Article
Endocrinology & Metabolism
Yizhuo Wang, Xiuhua Xu, Ai-min Yang, Jie Zhang, Zhuo-ye Luo, Yan Han, Na Cui, Qian Li, Baojun Shi, Zhi-ming Zhao, Gui-min Hao
Summary: This study aimed to investigate the optimal E-2 level to maximize the clinical pregnancy rate after fresh embryo transfer. By analyzing the serum E-2 levels and pregnancy outcomes, it was found that the maximal CPR was achieved when the serum E-2 level on the day of GnRH-ant initiation was 498 pg/ml, while CPR significantly declined when E-2 was greater than 894.4 pg/ml.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Genetics & Heredity
Zhishuai Zhang, Zhiyuan Sui, Jihu Zhang, Qingjin Li, Yongjie Zhang, Feng Xing
Summary: In this study, the genes associated with the initiation of puberty in Dolang sheep were explored using RNA-seq analysis. A total of 10 genes that have direct or indirect functions in the initiation of puberty in Dolang sheep were screened. The reliability of the RNA-Seq data was verified using quantitative real-time PCR. This study provided theoretical basis and candidate genes for the breeding of early-pubertal sheep and was beneficial for the protection, development, and utilization of the genetic resources of Xinjiang local sheep.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Esra Kutlu, Lker Tolga Ozgen, Huri Bulut, Abdurrahim Kocyigit, Savas Ustunova, Onder Huseyinbas, Emel Torun, Yasar Cesur
Summary: The study aimed to investigate the effects of irisin on pubertal development and the HPG axis in rats. The results showed that irisin triggered the onset of puberty in a dose-dependent manner and caused the excitatory system to dominate in the hypothalamic GnRH pulse generator.
Review
Cell Biology
Martin Montecino, Margarita E. Carrasco, Gino Nardocci
Summary: Genomic DNA in the eukaryotic nucleus is organized into chromatin through stable interactions with histone proteins and other nuclear components, contributing to differential control of access to key genetic information. Epigenetic mechanisms, such as DNA methylation and chromatin remodeling, play critical roles in regulating gene expression by modifying chromatin compaction levels for transcription activation and repression. The review discusses evidence supporting the role of these mechanisms in the transcriptional control of osteoblast-related genes, particularly at the Runx2 and Sp7 genes, which encode master regulators of osteogenic lineage.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Behavioral Sciences
Chih-Hsiang Lin, Sung-Chou Li, Ming-Hong Lin, Chen-Jui Ho, Yan-Ting Lu, Yuyu Lin, Pei-Hsien Lin, Kuo-Wang Tsai, Meng-Han Tsai
Summary: This study found that the methylation level of S100A6 gene was decreased in patients with autoimmune encephalitis (AE), and S100A6 promoted the infiltration of B lymphocytes across the blood-brain barrier. S100A6 antibodies could counteract the effect of S100A6, which may be a potential treatment target for AE.
BRAIN AND BEHAVIOR
(2023)
Article
Neurosciences
Matthew J. Armstrong, Yulin Jin, Selina M. Vattathil, Yanting Huang, Jason P. Schroeder, David A. Bennet, Zhaohui S. Qin, Thomas S. Wingo, Peng Jin
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder influenced by a complex interplay of environmental, epigenetic, and genetic factors. This study suggests that TET enzymes, particularly TET1, may contribute to AD pathogenesis by regulating the methylome. The loss of TET1 function increases AD-associated pathology.
NEUROBIOLOGY OF DISEASE
(2023)
Review
Medicine, Research & Experimental
Jiang Liu, Tangluo Li, Mindan Peng, Min Luo, Zihao Gui, Shuanglian Long, Zhongcheng Mo, Weiguo He
Summary: Makorin RING finger protein 3 (MKRN3) plays a crucial role in the development of pubertal onset by inhibiting the secretion of gonadotropin-releasing hormone (GnRH). Mutations of MKRN3 are the most common genetic cause of central precocious puberty (CPP). Recent studies have elucidated the functional mechanisms of MKRN3 in pubertal initiation and the occurrence of CPP.
CURRENT MOLECULAR MEDICINE
(2023)
Article
Cell Biology
Yuancheng Peng, Shan Jiang, Jiayu Wang, Xuewei Xu, Ximing Gong, Weihuan Jin, Chunxia Song, Zhiqiang Dong, Siyu Sun, Yunhai Li, Hao Yu
Summary: DA3 regulates lateral root initiation by modulating auxin signaling in the pericycle and endodermis. It negatively affects the levels of ARF7 and ARF19, but positively regulates the stability of SHY2/IAA3. DA3 inhibits the binding of ARF7 and ARF19 to LBD16, repressing its expression in the pericycle. Overall, DA3 acts with SHY2, ARF7, and ARF19 to coordinate auxin signaling and control lateral root initiation in Arabidopsis.
Article
Biochemistry & Molecular Biology
Noha Mousaad Elemam, Abdullah Imadeddin Malek, Esraa Elaraby Mahmoud, Waseem El-Huneidi, Iman M. Talaat
Summary: The BMP antagonist Gremlin-1 plays a crucial role in tissue differentiation and embryonic development. It can exert its function through both BMP dependent and independent pathways. Gremlin-1 is also involved in organ fibrosis and has recently been implicated in the initiation and progression of various types of cancers. Additionally, it contributes to the stemness state of cancer cells. This review explores the role of Gremlin-1 in breast, cervical, colorectal, and gastric cancers, as well as glioblastomas, and highlights its impact on cellular processes and signaling pathways involved in carcinogenesis. Gremlin-1 is suggested to be a promising prognostic biomarker and therapeutic target in cancer.
Article
Multidisciplinary Sciences
Ryan J. Smith, Minggao Liang, Adrian Kwan Ho Loe, Theodora Yung, Ji-Eun Kim, Matthew Hudson, Michael D. Wilson, Tae-Hee Kim
Summary: In this study, the researchers found that gastrointestinal mesenchymal cells control epithelial fate and function through Polycomb Repressive Complex 2-mediated chromatin bivalency. The results highlight the importance of mesenchymal-epithelial crosstalk in gut development and stem cell homeostasis.
NATURE COMMUNICATIONS
(2023)
Review
Cell Biology
Alicja Walewska, Adrian Janucik, Marlena Tynecka, Marcin Moniuszko, Andrzej Eljaszewicz
Summary: Mesenchymal stem cells (MSC) are versatile stem cells with the ability to differentiate into multiple cell types and modulate immune responses. Epigenetic modifications play a critical role in controlling MSC differentiation.
CELL DEATH & DISEASE
(2023)
Review
Cell Biology
Daniela Mauceri
Summary: Pain is an unpleasant sensation resulting from tissue damage, and when it persists after the injury has resolved, it becomes pathological. The transition from acute to chronic pain involves plasticity events along the neural pathways and alterations in gene expression. Epigenetic mechanisms play a crucial role in these adaptive processes in the nervous system.
Article
Computer Science, Interdisciplinary Applications
Apoorva Nisal, Urmila Diwekar, Elie Hobeika
Summary: This article discusses the importance of superovulation in the IVF process and the need for customized dosage protocols, as well as the development of a mathematical algorithm to provide personalized superovulation models.
COMPUTERS & CHEMICAL ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Zach H. Gray, Damayanti Chakraborty, Reuben R. Duttweiler, Gulnaz D. Alekbaeva, Sedona E. Murphy, Kashish Chetal, Fei Ji, Benjamin I. Ferman, Madison A. Honer, Zhentian Wang, Cynthia Myers, Renhong Sun, H. Umit Kaniskan, Monika Maria Toma, Elena A. Bondarenko, John N. Santoro, Christopher Miranda, Megan E. Dillingham, Ran Tang, Or Gozani, Jian Jin, Tomasz Skorski, Cihangir Duy, Hayan Lee, Ruslan I. Sadreyev, Johnathan R. Whetstine
Summary: MLL/KMT2A amplifications and rearrangements in leukemia are regulated by the balance of histone H3 lysine 9 mono- and di-methylation (H3K9me1/2) at the MLL/KMT2A locus. This balance is controlled by the interaction between lysine demethylase KDM3B and methyltransferase G9a/EHMT2. This study provides insights into the molecular mechanisms of MLL/KMT2A alterations and identifies potential drug targets for therapeutic intervention.
Review
Pathology
Soudeh Ghafouri-Fard, Hamed Shoorei, Toofan Sabernia, Bashdar Mahmud Hussen, Mohammad Taheri, Hasan Pourmoshtagh
Summary: CircRNAs play an important role in immune-related disorders by regulating immune system function and contributing to pathophysiology.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Oncology
Yihang Shen, Yuan-Hao Lee, Jayabal Panneerselvam, Jun Zhang, Lenora W. M. Loo, Peiwen Fei
Article
Pathology
Taotao Dong, Dong Yang, Rui Li, Lu Zhang, Hongchao Zhao, Yihang Shen, Xiaoli Zhang, Beihua Kong, Linlin Wang
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2016)
Article
Oncology
Bing Han, Yihang Shen, Piyan Zhang, Panneerselvam Jayabal, Raymond Che, Jun Zhang, Herbert Yu, Peiwen Fei
Article
Oncology
Shasha Zhou, Yihang Shen, Min Zheng, Linlin Wang, Raymond Che, Wanning Hu, Pin Li
Article
Oncology
Linlin Wang, Dong Yang, Jing Tian, Aiqin Gao, Yihang Shen, Xia Ren, Xia Li, Guosheng Jiang, Taotao Dong
Letter
Cell Biology
Linlin Wang, Yan Xue, Yihang Shen, Wei Li, Yan Cheng, Xiaoshuang Yan, Wansheng Shi, Juan Wang, Zhijuan Gong, Guanheng Yang, Chuanliang Guo, Yiye Zhou, Xiang Wang, Qi Zhou, Fanyi Zeng
Article
Multidisciplinary Sciences
Panneerselvam Jayabal, Chi Ma, Manoj Nepal, Yihang Shen, Raymond Che, James Turkson, Peiwen Fei
SCIENTIFIC REPORTS
(2017)
Article
Cell Biology
Chi Ma, Kanani Hokutan, Yihang Shen, Manoj Nepal, Jin-Hee Kim, Jun Zhang, Peiwen Fei
Article
Genetics & Heredity
Yihang Shen, Shasha Zhou, Xiaodong Zhao, Hua Li, Jielin Sun
FRONTIERS IN GENETICS
(2020)
Article
Biochemistry & Molecular Biology
Shasha Zhou, Shaolian Zang, Yanping Hu, Yifen Shen, Hua Li, Wenlian Chen, Pin Li, Yihang Shen
Summary: This study investigated the gene expression patterns in different pubertal stages in the hypothalamus and identified a subset of kisspeptin neurons using a specific membrane surface biomarker. It was also found that different cell types in the hypothalamus have distinct functions in neurogenesis, hormone secretion, and estradiol response, contributing to the complex regulatory network of the hypothalamic-pituitary-gonadal axis.
CELL AND BIOSCIENCE
(2022)
Article
Medicine, Research & Experimental
Yihang Shen, Hongchao Zhao, Lei Zhang, Yanping Hu, Li Cai, Jun Li, Shasha Zhou
Summary: The study revealed that changes in DNA hydroxymethylation and DNA methylation were associated with gene expression patterns during puberty in the arcuate nucleus, with SINEs playing a regulatory role in gene expression.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Cell Biology
Yanping Hu, Yifen Shen, Yang Zhao, Ying Tang, Chao Liu, Yongchun Gu, Tao Yang, Yihang Shen
Summary: In this study, ChIP-seq was used to investigate the genome-wide distribution of activated STAT proteins in colorectal cancer cells. It was found that the homodimers of STAT proteins predominantly occupied genomic DNA and STAT3 accounted for the largest proportion. The binding motif targeted by different STAT homodimers suggested distinct biological functions. The study also revealed NR5A2 as a specific co-activator of STAT3 and its role in CRC. These findings provide new insights into the design of STAT inhibitors for treating CRC and other diseases.
Article
Immunology
Yanping Hu, Jiuzhou Zhao, Yihang Shen, Chengjuan Zhang, Qingxin Xia, Guoqiang Zhang, Bo Wang, Bing Wei, Rentao Yu, Jie Ma, Yongjun Guo
Summary: The study found that CD8 + CD279+ cells are an independent prognostic factor for DFS in CRC patients, with high levels of CD8 + CD279+ cells associated with better DFS.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)