Article
Multidisciplinary Sciences
Ayoub Lassoued, Furu Zhang, Kazuhiro Kurokawa, Yan Liu, Marcel T. Bernucci, James A. Crowell, Donald T. Miller
Summary: Retinitis pigmentosa (RP) is a group of inherited retinal degenerative diseases, with cone photoreceptor death being the most debilitating phase. High-resolution retinal imaging methods and cone optoretinogram show promise in visualizing individual cone cells and their dysfunction in RP progression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Satoru Kanda, Takumi Hara, Ryosuke Fujino, Keiko Azuma, Hirotsugu Soga, Ryo Asaoka, Ryo Obata, Tatsuya Inoue
Summary: The study found that measuring the low FAF area is very useful for patients with cone-rod dystrophy. AF measurement reflects visual field damage, but not visual acuity (VA).
SCIENTIFIC REPORTS
(2021)
Article
Ophthalmology
Yuting Gong, Li Jia Chen, Chi Pui Pang, Haoyu Chen
Summary: Quantitative analysis of the optical intensity of the ellipsoid zone (EZ) on OCT images in RP patients revealed that the variation in EZ intensity can serve as a biomarker for early detection of photoreceptor degeneration, which is closely correlated with visual acuity.
ACTA OPHTHALMOLOGICA
(2021)
Article
Medicine, General & Internal
Fabrizio Giansanti, Giulio Vicini, Andrea Sodi, Cristina Nicolosi, Lavinia Bellari, Gianni Virgili, Stanislao Rizzo, Daniela Bacherini
Summary: Optical coherence tomography angiography (OCTA) revealed vascular abnormalities in patients with retinitis pigmentosa (RP), which were associated with choroidal atrophy and visual acuity loss.
Review
Medicine, General & Internal
Bingwen Lu, Guojun Chao, Like Xie
Summary: RP is a group of inherited retinal disorders, and OCTA technology can help understand, detect, and treat RP, playing an important role in future clinical research.
Article
Oncology
Alper Can Yilmaz, Ali Hakan Durukan
Summary: This study aimed to evaluate macular perfusion in retinitis pigmentosa (RP) patients using optical coherence tomography angiography (OCTA), and investigate the correlation between OCTA quantitative data and visual acuity (VA). The results showed reduced choriocapillary flow density, enlarged foveal avascular zone (FAZ), and decreased vessel density in both superficial and deep capillary plexus in RP patients compared to healthy controls. There was also a correlation between OCTA measurements and VA.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Medicine, General & Internal
Riccardo Cheloni, Daniel Jackson, Mariya Moosajee
Summary: This study characterized the natural history of patients with X-linked retinitis pigmentosa (RP) caused by RP2 mutations. The study found that patients with RP2 mutations exhibit rapid progression to outer retinal atrophy and early macular involvement, resulting in significant vision loss by age 30-40.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Joao Pedro Marques, Emmanuel Neves, Sara Geada, Ana Luisa Carvalho, Joaquim Murta, Jorge Saraiva, Rufino Silva
Summary: The frequency of CME and ERM is high in RP patients, highlighting the importance of screening for these potentially treatable conditions to improve the quality of life.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Daniel J. Jackson, Adam M. Dubis, Mariya Moosajee
Summary: This study reports the natural history of CNGB1-related RP and finds that it is a slowly progressive disease with patients maintaining visual acuity. Further research is needed to determine the clinical endpoints to be used in clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ophthalmology
Satoshi Okado, Yoshito Koyanagi, Taiga Inooka, Taro Kominami, Hiroko Terasaki, Koji M. Nishiguchi, Shinji Ueno
Summary: The study found that in the early stage of retinitis pigmentosa, the reduction of focal macular electroretinography amplitudes occurs before the shortening of the ellipsoid zone (EZ), indicating that the focal macular electroretinography amplitudes are an earlier indicator of macular dysfunction.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Article
Ophthalmology
Tomoko Hasegawa, Akio Oishi, Hanako Ohashi Ikeda, Shogo Numa, Manabu Miyata, Yuki Otsuka, Maho Oishi, Akitaka Tsujikawa
Summary: The study found that using EZ length is more suitable for detecting the progression of RP compared to MD and central retinal thickness. EZ length has the fastest annual change and is more sensitive to the progression of RP.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Article
Ophthalmology
Shaden H. Yassin, Yiqian Wang, William R. Freeman, Anna Heinke, Evan Walker, Truong Nguyen, Dirk-Uwe G. Bartsch, Cheolhong An, Shyamanga Borooah
Summary: The application of artificial intelligence technology in retinal imaging allows for more accurate overlaying of multimodal retinal images, providing better outcome measures and biomarkers for clinical trials.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Review
Medicine, General & Internal
Claudio Iovino, Clemente Maria Iodice, Danila Pisani, Luciana Damiano, Valentina Di Iorio, Francesco Testa, Francesca Simonelli
Summary: Optical coherence tomography angiography (OCT-A) is a valuable imaging technique for non-invasive, depth-resolved, motion-contrast, high-resolution imaging of retinal and choroidal vascular networks. It enhances our understanding of retinal and choroidal alterations in inherited retinal diseases (IRDs), which are clinically and genetically heterogeneous disorders. This review comprehensively summarizes the clinical applications of OCT-A in IRDs, highlighting significant vascular findings in various retinal dystrophies and discussing the advantages and limitations of this imaging modality.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Kosuke Nakajima, Tatsuya Inoue, Maiko Maruyama-Inoue, Yasuo Yanagi, Kazuaki Kadonosono, Asako Ogawa, Yohei Hashimoto, Keiko Azuma, Ryo Terao, Ryo Asaoka, Ryo Obata
Summary: The study analyzed vessel density around the optic nerve head in patients with RP using OCTA and found that vessel density in the deep layer around the ONH was significantly associated with visual field deterioration in RP patients.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Theresa H. Birtel, Johannes Birtel, Kristina Hess, Amelie C. Clemens, Moritz Lindner, Philipp Herrmann, Frank G. Holz, Martin Gliem
Summary: The study found that patients with RPGR-associated RP have increased RNFL thickness compared to healthy controls, with negative correlations with age, EZ width, and visual acuity. Therapeutic approaches may include gene replacement therapies.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Multidisciplinary Sciences
Xiaoting Mai, Shaofen Huang, Wen Chen, Tsz Kin Ng, Haoyu Chen
Summary: This article presents a small-animal-specific system for OCT examination and a detailed method for image analysis. The OCT examination of mice can facilitate the noninvasive detection and measurement of retinopathy.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Ophthalmology
Wenli Zhang, Tingkun Shi, Shirong Chen, Haoyu Chen
Summary: The study identified subfoveal scleral thickness and spherical equivalent refraction as independent risk factors for peripheral retinal changes (PRC) among children and adolescents with high myopia. Eyes with thinner subfoveal scleral thickness were associated with a higher risk of PRC.
INTERNATIONAL OPHTHALMOLOGY
(2022)
Article
Medicine, General & Internal
Weifen Gong, Haoyu Chen, Fan Yang, Shibin Lin, Chao Li, Geng Wang
Summary: Patients with constant and intermittent exotropia demonstrated larger inter-eye differences in ocular biometric parameters compared to normal control subjects. Early screening and intervention are recommended for children suspected of developing exotropia.
FRONTIERS IN MEDICINE
(2022)
Article
Engineering, Biomedical
Chenpu Yao, Meng Wang, Weifang Zhu, Haifan Huang, Fei Shi, Zhongyue Chen, Lianyu Wang, Tingting Wang, Yi Zhou, Yuanyuan Peng, Liangjiu Zhu, Haoyu Chen, Xinjian Chen
Summary: Hyper-reflective foci (HRF) are spot-shaped, block-shaped areas with high local contrast and reflectivity observed in retinal OCT images. They mainly manifest as hard exudates (HE) and microglia (MG). This paper introduces a novel GD-Net for joint segmentation of HE and MG in OCT images, which outperforms other state-of-the-art methods, demonstrating its effectiveness and potential for medical applications.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Editorial Material
Neurosciences
Dehui Xiang, Haoyu Chen, Jian Zheng, Vishal Jhanji
FRONTIERS IN NEUROSCIENCE
(2022)
Editorial Material
Medicine, General & Internal
Haoyu Chen, Vishal Jhanji, Rupesh Agrawal, Hua Yan
FRONTIERS IN MEDICINE
(2022)
Article
Ophthalmology
Zijing Huang, Kunliang Qiu, Jingsheng Yi, Hongjie Lin, Dezhi Zheng, Dingguo Huang, Guihua Zhang, Haoyu Chen, Jianlong Zheng, Yifan Wang, Danqi Fang, Weiqi Chen
Summary: This study describes the characteristics and treatment outcomes of diabetic retinopathy (DR) patients with extensively large areas of capillary non-perfusion (LACNP). LACNP is a hallmark of advanced DR and is associated with a high incidence of severe neovascular complications. Aggressive treatments can slow down DR progression and maintain visual acuity for a certain period of time.
Article
Ophthalmology
Xiangda Meng, Qihua Wang, Song Chen, Shijie Zhang, Jinguo Yu, Haibo Li, Xinkang Chen, Zhaoyang Wang, Wenzhen Yu, Zhi Zheng, Heding Zhou, Jing Luo, Zhiliang Wang, Haoyu Chen, Nan Wu, Dan Hu, Suihua Chen, Yong Wei, Haibin Cui, Huping Song, Huijin Chen, Yun Wang, Jie Zhong, Zhen Chen, Haokun Zhang, Tiantian Yang, Mengxuan Li, Yuanyuan Liu, Xue Dong, Mei Du, Xiaohong Wang, Xuyang Yao, Haotian Lin, Mulin Jun Li, Hua Yan
Summary: This study developed a machine learning model called "VisionGo" to predict the visual outcomes of vitrectomy surgery in eyes with no light perception (NLP) caused by open globe injury. The model showed better performance than ophthalmologists and the Ocular Trauma Score (OTS) in both pre-vitrectomy and intra-vitrectomy application scenarios. The results indicate that VisionGo is an accurate and reliable tool for predicting visual outcomes in OGI-NLP eyes.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Education & Educational Research
Hongxi Wang, Xulong Liao, Mingzhi Zhang, Chi Pui Pang, Haoyu Chen
Summary: This study compared the effectiveness of smartphone ophthalmoscope (SO) and direct ophthalmoscope (DO) in teaching ophthalmoscopy. The results showed that students scored higher and had better visualization of the fundus when using SO compared to DO.
MEDICAL EDUCATION ONLINE
(2023)
Article
Ophthalmology
Zijing Huang, Jianling Yang, Hongxi Wang, Binyao Chen, Dezhi Zheng, Haoyu Chen
Summary: This study integrated a MOOC into conventional clinical ophthalmology teaching and found that students in the SLMM group performed better in slitlamp practical skills, while those in the VATM group excelled in visual acuity tests. Most students believed that MOOC increased learning interests and motivation, and preferred it as an additional tool to traditional teaching methods rather than a replacement.
ASIA-PACIFIC JOURNAL OF OPHTHALMOLOGY
(2022)
Review
Ophthalmology
Huiyu Liang, Meiqin Zhang, Man Chen, Timothy P. H. Lin, Mingying Lai, Haoyu Chen
Summary: This study aimed to summarize the latest literature on the trends and incidence of ocular trauma during the COVID-19 pandemic. The results showed a reduction in overall eye injuries and significant changes in the spectrum of ocular trauma during the pandemic. The proportion of ocular trauma in eye emergency visits increased, while domestic ocular trauma increased and ocular trauma related to sports, outdoor activities, and occupational factors decreased during the pandemic. Chemical injury, photokeratitis, and mechanical eye injury caused by masks were reported to increase during the COVID-19 pandemic. Proper health education and supervision should be strengthened to prevent ocular injuries related to COVID-19 preventive interventions.
ASIA-PACIFIC JOURNAL OF OPHTHALMOLOGY
(2022)
Review
Ophthalmology
Haifan Huang, Nomdo M. Jansonius, Haoyu Chen, Leonoor I. Los
Summary: This review aimed to evaluate the role of hyperreflective dots (HRDs), detected using OCT, as a predictor of the treatment outcome in patients with diabetic macular edema (DME). Based on the current literature, the HRD numbers decrease with treatment, but it is not clear whether HRDs predict the treatment outcome in patients with DME.
OPHTHALMOLOGY RETINA
(2022)
Proceedings Paper
Computer Science, Interdisciplinary Applications
Ting Wang, Weifang Zhu, Meng Wang, Lianyu Wang, Zhongyue Chen, Tian Lin, Haoyu Chen, Xinjian Chen
Summary: In this study, a novel multi-view-based automatic aided diagnosis method for screening multiple diseases in retinal OCT images is proposed. The method utilizes a multi-view attention network trained on a large dataset of retinal diseases to achieve accurate disease screening. Experimental results demonstrate the effectiveness of the proposed method with an AUC of 0.9023.
MEDICAL IMAGING 2022: IMAGE PROCESSING
(2022)
Proceedings Paper
Computer Science, Interdisciplinary Applications
Chao Guo, Weifang Zhu, Ting Wang, Tian Lin, Haoyu Chen, Xinjian Chen
Summary: In this paper, a deep learning-based VSTA model is proposed for report generation from OCT images. By embedding semantic attention and visual attention into the model, as well as initializing attention weights with semantic tags based on image similarity, the prediction accuracy of the model is improved.
MEDICAL IMAGING 2022: IMAGE PROCESSING
(2022)
Review
Ophthalmology
Vivian W. K. Hui, Simon K. H. Szeto, Fangyao Tang, Dawei Yang, Haoyu Chen, Timothy Y. Y. Lai, Ao Rong, Shaochong Zhang, Peiquan Zhao, Paisan Ruamviboonsuk, Chi-Chun Lai, Andrew Chang, Taraprasad Das, Masahito Ohji, Suber S. Huang, Sobha Sivaprasad, Tien Yin Wong, Dennis S. C. Lam, Carol Y. Cheung
Summary: This review provides an update on spectral-domain OCT (SD-OCT)-based classifications for diabetic macular edema (DME) over the past 5 years. The review summarizes the proposed qualitative and quantitative parameters for DME severity, progression risk, and treatment outcome. It highlights the lack of consensus or guidelines on which parameters can reliably predict treatment outcomes. The review also emphasizes the importance of assessing the validity of biomarkers for treatment outcome and the need to update the current classification of diabetic retinal disease.
ASIA-PACIFIC JOURNAL OF OPHTHALMOLOGY
(2022)
