Magnoflorine Alleviates “M1” Polarized Macrophage-Induced Intervertebral Disc Degeneration Through Repressing the HMGB1/Myd88/NF-κB Pathway and NLRP3 Inflammasome

Morin attenuates pyroptosis of nucleus pulposus cells and ameliorates intervertebral disc degeneration via inhibition of the TXNIP/NLRP3/Caspase-1/IL-1β signaling pathway

(2021) Yifan Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Re-exposure to alarmin HMGB1 and cytokine IL-1 beta induces differential innate immune response generation in mouse brain

(2021) Sudeshna Das et al.   JOURNAL OF NEUROIMMUNOLOGY

Phillyrin protects mice from traumatic brain injury by inhibiting the inflammation of microglia via PPARγ signaling pathway

(2020) Qian Jiang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Advances in Chemistry and Bioactivity of Magnoflorine and Magnoflorine-Containing Extracts

(2020) Estera Okon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Magnoflorine: A review of its pharmacology, pharmacokinetics and toxicity

(2020) Tong Xu et al.   PHARMACOLOGICAL RESEARCH

Neuroprotective Effects of Ethyl Pyruvate against Aluminum Chloride-Induced Alzheimer’s Disease in Rats via Inhibiting Toll-Like Receptor 4

(2020) Vijaya Durga Chavali et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Magnoflorine Suppresses MAPK and NF-κB Signaling to Prevent Inflammatory Osteolysis Induced by Titanium Particles In Vivo and Osteoclastogenesis via RANKL In Vitro

(2020) Zhenyu Sun et al.   Frontiers in Pharmacology

Targeting Inflammation Driven by HMGB1

(2020) Huan Yang et al.   Frontiers in Immunology

Inhibition of phosphodiesterase-4 suppresses HMGB1/RAGE signaling pathway and NLRP3 inflammasome activation in mice exposed to chronic unpredictable mild stress

(2020) Jinfeng Xie et al.   BRAIN BEHAVIOR AND IMMUNITY

Resveratrol inhibits IL-1β-mediated nucleus pulposus cell apoptosis through regulating the PI3K/Akt pathway

(2019) Yanhai Jiang et al.   BIOSCIENCE REPORTS

Melatonin modulates IL-1β-induced extracellular matrix remodeling in human nucleus pulposus cells and attenuates rat intervertebral disc degeneration and inflammation

(2019) Yan Zhang et al.   Aging-US

MIR-140-5p affects chondrocyte proliferation, apoptosis, and inflammation by targeting HMGB1 in osteoarthritis

(2019) Yingjie Wang et al.   INFLAMMATION RESEARCH

Magnoflorine improves sensitivity to doxorubicin (DOX) of breast cancer cells via inducing apoptosis and autophagy through AKT/mTOR and p38 signaling pathways

(2019) Tian Wei et al.   BIOMEDICINE & PHARMACOTHERAPY

HMGB1 was negatively regulated by HSF1 and mediated the TLR4/MyD88/NF-κB signal pathway in asthma

(2019) Liqun Shang et al.   LIFE SCIENCES

Restoration of Autophagic Flux Rescues Oxidative Damage and Mitochondrial Dysfunction to Protect against Intervertebral Disc Degeneration

(2019) Liang Kang et al.   Oxidative Medicine and Cellular Longevity

Paeonol attenuates inflammation by targeting HMGB1 through upregulating miR-339-5p

(2019) Liyan Mei et al.   Scientific Reports

Extracellular HMGB1 as a therapeutic target in inflammatory diseases

(2018) Ulf Andersson et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Anti-HMGB1 Neutralizing Antibody Attenuates Periodontal Inflammation and Bone Resorption in a Murine Periodontitis Model

(2018) Chiaki Yoshihara-Hirata et al.   INFECTION AND IMMUNITY

Accumulation and localization of macrophage phenotypes with human intervertebral disc degeneration

(2018) Kenneth R. Nakazawa et al.   Spine Journal

MicroRNA-27a alleviates LPS-induced acute lung injury in mice via inhibiting inflammation and apoptosis through modulating TLR4/MyD88/NF-κB pathway

(2018) MinJie Ju et al.   CELL CYCLE

Magnoflorine Ameliorates Lipopolysaccharide-Induced Acute Lung Injury via Suppressing NF-κB and MAPK Activation

(2018) Shuai Guo et al.   Frontiers in Pharmacology

Antifungal activity of magnoflorine against Candida strains

(2018) Jaegoo Kim et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Macrophage heterogeneity and energy metabolism

(2017) Francisco Verdeguer et al.   EXPERIMENTAL CELL RESEARCH

IL-1 /HMGB1 signalling promotes the inflammatory cytokines release via TLR signalling in human intervertebral disc cells

(2016) F. Fang et al.   BIOSCIENCE REPORTS

Aging and age related stresses: a senescence mechanism of intervertebral disc degeneration

(2016) F. Wang et al.   OSTEOARTHRITIS AND CARTILAGE

Integrating immunometabolism and macrophage diversity

(2016) Maxim N. Artyomov et al.   SEMINARS IN IMMUNOLOGY

MiRNA-Mediated Macrophage Polarization and its Potential Role in the Regulation of Inflammatory Response

(2016) Kobina Essandoh et al.   SHOCK

Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome

(2015) Yiqing Yan et al.   CELL

NLRP3 at the interface of metabolism and inflammation

(2015) Moritz Haneklaus et al.   IMMUNOLOGICAL REVIEWS

HMGB1 promotes the activation of NLRP3 and caspase-8 inflammasomes via NF-κB pathway in acute glaucoma

(2015) Wei Chi et al.   Journal of Neuroinflammation

Mechanics and biology in intervertebral disc degeneration: a vicious circle

(2015) P.-P.A. Vergroesen et al.   OSTEOARTHRITIS AND CARTILAGE

THP-1 cell line: An in vitro cell model for immune modulation approach

(2014) Wasaporn Chanput et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Role of cytokines in intervertebral disc degeneration: pain and disc content

(2013) Makarand V. Risbud et al.   Nature Reviews Rheumatology

Toll-Like Receptor 4 (TLR4) Expression and Stimulation in a Model of Intervertebral Disc Inflammation and Degeneration

(2012) Neena E. Rajan et al.   SPINE

Characterization of polarized THP-1 macrophages and polarizing ability of LPS and food compounds

(2012) Wasaporn Chanput et al.   Food & Function

The use of THP-1 cells as a model for mimicking the function and regulation of monocytes and macrophages in the vasculature

(2011) Zhenyu Qin   ATHEROSCLEROSIS

Transcription profiles of LPS-stimulated THP-1 monocytes and macrophages: a tool to study inflammation modulating effects of food-derived compounds

(2010) Wasaporn Chanput et al.   Food & Function

The Nuclear Factor NF- B Pathway in Inflammation

(2009) T. Lawrence   Cold Spring Harbor Perspectives in Biology

Intervertebral Disc: Anatomy-Physiology-Pathophysiology-Treatment

(2008) P. Prithvi Raj   Pain Practice