Human embryo research, stem cell-derived embryo models and in vitro gametogenesis: Considerations leading to the revised ISSCR guidelines

The ISSCR Guidelines for Stem Cell Research and Clinical Translation were last revised in 2016. Since then, rapid progress has been made in research areas related to in vitro culture of human embryos, creation of stem cell-based embryo models, and in vitro gametogenesis. Therefore, a working group of international experts was convened to review the oversight process and provide an update to the guidelines. This report captures the discussion and summarizes the major recommendations made by this working group, with a specific emphasis on updating the categories of review and engagement with the specialized scientific and ethical oversight process.

Automated summary

Since the last revision in 2016, the ISSCR Guidelines for Stem Cell Research and Clinical Translation have seen rapid progress in research areas related to in vitro culture of human embryos, creation of stem cell-based embryo models, and in vitro gametogenesis. An international working group was convened to review the oversight process and provide an update to the guidelines, emphasizing on updating the categories of review and engagement with specialized scientific and ethical oversight process.