Recent research progress on circular RNAs: Biogenesis, properties, functions, and therapeutic potential

isoCirc catalogs full-length circular RNA isoforms in human transcriptomes

(2021) Ruijiao Xin et al.   Nature Communications

Hsa_circ_0070963 inhibits liver fibrosis via regulation of miR-223-3p and LEMD3

(2020) Dong Ji et al.   Aging-US

A Highly Conserved Circular RNA Is Required to Keep Neural Cells in a Progenitor State in the Mammalian Brain

(2020) Christin Suenkel et al.   Cell Reports

Deep Insights in Circular RNAs: from biogenesis to therapeutics

(2020) Peerzada Tajamul Mumtaz et al.   BIOLOGICAL PROCEDURES ONLINE

Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output

(2020) Qiyi Zhao et al.   CELL

CRISPR/Cas9: A preclinical and clinical perspective for the treatment of human diseases

(2020) Garima Sharma et al.   MOLECULAR THERAPY

Roles of circular RNAs in diabetic complications: From molecular mechanisms to therapeutic potential

(2020) Ji-Ru Zhang et al.   GENE

CircCDKN2B-AS1 interacts with IMP3 to stabilize hexokinase 2 mRNA and facilitate cervical squamous cell carcinoma aerobic glycolysis progression

(2020) Yanan Zhang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Tumor promoting effects of circRNA_001287 on renal cell carcinoma through miR-144-targeted CEP55

(2020) Jiafu Feng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Reconstruction of full-length circular RNAs enables isoform-level quantification

(2019) Yi Zheng et al.   Genome Medicine

Circular RNA Profiling by Illumina Sequencing via Template-Dependent Multiple Displacement Amplification

(2019) Ashirbad Guria et al.   Biomed Research International

Expanded Expression Landscape and Prioritization of Circular RNAs in Mammals

(2019) Peifeng Ji et al.   Cell Reports

Genome-wide profiling of circular RNAs in the rapidly growing shoots of moso bamboo (Phyllostachys edulis)

(2019) Yongsheng Wang et al.   PLANT AND CELL PHYSIOLOGY

A novel protein encoded by a circular RNA circPPP1R12A promotes tumor pathogenesis and metastasis of colon cancer via Hippo-YAP signaling

(2019) Xiao Zheng et al.   Molecular Cancer

hsa_circRNA_104597: a novel potential diagnostic and therapeutic biomarker for schizophrenia

(2019) Gaofeng Yao et al.   Biomarkers in Medicine

Structure and Degradation of Circular RNAs Regulate PKR Activation in Innate Immunity

(2019) Chu-Xiao Liu et al.   CELL

CircRASSF2 promotes laryngeal squamous cell carcinoma progression by regulating the miR-302b-3p/IGF-1R axis

(2019) Linli Tian et al.   CLINICAL SCIENCE

Circular RNA MAT2B Promotes Glycolysis and Malignancy of Hepatocellular Carcinoma Through the miR‐338‐3p/PKM2 Axis Under Hypoxic Stress

(2019) Qing Li et al.   HEPATOLOGY

Highly efficient expression of circular RNA aptamers in cells using autocatalytic transcripts

(2019) Jacob L. Litke et al.   NATURE BIOTECHNOLOGY

Characterization and cloning of grape circular RNAs identified the cold resistance-related Vv-circATS1

(2019) Zhen Gao et al.   PLANT PHYSIOLOGY

CircMTO1 inhibits liver fibrosis via regulation of miR‐17‐5p and Smad7

(2019) Wei Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Splicing factor derived circular RNA circUHRF1 accelerates oral squamous cell carcinoma tumorigenesis via feedback loop

(2019) Wei Zhao et al.   CELL DEATH AND DIFFERENTIATION

Circular RNAs: Biogenesis, Mechanism, and Function in Human Cancers

(2019) Xing Zhao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A unified mechanism for intron and exon definition and back-splicing

(2019) Xueni Li et al.   NATURE

The biogenesis, biology and characterization of circular RNAs

(2019) Lasse S. Kristensen et al.   NATURE REVIEWS GENETICS

Defining an evolutionarily conserved role of GW182 in circular RNA degradation

(2019) Ruirui Jia et al.   Cell Discovery

TGF-β- and lipopolysaccharide-induced upregulation of circular RNA PWWP2A promotes hepatic fibrosis via sponging miR-203 and miR-223

(2019) Wentao Liu et al.   Aging-US

Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis

(2019) Venkata Naga Srikanth Garikipati et al.   Nature Communications

Downregulated circular RNA hsa_circ_0001649 regulates proliferation, migration and invasion in cholangiocarcinoma cells

(2018) Yi Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hsa_circ_0000520, a potential new circular RNA biomarker, is involved in gastric carcinoma

(2018) Handong Sun et al.   Cancer Biomarkers

A Network of Noncoding Regulatory RNAs Acts in the Mammalian Brain

(2018) Benjamin Kleaveland et al.   CELL

A length-dependent evolutionarily conserved pathway controls nuclear export of circular RNAs

(2018) Chuan Huang et al.   GENES & DEVELOPMENT

A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion

(2018) Pengyan Xia et al.   IMMUNITY

Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma

(2018) Jian Yu et al.   JOURNAL OF HEPATOLOGY

A-to-I RNA editing — immune protector and transcriptome diversifier

(2018) Eli Eisenberg et al.   NATURE REVIEWS GENETICS

A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis

(2018) Maolei Zhang et al.   ONCOGENE

Balance between MAT2A intron detention and splicing is determined cotranscriptionally

(2018) Kathryn E. Pendleton et al.   RNA

Computational Strategies for Exploring Circular RNAs

(2018) Yuan Gao et al.   TRENDS IN GENETICS

Engineering circular RNA for potent and stable translation in eukaryotic cells

(2018) R. Alexander Wesselhoeft et al.   Nature Communications

Circular RNAs as novel regulators of β-cell functions in normal and disease conditions

(2018) Lisa Stoll et al.   Molecular Metabolism

CircScd1 Promotes Fatty Liver Disease via the Janus Kinase 2/Signal Transducer and Activator of Transcription 5 Pathway

(2018) Peifei Li et al.   DIGESTIVE DISEASES AND SCIENCES

CiRS-7 promotes growth and metastasis of esophageal squamous cell carcinoma via regulation of miR-7/HOXB13

(2018) Rui-chao Li et al.   Cell Death & Disease

Tissue-Dependent Expression and Translation of Circular RNAs with Recombinant AAV Vectors In Vivo

(2018) Rita M. Meganck et al.   Molecular Therapy-Nucleic Acids

CIRCpedia v2: An Updated Database for Comprehensive Circular RNA Annotation and Expression Comparison

(2018) Rui Dong et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Circular RNA circAGO2 drives cancer progression through facilitating HuR-repressed functions of AGO2-miRNA complexes

(2018) Yajun Chen et al.   CELL DEATH AND DIFFERENTIATION

CircRNA has_circ_0078710 acts as the sponge of microRNA-31 involved in hepatocellular carcinoma progression

(2018) Binhui Xie et al.   GENE

Differential expression of circular RNAs in hepatic tissue in a model of liver fibrosis and functional analysis of their target genes

(2018) Yuping Zhou et al.   HEPATOLOGY RESEARCH

A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma

(2018) Maolei Zhang et al.   Nature Communications

Evaluation of the inclusion of circular RNAs in mRNA profiling in forensic body fluid identification

(2017) Yaqi Zhang et al.   INTERNATIONAL JOURNAL OF LEGAL MEDICINE

Overexpression of Circular RNA ciRS-7 Abrogates the Tumor Suppressive Effect of miR-7 on Gastric Cancer via PTEN/PI3K/AKT Signaling Pathway

(2017) Haiyan Pan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Novel Role of FBXW7 Circular RNA in Repressing Glioma Tumorigenesis

(2017) Yibing Yang et al.   JNCI-Journal of the National Cancer Institute

Circular RNA_LARP4 inhibits cell proliferation and invasion of gastric cancer by sponging miR-424-5p and regulating LATS1 expression

(2017) Jing Zhang et al.   Molecular Cancer

Translation of CircRNAs

(2017) Nagarjuna Reddy Pamudurti et al.   MOLECULAR CELL

Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis

(2017) Ivano Legnini et al.   MOLECULAR CELL

The Output of Protein-Coding Genes Shifts to Circular RNAs When the Pre-mRNA Processing Machinery Is Limiting

(2017) Dongming Liang et al.   MOLECULAR CELL

Sensing Self and Foreign Circular RNAs by Intron Identity

(2017) Y. Grace Chen et al.   MOLECULAR CELL

DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome

(2017) Tuğçe Aktaş et al.   NATURE

CSCD: a database for cancer-specific circular RNAs

(2017) Siyu Xia et al.   NUCLEIC ACIDS RESEARCH

Circular RNAs in cancer: opportunities and challenges in the field

(2017) L S Kristensen et al.   ONCOGENE

Circular RNAs are abundantly expressed and upregulated during human epidermal stem cell differentiation

(2017) Lasse Sommer Kristensen et al.   RNA Biology

Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1

(2017) Kotb Abdelmohsen et al.   RNA Biology

Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function

(2017) Monika Piwecka et al.   SCIENCE

The circular RNA circBIRC6 participates in the molecular circuitry controlling human pluripotency

(2017) Chun-Ying Yu et al.   Nature Communications

FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons

(2017) Lorenzo Errichelli et al.   Nature Communications

Regulation of microRNAs function by circular RNAs in human cancer

(2017) Chao Han et al.   Oncotarget

Circular RNA hsa_circ_000984 promotes colon cancer growth and metastasis by sponging miR-106b

(2017) Xiao-Wu Xu et al.   Oncotarget

Peripheral blood circular RNA hsa_circ_0124644 can be used as a diagnostic biomarker of coronary artery disease

(2017) Zhenzhou Zhao et al.   Scientific Reports

A Circular RNA Binds To and Activates AKT Phosphorylation and Nuclear Localization Reducing Apoptosis and Enhancing Cardiac Repair

(2017) Yan Zeng et al.   Theranostics

Genome-Wide Maps of m6A circRNAs Identify Widespread and Cell-Type-Specific Methylation Patterns that Are Distinct from mRNAs

(2017) Chan Zhou et al.   Cell Reports

Identification of Circular RNAs and Their Targets in Leaves of Triticum aestivum L. under Dehydration Stress

(2017) Yuexia Wang et al.   Frontiers in Plant Science

Novel Role of FBXW7 Circular RNA in Repressing Glioma Tumorigenesis

(2017) Yibing Yang et al.   JNCI-Journal of the National Cancer Institute

Circular RNA expression is abundant and correlated to aggressiveness in early-stage bladder cancer

(2017) Trine Line Hauge Okholm et al.   npj Genomic Medicine

Genome-wide identification and characterization of circular RNAs by high throughput sequencing in soybean

(2017) Wei Zhao et al.   Scientific Reports

Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity

(2016) William W Du et al.   CELL DEATH AND DIFFERENTIATION

Dnmt3a and Dnmt3b Associate with Enhancers to Regulate Human Epidermal Stem Cell Homeostasis

(2016) Lorenzo Rinaldi et al.   Cell Stem Cell

Circular RNAs: analysis, expression and potential functions

(2016) Steven P. Barrett et al.   DEVELOPMENT

Diverse alternative back-splicing and alternative splicing landscape of circular RNAs

(2016) Xiao-Ou Zhang et al.   GENOME RESEARCH

Comprehensive Circular RNA Profiling Reveals That hsa_circ_0005075, a New Circular RNA Biomarker, Is Involved in Hepatocellular Crcinoma Development

(2016) Xingchen Shang et al.   MEDICINE

The rules and impact of nonsense-mediated mRNA decay in human cancers

(2016) Rik G H Lindeboom et al.   NATURE GENETICS

Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2

(2016) William W. Du et al.   NUCLEIC ACIDS RESEARCH

Identification of senescence-associated circular RNAs (SAC-RNAs) reveals senescence suppressor CircPVT1

(2016) Amaresh C. Panda et al.   NUCLEIC ACIDS RESEARCH

Circular RNAs: Unexpected outputs of many protein-coding genes

(2016) Jeremy E. Wilusz   RNA Biology

The emerging landscape of circular RNA in life processes

(2016) Shibin Qu et al.   RNA Biology

Dissecting the secondary structure of the circular RNA of a nuclear viroid in vivo: A “naked” rod-like conformation similar but not identical to that observed in vitro

(2016) Amparo López-Carrasco et al.   RNA Biology

Messenger RNA modifications: Form, distribution, and function

(2016) W. V. Gilbert et al.   SCIENCE

Circular RNA Expression: Its Potential Regulation and Function

(2016) Julia Salzman   TRENDS IN GENETICS

Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs

(2016) Qiupeng Zheng et al.   Nature Communications

Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans

(2016) Lesca M. Holdt et al.   Nature Communications

Circular RNA ZNF609 functions as a competitive endogenous RNA to regulate AKT3 expression by sponging miR-150-5p in Hirschsprung’s disease

(2016) Lei Peng et al.   Oncotarget

The Biogenesis of Nascent Circular RNAs

(2016) Yang Zhang et al.   Cell Reports

Circular RNA Related to the Chondrocyte ECM Regulates MMP13 Expression by Functioning as a MiR-136 ‘Sponge’ in Human Cartilage Degradation

(2016) Qiang Liu et al.   Scientific Reports

Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma

(2016) Zhenyu Zhong et al.   Scientific Reports

circRNADb: A comprehensive database for human circular RNAs with protein-coding annotations

(2016) Xiaoping Chen et al.   Scientific Reports

miRs-138 and -424 control palmitoylation-dependent CD95-mediated cell death by targeting acyl protein thioesterases 1 and 2 in CLL

(2015) V. Berg et al.   BLOOD

The RNA Binding Protein Quaking Regulates Formation of circRNAs

(2015) Simon J. Conn et al.   CELL

Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis

(2015) Yan Li et al.   CELL RESEARCH

Using circular RNA as a novel type of biomarker in the screening of gastric cancer

(2015) Peifei Li et al.   CLINICA CHIMICA ACTA

MicroRNA-138 regulates the balance of Th1/Th2 via targeting RUNX3 in psoriasis

(2015) Dandan Fu et al.   IMMUNOLOGY LETTERS

Exon Skipping Is Correlated with Exon Circularization

(2015) Steven Kelly et al.   JOURNAL OF MOLECULAR BIOLOGY

Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed

(2015) Agnieszka Rybak-Wolf et al.   MOLECULAR CELL

Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes

(2015) Søren Lykke-Andersen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Exon-intron circular RNAs regulate transcription in the nucleus

(2015) Zhaoyong Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Widespread noncoding circular RNAs in plants

(2015) Chu-Yu Ye et al.   NEW PHYTOLOGIST

RNA circularization strategies in vivo and in vitro

(2015) Sonja Petkovic et al.   NUCLEIC ACIDS RESEARCH

Metazoan tRNA introns generate stable circular RNAs in vivo

(2015) Zhipeng Lu et al.   RNA

Transcriptome-wide investigation of circular RNAs in rice

(2015) Tingting Lu et al.   RNA

Exon-intron circular RNAs regulate transcription in the nucleus

(2015) Zhaoyong Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rolling Circle Translation of Circular RNA in Living Human Cells

(2015) Naoko Abe et al.   Scientific Reports

Exon Circularization Requires Canonical Splice Signals

(2015) Stefan Starke et al.   Cell Reports

Analysis of Intron Sequences Reveals Hallmarks of Circular RNA Biogenesis in Animals

(2015) Andranik Ivanov et al.   Cell Reports

Single-cell RNA-seq transcriptome analysis of linear and circular RNAs in mouse preimplantation embryos

(2015) Xiaoying Fan et al.   GENOME BIOLOGY

CIRI: an efficient and unbiased algorithm for de novo circular RNA identification

(2015) Yuan Gao et al.   GENOME BIOLOGY

The circular RNA Cdr1as, via miR-7 and its targets, regulates insulin transcription and secretion in islet cells

(2015) Huanyu Xu et al.   Scientific Reports

Biogenesis of Circular RNAs

(2014) Quentin Vicens et al.   CELL

Complementary Sequence-Mediated Exon Circularization

(2014) Xiao-Ou Zhang et al.   CELL

FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis

(2014) Xu Zhao et al.   CELL RESEARCH

Short intronic repeat sequences facilitate circular RNA production

(2014) Dongming Liang et al.   GENES & DEVELOPMENT

Widespread intron retention in mammals functionally tunes transcriptomes

(2014) Ulrich Braunschweig et al.   GENOME RESEARCH

Circulating microRNA expression profiles in ovarian cancer

(2014) L. Ayaz et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY

circRNA Biogenesis Competes with Pre-mRNA Splicing

(2014) Reut Ashwal-Fluss et al.   MOLECULAR CELL

Detecting and characterizing circular RNAs

(2014) William R Jeck et al.   NATURE BIOTECHNOLOGY

Coupling mRNA processing with transcription in time and space

(2014) David L. Bentley   NATURE REVIEWS GENETICS

Repetitive RNA unwinding by RNA helicase A facilitates RNA annealing

(2014) Hye Ran Koh et al.   NUCLEIC ACIDS RESEARCH

Circular RNA Is Expressed across the Eukaryotic Tree of Life

(2014) Peter L. Wang et al.   PLoS One

Efficient backsplicing produces translatable circular mRNAs

(2014) Yang Wang et al.   RNA

Up-regulation of microRNA-138 induce radiosensitization in lung cancer cells

(2014) Hui Yang et al.   TUMOR BIOLOGY

Genome-wide Analysis of Drosophila Circular RNAs Reveals Their Structural and Sequence Properties and Age-Dependent Neural Accumulation

(2014) Jakub O. Westholm et al.   Cell Reports

The functional consequences of intron retention: Alternative splicing coupled to NMD as a regulator of gene expression

(2013) Ying Ge et al.   BIOESSAYS

MicroRNA-138 suppresses ovarian cancer cell invasion and metastasis by targeting SOX4 and HIF-1α

(2013) Yu-Ming Yeh et al.   INTERNATIONAL JOURNAL OF CANCER

Down-regulation of miR-138 promotes colorectal cancer metastasis via directly targeting TWIST2

(2013) Limin Long et al.   Journal of Translational Medicine

Circular Intronic Long Noncoding RNAs

(2013) Yang Zhang et al.   MOLECULAR CELL

Natural RNA circles function as efficient microRNA sponges

(2013) Thomas B. Hansen et al.   NATURE

Circular RNAs are a large class of animal RNAs with regulatory potency

(2013) Sebastian Memczak et al.   NATURE

From pseudo-ceRNAs to circ-ceRNAs: a tale of cross-talk and competition

(2013) Riccardo Taulli et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cell-Type Specific Features of Circular RNA Expression

(2013) Julia Salzman et al.   PLoS Genetics

Circular RNA (circRNA) in Alzheimer's disease (AD)

(2013) Walter J. Lukiw   Frontiers in Genetics

microRNA-7 is a novel inhibitor of YY1 contributing to colorectal tumorigenesis

(2012) N Zhang et al.   ONCOGENE

MicroRNA-7 functions as an anti-metastatic microRNA in gastric cancer by targeting insulin-like growth factor-1 receptor

(2012) X Zhao et al.   ONCOGENE

Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types

(2012) Julia Salzman et al.   PLoS One

Circular RNAs are abundant, conserved, and associated with ALU repeats

(2012) W. R. Jeck et al.   RNA

miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA

(2011) Thomas B Hansen et al.   EMBO JOURNAL

CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing

(2011) Sanjeev Shukla et al.   NATURE

Genomewide characterization of non-polyadenylated RNAs

(2011) Li Yang et al.   GENOME BIOLOGY

Repression of  -synuclein expression and toxicity by microRNA-7

(2009) E. Junn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

microRNA-7 Inhibits the Epidermal Growth Factor Receptor and the Akt Pathway and Is Down-regulated in Glioblastoma

(2008) B. Kefas et al.   CANCER RESEARCH

MicroRNA-7, a Homeobox D10 Target, Inhibits p21-Activated Kinase 1 and Regulates Its Functions

(2008) S. D. N. Reddy et al.   CANCER RESEARCH