals, with good tolerability.
DIABETES OBESITY & METABOLISM
(2022)
Article
Gastroenterology & Hepatology
Huiyul Park, Eileen L. Yoon, Mimi Kim, Seon Cho, Eun-Hee Nah, Dae Won Jun
Summary: This study investigated the proportion of subjects with metabolic dysfunction-associated fatty liver disease (MAFLD) and assessed the fibrosis and cardiovascular risk in metabolically healthy MAFLD subjects. The results showed that 26.6% of MAFLD subjects were metabolically healthy and had comparable fibrosis burden and cardiovascular risk to the healthy control group.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Letter
Gastroenterology & Hepatology
Eileen L. Yoon, Huiyul Park, Dae Won Jun
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Young Eun Chon, Seong Yong Park, Han Pyo Hong, Donghee Son, Jonghyun Lee, Eileen Yoon, Soon Sun Kim, Sang Bong Ahn, Soung Won Jeong, Dae Won Jun
Summary: This study analyzed the trends in hepatocellular carcinoma (HCC) incidence in South Korea over 10 years and predicted an increase in HCC incidence among elderly individuals in 2028.
CLINICAL AND MOLECULAR HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Mimi Kim, Eileen Laurel Yoon, Jonghyun Lee, Seon Cho, Chul-Min Lee, Bo Kyeong Kang, Huiyul Park, Dae Won Jun, Eun-Hee Nah
Summary: This study compared the diagnostic performance of different noninvasive tests for hepatic fibrosis and found that APRI performed the best in patients aged 45 and younger, especially in cases of chronic viral hepatitis and alcoholic fatty liver disease. The APRI showed good sensitivity and specificity in the population and can be considered as the primary test for young adults (45 and younger).
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Eunji Ko, Eileen L. Yoon, Dae Won Jun
Summary: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, with an estimated prevalence of 25%. NAFLD is a major cause of liver cirrhosis, hepatocellular carcinoma, and death. Cardiovascular disease risk also increases with NAFLD severity.
CLINICAL AND MOLECULAR HEPATOLOGY
(2023)
Letter
Gastroenterology & Hepatology
Seung Min Lee, Dae Won Jun
CLINICAL AND MOLECULAR HEPATOLOGY
(2023)
Article
Biology
Eun Jeoung Lee, Yun Kim, Ji Eun Kim, Eileen Laurel Yoon, Sung Ryol Lee, Dae Won Jun
Summary: ALS-L1023, extracted from lemon balm, is a natural medicine with anti-angiogenesis properties. This study aimed to investigate the potential of ALS-L1023 in alleviating liver fibrosis in a non-alcoholic fatty liver disease (NAFLD) model. Results showed that ALS-L1023 treatment led to decreased levels of liver enzymes and fibrosis area compared to the control group. RNA sequencing revealed lower expression of genes related to the hedgehog-signaling pathway in the responder group. These findings suggest that ALS-L1023 may be a promising treatment for liver fibrosis in NAFLD.
Article
Gastroenterology & Hepatology
Young Eun Chon, Aejeong Jo, Eileen L. Yoon, Jonghyun Lee, Ho Gyun Shin, Min Jung Ko, Dae Won Jun
Summary: This study aimed to investigate the nationwide incidence and care cascade status of hepatitis C virus (HCV) infection in Korea. The new HCV infection rate in Korea was 17.2 per 100,000 person-years in 2019, with the highest rate in patients aged 50 to 59 years. Among newly infected HCV patients, the linkage to care rate was 78.2% and the treatment rate was 58.1% within 1.5 years.
Letter
Gastroenterology & Hepatology
Huiyul Park, Eileen L. Yoon, Mimi Kim, Sun-Hong Kwon, Dae Won Jun, Hye-Lin Kim
Article
Oncology
Jihye Kim, Moon Haeng Hur, Seung Up Kim, Jin-Wook Kim, Dong Hyun Sinn, Hyun Woong Lee, Moon Young Kim, Jae Youn Cheong, Yong Jin Jung, Han Ah Lee, Young-Joo Jin, Jun Sik Yoon, Sung-Jae Park, Chang Hun Lee, In Hee Kim, June Sung Lee, Young Youn Cho, Hyung Joon Kim, Soo Young Park, Yeon Seok Seo, Hyunwoo Oh, Dae Won Jun, Mi Na Kim, Young Chang, Jae Young Jang, Sang Youn Hwang, Yoon Jun Kim
Summary: This study compared the effectiveness of entecavir and tenofovir disoproxil fumarate in preventing hepatocellular carcinoma among patients with chronic hepatitis B. The study found that the two antivirals had similar efficacy in preventing HCC and had comparable rates of other outcomes. However, the tenofovir disoproxil fumarate group had more side effects, leading to some patients needing to switch initial antiviral medications.
Article
Chemistry, Medicinal
Gi-Ae Kim, Hyun Chin Cho, Soung Won Jeong, Bo-Kyeong Kang, Mimi Kim, Seungwon Jung, Jungwook Hwang, Eileen L. Yoon, Dae Won Jun
Summary: Preclinical data have shown that ALS-L1023, an herbal extract from Melissa officinalis, can reduce visceral fat and hepatic steatosis. In this study, we evaluated the safety and efficacy of ALS-L1023 as a treatment for non-alcoholic fatty liver disease (NAFLD). The results showed that ALS-L1023 could significantly reduce hepatic fat content and improve liver stiffness in patients with NAFLD, with no significant differences in adverse events among the study groups.
Editorial Material
Gastroenterology & Hepatology
Eileen Laurel Yoon, Dae Won Jun
CLINICAL AND MOLECULAR HEPATOLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Joo Hyun Oh, Dae Won Jun
CLINICAL AND MOLECULAR HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Sang Yi Moon, Yang Hyun Baek, Se Young Jang, Dae Won Jun, Ki Tae Yoon, Young Youn Cho, Hoon Gil Jo, Ae Jeong Jo
Summary: This study compared the diagnostic performance of serum M2BPGi and other serological panels in the diagnosis of fibrosis in patients with NAFLD, and proposed an improved two-step diagnostic algorithm. The results showed that serum M2BPGi performed well in predicting the stage of liver fibrosis, and the algorithm can improve the diagnostic accuracy of fibrosis and reduce unnecessary tests.
Article
Gastroenterology & Hepatology
Huiyul Park, Eileen L. Yoon, Mimi Kim, Jonghyun Lee, Hye-Lin Kim, Seon Cho, Eun-Hee Nah, Dae Won Jun
Summary: The FIB-4 index and the NAFLD fibrosis score can be used as noninvasive screening methods for advanced fibrosis in patients with NAFLD. This study found that the performance of FIB-4 in at-risk individuals at health check-up centers was similar to that observed in patients with NAFLD.
HEPATOLOGY COMMUNICATIONS
(2023)
