Alternative Splicing: A Key Mediator of Diabetic Vasculopathy

Two RECK Splice Variants (Long and Short) Are Differentially Expressed in Patients with Stable and Unstable Coronary Artery Disease: A Pilot Study

(2021) Chiara Vancheri et al.   Genes

Bifunctional small molecule-oligonucleotide hybrid as microRNA inhibitor

(2020) Umesh Bhattarai et al.   BIOORGANIC & MEDICINAL CHEMISTRY

An exon skipping screen identifies antitumor drugs that are potent modulators of pre-mRNA splicing, suggesting new therapeutic applications

(2020) Yihui Shi et al.   PLoS One

Targeting QKI-7 in vivo restores endothelial cell function in diabetes

(2020) Chunbo Yang et al.   Nature Communications

VEGF-A splice variants bind VEGFRs with differential affinities

(2020) Spencer B. Mamer et al.   Scientific Reports

Targeting alternative splicing by RNAi: from the differential impact on splice variants to triggering artificial pre-mRNA splicing

(2020) Armin Fuchs et al.   NUCLEIC ACIDS RESEARCH

Diabetic endotheliopathy: RNA-binding proteins as new therapeutic targets

(2020) Victoria A. Cornelius et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Alternative Splicing in Angiogenesis

(2019) Elizabeth Bowler et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The RNA binding protein QKI controls alternative splicing as a model of vascular therapies

(2019) Rachel Caines et al.   JOURNAL OF CELL SCIENCE

N-glycosylation-defective splice variants of neuropilin-1 promote metastasis by activating endosomal signals

(2019) Xiuping Huang et al.   Nature Communications

Human iPSCs-Derived Endothelial Cells with Mutation in HNF1A as a Model of Maturity-Onset Diabetes of the Young

(2019) Kachamakova-Trojanowska et al.   Cells

Positive and Negative Regulation of Angiogenesis by Soluble Vascular Endothelial Growth Factor Receptor-1

(2018) Cristina Failla et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Association between the expression of vascular endothelial growth factors and metabolic syndrome or its components: a systematic review and meta-analysis

(2018) Mohammad Ishraq Zafar et al.   Diabetology & Metabolic Syndrome

Role of alternative splicing of VEGF-A in the development of atherosclerosis

(2018) Naishi Zhao et al.   Aging-US

The Different Effects of VEGFA121 and VEGFA165 on Regulating Angiogenesis Depend on Phosphorylation Sites of VEGFR2

(2017) Wang Shiying et al.   INFLAMMATORY BOWEL DISEASES

Abnormalities in alternative splicing in diabetes: therapeutic targets

(2017) Zodwa Dlamini et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Quaking Is a Key Regulator of Endothelial Cell Differentiation, Neovascularization, and Angiogenesis

(2017) Amy Cochrane et al.   STEM CELLS

Macro- and microvascular endothelial dysfunction in diabetes

(2017) Yi Shi et al.   Journal of Diabetes

Angiogenesis in the atherosclerotic plaque

(2017) Caroline Camaré et al.   Redox Biology

Distinctive role of vasohibin-1A and its splicing variant vasohibin-1B in tumor angiogenesis

(2016) S Horie et al.   CANCER GENE THERAPY

Evidence for Pro-angiogenic Functions of VEGF-Ax

(2016) Hong Xin et al.   CELL

Structure-function studies ofHNF1A(MODY3) gene mutations in South Indian patients with monogenic diabetes

(2016) K. Balamurugan et al.   CLINICAL GENETICS

Altered ratios of pro- and anti-angiogenic VEGF-A variants and pericyte expression of DLL4 disrupt vascular maturation in infantile haemangioma

(2016) Xi Ye et al.   JOURNAL OF PATHOLOGY

Splice-switching antisense oligonucleotides as therapeutic drugs

(2016) Mallory A. Havens et al.   NUCLEIC ACIDS RESEARCH

A Novel Physiological Glycosaminoglycan-Deficient Splice Variant of Neuropilin-1 Is Anti-Tumorigenic In Vitro and In Vivo

(2016) Céline Hendricks et al.   PLoS One

The RNA-binding protein quaking maintains endothelial barrier function and affects VE-cadherin and β-catenin protein expression

(2016) Ruben G. de Bruin et al.   Scientific Reports

mRNAtrans -splicing in gene therapy for genetic diseases

(2016) Adeline Berger et al.   Wiley Interdisciplinary Reviews-RNA

Expression Profiling of Genes Related to Endothelial Cells Biology in Patients with Type 2 Diabetes and Patients with Prediabetes

(2016) Sara Moradipoor et al.   Biomed Research International

Lack of Fibronectin Extra Domain A Alternative Splicing Exacerbates Endothelial Dysfunction in Diabetes

(2016) Gianluca Gortan Cappellari et al.   Scientific Reports

Endothelial Cell Metabolism in Normal and Diseased Vasculature

(2015) Guy Eelen et al.   CIRCULATION RESEARCH

Structural Basis for VEGF-C Binding to Neuropilin-2 and Sequestration by a Soluble Splice Form

(2015) Matthew W. Parker et al.   STRUCTURE

The alternative splicing factor Nova2 regulates vascular development and lumen formation

(2015) Costanza Giampietro et al.   Nature Communications

Alternatively Spliced Tissue Factor Promotes Plaque Angiogenesis Through the Activation of Hypoxia-Inducible Factor-1α and Vascular Endothelial Growth Factor Signaling

(2014) Chiara Giannarelli et al.   CIRCULATION

Antiangiogenic Actions of Vascular Endothelial Growth Factor-A 165 b, an Inhibitory Isoform of Vascular Endothelial Growth Factor-A, in Human Obesity

(2014) Doan T.M. Ngo et al.   CIRCULATION

Vascular Endothelial Growth Factor-A165b Is Protective and Restores Endothelial Glycocalyx in Diabetic Nephropathy

(2014) S. Oltean et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

An antiangiogenic isoform of VEGF-A contributes to impaired vascularization in peripheral artery disease

(2014) Ryosuke Kikuchi et al.   NATURE MEDICINE

VEGF-A165b Is an Endogenous Neuroprotective Splice Isoform of Vascular Endothelial Growth Factor A in Vivo and in Vitro

(2013) Nicholas Beazley-Long et al.   AMERICAN JOURNAL OF PATHOLOGY

Endothelial dysfunction — A major mediator of diabetic vascular disease

(2013) Cristina M. Sena et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Structure-function studies of STAR family Quaking proteins bound to their in vivo RNA target sites

(2013) M. Teplova et al.   GENES & DEVELOPMENT

Hypo- and Hyperglycemia Impair Endothelial Cell Actin Alignment and Nitric Oxide Synthase Activation in Response to Shear Stress

(2013) Steven Frank Kemeny et al.   PLoS One

MicroRNA-214 inhibits angiogenesis by targeting Quaking and reducing angiogenic growth factor release

(2012) Alain van Mil et al.   CARDIOVASCULAR RESEARCH

Hyperglycemia and oxidative stress in cultured endothelial cells – a comparison of primary endothelial cells with an immortalized endothelial cell line

(2012) Susanne Karbach et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Splicing Factor Polymorphisms, the Control of VEGF Isoforms and Association with Angiogenic Eye Disease

(2011) J. G. Carter et al.   CURRENT EYE RESEARCH

Vascular Endothelial Growth Factor (VEGF) in the Pathogenesis of Diabetic Nephropathy of Type 1 Diabetes Mellitus

(2010) Maria Mironidou-Tzouveleki et al.   CURRENT DRUG TARGETS

Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress

(2010) O. Brouwers et al.   DIABETOLOGIA

Cardiovascular risk in women with diabetes

(2010) A.A. Rivellese et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches

(2009) Mo Chen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Pathology of Atherosclerosis: Plaque Development and Plaque Responses to Medical Treatment

(2008) William Insull   AMERICAN JOURNAL OF MEDICINE

Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors

(2008) D. G. Nowak et al.   JOURNAL OF CELL SCIENCE

Diabetes Reduces Aortic Endothelial Gap Junctions in ApoE-deficient Mice: Simvastatin Exacerbates the Reduction

(2008) Charles Jia-Yin Hou et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Neurovascular signalling defects in neurodegeneration

(2008) Serena Zacchigna et al.   NATURE REVIEWS NEUROSCIENCE