Article
Multidisciplinary Sciences
Zuozhong Xie, Hong Xiang, Jingkun Li, Xiaowei Zhang, Wei Li, Guolin Tan
Summary: This study demonstrates that SNHG20 is overexpressed in LSCC and promotes cell proliferation, migration, and invasion in LSCC cells through the miR-342-3p/MTDH axis.
Article
Cell Biology
Pengyu Ren, Xiaorong Niu, Ruimin Zhao, Junsong Liu, Wanli Ren, Hao Dai, Jiayu Chen, Jinfeng Yan, Baiya Li, Yuan Shao, Yanxia Bai, Peng Han
Summary: This study found that the overexpression of AGAP2-AS1 is associated with cell proliferation and invasion in laryngeal squamous cell carcinoma. AGAP2-AS1 functions through regulating the miR-193a-3p/LOXL4 axis.
Article
Biochemistry & Molecular Biology
Yun Li, Bingjie Tang, Kexing Lyu, Huijun Yue, Fanqin Wei, Yang Xu, Siyu Chen, Yu Lin, Zhimou Cai, Xueqin Guo, Chunwei Li, Wenbin Lei
Summary: The study suggests that low expression of lncRNA SBF2-AS1 is associated with poor prognosis in patients with laryngeal squamous cell carcinoma, as it promotes metastasis and epithelial-mesenchymal transition of LSCC cells. SBF2-AS1 acts as a competing endogenous RNA to upregulate TGFBR2 expression by sponging miR-302b-3p, indicating its potential as a prognostic biomarker and therapeutic target for LSCC.
MOLECULAR CARCINOGENESIS
(2022)
Article
Biotechnology & Applied Microbiology
Yu Shuang, Jing Liu, Juntao Niu, Wenyu Guo, Chao Li
Summary: Abnormal expression of the novel circRNA circPPFIA1 was found to promote the progression of laryngeal squamous cell carcinoma (LSCC) by enhancing cell proliferation, migration, and invasion. This effect was mediated through the miR-340-3p/ELK1 signaling axis, highlighting circPPFIA1 as a potential prognostic or therapeutic target for LSCC.
Article
Biochemistry & Molecular Biology
Yunpeng Sun, Xue Shan, Jiantao Guo, Xuguang Liu, Dashi Ma
Summary: Abnormal levels of CHI3L1 and lnc TUG1 are closely associated with the progression of myocardial fibrosis. This study investigated the role of CHI3L1 in regulating myocardial fibrosis and found that CHI3L1 upregulates the expression of lnc TUG1. The interaction between lnc TUG1 and miR-495-3p/ETS1 axis was also examined.
Article
Cell Biology
Kang Wang, Qing Luo, Yingfeng Zhang, Xin Xie, Wenhao Cheng, Qiunan Yao, Yingying Chen, Hong Ren, Jiuping Li, Zuanqin Pan
Summary: This study investigated the functions and potential molecular mechanism of LINC01296 in the progression of cutaneous malignant melanoma (CMM) through the regulation of the miR-324-3p/MAPK1 axis. The up-regulation of LINC01296 was found in CMM tissues and cell lines, and its over-expression promoted cell proliferation in CMM cell lines. Further investigations revealed that LINC01296 interacted with miR-324-3p and that MAPK1 was the target mRNA of miR-324-3p. Rescue experiments suggested a positive regulatory association between LINC01296 and MAPK1 in CMM cells.
Article
Biotechnology & Applied Microbiology
Xiaoxu Liu, Jing Wu, Bo Yang, Yuanyuan Zhao, Yafan Wang, Shuhong Pan, Suibing Miao, Xiaohua Wu
Summary: This study found that the hsa_circ_0005991/miR-30b-3p/Cdc42EP1 axis promotes the epithelial-mesenchymal transition process in endometriosis, providing a theoretical basis for the mechanism exploration and therapy of this disease.
Article
Biochemistry & Molecular Biology
Hao Li, Di Wang, Bolong Yi, Heng Cai, Yipeng Wang, Xin Lou, Zhuo Xi, Zhen Li
Summary: This study identified the SUMOylation of IGF2BP2 in regulating the OIP5-AS1/miR-495-3p axis to promote VM formation in glioma cells and xenograft growth in nude mice, offering a new perspective for molecular targeted therapy of glioma.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Orthopedics
Yumei Bai, Yanghua Li, Juan Bai, Yumei Zhang
Summary: This study revealed that hsa_circ_0004674 facilitated the doxorubicin (DXR) resistance of osteosarcoma (OS) through regulating the miR-342-3p/FBN1 axis, suggesting that hsa_circ_0004674 could be a promising target for OS chemoresistance.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Cell Biology
Daqing Fan, Youhua Zhu
Summary: The aim of this study was to investigate the role and mechanism of circular RNA 0120175 (circ_0120175) in the development of laryngeal squamous cell carcinoma (LSCC). The study found that circ_0120175 abundance was increased in LSCC and was associated with advanced tumor staging, lymph node metastasis, and poor prognosis. Circ_0120175 acted as a sponge for miR-330-3p and increased the expression of SLC7A11, promoting cell proliferation, migration, and invasion while inhibiting apoptosis in LSCC cells.
JOURNAL OF MOLECULAR HISTOLOGY
(2022)
Article
Cell Biology
Zhen Li, Zhiqiang Lang, Ting Wang, Guimei Qu, Wu Sui, Jing Liu
Summary: This study evaluated the role of lncRNA SNHG22 in the progression of gastric cancer. It was found that SNHG22 promotes the proliferation, migration, and invasion of gastric cancer cells via the miR-101-3p/E2F2 axis and may serve as a potential prognostic indicator in gastric cancer.
Article
Oncology
Qi Yu, Xinxing Li, Tianda Feng
Summary: The study revealed that GLIDR is highly expressed in glioma cells and affects cell proliferation and apoptosis by targeting miR-4677-3p to regulate the expression of MAGI2. This finding provides a new perspective for the treatment of glioma.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Oncology
Hao Xu, Xin Miao, Xin Li, Haofei Chen, Bo Zhang, Wence Zhou
Summary: This study revealed the role of SNHG16 in pancreatic cancer, where it promotes the progression of cancer by regulating the miR-302b-3p/SLC2A4 axis. Knockdown of SNHG16 can reduce the proliferation, invasion, and migration abilities of tumor cells.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Zhengmao Li, Yong Fu, Wei Ouyang, Min He, Yu Wang, Xin Wang, Wenfu Tan
Summary: This study reveals that circ_0016347 contributes to the progression of osteosarcoma through the modulation of the miR-1225-3p/KCNH1 axis. This suggests that circ_0016347 may serve as a promising biomarker for osteosarcoma therapy.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2023)
Article
Biotechnology & Applied Microbiology
Li-Na You, Qin-Wen Tai, Lin Xu, Yi Hao, Wen-Jia Guo, Qiao Zhang, Qing Tong, Heng Zhang, Wu-Kui Huang
Summary: The study found that exosome-carried LINC00161 promotes HCC tumorigenesis by inhibiting miR-590-3p to activate the ROCK2 signaling pathway, suggesting that LINC00161 may be used as potential targets to improve HCC treatment efficiency.
CANCER GENE THERAPY
(2021)