Article
Optics
Kari V. Vienola, Denise Valente, Robert J. Zawadzki, Ravi S. Jonnal
Summary: Optoretinography (ORG) is a noninvasive and objective tool for testing neural function in the retina. It has the potential to transform ophthalmic care and clinical trials of therapeutics for visual function. The article presents an alternative approach that monitors the velocity of retinal features instead of tracking their positions, reducing the complexity and cost of position-based methods.
Article
Multidisciplinary Sciences
Satoru Kanda, Takumi Hara, Ryosuke Fujino, Keiko Azuma, Hirotsugu Soga, Ryo Asaoka, Ryo Obata, Tatsuya Inoue
Summary: The study found that measuring the low FAF area is very useful for patients with cone-rod dystrophy. AF measurement reflects visual field damage, but not visual acuity (VA).
SCIENTIFIC REPORTS
(2021)
Article
Ophthalmology
Paul. S. Micevych, Jessica Wong, Hao Zhou, Ruikan. K. Wang, Travis. C. Porco, Joseph Carroll, Austin Roorda, Jacque. L. Duncan
Summary: This study compared cone structure and function between patients with RPGR and USH2A-related retinal degeneration. It found that outer retinal structure and choriocapillaris perfusion were more abnormal in patients with RPGR-related retinal degeneration compared to those with USH2A-related retinal degeneration. However, there were no significant differences in below-normal regional sensitivity between rod-cone degeneration associated with variants in these 2 genes expressed at the photoreceptor-connecting cilium.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Medicine, General & Internal
Fabrizio Giansanti, Giulio Vicini, Andrea Sodi, Cristina Nicolosi, Lavinia Bellari, Gianni Virgili, Stanislao Rizzo, Daniela Bacherini
Summary: Optical coherence tomography angiography (OCTA) revealed vascular abnormalities in patients with retinitis pigmentosa (RP), which were associated with choroidal atrophy and visual acuity loss.
Article
Ophthalmology
B. Poornachandra, Devanshi Bhanushali, Mukunda Chaitanya Akkali, Chaitra Jayadev, Vivek Singh, Santosh Gopi Krishna Gadde, Naresh Kumar Yadav
Summary: Adaptive optics is a sensitive and accurate tool to analyze photoreceptor damage in solar retinopathy patients. It can be used as an adjunct for better understanding of the pathology and to observe or predict changes in these patients.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Biochemical Research Methods
Guangying Ma, Taeyoon Son, Tae-Hoon Kim, Xincheng Yao
Summary: The study aims to verify the anatomic correlate of the second outer retina band in OCT using IOS imaging, and demonstrates the potential for concurrent ORG of phototransduction activation and energy metabolism in retinal photoreceptors. The rapid IOS change at the outer segment reflects phototransduction activation, while the slower change at the inner segment may indicate energy metabolism due to mitochondria activation. The consistency of distribution supports the IS ellipsoid as the source of the 2nd OCT band.
JOURNAL OF BIOPHOTONICS
(2021)
Article
Ophthalmology
Danial Roshandel, Tina M. Lamey, Jason Charng, Rachael C. Heath Jeffery, Terri L. McLaren, Jennifer A. Thompson, John N. De Roach, Samuel McLenachan, David A. Mackey, Fred K. Chen
Summary: Microperimetry and adaptive optics imaging revealed early functional and structural changes in asymptomatic RPGR mutation carriers, suggesting the importance of considering these assessments in the clinical evaluation of these patients.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Jasdeep S. Gill, Vasileios Theofylaktopoulos, Andreas Mitsios, Sarah Houston, Ahmed M. Hagag, Adam M. Dubis, Mariya Moosajee
Summary: This study evaluated retinal imaging in USH2A retinopathy patients and found that EZ width is the most sensitive biomarker of structural and functional decline, making it a promising trial endpoint.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Alper Can Yilmaz, Ali Hakan Durukan
Summary: This study aimed to evaluate macular perfusion in retinitis pigmentosa (RP) patients using optical coherence tomography angiography (OCTA), and investigate the correlation between OCTA quantitative data and visual acuity (VA). The results showed reduced choriocapillary flow density, enlarged foveal avascular zone (FAZ), and decreased vessel density in both superficial and deep capillary plexus in RP patients compared to healthy controls. There was also a correlation between OCTA measurements and VA.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Cell Biology
Lucie Crouzier, Camille Diez, Elodie M. Richard, Nicolas Cubedo, Clement Barbereau, Mireille Rossel, Thomas Delaunay, Tangui Maurice, Benjamin Delprat
Summary: Retinitis pigmentosa (RP) is a common inherited retinal degeneration disease with no current treatment available. The zebrafish pde6a(Q70X) mutant serves as an ideal model for studying the progression of RP and potential treatments.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Ophthalmology
Felix Datlinger, Lorenz Wassermann, Adrian Reumueller, Dorottya Hajdu, Irene Steiner, Matthias Salas, Wolfgang Drexler, Michael Pircher, Ursula Schmidt-Erfurth, Andreas Pollreisz
Summary: This study assessed density and morphology of cone photoreceptors and retinal sensitivity in ischemic compared to nonischemic retinal capillary areas of diabetic eyes. Severe alterations of cone PR morphology and reduction of retinal sensitivity were observed in areas affected by capillary nonperfusion, emphasizing the importance of preventing impaired capillary circulation in patients with DR.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Multidisciplinary Sciences
Tae-Hoon Kim, Jie Ding, Xincheng Yao
Summary: This study demonstrates the use of functional optical coherence tomography (OCT) for in vivo monitoring of dark adaptation kinetics in mouse retina. The findings suggest that functional OCT can provide objective assessment of the physiological integrity of retinal photoreceptors and potential for early diagnosis and intervention.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Riccardo Cheloni, Daniel Jackson, Mariya Moosajee
Summary: This study characterized the natural history of patients with X-linked retinitis pigmentosa (RP) caused by RP2 mutations. The study found that patients with RP2 mutations exhibit rapid progression to outer retinal atrophy and early macular involvement, resulting in significant vision loss by age 30-40.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Joao Pedro Marques, Emmanuel Neves, Sara Geada, Ana Luisa Carvalho, Joaquim Murta, Jorge Saraiva, Rufino Silva
Summary: The frequency of CME and ERM is high in RP patients, highlighting the importance of screening for these potentially treatable conditions to improve the quality of life.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Biochemical Research Methods
Xiaoyun Jiang, Teng Liu, Vimal Prabhu Pandiyan, Emily Slezak, Ramkumar Sabesan
Summary: Optoretinography (ORG) has the potential to be an effective biomarker for light-evoked retinal activity. A new system, CoARSE, was developed to capture retinal activity without adaptive optics. The system showed promising results for the clinical application of ORG.
BIOMEDICAL OPTICS EXPRESS
(2022)
Article
Multidisciplinary Sciences
Furu Zhang, Kazuhiro Kurokawa, Ayoub Lassoued, James A. Crowell, Donald T. Miller
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Biochemical Research Methods
Yujia Huang, Michelle Cua, Joshua Brake, Yan Liu, Changhuei Yang
JOURNAL OF BIOMEDICAL OPTICS
(2020)
Article
Nanoscience & Nanotechnology
Jiamiao Yang, Lei Li, Jingwei Li, Zhongtao Cheng, Yan Liu, Lihong V. Wang
Article
Multidisciplinary Sciences
Jiamiao Yang, Lei Li, Anton A. Shemetov, Sangjun Lee, Yuan Zhao, Yan Liu, Yuecheng Shen, Jingwei Li, Yuki Oka, Vladislav V. Verkhusha, Lihong V. Wang
Article
Optics
Haowen Ruan, Yan Liu, Jian Xu, Yujia Huang, Changhuei Yang
Article
Optics
Yan Liu, Ruizhi Cao, Jian Xu, Haowen Ruan, Changhuei Yang
Article
Optics
Yuecheng Shen, Zeyu Hu, Daixuan Wu, Cheng Ma, Yan Liu
Summary: The iterative method described in this work significantly reduces the phase differences between measured phases and desired ones, effectively decreasing phase error in liquid crystal-based spatial light modulators (SLMs). Through Michelson interferometry, this iterative calibration approach demonstrates improved performance in calibrating SLMs for various applications.
OPTICS COMMUNICATIONS
(2021)
Article
Optics
Muhammad Mohsin Qureshi, Yan Liu, Khuong Duy Mac, Minsung Kim, Abdul Mohaimen Safi, Euiheon Chung
Summary: The optical speckle image velocimetry (OSIV) technique provides a quantitative blood flow vector map with high linearity range and temporal resolution, without the need for a high-speed camera. It has been successfully applied to monitor real-time dynamic changes in blood flow during stroke process, offering a valuable tool for studying healthy and diseased brains.
Article
Computer Science, Interdisciplinary Applications
Jingyi Zhu, Chao Liu, Yan Liu, Jiangbo Chen, Yachao Zhang, Kuanming Yao, Lidai Wang
Summary: Researchers have developed a self-fluence-compensated OR-PAM technique to improve the accuracy of sO(2) imaging, especially for brain vascular imaging. Through validation in numerical and physical phantoms, it was found that this compensation method can effectively reduce errors in sO(2) imaging.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2021)
Article
Multidisciplinary Sciences
Jiawei Luo, Yan Liu, Daixuan Wu, Xiao Xu, Lijie Shao, Yuanhua Feng, Jingshun Pan, Jiayu Zhao, Yuecheng Shen, Zhaohui Li
Summary: By developing a quaternary phase encoding scheme, single-exposure time-reversed ultrasonically encoded optical focusing with full-phase modulations is achieved, marking an important step towards in vivo deep tissue applications of wavefront shaping.
Article
Multidisciplinary Sciences
Karen M. Hampson, Raphael Turcotte, Donald T. Miller, Kazuhiro Kurokawa, Jared R. Males, Na Ji, Martin J. Booth
Summary: Adaptive optics is a technique for correcting optical aberrations that has been widely applied in astronomy, vision science, and microscopy. It allows for the detection of retinal changes at the cellular level, study of visual system operation, assessment of ocular health, and advancements in imaging of thick tissue specimens.
NATURE REVIEWS METHODS PRIMERS
(2021)