Synthesis of Indofulvin Pseudo‐Natural Products Yields a New Autophagy Inhibitor Chemotype

Pseudo Natural Products ‐ Chemical Evolution of Natural Product Structure

(2021) Herbert Waldmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Phenotyping reveals the targets of a pseudo-natural product autophagy inhibitor

(2020) Herbert Waldmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Principle and design of pseudo-natural products

(2020) George Karageorgis et al.   Nature Chemistry

Pseudo-natural products and natural product-inspired methods in chemical biology and drug discovery

(2020) Michael Grigalunas et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Morphological Profiling Identifies a Common Mode of Action for Small Molecules with Different Targets

(2020) Tabea Schneidewind et al.   CHEMBIOCHEM

Modulation of autophagy by the novel mitochondrial complex I inhibitor Authipyrin

(2019) Nadine Kaiser et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, Synthesis and Phenotypic Profiling of Pyrano-Furo-Pyridone Pseudo Natural Products

(2019) Herbert Waldmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biomedical Implications of Autophagy in Macromolecule Storage Disorders

(2019) Adina Maria Palhegyi et al.   Frontiers in Cell and Developmental Biology

Synthesis of Indomorphan Pseudo-Natural Product Inhibitors of Glucose Transporters GLUT-1 and -3

(2019) Javier Ceballos et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Controllable Synthesis of Polyheterocyclic Spirooxindoles and 3,3‐Bistryptophol Oxindoles via Fe(ClO 4 ) 3  ⋅ 6H 2 O‐Promoted Hetero‐Pictet‐Spengler Reaction

(2019) Jun‐Rong Song et al.   ADVANCED SYNTHESIS & CATALYSIS

Highly Acidic Conjugate-Base-Stabilized Carboxylic Acids Catalyze Enantioselective oxa-Pictet-Spengler Reactions with Ketals

(2019) Zhengbo Zhu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

(2018) Mario Mauthe et al.   Autophagy

Discovery of the novel autophagy inhibitor aumitin that targets mitochondrial complex I

(2018) Lucas Robke et al.   Chemical Science

Fragment-Based Screening of a Natural Product Library against 62 Potential Malaria Drug Targets Employing Native Mass Spectrometry

(2018) Hoan Vu et al.   ACS Infectious Diseases

Tryptophol and derivatives: natural occurrence and applications to the synthesis of bioactive compounds

(2018) Alessandro Palmieri et al.   NATURAL PRODUCT REPORTS

Chromopynones are pseudo natural product glucose uptake inhibitors targeting glucose transporters GLUT-1 and -3

(2018) George Karageorgis et al.   Nature Chemistry

Autophagy in Cancer: Regulation by Small Molecules

(2018) Allison S. Limpert et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Establishing Consensus Stereostructures for the Naphthoquinonopyrano-γ-lactone Natural Products (-)-Arizonin B1 and (-)-Arizonin C1 by Total Syntheses. Diastereocontrol of Oxa-Pictet-Spengler Cyclizations by Protective-Group Optimization

(2017) Markus Neumeyer et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Data-analysis strategies for image-based cell profiling

(2017) Juan C Caicedo et al.   NATURE METHODS

Design, synthesis and biological evaluation of novel chiral oxazino-indoles as potential and selective neuroprotective agents against Aβ25–35-induced neuronal damage

(2016) Jing Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

p62 links the autophagy pathway and the ubiqutin–proteasome system upon ubiquitinated protein degradation

(2016) Wei Jing Liu et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Hybrid molecules: The privileged scaffolds for various pharmaceuticals

(2016) Shaveta et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Nitrated Confined Imidodiphosphates Enable a Catalytic Asymmetric Oxa-Pictet–Spengler Reaction

(2016) Sayantani Das et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chromosome missegregation during anaphase triggers p53 cell cycle arrest through histone H3.3 Ser31 phosphorylation

(2016) Edward H. Hinchcliffe et al.   NATURE CELL BIOLOGY

Cell Painting, a high-content image-based assay for morphological profiling using multiplexed fluorescent dyes

(2016) Mark-Anthony Bray et al.   Nature Protocols

Design and synthesis of analogues of natural products

(2015) Martin E. Maier   ORGANIC & BIOMOLECULAR CHEMISTRY

The Chemistry of Griseofulvin

(2014) Asger B. Petersen et al.   CHEMICAL REVIEWS

Rational approaches, design strategies, structure activity relationship and mechanistic insights for anticancer hybrids

(2014) Kunal Nepali et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Biology-Oriented Synthesis: Harnessing the Power of Evolution

(2014) Hilde van Hattum et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery of Spiro[cyclohexane-dihydropyrano[3,4-b]indole]-amines as Potent NOP and Opioid Receptor Agonists

(2014) Stefan Schunk et al.   ACS Medicinal Chemistry Letters

Autophagy: A critical regulator of cellular metabolism and homeostasis

(2013) Stefan W. Ryter et al.   MOLECULES AND CELLS

A ring-distortion strategy to construct stereochemically complex and structurally diverse compounds from natural products

(2013) Robert W. Huigens III et al.   Nature Chemistry

Multiplex Cytological Profiling Assay to Measure Diverse Cellular States

(2013) Sigrun M. Gustafsdottir et al.   PLoS One

Catalytic enantioselective synthesis of 2-(2-hydroxyethyl)indole scaffolds via consecutive intramolecular amido-cupration of allenes and asymmetric addition of carbonyl compounds

(2013) Prasanna Kumara Chikkade et al.   Chemical Science

A Natural Product Inspired Tetrahydropyran Collection Yields Mitosis Modulators that Synergistically Target CSE1L and Tubulin

(2012) Tobias Voigt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Autophagy-regulating small molecules and their therapeutic applications

(2012) Kyung-Hwa Baek et al.   CHEMICAL SOCIETY REVIEWS

Why is autophagy important in human diseases?

(2012) Kaipeng Jing et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Natural-product-derived fragments for fragment-based ligand discovery

(2012) Björn Over et al.   Nature Chemistry

The Pictet-Spengler Reaction in Nature and in Organic Chemistry

(2011) Joachim Stöckigt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

(2011) Jisun Lee et al.   BIOCHEMICAL JOURNAL

Mitochondria and autophagy: Critical interplay between the two homeostats

(2011) Koji Okamoto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Hybrid Molecules Incorporating Natural Products: Applications in Cancer Therapy, Neurodegenerative Disorders and Beyond

(2011) M. Decker   CURRENT MEDICINAL CHEMISTRY

Synthesis of Oxacycles Employing the Oxa-Pictet-Spengler Reaction: Recent Developments and New Prospects

(2011) Enrique L. Larghi et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Triflic acid adsorbed on silica gel as an efficient and recyclable catalyst for the addition of β-dicarbonyl compounds to alcohols and alkenes

(2010) Pei Nian Liu et al.   GREEN CHEMISTRY

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Screen for Chemical Modulators of Autophagy Reveals Novel Therapeutic Inhibitors of mTORC1 Signaling

(2009) Aruna D. Balgi et al.   PLoS One

Natural products as an inspiration in the diversity-oriented synthesis of bioactive compound libraries

(2008) Christopher Cordier et al.   NATURAL PRODUCT REPORTS

Natural Product-likeness Score and Its Application for Prioritization of Compound Libraries

(2007) Peter Ertl et al.   Journal of Chemical Information and Modeling